메뉴 건너뛰기




Volumn 295, Issue 2, 2004, Pages 469-487

Human neuroblastoma cells exposed to hypoxia: Induction of genes associated with growth, survival, and aggressive behavior

Author keywords

Dedifferentiation; Differentiation; Hypoxia; Microarray; Neuroblastoma; Survival; Tumor

Indexed keywords

ADRENOMEDULLIN; GLUCOSE; INHIBITOR OF DIFFERENTIATION 2; IRON; METALLOTHIONEIN; MULTIDRUG RESISTANCE PROTEIN 1; NEUROPILIN 1; SECRETOGRANIN II; SECRETONEURIN; SOMATOMEDIN B; TRANSCRIPTION FACTOR; VASCULOTROPIN;

EID: 1842861743     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2004.01.013     Document Type: Article
Times cited : (107)

References (89)
  • 1
    • 0034176782 scopus 로고    scopus 로고
    • Exploiting the hypoxic cancer cell: Mechanisms and therapeutic strategies
    • Brown J.M. Exploiting the hypoxic cancer cell: mechanisms and therapeutic strategies. Mol. Med. Today. 6:2000;157-162.
    • (2000) Mol. Med. Today , vol.6 , pp. 157-162
    • Brown, J.M.1
  • 2
    • 0035677961 scopus 로고    scopus 로고
    • Treatment resistance of solid tumors
    • Vaupel P., Thews O., Hoeckel M. Treatment resistance of solid tumors. Med. Oncol. 18:2001;243-259.
    • (2001) Med. Oncol. , vol.18 , pp. 243-259
    • Vaupel, P.1    Thews, O.2    Hoeckel, M.3
  • 5
    • 0029753768 scopus 로고    scopus 로고
    • Genetic instability induced by the tumor microenvironment
    • Reynolds T.Y., Rockwell S., Glazer P.M. Genetic instability induced by the tumor microenvironment. Cancer Res. 56:1996;5754-5757.
    • (1996) Cancer Res. , vol.56 , pp. 5754-5757
    • Reynolds, T.Y.1    Rockwell, S.2    Glazer, P.M.3
  • 7
    • 0029061588 scopus 로고
    • Biochemical evidence for a mature phenotype in morphologically poorly differentiated neuroblastomas with a favourable outcome
    • Hedborg F., Bjelfman C., Sparen P., Sandstedt B., Påhlman S. Biochemical evidence for a mature phenotype in morphologically poorly differentiated neuroblastomas with a favourable outcome. Eur. J. Cancer. 4:1995;435-443.
    • (1995) Eur. J. Cancer , vol.4 , pp. 435-443
    • Hedborg, F.1    Bjelfman, C.2    Sparen, P.3    Sandstedt, B.4    Påhlman, S.5
  • 9
    • 0025107309 scopus 로고
    • Expression of the neuronal form of pp60c-src in neuroblastoma in relation to clinical stage and prognosis
    • Bjelfman C., Hedborg F., Johansson I., Nordenskjöld M., Påhlman S. Expression of the neuronal form of pp60c-src in neuroblastoma in relation to clinical stage and prognosis. Cancer Res. 50:1990;6908-6914.
    • (1990) Cancer Res. , vol.50 , pp. 6908-6914
    • Bjelfman, C.1    Hedborg, F.2    Johansson, I.3    Nordenskjöld, M.4    Påhlman, S.5
  • 11
    • 0029852033 scopus 로고    scopus 로고
    • A developmental model of neuroblastoma: Differentiating stroma-poor tumors' progress along an extra-adrenal chromaffin lineage
    • Hoehner J.C., Gestblom C., Hedborg F., Sandstedt B., Olsen L., Påhlman S. A developmental model of neuroblastoma: differentiating stroma-poor tumors' progress along an extra-adrenal chromaffin lineage. Lab. Invest. 75:1996;659-675.
    • (1996) Lab. Invest. , vol.75 , pp. 659-675
    • Hoehner, J.C.1    Gestblom, C.2    Hedborg, F.3    Sandstedt, B.4    Olsen, L.5    Påhlman, S.6
  • 12
    • 0031022022 scopus 로고    scopus 로고
    • In vivo spontaneous neuronal to neuroendocrine lineage conversion in a subset of neuroblastomas
    • Gestblom C., Hoehner J.C., Hedborg F., Sandstedt B., Påhlman S. In vivo spontaneous neuronal to neuroendocrine lineage conversion in a subset of neuroblastomas. Am. J. Pathol. 150:1997;107-117.
    • (1997) Am. J. Pathol. , vol.150 , pp. 107-117
    • Gestblom, C.1    Hoehner, J.C.2    Hedborg, F.3    Sandstedt, B.4    Påhlman, S.5
  • 13
    • 0002524903 scopus 로고    scopus 로고
    • Development of the neural crest and sympathetic nervous system
    • G.M. Brodeur, T. Sawada, Y. Tsuchida, & P.A. Voute. Amsterdam: Elsevier
    • Påhlman S., Hedborg F. Development of the neural crest and sympathetic nervous system. Brodeur G.M., Sawada T., Tsuchida Y., Voute P.A. Neuroblastoma. 2000;Elsevier, Amsterdam.
    • (2000) Neuroblastoma
    • Påhlman, S.1    Hedborg, F.2
  • 14
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang G.L., Jiang B.H., Rue E.A., Semenza G.L. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. U. S. A. 92:1995;5510-5514.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 15
    • 0032213236 scopus 로고    scopus 로고
    • The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
    • Tian H., Hammer R.E., Matsumoto A.M., Russell D.W., McKnight S.L. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev. 12:1998;3320-3324.
    • (1998) Genes Dev. , vol.12 , pp. 3320-3324
    • Tian, H.1    Hammer, R.E.2    Matsumoto, A.M.3    Russell, D.W.4    McKnight, S.L.5
  • 17
    • 0031000736 scopus 로고    scopus 로고
    • A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development
    • Ema M., Taya S., Yokotani N., Sogawa K., Matsuda Y., Fujii-Kuriyama Y. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc. Natl. Acad. Sci. U. S. A. 94:1997;4273-4278.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 4273-4278
    • Ema, M.1    Taya, S.2    Yokotani, N.3    Sogawa, K.4    Matsuda, Y.5    Fujii-Kuriyama, Y.6
  • 18
    • 0033118983 scopus 로고    scopus 로고
    • Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: Their stabilization and redox signal-induced interaction with CBP/p300
    • Ema M., Hirota K., Mimura J., Abe H., Yodoi J., Sogawa K., Poellinger L., Fujii-Kuriyama Y. Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO J. 18:1999;1905-1914.
    • (1999) EMBO J. , vol.18 , pp. 1905-1914
    • Ema, M.1    Hirota, K.2    Mimura, J.3    Abe, H.4    Yodoi, J.5    Sogawa, K.6    Poellinger, L.7    Fujii-Kuriyama, Y.8
  • 21
    • 0034307432 scopus 로고    scopus 로고
    • Culture in reduced levels of oxygen promotes clonogenic sympathoadrenal differentiation by isolated neural crest stem cells
    • Morrison S.J., Csete M., Groves A.K., Melega W., Wold B., Anderson D.J. Culture in reduced levels of oxygen promotes clonogenic sympathoadrenal differentiation by isolated neural crest stem cells. J. Neurosci. 20:2000;7370-7376.
    • (2000) J. Neurosci. , vol.20 , pp. 7370-7376
    • Morrison, S.J.1    Csete, M.2    Groves, A.K.3    Melega, W.4    Wold, B.5    Anderson, D.J.6
  • 22
    • 0036198010 scopus 로고    scopus 로고
    • Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: A mechanism for regulation of adipogenesis by hypoxia
    • Yun Z., Maecker H.L., Johnson R.S., Giaccia A.J. Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Dev. Cell Biol. 2:2002;331-341.
    • (2002) Dev. Cell Biol. , vol.2 , pp. 331-341
    • Yun, Z.1    Maecker, H.L.2    Johnson, R.S.3    Giaccia, A.J.4
  • 23
    • 0037099005 scopus 로고    scopus 로고
    • BioArray software environment: A platform for comprehensive management and analysis of microarray data
    • (SOFTWARE0003)
    • Saal L.H., Troein J., Vallon-Christersson J., Gruvberger S., Borg Å., Peterson C. BioArray software environment: a platform for comprehensive management and analysis of microarray data. Genome Biol. 3:2002;1-6. (SOFTWARE0003).
    • (2002) Genome Biol. , vol.3 , pp. 1-6
    • Saal, L.H.1    Troein, J.2    Vallon-Christersson, J.3    Gruvberger, S.4    Borg, Å.5    Peterson, C.6
  • 24
    • 1342294092 scopus 로고    scopus 로고
    • Normalization for cDNA microarray data: A robust composite method addressing single and multiple slide systematic variation
    • Yang Y.H., Dudoit S., Luu P., Lin D.M., Peng V., Ngai J., Speed T.P. Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res. 15:2002;e15.
    • (2002) Nucleic Acids Res. , vol.15 , pp. 15
    • Yang, Y.H.1    Dudoit, S.2    Luu, P.3    Lin, D.M.4    Peng, V.5    Ngai, J.6    Speed, T.P.7
  • 25
    • 0036534582 scopus 로고    scopus 로고
    • Elimination of primer-dimer artifacts and genomic coamplification using a two-step SYBR green I real-time RT-PCR
    • Vandesompele J., De Paepe A., Speleman F. Elimination of primer-dimer artifacts and genomic coamplification using a two-step SYBR green I real-time RT-PCR. Anal. Biochem. 303:2002;95-98.
    • (2002) Anal. Biochem. , vol.303 , pp. 95-98
    • Vandesompele, J.1    De Paepe, A.2    Speleman, F.3
  • 27
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • (RESEARCH0034)
    • Vandesompele J., De Preter K., Pattyn F., Poppe B., Van Roy N., De Paepe A., Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 3:2002;1-12. (RESEARCH0034).
    • (2002) Genome Biol. , vol.3 , pp. 1-12
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3    Poppe, B.4    Van Roy, N.5    De Paepe, A.6    Speleman, F.7
  • 29
    • 0035132847 scopus 로고    scopus 로고
    • Evidence for the development of p53 mutations after cytotoxic therapy in a neuroblastoma cell line
    • Tweddle D.A., Malcolm A.J., Bown N., Pearson A.D., Lunec J. Evidence for the development of p53 mutations after cytotoxic therapy in a neuroblastoma cell line. Cancer Res. 61:2001;8-13.
    • (2001) Cancer Res. , vol.61 , pp. 8-13
    • Tweddle, D.A.1    Malcolm, A.J.2    Bown, N.3    Pearson, A.D.4    Lunec, J.5
  • 31
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumour growth
    • Harris A.L. Hypoxia - A key regulatory factor in tumour growth. Nat. Rev., Cancer. 2:2002;38-47.
    • (2002) Nat. Rev., Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 32
    • 0028068606 scopus 로고
    • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    • Semenza G.L., Roth P.H., Fang H.M., Wang G.L. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. Biol. Chem. 269:1994;23757-23763.
    • (1994) J. Biol. Chem. , vol.269 , pp. 23757-23763
    • Semenza, G.L.1    Roth, P.H.2    Fang, H.M.3    Wang, G.L.4
  • 33
    • 0035418586 scopus 로고    scopus 로고
    • Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: Correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix
    • Loncaster J.A., Harris A.L., Davidson S.E., Logue J.P., Hunter R.D., Wycoff C.C., Pastorek J., Ratcliffe P.J., Stratford I.J., West C.M. Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res. 61:2001;6394-6399.
    • (2001) Cancer Res. , vol.61 , pp. 6394-6399
    • Loncaster, J.A.1    Harris, A.L.2    Davidson, S.E.3    Logue, J.P.4    Hunter, R.D.5    Wycoff, C.C.6    Pastorek, J.7    Ratcliffe, P.J.8    Stratford, I.J.9    West, C.M.10
  • 36
    • 0033006387 scopus 로고    scopus 로고
    • N-myc-dependent repression of ndr1, a gene identified by direct subtraction of whole mouse embryo cDNAs between wild type and N-myc mutant
    • Shimono A., Okuda T., Kondoh H. N-myc-dependent repression of ndr1, a gene identified by direct subtraction of whole mouse embryo cDNAs between wild type and N-myc mutant. Mech. Dev. 83:1999;39-52.
    • (1999) Mech. Dev. , vol.83 , pp. 39-52
    • Shimono, A.1    Okuda, T.2    Kondoh, H.3
  • 37
    • 0034663894 scopus 로고    scopus 로고
    • Mechanism of regulation of the hypoxia-inducible factor-1alpha by the von hippel-lindau tumor suppressor protein
    • Tanimoto K., Makino Y., Pereira T., Poellinger L. Mechanism of regulation of the hypoxia-inducible factor-1alpha by the von hippel-lindau tumor suppressor protein. EMBO J. 19:2000;4298-4309.
    • (2000) EMBO J. , vol.19 , pp. 4298-4309
    • Tanimoto, K.1    Makino, Y.2    Pereira, T.3    Poellinger, L.4
  • 38
    • 0033525830 scopus 로고    scopus 로고
    • Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway
    • Kallio P.J., Wilson W.J., O'Brien S., Makino Y., Poellinger L. Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway. J. Biol. Chem. 274:1999;6519-6525.
    • (1999) J. Biol. Chem. , vol.274 , pp. 6519-6525
    • Kallio, P.J.1    Wilson, W.J.2    O'Brien, S.3    Makino, Y.4    Poellinger, L.5
  • 39
    • 0030816323 scopus 로고    scopus 로고
    • Synaptopodin: An actin-associated protein in telencephalic dendrites and renal podocytes
    • Mundel P., Heid H.W., Mundel T.M., Kruger M., Reiser J., Kriz W. Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes. J. Cell Biol. 139:1997;193-204.
    • (1997) J. Cell Biol. , vol.139 , pp. 193-204
    • Mundel, P.1    Heid, H.W.2    Mundel, T.M.3    Kruger, M.4    Reiser, J.5    Kriz, W.6
  • 41
    • 0033980393 scopus 로고    scopus 로고
    • Helix-loop-helix proteins: Regulators of transcription in eucaryotic organisms
    • Massari M.E., Murre C. Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol. Cell. Biol. 20:2000;429-440.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 429-440
    • Massari, M.E.1    Murre, C.2
  • 42
    • 0026539165 scopus 로고
    • DNA binding and transcriptional regulatory activity of mammalian achaete-scute homologous (MASH) proteins revealed by interaction with a muscle-specific enhancer
    • Johnson J.E., Birren S.J., Saito T., Anderson D.J. DNA binding and transcriptional regulatory activity of mammalian achaete-scute homologous (MASH) proteins revealed by interaction with a muscle-specific enhancer. Proc. Natl. Acad. Sci. U. S. A. 89:1992;3596-3600.
    • (1992) Proc. Natl. Acad. Sci. U. S. A. , vol.89 , pp. 3596-3600
    • Johnson, J.E.1    Birren, S.J.2    Saito, T.3    Anderson, D.J.4
  • 43
    • 0034721779 scopus 로고    scopus 로고
    • The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function
    • [In Process Citation]
    • Firulli B.A., Hadzic D.B., McDaid J.R., Firulli A.B. The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. [In Process Citation] J. Biol. Chem. 275:2000;33567-33573.
    • (2000) J. Biol. Chem. , vol.275 , pp. 33567-33573
    • Firulli, B.A.1    Hadzic, D.B.2    McDaid, J.R.3    Firulli, A.B.4
  • 44
    • 0037088678 scopus 로고    scopus 로고
    • Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation
    • Jögi A., Persson P., Grynfeld A., Påhlman S., Axelson H. Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation. J. Biol. Chem. 277:2002;9118-9126.
    • (2002) J. Biol. Chem. , vol.277 , pp. 9118-9126
    • Jögi, A.1    Persson, P.2    Grynfeld, A.3    Påhlman, S.4    Axelson, H.5
  • 45
    • 0025415390 scopus 로고
    • Human neuroblastoma tumor cell lines correspond to the arrested differentiation of chromaffin adrenal medullary neuroblasts
    • Cooper M.J., Hutchins G.M., Cohen P.S., Helman L.J., Mennie R.J., Israel M.A. Human neuroblastoma tumor cell lines correspond to the arrested differentiation of chromaffin adrenal medullary neuroblasts. Cell Growth Differ. 1:1990;149-159.
    • (1990) Cell Growth Differ. , vol.1 , pp. 149-159
    • Cooper, M.J.1    Hutchins, G.M.2    Cohen, P.S.3    Helman, L.J.4    Mennie, R.J.5    Israel, M.A.6
  • 46
    • 0037457658 scopus 로고    scopus 로고
    • High delta-like 1 expression in a subset of neuroblastoma cell lines corresponds to a differentiated chromaffin cell type
    • Van Limpt V.A., Chan A.J., Van Sluis P.G., Caron H.N., Van Noesel C.J., Versteeg R. High delta-like 1 expression in a subset of neuroblastoma cell lines corresponds to a differentiated chromaffin cell type. Int. J. Cancer. 105:2003;61-69.
    • (2003) Int. J. Cancer , vol.105 , pp. 61-69
    • Van Limpt, V.A.1    Chan, A.J.2    Van Sluis, P.G.3    Caron, H.N.4    Van Noesel, C.J.5    Versteeg, R.6
  • 47
    • 0022532417 scopus 로고
    • Mitogenic response of human SH-SY5Y neuroblastoma cells to insulin-like growth factor I and II is dependent on the stage of differentiation
    • Mattsson M.E., Enberg G., Ruusala A.I., Hall K., Påhlman S. Mitogenic response of human SH-SY5Y neuroblastoma cells to insulin-like growth factor I and II is dependent on the stage of differentiation. J. Cell Biol. 102:1986;1949-1954.
    • (1986) J. Cell Biol. , vol.102 , pp. 1949-1954
    • Mattsson, M.E.1    Enberg, G.2    Ruusala, A.I.3    Hall, K.4    Påhlman, S.5
  • 48
    • 0025257203 scopus 로고
    • Mitogenically uncoupled insulin and IGF-I receptors of differentiated human neuroblastoma cells are functional and mediate ligand-induced signals
    • Mattsson M.E., Hammerling U., Mohall E., Hall K., Påhlman S. Mitogenically uncoupled insulin and IGF-I receptors of differentiated human neuroblastoma cells are functional and mediate ligand-induced signals. Growth Factors. 2:1990;251-265.
    • (1990) Growth Factors , vol.2 , pp. 251-265
    • Mattsson, M.E.1    Hammerling, U.2    Mohall, E.3    Hall, K.4    Påhlman, S.5
  • 49
    • 0032549799 scopus 로고    scopus 로고
    • Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
    • Soker S., Takashima S., Miao H.Q., Neufeld G., Klagsbrun M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell. 92:1998;735-745.
    • (1998) Cell , vol.92 , pp. 735-745
    • Soker, S.1    Takashima, S.2    Miao, H.Q.3    Neufeld, G.4    Klagsbrun, M.5
  • 51
    • 0036200075 scopus 로고    scopus 로고
    • Metallothionein 2A expression is associated with cell proliferation in breast cancer
    • Jin R., Chow V.T., Tan P.H., Dheen S.T., Duan W., Bay B.H. Metallothionein 2A expression is associated with cell proliferation in breast cancer. Carcinogenesis. 23:2002;81-86.
    • (2002) Carcinogenesis , vol.23 , pp. 81-86
    • Jin, R.1    Chow, V.T.2    Tan, P.H.3    Dheen, S.T.4    Duan, W.5    Bay, B.H.6
  • 52
    • 0027772721 scopus 로고
    • Metallothionein and anticancer agents: The role of metallothionein in cancer chemotherapy
    • Doz F., Roosen N., Rosenblum M.L. Metallothionein and anticancer agents: the role of metallothionein in cancer chemotherapy. J. Neurooncol. 17:1993;123-129.
    • (1993) J. Neurooncol. , vol.17 , pp. 123-129
    • Doz, F.1    Roosen, N.2    Rosenblum, M.L.3
  • 54
    • 0023084410 scopus 로고
    • Protective function of metallothionein against certain anticancer agents
    • Endresen L., Rugstad H.E. Protective function of metallothionein against certain anticancer agents. Experientia, Suppl. 52:1987;595-602.
    • (1987) Experientia, Suppl. , vol.52 , pp. 595-602
    • Endresen, L.1    Rugstad, H.E.2
  • 55
    • 0028143697 scopus 로고
    • Metallothionein in carcinogenesis and cancer chemotherapy
    • Ebadi M., Iversen P.L. Metallothionein in carcinogenesis and cancer chemotherapy. Gen. Pharmacol. 25:1994;1297-1310.
    • (1994) Gen. Pharmacol. , vol.25 , pp. 1297-1310
    • Ebadi, M.1    Iversen, P.L.2
  • 56
    • 0023696141 scopus 로고
    • Overexpression of metallothionein confers resistance to anticancer drugs
    • Kelley S.L., Basu A., Teicher B.A., Hacker M.P., Hamer D.H., Lazo J.S. Overexpression of metallothionein confers resistance to anticancer drugs. Science. 241:1988;1813-1815.
    • (1988) Science , vol.241 , pp. 1813-1815
    • Kelley, S.L.1    Basu, A.2    Teicher, B.A.3    Hacker, M.P.4    Hamer, D.H.5    Lazo, J.S.6
  • 59
    • 0038788826 scopus 로고    scopus 로고
    • Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): Role of cytoplasmic trapping of HIF-2alpha
    • Park S.K., Dadak A.M., Haase V.H., Fontana L., Giaccia A.J., Johnson R.S. Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol. Cell. Biol. 23:2003;4959-4971.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 4959-4971
    • Park, S.K.1    Dadak, A.M.2    Haase, V.H.3    Fontana, L.4    Giaccia, A.J.5    Johnson, R.S.6
  • 60
    • 0030974517 scopus 로고    scopus 로고
    • Spatial association of apoptosis-related gene expression and cellular death in clinical neuroblastoma
    • Hoehner J.C., Gestblom C., Olsen L., Påhlman S. Spatial association of apoptosis-related gene expression and cellular death in clinical neuroblastoma. Br. J. Cancer. 75:1997;1185-1194.
    • (1997) Br. J. Cancer , vol.75 , pp. 1185-1194
    • Hoehner, J.C.1    Gestblom, C.2    Olsen, L.3    Påhlman, S.4
  • 61
    • 0037387731 scopus 로고    scopus 로고
    • Evidence for hypoxia-induced neuronal-to-chromaffin metaplasia in neuroblastoma
    • Berthold F., Schilling F., Harms D., Sandstedt B., Franklin G. Evidence for hypoxia-induced neuronal-to-chromaffin metaplasia in neuroblastoma. FASEB J. 17:2003;598-609.
    • (2003) FASEB J. , vol.17 , pp. 598-609
    • Berthold, F.1    Schilling, F.2    Harms, D.3    Sandstedt, B.4    Franklin, G.5
  • 63
    • 0034699326 scopus 로고    scopus 로고
    • Hypoxia-induced VEGF enhances tumor survivability via suppression of serum deprivation-induced apoptosis
    • Baek J.H., Jang J.E., Kang C.M., Chung H.Y., Kim N.D., Kim K.W. Hypoxia-induced VEGF enhances tumor survivability via suppression of serum deprivation-induced apoptosis. Oncogene. 19:2000;4621-4631.
    • (2000) Oncogene , vol.19 , pp. 4621-4631
    • Baek, J.H.1    Jang, J.E.2    Kang, C.M.3    Chung, H.Y.4    Kim, N.D.5    Kim, K.W.6
  • 64
    • 0034813957 scopus 로고    scopus 로고
    • Hypoxia promotes apoptosis of human neuroblastoma cell lines with enhanced N-myc expression
    • Rössler J., Schwab M., Havers W., Schweigerer L. Hypoxia promotes apoptosis of human neuroblastoma cell lines with enhanced N-myc expression. Biochem. Biophys. Res. Commun. 281:2001;272-276.
    • (2001) Biochem. Biophys. Res. Commun. , vol.281 , pp. 272-276
    • Rössler, J.1    Schwab, M.2    Havers, W.3    Schweigerer, L.4
  • 65
    • 0035422178 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells
    • Bachelder R.E., Crago A., Chung J., Wendt M.A., Shaw L.M., Robinson G., Mercurio A.M. Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells. Cancer Res. 61:2001;5736-5740.
    • (2001) Cancer Res. , vol.61 , pp. 5736-5740
    • Bachelder, R.E.1    Crago, A.2    Chung, J.3    Wendt, M.A.4    Shaw, L.M.5    Robinson, G.6    Mercurio, A.M.7
  • 67
    • 0028038917 scopus 로고
    • Basic FGF and IGF-I promote differentiation of human SH-SY5Y neuroblastoma cells in culture
    • Lavenius E., Parrow V., Nånberg E., Påhlman S. Basic FGF and IGF-I promote differentiation of human SH-SY5Y neuroblastoma cells in culture. Growth Factors. 10:1994;29-39.
    • (1994) Growth Factors , vol.10 , pp. 29-39
    • Lavenius, E.1    Parrow, V.2    Nånberg, E.3    Påhlman, S.4
  • 68
    • 0025883971 scopus 로고
    • Insulin-like growth factor I shifts from promoting cell division to potentiating maturation during neuronal differentiation
    • Påhlman S., Meyerson G., Lindgren E., Schalling M., Johansson I. Insulin-like growth factor I shifts from promoting cell division to potentiating maturation during neuronal differentiation. Proc. Natl. Acad. Sci. U. S. A. 88:1991;9994-9998.
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 9994-9998
    • Påhlman, S.1    Meyerson, G.2    Lindgren, E.3    Schalling, M.4    Johansson, I.5
  • 69
    • 0033937809 scopus 로고    scopus 로고
    • IGF-I receptor activation and BCL-2 overexpression prevent early apoptotic events in human neuroblastoma
    • van Golen C.M., Castle V.P., Feldman E.L. IGF-I receptor activation and BCL-2 overexpression prevent early apoptotic events in human neuroblastoma. Cell Death Differ. 7:2000;654-665.
    • (2000) Cell Death Differ. , vol.7 , pp. 654-665
    • Van Golen, C.M.1    Castle, V.P.2    Feldman, E.L.3
  • 70
    • 0036602802 scopus 로고    scopus 로고
    • Metallothionein isoform 3 expression inhibits cell growth and increases drug resistance of PC-3 prostate cancer cells
    • Dutta R., Sens D.A., Somji S., Sens M.A., Garrett S.H. Metallothionein isoform 3 expression inhibits cell growth and increases drug resistance of PC-3 prostate cancer cells. Prostate. 52:2002;89-97.
    • (2002) Prostate , vol.52 , pp. 89-97
    • Dutta, R.1    Sens, D.A.2    Somji, S.3    Sens, M.A.4    Garrett, S.H.5
  • 71
    • 0037194348 scopus 로고    scopus 로고
    • Protein expression profiles indicative for drug resistance of non-small cell lung cancer
    • Volm M., Koomagi R., Mattern J., Efferth T. Protein expression profiles indicative for drug resistance of non-small cell lung cancer. Br. J. Cancer. 87:2002;251-257.
    • (2002) Br. J. Cancer , vol.87 , pp. 251-257
    • Volm, M.1    Koomagi, R.2    Mattern, J.3    Efferth, T.4
  • 72
    • 0029135399 scopus 로고
    • Up-regulation of resistance-related proteins in human lung tumors with poor vascularization
    • Koomagi R., Mattern J., Volm M. Up-regulation of resistance-related proteins in human lung tumors with poor vascularization. Carcinogenesis. 16:1995;2129-2133.
    • (1995) Carcinogenesis , vol.16 , pp. 2129-2133
    • Koomagi, R.1    Mattern, J.2    Volm, M.3
  • 73
    • 0030037148 scopus 로고    scopus 로고
    • Association of resistance-related protein expression with poor vascularization and low levels of oxygen in human rectal cancer
    • Mattern J., Kallinowski F., Herfarth C., Volm M. Association of resistance-related protein expression with poor vascularization and low levels of oxygen in human rectal cancer. Int. J. Cancer. 67:1996;20-23.
    • (1996) Int. J. Cancer , vol.67 , pp. 20-23
    • Mattern, J.1    Kallinowski, F.2    Herfarth, C.3    Volm, M.4
  • 74
    • 0032524711 scopus 로고    scopus 로고
    • Alterations in GLUT1 and GLUT3 glucose transporter gene expression following unilateral hypoxia-ischemia in the immature rat brain
    • Vannucci S.J., Reinhart R., Maher F., Bondy C.A., Lee W.H., Vannucci R.C., Simpson I.A. Alterations in GLUT1 and GLUT3 glucose transporter gene expression following unilateral hypoxia-ischemia in the immature rat brain. Brain Res., Dev. Brain Res. 107:1998;255-264.
    • (1998) Brain Res., Dev. Brain Res. , vol.107 , pp. 255-264
    • Vannucci, S.J.1    Reinhart, R.2    Maher, F.3    Bondy, C.A.4    Lee, W.H.5    Vannucci, R.C.6    Simpson, I.A.7
  • 77
    • 0037093202 scopus 로고    scopus 로고
    • Regulation of ferritin genes and protein
    • Torti F.M., Torti S.V. Regulation of ferritin genes and protein. Blood. 99:2002;3505-3516.
    • (2002) Blood , vol.99 , pp. 3505-3516
    • Torti, F.M.1    Torti, S.V.2
  • 78
    • 0031041377 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia
    • Lee P.J., Jiang B.H., Chin B.Y., Iyer N.V., Alam J., Semenza G.L., Choi A.M. Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia. J. Biol. Chem. 272:1997;5375-5381.
    • (1997) J. Biol. Chem. , vol.272 , pp. 5375-5381
    • Lee, P.J.1    Jiang, B.H.2    Chin, B.Y.3    Iyer, N.V.4    Alam, J.5    Semenza, G.L.6    Choi, A.M.7
  • 79
    • 0027979247 scopus 로고
    • Hypoxia increases rate of transcription and stability of tyrosine hydroxylase mRNA in pheochromocytoma (PC12) cells
    • Czyzyk-Krzeska M.F., Furnari B.A., Lawson E.E., Millhorn D.E. Hypoxia increases rate of transcription and stability of tyrosine hydroxylase mRNA in pheochromocytoma (PC12) cells. J. Biol. Chem. 269:1994;760-764.
    • (1994) J. Biol. Chem. , vol.269 , pp. 760-764
    • Czyzyk-Krzeska, M.F.1    Furnari, B.A.2    Lawson, E.E.3    Millhorn, D.E.4
  • 80
    • 0032504165 scopus 로고    scopus 로고
    • Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes
    • Cormier-Regard S., Nguyen S.V., Claycomb W.C. Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes. J. Biol. Chem. 273:1998;17787-17792.
    • (1998) J. Biol. Chem. , vol.273 , pp. 17787-17792
    • Cormier-Regard, S.1    Nguyen, S.V.2    Claycomb, W.C.3
  • 82
    • 0029944965 scopus 로고    scopus 로고
    • Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
    • Jiang B.H., Rue E., Wang G.L., Roe R., Semenza G.L. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J. Biol. Chem. 271:1996;17771-17778.
    • (1996) J. Biol. Chem. , vol.271 , pp. 17771-17778
    • Jiang, B.H.1    Rue, E.2    Wang, G.L.3    Roe, R.4    Semenza, G.L.5
  • 83
    • 0031870653 scopus 로고    scopus 로고
    • Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2alpha
    • Flamme I., Krieg M., Plate K.H. Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2alpha. Am. J. Pathol. 153:1998;25-29.
    • (1998) Am. J. Pathol. , vol.153 , pp. 25-29
    • Flamme, I.1    Krieg, M.2    Plate, K.H.3
  • 85
    • 0033566693 scopus 로고    scopus 로고
    • Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2
    • Feldser D., Agani F., Iyer N.V., Pak B., Ferreira G., Semenza G. Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Res. 59:1999;3915-3918.
    • (1999) Cancer Res. , vol.59 , pp. 3915-3918
    • Feldser, D.1    Agani, F.2    Iyer, N.V.3    Pak, B.4    Ferreira, G.5    Semenza, G.6
  • 88
    • 0030974127 scopus 로고    scopus 로고
    • Conservation of the Drosophila lateral inhibition pathway in human lung cancer: A hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression
    • Chen H., Thiagalingam A., Chopra H., Borges M.W., Feder J.N., Nelkin B.D., Baylin S.B., Ball D.W. Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression. Proc. Natl. Acad. Sci. U. S. A. 94:1997;5355-5360.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 5355-5360
    • Chen, H.1    Thiagalingam, A.2    Chopra, H.3    Borges, M.W.4    Feder, J.N.5    Nelkin, B.D.6    Baylin, S.B.7    Ball, D.W.8
  • 89
    • 0025238437 scopus 로고
    • The protein Id: A negative regulator of helix-loop-helix DNA binding proteins
    • Benezra R., Davis R.L., Lockshon D., Turner D.L., Weintraub H. The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell. 61:1990;49-59.
    • (1990) Cell , vol.61 , pp. 49-59
    • Benezra, R.1    Davis, R.L.2    Lockshon, D.3    Turner, D.L.4    Weintraub, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.