-
1
-
-
0027092333
-
Transcription factors, translocations, and leukemia
-
Nichols, J. & Nimer, S. D. Transcription factors, translocations, and leukemia. Blood 80, 2953-2983 (1992).
-
(1992)
Blood
, vol.80
, pp. 2953-2983
-
-
Nichols, J.1
Nimer, S.D.2
-
2
-
-
0019274901
-
Hemopoietic stem cell differentiation
-
Till, J. E. & McCulloch, E. A. Hemopoietic stem cell differentiation. Biochim. Biophys. Acta 605, 431-459 (1980).
-
(1980)
Biochim. Biophys. Acta
, vol.605
, pp. 431-459
-
-
Till, J.E.1
McCulloch, E.A.2
-
3
-
-
0027325195
-
Differentiation and proliferation of hematopoietic stem cells
-
Ogawa, M. Differentiation and proliferation of hematopoietic stem cells. Blood 81, 2844-2853 (1993).
-
(1993)
Blood
, vol.81
, pp. 2844-2853
-
-
Ogawa, M.1
-
4
-
-
0023922373
-
Purification and characterization of mouse hematopoietic stem cells
-
Spangrude, G. J., Heimfeld, S. & Weissman, I. L. Purification and characterization of mouse hematopoietic stem cells. Science 241, 58-62 (1988).
-
(1988)
Science
, vol.241
, pp. 58-62
-
-
Spangrude, G.J.1
Heimfeld, S.2
Weissman, I.L.3
-
5
-
-
0034624828
-
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
-
Akashi, K., Traver, D., Miyamoto, T. & Weissman, I. L. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404, 193-197 (2000). Describes the methodology for isolation and analysis of progenitors at precisely defined functional stages of differentiation.
-
(2000)
Nature
, vol.404
, pp. 193-197
-
-
Akashi, K.1
Traver, D.2
Miyamoto, T.3
Weissman, I.L.4
-
6
-
-
0036070180
-
Myeloid or lymphoid promiscuity as a cntical step in hematopoietic lineage commitment
-
Miyamoto, T. et al. Myeloid or lymphoid promiscuity as a cntical step in hematopoietic lineage commitment. Dev. Cell 3, 137-147 (2002).
-
(2002)
Dev. Cell
, vol.3
, pp. 137-147
-
-
Miyamoto, T.1
-
7
-
-
17944376561
-
AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations
-
Yuan, Y. et al. AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations. Proc. Natl Acad. Sci. USA 98, 10398-10403 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 10398-10403
-
-
Yuan, Y.1
-
8
-
-
0029876726
-
The transcriptional control of hematopoiesis
-
Shivdasani, R. A. & Orkin, S. H. The transcriptional control of hematopoiesis. Blood 87, 4025-4039 (1996).
-
(1996)
Blood
, vol.87
, pp. 4025-4039
-
-
Shivdasani, R.A.1
Orkin, S.H.2
-
9
-
-
0030854907
-
Transcription factors, normal myeloid development, and leukemia
-
Tenen, D. G., Hromas, R., Licht, J. D. & Zhang, D.-E. Transcription factors, normal myeloid development, and leukemia. Blood 90, 489-519 (1997).
-
(1997)
Blood
, vol.90
, pp. 489-519
-
-
Tenen, D.G.1
Hromas, R.2
Licht, J.D.3
Zhang, D.-E.4
-
10
-
-
0142144295
-
-
(ed. Zon, L. I.) (Oxford University Press, New York)
-
Tenen, D. G. Hematopoiesis (ed. Zon, L. I.) 417-428 (Oxford University Press, New York, 2001).
-
(2001)
Hematopoiesis
, pp. 417-428
-
-
Tenen, D.G.1
-
11
-
-
0034941566
-
Dichotomy of AML1-ETO functions: Growth arrest versus block of differentiation
-
Burel, S.A. et al. Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation. Mol. Cell. Biol. 21, 5577-5590 (2001).
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 5577-5590
-
-
Burel, S.A.1
-
12
-
-
0036317908
-
Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation
-
De Guzman, C. G. et al. Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation. Mol. Cell. Biol. 22, 5508-5517 (2002).
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 5508-5517
-
-
De Guzman, C.G.1
-
13
-
-
0036636857
-
Core-binding factors in haematopoiesis and leukaemia
-
Speck, N. A. & Gilliland, D. G. Core-binding factors in haematopoiesis and leukaemia. Nature Rev. Cancer 2, 502-513 (2002).
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 502-513
-
-
Speck, N.A.1
Gilliland, D.G.2
-
14
-
-
0029019659
-
AML1 and the 8:21 and 3; 21 translocations in acute and chronic myeloid leukemia
-
Nuclfora, G. & Rowley, J. D. AML1 and the 8:21 and 3;21 translocations in acute and chronic myeloid leukemia. Blood 86, 1-14 (1995).
-
(1995)
Blood
, vol.86
, pp. 1-14
-
-
Nuclfora, G.1
Rowley, J.D.2
-
15
-
-
0035865459
-
Dimerization with PEBP2β protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation
-
Huang, G. et al. Dimerization with PEBP2β protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation. EMBO J. 20, 723-733 (2001).
-
(2001)
EMBO J.
, vol.20
, pp. 723-733
-
-
Huang, G.1
-
16
-
-
0034303586
-
Diversification of haematopoietic stem cells to specific lineages
-
Orkin, S. H. Diversification of haematopoietic stem cells to specific lineages. Nature Rev. Genet. 1, 57-64 (2000).
-
(2000)
Nature Rev. Genet.
, vol.1
, pp. 57-64
-
-
Orkin, S.H.1
-
17
-
-
0033151624
-
Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: Functional antagonism in erythroid cells
-
Rekhtman, N., Radparvar, F., Evans, T. & Skouitchi, A. I. Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells. Genes Dev. 13, 1398-1411 (1999).
-
(1999)
Genes Dev.
, vol.13
, pp. 1398-1411
-
-
Rekhtman, N.1
Radparvar, F.2
Evans, T.3
Skouitchi, A.I.4
-
18
-
-
0033587755
-
Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1
-
Zhang, P. et al. Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1. Proc. Natl Acad. Sci. USA 96, 8705-8710 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 8705-8710
-
-
Zhang, P.1
-
19
-
-
0034656393
-
GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1 dependent transcription
-
Nerlov, C., Querfurth, E., Kulessa, H. & Graf, T. GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1 dependent transcription. Blood 95, 2543-2551 (2000).
-
(2000)
Blood
, vol.95
, pp. 2543-2551
-
-
Nerlov, C.1
Querfurth, E.2
Kulessa, H.3
Graf, T.4
-
20
-
-
3543031901
-
-
(ed. Zon, L. I) (Oxford University Press, New York)
-
Nerlov, C., Tenen, D. G. & Graf, T. Hematopoiesis: A Developmental Approach (ed. Zon, L. I) 363-367 (Oxford University Press, New York, 2001).
-
(2001)
Hematopoiesis: A Developmental Approach
, pp. 363-367
-
-
Nerlov, C.1
Tenen, D.G.2
Graf, T.3
-
21
-
-
0030963918
-
A 'knockdown' mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1
-
Mcdevitt, M. A., Shivdasani, R. A., Fujiwara, Y., Yang, H. D. & Orkin, S. H. A 'knockdown' mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1. Proc. Natl Acad. Sci. USA 94, 6781-6785 (1997).
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 6781-6785
-
-
Mcdevitt, M.A.1
Shivdasani, R.A.2
Fujiwara, Y.3
Yang, H.D.4
Orkin, S.H.5
-
22
-
-
0036258216
-
Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation
-
Cantor, A. B., Katz, S. G. & Orkin, S. H. Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation. Mol. Cell. Biol. 22, 4268-4279 (2002).
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 4268-4279
-
-
Cantor, A.B.1
Katz, S.G.2
Orkin, S.H.3
-
23
-
-
0142175182
-
-
(eds Wolff, L. & Perkins, A. S.) (Springer, Heidelberg)
-
Zhang, D.-E. et al. Molecular Aspects of Myeloid Stem Cell Development (eds Wolff, L. & Perkins, A. S.) 137-147 (Springer, Heidelberg, 1996).
-
(1996)
Molecular Aspects of Myeloid Stem Cell Development
, pp. 137-147
-
-
Zhang, D.-E.1
-
24
-
-
0142144297
-
-
(eds Ravid, K. & Ucht, J.) (Wiley & Sons, New York
-
Tenen, D. G. Transcription Factors: Normal and Malignant Development of Blood Cells (eds Ravid, K. & Ucht, J.) 103-115 (Wiley & Sons, New York, 2001).
-
(2001)
Transcription Factors: Normal and Malignant Development of Blood Cells
, pp. 103-115
-
-
Tenen, D.G.1
-
25
-
-
0030061554
-
AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
-
Okuda, T., van Deursen, J., Hiebert, S. W., Grosveld, G. & Downing, J. R. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84, 321-330 (1996).
-
(1996)
Cell
, vol.84
, pp. 321-330
-
-
Okuda, T.1
Van Deursen, J.2
Hiebert, S.W.3
Grosveld, G.4
Downing, J.R.5
-
26
-
-
0029918597
-
Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoesis
-
Wang, Q. et al. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoesis. Proc. Natl Acad. Sci. USA 93, 3444-3449 (1996).
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 3444-3449
-
-
Wang, Q.1
-
27
-
-
0028136726
-
The transcnption factor PU.1 is required for the development of multiple hematopoietic lineages
-
Scott, E. W., Simon, M. C., Anastai, J. & Singh, H. The transcnption factor PU.1 is required for the development of multiple hematopoietic lineages. Science 265, 1573-1577 (1994).
-
(1994)
Science
, vol.265
, pp. 1573-1577
-
-
Scott, E.W.1
Simon, M.C.2
Anastai, J.3
Singh, H.4
-
28
-
-
0242549003
-
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
-
McKercher, S. R. et al. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J. 15, 5647-5658 (1996).
-
(1996)
EMBO J.
, vol.15
, pp. 5647-5658
-
-
McKercher, S.R.1
-
29
-
-
0032479989
-
PU.1 regulates both cytokine dependent proliferation and differentiation of granulocyte/macrophage progenitors
-
DeKoter, R. P., Walsh, J. C. & Singh, H. PU.1 regulates both cytokine dependent proliferation and differentiation of granulocyte/macrophage progenitors. EMBO J. 17, 4456-4468 (1998). Shows that PU.1-deficient cells are blocked at an early stage of myeloid maturation, and that introduction of PU.1 (but not cytokine signalling) restores differentiation.
-
(1998)
EMBO J.
, vol.17
, pp. 4456-4468
-
-
DeKoter, R.P.1
Walsh, J.C.2
Singh, H.3
-
30
-
-
0033214311
-
PU.1 and the granulocyte- and macrophage colony-stimulating factor receptors play distinct roles in late-stage myeloid cell differentiation
-
Anderson, K. L. et al. PU.1 and the granulocyte- and macrophage colony-stimulating factor receptors play distinct roles in late-stage myeloid cell differentiation. Blood 94, 2310-2318 (1999).
-
(1999)
Blood
, vol.94
, pp. 2310-2318
-
-
Anderson, K.L.1
-
31
-
-
0037100304
-
The granulocytic inducer C/EBPα inactivates the myeloid master gene PU.1: Possible role in lineage commitment decisions
-
Reddy, V. et al. The granulocytic inducer C/EBPα inactivates the myeloid master gene PU.1: possible role in lineage commitment decisions. Blood 100, 483-490 (2002).
-
(2002)
Blood
, vol.100
, pp. 483-490
-
-
Reddy, V.1
-
32
-
-
0031835661
-
CCAAT/enhancer binding protein-α is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors
-
Radomska, H. S. et al. CCAAT/enhancer binding protein-α is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors. Mol. Cell. Biol. 18, 4301-4314 (1998).
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 4301-4314
-
-
Radomska, H.S.1
-
33
-
-
79960971577
-
C/EBPα deficiency blocks granulocytic differentiation at the common myeloid progenitor stage in both adult and fetal liver myelopoiesis
-
Zhang, P. et al. C/EBPα deficiency blocks granulocytic differentiation at the common myeloid progenitor stage in both adult and fetal liver myelopoiesis. Blood 98, 792a (2001).
-
(2001)
Blood
, vol.98
-
-
Zhang, P.1
-
34
-
-
0029121366
-
PU.1 (Spi-1) and C/EBPa regulate the expression of the granulocyte-macrophage colony-stimuating factor receptor-α gene
-
Hohaus, S. et al. PU.1 (Spi-1) and C/EBPa regulate the expression of the granulocyte-macrophage colony-stimuating factor receptor-α gene. Mol. Cell. Biol. 15, 5830-5845 (1995).
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 5830-5845
-
-
Hohaus, S.1
-
35
-
-
0028120907
-
The macrophage transcription factor PU.1 directs tissue specific expression of the macrophage colony stimulating factor receptor
-
Zhang, D.-E., Hetherington, C. J., Chen, H. M. & Tenen, D. G. The macrophage transcription factor PU.1 directs tissue specific expression of the macrophage colony stimulating factor receptor. Mol. Cell. Biol. 14, 373-381 (1994).
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 373-381
-
-
Zhang, D.-E.1
Hetherington, C.J.2
Chen, H.M.3
Tenen, D.G.4
-
36
-
-
0029793902
-
PU.1 (Spi-1) and C/EBPα regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells
-
Smith, L. T., Hohaus, S., Gonzalez, D. A., Dziennis, S. E. & Tenen, D. G. PU.1 (Spi-1) and C/EBPα regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells. Blood 88, 1234-1247 (1996).
-
(1996)
Blood
, vol.88
, pp. 1234-1247
-
-
Smith, L.T.1
Hohaus, S.2
Gonzalez, D.A.3
Dziennis, S.E.4
Tenen, D.G.5
-
37
-
-
0032526324
-
Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPα
-
Iwama, A. et al. Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPα. Nucl. Acids Res. 26, 3034-3043 (1998).
-
(1998)
Nucl. Acids Res.
, vol.26
, pp. 3034-3043
-
-
Iwama, A.1
-
38
-
-
0031029557
-
Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice
-
Zhang, D.-E. et al. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice. Proc. Natl Acad. Sci. USA 94, 569-574 (1997). First demonstration that targeted disruption of C/EBPα results in an earty granulocytic differentiation block.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 569-574
-
-
Zhang, D.-E.1
-
39
-
-
0033564978
-
C/EBPα bypasses granulocyte colony-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D cl3 myeloblasts
-
Wang, X., Scott, E. W., Sawyers, C. L. & Friedman, A. D. C/ EBPα bypasses granulocyte colony-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D cl3 myeloblasts. Blood 94, 560-571 (1999).
-
(1999)
Blood
, vol.94
, pp. 560-571
-
-
Wang, X.1
Scott, E.W.2
Sawyers, C.L.3
Friedman, A.D.4
-
40
-
-
0029976068
-
CCAAT/enhancer-binding protein a (C/EBPα) inhibits cell proliferation though the p21 (WAF-1/ CIP-1/SDI-1) protein
-
Timchenko, N. A., Wilde, M., Nakanishi, M., Smith, J. R. & Darlington, G. J. CCAAT/enhancer-binding protein a (C/EBPα) inhibits cell proliferation though the p21 (WAF-1/ CIP-1/SDI-1) protein. Genes Dev. 10, 804-815 (1996).
-
(1996)
Genes Dev.
, vol.10
, pp. 804-815
-
-
Timchenko, N.A.1
Wilde, M.2
Nakanishi, M.3
Smith, J.R.4
Darlington, G.J.5
-
41
-
-
0034740215
-
C/EBPα arrests cell proliferation through direct inhibition of Cdk2 and Cdk4
-
Wang, H. et al. C/EBPα arrests cell proliferation through direct inhibition of Cdk2 and Cdk4. Mol. Cell 8, 817-828 (2001).
-
(2001)
Mol. Cell
, vol.8
, pp. 817-828
-
-
Wang, H.1
-
42
-
-
0035005526
-
C-myc is a critical target for C/EBPα in granulopoiesis
-
Johansen, L. M. et al. C-myc is a critical target for C/EBPα in granulopoiesis. Mol. Cell. Biol. 21, 3789-3806 (2001).
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3789-3806
-
-
Johansen, L.M.1
-
43
-
-
0035913913
-
E2F repression by C/EBPα is required for adipogenesis and granulopoiesis in vivo
-
Porse, B. T. et al. E2F repression by C/EBPα is required for adipogenesis and granulopoiesis in vivo. Cell 107, 247-258 (2001). Shows the important link between the ability of C/EBPα to inhibit the cell-cycle-promoting gene E2F and the ability to induce granulocytic differentiation.
-
(2001)
Cell
, vol.107
, pp. 247-258
-
-
Porse, B.T.1
-
44
-
-
0025786584
-
Activation of the erythropoietin receptor promoter by transcription factor GATA-1
-
Zon, L. I., Youssoufian, H., Mather, C., Lodish, H. F. & Orkin, S. H. Activation of the erythropoietin receptor promoter by transcription factor GATA-1. Proc. Natl Acad. Sci. USA 88, 10638-10641 (1991).
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 10638-10641
-
-
Zon, L.I.1
Youssoufian, H.2
Mather, C.3
Lodish, H.F.4
Orkin, S.H.5
-
45
-
-
0028798816
-
Autoregulation of the human C/EBPα gene by stimulation of upstream stimulatory factor binding
-
Timchenko, N. et al. Autoregulation of the human C/EBPα gene by stimulation of upstream stimulatory factor binding. Mol. Cell. Biol. 15, 1192-1202 (1995).
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 1192-1202
-
-
Timchenko, N.1
-
46
-
-
0028826488
-
PU.1 (Spi-1) autoregulates its expression in myeloid cells
-
Chen, H. M. et al. PU.1 (Spi-1) autoregulates its expression in myeloid cells. Oncogene 11, 1549-1560 (1995).
-
(1995)
Oncogene
, vol.11
, pp. 1549-1560
-
-
Chen, H.M.1
-
47
-
-
0035892121
-
Regulation of the PU.1 gene by distal elements
-
Li, Y. et al. Regulation of the PU.1 gene by distal elements. Blood 98, 2958-2965 (2001).
-
(2001)
Blood
, vol.98
, pp. 2958-2965
-
-
Li, Y.1
-
48
-
-
0035529053
-
Cooperation between C/EBPα TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation
-
Pedersen, T. A., Kowenz-Leutz, E., Leutz, A. & Nerlov, C. Cooperation between C/EBPα TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation. Genes Dev. 15, 3208-3216 (2001).
-
(2001)
Genes Dev.
, vol.15
, pp. 3208-3216
-
-
Pedersen, T.A.1
Kowenz-Leutz, E.2
Leutz, A.3
Nerlov, C.4
-
49
-
-
0032555932
-
Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein α (C/EBPα) is critical for granulopoiesis
-
Zhang, P. et al. Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein α (C/EBPα) is critical for granulopoiesis. J. Exp. Med. 188, 1173-1184 (1998).
-
(1998)
J. Exp. Med.
, vol.188
, pp. 1173-1184
-
-
Zhang, P.1
-
50
-
-
0035798414
-
McBindall: A better name for CCAAT/enhancer binding proteins?
-
McKnight, S. L. McBindall: a better name for CCAAT/enhancer binding proteins? Cell 107, 259-261 (2001).
-
(2001)
Cell
, vol.107
, pp. 259-261
-
-
McKnight, S.L.1
-
51
-
-
0033180211
-
Reversible tumorigenesis by MYC in hematopoietic lineages
-
Felsher, D. W. & Bishop, J. M. Reversible tumorigenesis by MYC in hematopoietic lineages. Mol. Cell 4, 199-207 (1999).
-
(1999)
Mol. Cell
, vol.4
, pp. 199-207
-
-
Felsher, D.W.1
Bishop, J.M.2
-
52
-
-
0037438380
-
The effects of Bcr-Abl on C/EBP transcription-factor regulation and neutrophilic differentiation are reversed by the Abl kinase inhibitor imatinib mesylate
-
Schuster, C. et al. The effects of Bcr-Abl on C/EBP transcription-factor regulation and neutrophilic differentiation are reversed by the Abl kinase inhibitor imatinib mesylate. Blood 101, 655-663 (2003).
-
(2003)
Blood
, vol.101
, pp. 655-663
-
-
Schuster, C.1
-
53
-
-
0026716011
-
Cell cycle-dependent initiation and lineage-dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors
-
Sposi, N. M. et al. Cell cycle-dependent initiation and lineage-dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors. Proc. Natl Acad. Sci. USA 89, 6353-6357 (1992).
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 6353-6357
-
-
Sposi, N.M.1
-
54
-
-
0034603080
-
Expression of the AML-1 oncogene shortens the G(1) phase of the cell cycle
-
Strom, D. K. et al. Expression of the AML-1 oncogene shortens the G(1) phase of the cell cycle. J. Biol. Chem. 275, 3438-3445 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 3438-3445
-
-
Strom, D.K.1
-
55
-
-
85047696566
-
AML1 stimulates G1 to S progression via its transactivation domain
-
Bernardin, F. & Friedman, A. D. AML1 stimulates G1 to S progression via its transactivation domain. Oncogene 21, 3247-3252 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 3247-3252
-
-
Bernardin, F.1
Friedman, A.D.2
-
56
-
-
0028954304
-
Analysis of hematopoiesis in max 41 transgenic mice that exhibit sustained elevations of blood granulocytes and monocytes
-
Metcalf, D., Lindeman, G. J. & Nicola, N. A. Analysis of hematopoiesis in max 41 transgenic mice that exhibit sustained elevations of blood granulocytes and monocytes. Blood 85, 2364-2370 (1995).
-
(1995)
Blood
, vol.85
, pp. 2364-2370
-
-
Metcalf, D.1
Lindeman, G.J.2
Nicola, N.A.3
-
58
-
-
0027136259
-
Hematopoietic regulators: Redundancy or subtlety
-
Metcalf, D. Hematopoietic regulators: redundancy or subtlety. Blood 82, 3515-3523 (1993).
-
(1993)
Blood
, vol.82
, pp. 3515-3523
-
-
Metcalf, D.1
-
59
-
-
0023928595
-
Heparan sulphate bound growth factors: A mechanism for stromal cell mediated haemopoiesis
-
Roberts, R. et al. Heparan sulphate bound growth factors: a mechanism for stromal cell mediated haemopoiesis. Nature 332, 376-378 (1988).
-
(1988)
Nature
, vol.332
, pp. 376-378
-
-
Roberts, R.1
-
60
-
-
0027261321
-
Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors
-
Fairbairn, L. J., Cowling, G. J., Reipert, B. M. & Dexter, T. M. Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors. Cell 74, 823-832 (1993).
-
(1993)
Cell
, vol.74
, pp. 823-832
-
-
Fairbairn, L.J.1
Cowling, G.J.2
Reipert, B.M.3
Dexter, T.M.4
-
61
-
-
0027738701
-
Upregulation of lineage specific receptors and ligands in multipotential prognitor cells is part of an endogenous program of differentiation
-
Just, U. et al. Upregulation of lineage specific receptors and ligands in multipotential prognitor cells is part of an endogenous program of differentiation. Growth Factors 9, 291-300 (1993).
-
(1993)
Growth Factors
, vol.9
, pp. 291-300
-
-
Just, U.1
-
62
-
-
0028021829
-
Inhibition of hemetopoiesis by competitive binding of the transcription factor PU.1
-
Vaso, M. T. et al. Inhibition of hemetopoiesis by competitive binding of the transcription factor PU.1. Proc. Natl Acad. Sci. USA 91, 7932-7936 (1994).
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 7932-7936
-
-
Vaso, M.T.1
-
63
-
-
0030954167
-
Multilineage gene expression precedes commitment in the hematopoietic system
-
Hu, M. et al. Multilineage gene expression precedes commitment in the hematopoietic system. Genes Dev. 11, 774-785 (1997).
-
(1997)
Genes Dev.
, vol.11
, pp. 774-785
-
-
Hu, M.1
-
64
-
-
0034667672
-
PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding
-
Zhang, P. et al. PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding. Blood 96, 2641-2648 (2000).
-
(2000)
Blood
, vol.96
, pp. 2641-2648
-
-
Zhang, P.1
-
65
-
-
0017162163
-
Proposals for the classification of the acute leukaemias. French-American-British (FAB) cooperative group
-
Bennett, J. M. et al. Proposals for the classification of the acute leukaemias. French-American-British (FAB) cooperative group. Br. J. Haematol 33, 451-458 (1976). A landmark paper that established a classification system of AML on the basis of differentiation status.
-
(1976)
Br. J. Haematol.
, vol.33
, pp. 451-458
-
-
Bennett, J.M.1
-
66
-
-
0036234659
-
Unique molecular and cellular features of acute myelogenous leukemia stem cells
-
Jordan, C. T. Unique molecular and cellular features of acute myelogenous leukemia stem cells. Leukemia 16, 559-562 (2002).
-
(2002)
Leukemia
, vol.16
, pp. 559-562
-
-
Jordan, C.T.1
-
67
-
-
0034525530
-
Proliferative status of primitive hematopoietic progenitors from patients with acute myelogenous leukemia (AML)
-
Guan, Y. & Hogge, D. E. Proliferative status of primitive hematopoietic progenitors from patients with acute myelogenous leukemia (AML). Leukemia 14, 2135-2141 (2000).
-
(2000)
Leukemia
, vol.14
, pp. 2135-2141
-
-
Guan, Y.1
Hogge, D.E.2
-
68
-
-
0036340784
-
BCR-ABL suppresses C/EBPα expression through inhibitory activity of hnRNP E2
-
Perrotti, D. et al. BCR-ABL suppresses C/EBPα expression through inhibitory activity of hnRNP E2. Nature Genet. 30, 48-58 (2001). Describes yet another mechanism of inactivation of C/EBPα in AML - that involving the downregulation of C/EBPα through post-transcriptional mechanisms as the chronic (proliferative) phase transforms to acute leukaemia.
-
(2001)
Nature Genet.
, vol.30
, pp. 48-58
-
-
Perrotti, D.1
-
69
-
-
0032188805
-
The importance of diagnostic cytogenetics on outcome in AML: Analysis of 1,612 patients entered into the MRC AML 10 trial
-
The Medical Research Council Adult and Children's Leukaemia Working Parties
-
Grimwade, D. et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood 92, 2322-2333 (1998).
-
(1998)
Blood
, vol.92
, pp. 2322-2333
-
-
Grimwade, D.1
-
70
-
-
0037108111
-
Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: A study from the Acute Leukemia French Association (ALFA)
-
Preudhomme, C. et al. Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA). Blood 100, 2717-2723 (2002). Relates the status of C/EBPα mutations, with and without FLT3-ITD, to prognosis, and proposes a new classification of AML based on C/EBPα mutation status.
-
(2002)
Blood
, vol.100
, pp. 2717-2723
-
-
Preudhomme, C.1
-
71
-
-
0025746321
-
t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1
-
Miyoshi, H. et al. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc. Natl Acad. Sci. USA 88, 10431-10434 (1991).
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 10431-10434
-
-
Miyoshi, H.1
-
72
-
-
0032830638
-
Haploinsuficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia
-
Song, W. J. et al. Haploinsuficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nature Genet. 23, 166-175 (1999). Reports the haploinsufficiency of an important haematopoietic transcription factor that leads to a propensity to develop AML.
-
(1999)
Nature Genet.
, vol.23
, pp. 166-175
-
-
Song, W.J.1
-
73
-
-
0033559746
-
Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2αB gene associated with myeloblastic leukemias
-
Osato, M. et al. Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2αB gene associated with myeloblastic leukemias. Blood 93, 1817-1824 (1999). This study, along with reference 74, shows that AML1 could be involved in the pathogenesis of AML through a mechanism other than translocation, and that AML1 mutations were associated with a distinct differentiation subtype of AML.
-
(1999)
Blood
, vol.93
, pp. 1817-1824
-
-
Osato, M.1
-
74
-
-
0034667690
-
o acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21
-
o acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21. Blood 98, 2862-2869 (2000).
-
(2000)
Blood
, vol.98
, pp. 2862-2869
-
-
Preudhomme, C.1
-
75
-
-
0037082499
-
In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia (FPD/AML): Implications for mechanisms of pathogenesis
-
Michaud, J. et al. In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia (FPD/AML): implications for mechanisms of pathogenesis. Blood 99, 1364-1372 (2002).
-
(2002)
Blood
, vol.99
, pp. 1364-1372
-
-
Michaud, J.1
-
76
-
-
0037702768
-
AML1 is required for megakaryocytic maturation in adult hematopoiesis
-
Ichikawa, H. et al. AML1 is required for megakaryocytic maturation in adult hematopoiesis. Blood 100, 130a (2003).
-
(2003)
Blood
, vol.100
-
-
Ichikawa, H.1
-
77
-
-
0037092550
-
Unlike AML1, CBFβ is not deregulated by point mutations in acute myeloid leukemia and in myelodysplastic syndromes
-
Leroy, H. et al. Unlike AML1, CBFβ is not deregulated by point mutations in acute myeloid leukemia and in myelodysplastic syndromes. Blood 99, 3848-3850 (2002).
-
(2002)
Blood
, vol.99
, pp. 3848-3850
-
-
Leroy, H.1
-
78
-
-
0030588487
-
The CBFβ subunit is essential for CBFα2 (AML1) function in vivo
-
Wang, Q. et al. The CBFβ subunit is essential for CBFα2 (AML1) function in vivo Cell 87, 697-708 (1996).
-
(1996)
Cell
, vol.87
, pp. 697-708
-
-
Wang, Q.1
-
79
-
-
0029973591
-
Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta
-
Sasaki, K. et al. Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta. Proc. Natl Acad. Sci. USA 93, 12359-12363 (1996).
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 12359-12363
-
-
Sasaki, K.1
-
80
-
-
18344372734
-
C/EBP-β C/EBP-δ, PU.1, AML1 genes: Mutational analysis in 381 samples of hematopoietic and solid malignancies
-
Vegesna, V. et al. C/EBP-β C/EBP-δ, PU.1, AML1 genes: mutational analysis in 381 samples of hematopoietic and solid malignancies. Leuk. Res. 26, 451-457 (2002).
-
(2002)
Leuk. Res.
, vol.26
, pp. 451-457
-
-
Vegesna, V.1
-
81
-
-
0036682473
-
PU.1 mutations are associated with acute myeloid leukemia
-
Mueller, B. U. et al. PU.1 mutations are associated with acute myeloid leukemia. Blood 100, 998-1007 (2002).
-
(2002)
Blood
, vol.100
, pp. 998-1007
-
-
Mueller, B.U.1
-
82
-
-
0035353165
-
PU.1 exhibits partial functional redundancy with Spi-B, but not with Ets-1 or Elf-1
-
Garrett-Sinha, L. A., Dahl, R., Rao, S., Barton, K. P. & Simon, M. C. PU.1 exhibits partial functional redundancy with Spi-B, but not with Ets-1 or Elf-1. Blood 97, 2908-2912 (2001).
-
(2001)
Blood
, vol.97
, pp. 2908-2912
-
-
Garrett-Sinha, L.A.1
Dahl, R.2
Rao, S.3
Barton, K.P.4
Simon, M.C.5
-
83
-
-
0031972701
-
The t(8:21) fusion product, AML-1-ETO, associates with C/EBP-α, inhibits C/EBP-α-dependent transcription, and blocks granulocytic differentiation
-
Westendorf, J. J. et al. The t(8:21) fusion product, AML-1-ETO, associates with C/EBP-α, inhibits C/EBP-α-dependent transcription, and blocks granulocytic differentiation. Mol. Cell. Biol. 18, 322-333 (1998). Established that the mechanism of differentiation block induced by AML1-ETO involved inhibition of C/EBPα that is required for granulocyte differentiation.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 322-333
-
-
Westendorf, J.J.1
-
84
-
-
0037222293
-
The myeloid master regulator PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia
-
Vangala, R. K. et al. The myeloid master regulator PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia. Blood 101, 270-277 (2002).
-
(2002)
Blood
, vol.101
, pp. 270-277
-
-
Vangala, R.K.1
-
85
-
-
0035093813
-
Dominant negative mutations of CEBPα, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia
-
Pabst, T. et al. Dominant negative mutations of CEBPα, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia. Nature Genet. 27, 263-270 (2001). The first report of C/EBPα mutations in AML, this also describes a dominant-negative mechanism that could explain how mutation of one allele could inhibit the differentiation function of the other (wild-type) allele.
-
(2001)
Nature Genet.
, vol.27
, pp. 263-270
-
-
Pabst, T.1
-
86
-
-
0037082508
-
Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein-α in myelodysplastic syndromes and acute myeloid leukemias
-
Gombart, A. F. et al. Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein-α in myelodysplastic syndromes and acute myeloid leukemias. Blood 99, 1332-1340 (2002).
-
(2002)
Blood
, vol.99
, pp. 1332-1340
-
-
Gombart, A.F.1
-
87
-
-
0036727413
-
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down Syndrome
-
Wechsler, J. M. M. A., Anastasi, J., Karp, J. E., LeBeau, M. M. & Crispino, J. D. Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down Syndrome. Nature Genet. 32, 148-152 (2002).
-
(2002)
Nature Genet.
, vol.32
, pp. 148-152
-
-
Wechsler, J.M.M.A.1
Anastasi, J.2
Karp, J.E.3
LeBeau, M.M.4
Crispino, J.D.5
-
88
-
-
0028894781
-
The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line
-
Visvader, J. E., Crossley, M., Hill, J., Orkin, S. H. & Adams, J. M. The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line. Mol. Cell. Biol. 15, 634-641 (1995).
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 634-641
-
-
Visvader, J.E.1
Crossley, M.2
Hill, J.3
Orkin, S.H.4
Adams, J.M.5
-
89
-
-
0031024994
-
Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line
-
Weiss, M. J., Yu, C. & Orkin, S. H. Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. Mol. Cell. Biol. 17, 1642-1651 (1997).
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 1642-1651
-
-
Weiss, M.J.1
Yu, C.2
Orkin, S.H.3
-
90
-
-
0035903475
-
In vivo requirements for GATA-1 functional domains during primitive and definitive erythropoiesis
-
Shimizu, R., Takahashi, S., Ohneda, K., Engel, J. D. & Yamamoto, M. In vivo requirements for GATA-1 functional domains during primitive and definitive erythropoiesis. EMBO J. 20, 5250-5260 (2001).
-
(2001)
EMBO J.
, vol.20
, pp. 5250-5260
-
-
Shimizu, R.1
Takahashi, S.2
Ohneda, K.3
Engel, J.D.4
Yamamoto, M.5
-
91
-
-
0035047652
-
AML1-ETO downregulates the granulocytic differentiation factor C/EBPα in t(8;21) myeloid leukemia
-
Pabst, T., Mueller, B. U., Harakawa, N., Zhang, D.-E. & Tenen, D. G. AML1-ETO downregulates the granulocytic differentiation factor C/EBPα in t(8;21) myeloid leukemia. Nature Med. 7, 444-451 (2001).
-
(2001)
Nature Med.
, vol.7
, pp. 444-451
-
-
Pabst, T.1
Mueller, B.U.2
Harakawa, N.3
Zhang, D.-E.4
Tenen, D.G.5
-
92
-
-
0033569406
-
Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
-
Golub, T. R. et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 286, 531-537 (1999).
-
(1999)
Science
, vol.286
, pp. 531-537
-
-
Golub, T.R.1
-
93
-
-
0032694990
-
CCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment
-
Park, D. J. et al. CCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment. J. Clin. Invest. 103, 1399-1408 (1999).
-
(1999)
J. Clin. Invest.
, vol.103
, pp. 1399-1408
-
-
Park, D.J.1
-
94
-
-
0037307675
-
CCAAT/enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia
-
Truong, B. T. H. et al. CCAAT/enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia. Blood 101, 1141-1148 (2003).
-
(2003)
Blood
, vol.101
, pp. 1141-1148
-
-
Truong, B.T.H.1
-
95
-
-
79960971614
-
C/EBPβ is an important target of PML-RARA during ATRA induced differentiation of APL cells
-
Duprez, E. A., Koch, H. & Tenen, D. G. C/EBPβ is an important target of PML-RARA during ATRA induced differentiation of APL cells. Blood 98, 833a (2001).
-
(2001)
Blood
, vol.98
-
-
Duprez, E.A.1
Koch, H.2
Tenen, D.G.3
-
96
-
-
0035500922
-
Loss of PU.1 expression following inhibition of histone deacetylases
-
Laribee, R. N. & Klemsz, M. J. Loss of PU.1 expression following inhibition of histone deacetylases. J. Immunol. 167, 5160-5166 (2001).
-
(2001)
J. Immunol.
, vol.167
, pp. 5160-5166
-
-
Laribee, R.N.1
Klemsz, M.J.2
-
97
-
-
0037081084
-
Down-regulation and antiproliferative role of C/EBPα in lung cancer
-
Halmos, B. et al. Down-regulation and antiproliferative role of C/EBPα in lung cancer. Cancer Res. 62, 528-534 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 528-534
-
-
Halmos, B.1
-
99
-
-
0031471203
-
Intercellular trafficking and protein delivery by a herpesvirus structural protein
-
Elliott, G. & O'Hare, P. Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell 88, 223-233 (1997).
-
(1997)
Cell
, vol.88
, pp. 223-233
-
-
Elliott, G.1
O'Hare, P.2
-
100
-
-
0033520487
-
In vivo protein transduction: Delivery of a biologically active protein into the mouse
-
Schwarze, S. R., Ho, A., Vocero-Akbani, A. & Dowdy, S. F. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 285, 1569-1572 (1999).
-
(1999)
Science
, vol.285
, pp. 1569-1572
-
-
Schwarze, S.R.1
Ho, A.2
Vocero-Akbani, A.3
Dowdy, S.F.4
-
101
-
-
0035893252
-
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-Ras
-
Jackson, E. L. et al. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-Ras. Genes Dev. 15, 3243-3248 (2001).
-
(2001)
Genes Dev.
, vol.15
, pp. 3243-3248
-
-
Jackson, E.L.1
-
102
-
-
0030789242
-
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
-
Bonnet, D. & Dick, J. E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nature Med. 3, 730-737 (1997).
-
(1997)
Nature Med.
, vol.3
, pp. 730-737
-
-
Bonnet, D.1
Dick, J.E.2
-
103
-
-
0034691092
-
AML1-ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8; 21 chromosomal translocation
-
Miyamoto, T., Weissman, I. L. & Akashi, K. AML1-ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation. Proc. Natl Acad. Sci. USA 97, 7521-7526 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 7521-7526
-
-
Miyamoto, T.1
Weissman, I.L.2
Akashi, K.3
-
104
-
-
0035889155
-
Multipotent hematopoietic cell lines derived from C/EBPα (-/-) knock out mice display macrophage-colony-stimulating factor, granulocyte-colony-stimulating factor, and retinoic acid-induced granulocytic differentiation
-
Collins, S. J., Ulmer, J. Purton, L. E. & Darlington, G. Multipotent hematopoietic cell lines derived from C/EBPα (-/-) knock out mice display macrophage-colony-stimulating factor, granulocyte-colony-stimulating factor, and retinoic acid-induced granulocytic differentiation. Blood 98, 2382-2388 (2001).
-
(2001)
Blood
, vol.98
, pp. 2382-2388
-
-
Collins, S.J.1
Ulmer, J.2
Purton, L.E.3
Darlington, G.4
-
105
-
-
0037097736
-
Induction of granulocytic differentiation by two pathways
-
Zhang, P. et al. Induction of granulocytic differentiation by two pathways. Blood 99, 4406-4412 (2002).
-
(2002)
Blood
, vol.99
, pp. 4406-4412
-
-
Zhang, P.1
-
106
-
-
0030592517
-
Lessons from hereditary colorectal cancer
-
Kinzler, K. W. & Vogelstein, B. Lessons from hereditary colorectal cancer. Cell 87, 159-170 (1996).
-
(1996)
Cell
, vol.87
, pp. 159-170
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
107
-
-
0036463950
-
Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia
-
Higuchi, M. et al. Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia. Cancer Cell 1, 75-87 (2002).
-
(2002)
Cancer Cell
, vol.1
, pp. 75-87
-
-
Higuchi, M.1
-
108
-
-
0032126364
-
Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia
-
Traver, D., Akashi, K., Weissman, I. L. & Lagasse, E. Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia. Immunity 9, 47-57 (1998).
-
(1998)
Immunity
, vol.9
, pp. 47-57
-
-
Traver, D.1
Akashi, K.2
Weissman, I.L.3
Lagasse, E.4
-
109
-
-
0035886024
-
Nuclear factor-κB is constitutively activated in primitive human acute myelogenous leukemia cells
-
Guzman, M. L. et al. Nuclear factor-κB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood 98, 2301-2307 (2001).
-
(2001)
Blood
, vol.98
, pp. 2301-2307
-
-
Guzman, M.L.1
-
110
-
-
0035910748
-
BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PML-RARα) to block neutrophil differentiation and initiate acute leukemia
-
Kogan, S. C. et al. BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PML-RARα) to block neutrophil differentiation and initiate acute leukemia. J. Exp. Med. 193, 531-543 (2001).
-
(2001)
J. Exp. Med.
, vol.193
, pp. 531-543
-
-
Kogan, S.C.1
-
111
-
-
0035895056
-
Receptor- and mitochondrial-mediated apoptosis in acute leukemia: A translational view
-
Schimmer, A. D., Hedley, D. W., Penn, L. Z. & Minden, M. D. Receptor- and mitochondrial-mediated apoptosis in acute leukemia: a translational view. Blood 98, 3541-3553 (2001).
-
(2001)
Blood
, vol.98
, pp. 3541-3553
-
-
Schimmer, A.D.1
Hedley, D.W.2
Penn, L.Z.3
Minden, M.D.4
-
112
-
-
0034052854
-
Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1
-
Nichols, K. E. et al. Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1. Nature Genet. 24, 266-270 (2000).
-
(2000)
Nature Genet.
, vol.24
, pp. 266-270
-
-
Nichols, K.E.1
-
113
-
-
0033582475
-
C-Jun is a JNK-independent coactivator of the PU.1 transcription factor
-
Behre, G. et al. C-Jun is a JNK-independent coactivator of the PU.1 transcription factor. J. Biol. Chem. 274, 4939-4946 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 4939-4946
-
-
Behre, G.1
-
114
-
-
0037197968
-
Differential regulation of the human and murine CD 34 genes in hematopoietic stem cells
-
Okuno, Y. et al. Differential regulation of the human and murine CD34 genes in hematopoietic stem cells. Proc. Natl Acad. Sci. USA 99, 6246-6251 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 6246-6251
-
-
Okuno, Y.1
-
115
-
-
0026029709
-
CCAAT/enhancer binding protein gene promoter: Binding of nuclear factors during differentiation of 3T3-L1 preadipocytes
-
Christy, R. J., Kaestner, K. H., Geiman, D. E. & Lane, M. D. CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes. Proc. Natl Acad. Sci. USA 88, 2593-2597 (1991).
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 2593-2597
-
-
Christy, R.J.1
Kaestner, K.H.2
Geiman, D.E.3
Lane, M.D.4
-
116
-
-
0027276292
-
High level activity of the mouse CCAAT/enhancer binding protein (C/EBPα) gene promoter involves autoregulation and several ubiquitous transcription factors
-
Legraverend, C., Antonson, P., Flodby P. & Xanthopoulos, K. G. High level activity of the mouse CCAAT/enhancer binding protein (C/EBPα) gene promoter involves autoregulation and several ubiquitous transcription factors. Nucl. Acids Res. 21, 1735-1742 (1993).
-
(1993)
Nucl. Acids Res.
, vol.21
, pp. 1735-1742
-
-
Legraverend, C.1
Antonson, P.2
Flodby, P.3
Xanthopoulos, K.G.4
-
117
-
-
0034970803
-
AML1 and AML1 fusion protein AML1-ETO in myeloid gene regulation and leukemogenesis
-
Zhang, D.-E., Burel, S. A., Zhou, L., Hethenngton, C. J. & Yuan, Y. AML1 and AML1 fusion protein AML1-ETO in myeloid gene regulation and leukemogenesis. Blood Cells Mol. Dis. 27, 368-376 (2001).
-
(2001)
Blood Cells Mol. Dis.
, vol.27
, pp. 368-376
-
-
Zhang, D.-E.1
Burel, S.A.2
Zhou, L.3
Hethenngton, C.J.4
Yuan, Y.5
-
118
-
-
0029045087
-
The t(12;21) of acute lymphoblastic leukemia results in a TEL-AML1 gene fusion
-
Romana, S. P. et al. The t(12;21) of acute lymphoblastic leukemia results in a TEL-AML1 gene fusion. Blood 85, 3662-3670 (1995).
-
(1995)
Blood
, vol.85
, pp. 3662-3670
-
-
Romana, S.P.1
-
119
-
-
0029004541
-
Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia
-
Golub, T. R. et al. Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc. Natl Acad. Sci. USA 92, 4917-4921 (1995).
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 4917-4921
-
-
Golub, T.R.1
-
120
-
-
18344389720
-
Causal relationship between the loss of RUNX3 expression and gastric cancer
-
Li, Q. L. et al. Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell 109, 113-124 (2002).
-
(2002)
Cell
, vol.109
, pp. 113-124
-
-
Li, Q.L.1
-
121
-
-
0029746172
-
Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein-α
-
Flodby, P., Barlow, C., Kylefjord, H., Ahrlund-Richter, L. & Xanthopoulos, K. G. Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein-α. J. Biol. Chem. 271, 24753-24760 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 24753-24760
-
-
Flodby, P.1
Barlow, C.2
Kylefjord, H.3
Ahrlund-Richter, L.4
Xanthopoulos, K.G.5
-
122
-
-
0032525340
-
C/EBPβ but not C/EBPα, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland
-
Seagroves, T. N. et al. C/EBPβ but not C/EBPα, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland. Genes Dev. 12, 1917-1928 (1998).
-
(1998)
Genes Dev.
, vol.12
, pp. 1917-1928
-
-
Seagroves, T.N.1
-
123
-
-
0031283125
-
Overexpression of C/EBPβ-LIP, a naturally occurring, dominant-negative transcription factor, in human breast cancer
-
Zahnow, C. A., Younes, P., Laucirica, R. & Rosen, J. M. Overexpression of C/EBPβ-LIP, a naturally occurring, dominant-negative transcription factor, in human breast cancer. J. Natl Cancer Inst. 89, 1887-1891 (1997).
-
(1997)
J. Natl. Cancer Inst.
, vol.89
, pp. 1887-1891
-
-
Zahnow, C.A.1
Younes, P.2
Laucirica, R.3
Rosen, J.M.4
-
124
-
-
0029156782
-
CCAAT/enhancer binding protein-alpha amino acid motifs with dual TBP and TFIIB binding ability co-operate to activate transcription in both yeast and mammalian cells
-
Nerlov, C. & Ziff, E. B. CCAAT/enhancer binding protein-alpha amino acid motifs with dual TBP and TFIIB binding ability co-operate to activate transcription in both yeast and mammalian cells. EMBO J. 14, 4318-4328 (1995).
-
(1995)
EMBO J.
, vol.14
, pp. 4318-4328
-
-
Nerlov, C.1
Ziff, E.B.2
-
125
-
-
0025131536
-
Identification of two polypeptide segments of CCAAT/enhancer binding protein required for transcriptional activation of the serum albumin gene
-
Friedman, A. D. & McKnight, S. L. Identification of two polypeptide segments of CCAAT/enhancer binding protein required for transcriptional activation of the serum albumin gene. Genes Dev. 4, 1416-1426 (1990).
-
(1990)
Genes Dev.
, vol.4
, pp. 1416-1426
-
-
Friedman, A.D.1
McKnight, S.L.2
|