Long-term hypothermia reduces infarct volume in aged rats after focal ischemia

Neuroscience Letters

Volumn 438, Issue 2, 2008, Pages 180-185

  Florian, Baltromejus ^a   Vintilescu, Raluca ^a,c   Balseanu, Adrian Tudor ^a,c   Buga, Ana Maria ^a,c   Grisk, Olaf ^a   Walker, Lary C ^b   Kessler, Christof ^a   Popa Wagner, Aurel ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MEDICINE AND PHARMACY OF CRAIOVA   (Romania)

Author keywords

Aging; Hypothermia; Ischemia; Rat; Stroke; Therapy

Indexed keywords

CASPASE 12; GLUCOSE REGULATED PROTEIN 78; HYDROGEN SULFIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA;

AGING; AIR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; GENETIC TRANSCRIPTION; HYPOTHERMIA; INFLAMMATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROLOGIC DISEASE; NEUROPHYSIOLOGY; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT; SENSORIMOTOR FUNCTION; SPRAGUE DAWLEY RAT; STROKE;

AGING; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BODY TEMPERATURE; BRAIN; BRAIN INFARCTION; BRAIN ISCHEMIA; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; ENCEPHALITIS; HYDROGEN SULFIDE; HYPOTHERMIA, INDUCED; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMATION MEDIATORS; MALE; MOVEMENT DISORDERS; OXIDATIVE PHOSPHORYLATION; OXIDATIVE PHOSPHORYLATION COUPLING FACTORS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 43849083902     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.04.020     Document Type: Article

References (27)

1. Anuar F., Whiteman M., Siau J.L., Kwong S.E., Bhatia M., and Moore. Nitric oxide-releasing flurbiprofen reduces formation of proinflammatory hydrogen sulfide in lipopolysaccharide-treated rat. Br. J. Pharmacol. 147 (2006) 966-974
2. Badan I., Buchhold B., Hamm A., Gratz M., Walker L.C., Platt D., Kessler Ch., and Popa-Wagner A. Accelerated glial reactivity to stroke in aged rats correlates with reduced functional recovery. J. Cereb. Blood Flow Metab. 23 (2003) 845-854
3. Barnett H.J. Stroke prevention in the elderly. Clin. Exp. Hypertens. 24 (2002) 563-571
4. 2S induces a suspended animation-like state in mice. Science 308 (2005) 518
5. Cezary W., and Di Napoli M. Ubiquitin-Proteasome system and proteasome inhibition: new strategies in stroke therapy. Stroke 35 (2004) 1506-1518
6. De Georgia M.A., Krieger D.W., Abou-Chebl A., Devlin T.G., Jauss M., Davis S.M., Koroshetz W.J., Rordorf G., and Warach S. Cooling for acute ischemic brain damage (COOL AID): a feasibility trial of endovascular cooling. Neurology 63 (2004) 312-317
7. Den Hertog H., van der Worp B., van Gemert M., and Dippel D. Therapeutic hypothermia in acute ischemic stroke. Expert Rev. Neurother. 7 (2007) 155-164
8. Dirnagl U. Bench to bedside: the quest for quality in experimental stroke research. J. Cereb. Blood Flow Metab. 26 (2006) 1465-1478
9. Dorman D.C., Struve M.F., Gross E.A., and Brenneman K.A. Respiratory tract toxicity of inhaled hydrogen sulfide in Fischer-344 rats, Sprague-Dawley rats, and B6C3F1 mice following subchronic (90-day) exposure. Toxicol. Appl. Pharmacol. 198 (2004) 29-39
10. Elrod J.W., Calvert J.W., Morrison J., Doeller J.E., Kraus D.W., Tao L., Jiao X., Scalia R., Kiss L., Szabo C., Kimura H., Chow C.W., and Lefer D.J. Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 15560-15565
11. Hotchkiss S.R., and Nicholson D.W. Apoptosis and caspases regulate death and inflammation in sepsis. Nat. Rev. Immunol. 6 (2006) 813-822
12. Kollmar R., Blank T., Han J.L., Georgiadis D., and Schwab S. Different degrees of hypothermia after experimental stroke. Short- and long-term outcome. Stroke 38 (2007) 1585-1589
13. Lees K.R., Zivin J.A., Ashwood T., Davalos A., Davis S.M., Diener H.C., Grotta J., Lyden P., Shuaib A., Hardemark H.G., and Wasiewski W.W. Stroke-Acute Ischemic NXY Treatment (SAINT I). Trial Investigators NXY-059 for acute ischemic stroke. N. Engl. J. Med. 354 (2006) 588-600
14. Li J., Zhang G., Cai S., and Redington A.N. Effect of inhaled hydrogen sulfide on metabolic responses in anesthetized, paralyzed, and mechanically ventilated piglets. Pediatr. Crit. Care Med. 9 (2008) 110-112
15. Lindner M.D., Gribkoff V.K., Donlan N.A., and Jones T.A. Long-lasting functional disabilities in middle-aged rats with small cerebral infarcts. J. Neurosci. 23 (2003) 10913-10922
16. Lou L.X., Geng B., Du J.B., and Tang C.S. Hydrogen sulphide-induced hypothermia attenuates stress-related ulceration in rats. Clin. Exp. Pharmacol. Physiol. 35 (2008) 223-228
17. Luan X., Li J., McAllister J.P., Diaz F.G., Clark J.C., Fessler R.D., and Ding Y. Regional brain cooling induced by vascular saline infusion into ischemic territory reduces brain inflammation in stroke. Acta Neuropathol. (Berl.) 107 (2004) 227-234
18. Markus T.M., Tsai S.Y., Bollnow M.R., Farrer R.G., O'Brien T.E., Kindler-Baumann D.R., Rausch M., Rudin M., Wiessner C., Mir A.K., Schwab M.E., and Kartje G.L. Recovery and brain reorganization after stroke in adult and aged rats. Ann. Neurol. 58 (2005) 950-953
19. Martinon F., and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 117 (2004) 561-574
20. Miyazawa T., Tamura A., Fukui S., and Hossmann K.A. Effect of mild hypothermia on focal cerebral ischemia. Rev. Exp. Stud. Neurol. Res. 25 (2003) 457-464
21. 2S preconditioning-induced PKC activation regulates intracellular calcium handling in rat cardiomyocytes. Am. J. Physiol. Cell Physiol. 294 (2008) 169-177
22. Popa-Wagner A., Schroder E., Schmoll H., Walker L.C., and Kessler C. Upregulation of MAP1B and MAP2 in the rat brain after middle cerebral artery occlusion: effect of age. J. Cereb. Blood Flow Metab. 19 (1999) 425-434
23. Sacco R.L., Chong J.Y., Prabhakaran S., and Elkind M.S. Experimental treatments for acute ischaemic stroke. Lancet 369 (2007) 331-341
24. Schwab S., Schwarz S., Spranger M., Keller E., Bertram M., and Hacke W. Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction. Stroke 29 (1998) 2461-2466
25. Sivarajah A., McDonald M.C., and Thiemermann C. The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the rat. Shock 26 (2006) 154-161
26. Zhang Z., Huang H., Liu P., Tang C., and Wang J. Hydrogen sulfide contributes to cardioprotection during ischemia-reperfusion injury by opening K ATP channels. Can. J. Physiol. Pharmacol. 85 (2007) 1248-1253
27. Zhu Y.Z., Wang Z.J., Ho P., Loke Y.Y., Zho Y.C., Huang S.H., Than C.S., Witheman M., LU J., and Moore P. Hydrogen sulfide and its possible roles in myocardial ischemia in experimental rats. J. Appl. Physiol. 102 (2007) 261-268