메뉴 건너뛰기




Volumn 3, Issue 2, 2003, Pages 89-101

Disruption of differentiation in human cancer: AML shows the way

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; CCAAT ENHANCER BINDING PROTEIN BETA; LEUCINE ZIPPER PROTEIN; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR;

EID: 0037315894     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc989     Document Type: Review
Times cited : (531)

References (125)
  • 1
    • 0027092333 scopus 로고
    • Transcription factors, translocations, and leukemia
    • Nichols, J. & Nimer, S. D. Transcription factors, translocations, and leukemia. Blood 80, 2953-2983 (1992).
    • (1992) Blood , vol.80 , pp. 2953-2983
    • Nichols, J.1    Nimer, S.D.2
  • 2
    • 0019274901 scopus 로고
    • Hemopoietic stem cell differentiation
    • Till, J. E. & McCulloch, E. A. Hemopoietic stem cell differentiation. Biochim. Biophys. Acta 605, 431-459 (1980).
    • (1980) Biochim. Biophys. Acta , vol.605 , pp. 431-459
    • Till, J.E.1    McCulloch, E.A.2
  • 3
    • 0027325195 scopus 로고
    • Differentiation and proliferation of hematopoietic stem cells
    • Ogawa, M. Differentiation and proliferation of hematopoietic stem cells. Blood 81, 2844-2853 (1993).
    • (1993) Blood , vol.81 , pp. 2844-2853
    • Ogawa, M.1
  • 4
    • 0023922373 scopus 로고
    • Purification and characterization of mouse hematopoietic stem cells
    • Spangrude, G. J., Heimfeld, S. & Weissman, I. L. Purification and characterization of mouse hematopoietic stem cells. Science 241, 58-62 (1988).
    • (1988) Science , vol.241 , pp. 58-62
    • Spangrude, G.J.1    Heimfeld, S.2    Weissman, I.L.3
  • 5
    • 0034624828 scopus 로고    scopus 로고
    • A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    • Akashi, K., Traver, D., Miyamoto, T. & Weissman, I. L. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404, 193-197 (2000). Describes the methodology for isolation and analysis of progenitors at precisely defined functional stages of differentiation.
    • (2000) Nature , vol.404 , pp. 193-197
    • Akashi, K.1    Traver, D.2    Miyamoto, T.3    Weissman, I.L.4
  • 6
    • 0036070180 scopus 로고    scopus 로고
    • Myeloid or lymphoid promiscuity as a cntical step in hematopoietic lineage commitment
    • Miyamoto, T. et al. Myeloid or lymphoid promiscuity as a cntical step in hematopoietic lineage commitment. Dev. Cell 3, 137-147 (2002).
    • (2002) Dev. Cell , vol.3 , pp. 137-147
    • Miyamoto, T.1
  • 7
    • 17944376561 scopus 로고    scopus 로고
    • AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations
    • Yuan, Y. et al. AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations. Proc. Natl Acad. Sci. USA 98, 10398-10403 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 10398-10403
    • Yuan, Y.1
  • 8
    • 0029876726 scopus 로고    scopus 로고
    • The transcriptional control of hematopoiesis
    • Shivdasani, R. A. & Orkin, S. H. The transcriptional control of hematopoiesis. Blood 87, 4025-4039 (1996).
    • (1996) Blood , vol.87 , pp. 4025-4039
    • Shivdasani, R.A.1    Orkin, S.H.2
  • 9
    • 0030854907 scopus 로고    scopus 로고
    • Transcription factors, normal myeloid development, and leukemia
    • Tenen, D. G., Hromas, R., Licht, J. D. & Zhang, D.-E. Transcription factors, normal myeloid development, and leukemia. Blood 90, 489-519 (1997).
    • (1997) Blood , vol.90 , pp. 489-519
    • Tenen, D.G.1    Hromas, R.2    Licht, J.D.3    Zhang, D.-E.4
  • 10
    • 0142144295 scopus 로고    scopus 로고
    • (ed. Zon, L. I.) (Oxford University Press, New York)
    • Tenen, D. G. Hematopoiesis (ed. Zon, L. I.) 417-428 (Oxford University Press, New York, 2001).
    • (2001) Hematopoiesis , pp. 417-428
    • Tenen, D.G.1
  • 11
    • 0034941566 scopus 로고    scopus 로고
    • Dichotomy of AML1-ETO functions: Growth arrest versus block of differentiation
    • Burel, S.A. et al. Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation. Mol. Cell. Biol. 21, 5577-5590 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 5577-5590
    • Burel, S.A.1
  • 12
    • 0036317908 scopus 로고    scopus 로고
    • Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation
    • De Guzman, C. G. et al. Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation. Mol. Cell. Biol. 22, 5508-5517 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 5508-5517
    • De Guzman, C.G.1
  • 13
    • 0036636857 scopus 로고    scopus 로고
    • Core-binding factors in haematopoiesis and leukaemia
    • Speck, N. A. & Gilliland, D. G. Core-binding factors in haematopoiesis and leukaemia. Nature Rev. Cancer 2, 502-513 (2002).
    • (2002) Nature Rev. Cancer , vol.2 , pp. 502-513
    • Speck, N.A.1    Gilliland, D.G.2
  • 14
    • 0029019659 scopus 로고
    • AML1 and the 8:21 and 3; 21 translocations in acute and chronic myeloid leukemia
    • Nuclfora, G. & Rowley, J. D. AML1 and the 8:21 and 3;21 translocations in acute and chronic myeloid leukemia. Blood 86, 1-14 (1995).
    • (1995) Blood , vol.86 , pp. 1-14
    • Nuclfora, G.1    Rowley, J.D.2
  • 15
    • 0035865459 scopus 로고    scopus 로고
    • Dimerization with PEBP2β protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation
    • Huang, G. et al. Dimerization with PEBP2β protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation. EMBO J. 20, 723-733 (2001).
    • (2001) EMBO J. , vol.20 , pp. 723-733
    • Huang, G.1
  • 16
    • 0034303586 scopus 로고    scopus 로고
    • Diversification of haematopoietic stem cells to specific lineages
    • Orkin, S. H. Diversification of haematopoietic stem cells to specific lineages. Nature Rev. Genet. 1, 57-64 (2000).
    • (2000) Nature Rev. Genet. , vol.1 , pp. 57-64
    • Orkin, S.H.1
  • 17
    • 0033151624 scopus 로고    scopus 로고
    • Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: Functional antagonism in erythroid cells
    • Rekhtman, N., Radparvar, F., Evans, T. & Skouitchi, A. I. Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells. Genes Dev. 13, 1398-1411 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 1398-1411
    • Rekhtman, N.1    Radparvar, F.2    Evans, T.3    Skouitchi, A.I.4
  • 18
    • 0033587755 scopus 로고    scopus 로고
    • Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1
    • Zhang, P. et al. Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1. Proc. Natl Acad. Sci. USA 96, 8705-8710 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 8705-8710
    • Zhang, P.1
  • 19
    • 0034656393 scopus 로고    scopus 로고
    • GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1 dependent transcription
    • Nerlov, C., Querfurth, E., Kulessa, H. & Graf, T. GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1 dependent transcription. Blood 95, 2543-2551 (2000).
    • (2000) Blood , vol.95 , pp. 2543-2551
    • Nerlov, C.1    Querfurth, E.2    Kulessa, H.3    Graf, T.4
  • 21
    • 0030963918 scopus 로고    scopus 로고
    • A 'knockdown' mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1
    • Mcdevitt, M. A., Shivdasani, R. A., Fujiwara, Y., Yang, H. D. & Orkin, S. H. A 'knockdown' mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1. Proc. Natl Acad. Sci. USA 94, 6781-6785 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 6781-6785
    • Mcdevitt, M.A.1    Shivdasani, R.A.2    Fujiwara, Y.3    Yang, H.D.4    Orkin, S.H.5
  • 22
    • 0036258216 scopus 로고    scopus 로고
    • Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation
    • Cantor, A. B., Katz, S. G. & Orkin, S. H. Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation. Mol. Cell. Biol. 22, 4268-4279 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 4268-4279
    • Cantor, A.B.1    Katz, S.G.2    Orkin, S.H.3
  • 25
    • 0030061554 scopus 로고    scopus 로고
    • AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
    • Okuda, T., van Deursen, J., Hiebert, S. W., Grosveld, G. & Downing, J. R. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84, 321-330 (1996).
    • (1996) Cell , vol.84 , pp. 321-330
    • Okuda, T.1    Van Deursen, J.2    Hiebert, S.W.3    Grosveld, G.4    Downing, J.R.5
  • 26
    • 0029918597 scopus 로고    scopus 로고
    • Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoesis
    • Wang, Q. et al. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoesis. Proc. Natl Acad. Sci. USA 93, 3444-3449 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3444-3449
    • Wang, Q.1
  • 27
    • 0028136726 scopus 로고
    • The transcnption factor PU.1 is required for the development of multiple hematopoietic lineages
    • Scott, E. W., Simon, M. C., Anastai, J. & Singh, H. The transcnption factor PU.1 is required for the development of multiple hematopoietic lineages. Science 265, 1573-1577 (1994).
    • (1994) Science , vol.265 , pp. 1573-1577
    • Scott, E.W.1    Simon, M.C.2    Anastai, J.3    Singh, H.4
  • 28
    • 0242549003 scopus 로고    scopus 로고
    • Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
    • McKercher, S. R. et al. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J. 15, 5647-5658 (1996).
    • (1996) EMBO J. , vol.15 , pp. 5647-5658
    • McKercher, S.R.1
  • 29
    • 0032479989 scopus 로고    scopus 로고
    • PU.1 regulates both cytokine dependent proliferation and differentiation of granulocyte/macrophage progenitors
    • DeKoter, R. P., Walsh, J. C. & Singh, H. PU.1 regulates both cytokine dependent proliferation and differentiation of granulocyte/macrophage progenitors. EMBO J. 17, 4456-4468 (1998). Shows that PU.1-deficient cells are blocked at an early stage of myeloid maturation, and that introduction of PU.1 (but not cytokine signalling) restores differentiation.
    • (1998) EMBO J. , vol.17 , pp. 4456-4468
    • DeKoter, R.P.1    Walsh, J.C.2    Singh, H.3
  • 30
    • 0033214311 scopus 로고    scopus 로고
    • PU.1 and the granulocyte- and macrophage colony-stimulating factor receptors play distinct roles in late-stage myeloid cell differentiation
    • Anderson, K. L. et al. PU.1 and the granulocyte- and macrophage colony-stimulating factor receptors play distinct roles in late-stage myeloid cell differentiation. Blood 94, 2310-2318 (1999).
    • (1999) Blood , vol.94 , pp. 2310-2318
    • Anderson, K.L.1
  • 31
    • 0037100304 scopus 로고    scopus 로고
    • The granulocytic inducer C/EBPα inactivates the myeloid master gene PU.1: Possible role in lineage commitment decisions
    • Reddy, V. et al. The granulocytic inducer C/EBPα inactivates the myeloid master gene PU.1: possible role in lineage commitment decisions. Blood 100, 483-490 (2002).
    • (2002) Blood , vol.100 , pp. 483-490
    • Reddy, V.1
  • 32
    • 0031835661 scopus 로고    scopus 로고
    • CCAAT/enhancer binding protein-α is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors
    • Radomska, H. S. et al. CCAAT/enhancer binding protein-α is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors. Mol. Cell. Biol. 18, 4301-4314 (1998).
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 4301-4314
    • Radomska, H.S.1
  • 33
    • 79960971577 scopus 로고    scopus 로고
    • C/EBPα deficiency blocks granulocytic differentiation at the common myeloid progenitor stage in both adult and fetal liver myelopoiesis
    • Zhang, P. et al. C/EBPα deficiency blocks granulocytic differentiation at the common myeloid progenitor stage in both adult and fetal liver myelopoiesis. Blood 98, 792a (2001).
    • (2001) Blood , vol.98
    • Zhang, P.1
  • 34
    • 0029121366 scopus 로고
    • PU.1 (Spi-1) and C/EBPa regulate the expression of the granulocyte-macrophage colony-stimuating factor receptor-α gene
    • Hohaus, S. et al. PU.1 (Spi-1) and C/EBPa regulate the expression of the granulocyte-macrophage colony-stimuating factor receptor-α gene. Mol. Cell. Biol. 15, 5830-5845 (1995).
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 5830-5845
    • Hohaus, S.1
  • 35
    • 0028120907 scopus 로고
    • The macrophage transcription factor PU.1 directs tissue specific expression of the macrophage colony stimulating factor receptor
    • Zhang, D.-E., Hetherington, C. J., Chen, H. M. & Tenen, D. G. The macrophage transcription factor PU.1 directs tissue specific expression of the macrophage colony stimulating factor receptor. Mol. Cell. Biol. 14, 373-381 (1994).
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 373-381
    • Zhang, D.-E.1    Hetherington, C.J.2    Chen, H.M.3    Tenen, D.G.4
  • 36
    • 0029793902 scopus 로고    scopus 로고
    • PU.1 (Spi-1) and C/EBPα regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells
    • Smith, L. T., Hohaus, S., Gonzalez, D. A., Dziennis, S. E. & Tenen, D. G. PU.1 (Spi-1) and C/EBPα regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells. Blood 88, 1234-1247 (1996).
    • (1996) Blood , vol.88 , pp. 1234-1247
    • Smith, L.T.1    Hohaus, S.2    Gonzalez, D.A.3    Dziennis, S.E.4    Tenen, D.G.5
  • 37
    • 0032526324 scopus 로고    scopus 로고
    • Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPα
    • Iwama, A. et al. Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPα. Nucl. Acids Res. 26, 3034-3043 (1998).
    • (1998) Nucl. Acids Res. , vol.26 , pp. 3034-3043
    • Iwama, A.1
  • 38
    • 0031029557 scopus 로고    scopus 로고
    • Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice
    • Zhang, D.-E. et al. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice. Proc. Natl Acad. Sci. USA 94, 569-574 (1997). First demonstration that targeted disruption of C/EBPα results in an earty granulocytic differentiation block.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 569-574
    • Zhang, D.-E.1
  • 39
    • 0033564978 scopus 로고    scopus 로고
    • C/EBPα bypasses granulocyte colony-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D cl3 myeloblasts
    • Wang, X., Scott, E. W., Sawyers, C. L. & Friedman, A. D. C/ EBPα bypasses granulocyte colony-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D cl3 myeloblasts. Blood 94, 560-571 (1999).
    • (1999) Blood , vol.94 , pp. 560-571
    • Wang, X.1    Scott, E.W.2    Sawyers, C.L.3    Friedman, A.D.4
  • 40
    • 0029976068 scopus 로고    scopus 로고
    • CCAAT/enhancer-binding protein a (C/EBPα) inhibits cell proliferation though the p21 (WAF-1/ CIP-1/SDI-1) protein
    • Timchenko, N. A., Wilde, M., Nakanishi, M., Smith, J. R. & Darlington, G. J. CCAAT/enhancer-binding protein a (C/EBPα) inhibits cell proliferation though the p21 (WAF-1/ CIP-1/SDI-1) protein. Genes Dev. 10, 804-815 (1996).
    • (1996) Genes Dev. , vol.10 , pp. 804-815
    • Timchenko, N.A.1    Wilde, M.2    Nakanishi, M.3    Smith, J.R.4    Darlington, G.J.5
  • 41
    • 0034740215 scopus 로고    scopus 로고
    • C/EBPα arrests cell proliferation through direct inhibition of Cdk2 and Cdk4
    • Wang, H. et al. C/EBPα arrests cell proliferation through direct inhibition of Cdk2 and Cdk4. Mol. Cell 8, 817-828 (2001).
    • (2001) Mol. Cell , vol.8 , pp. 817-828
    • Wang, H.1
  • 42
    • 0035005526 scopus 로고    scopus 로고
    • C-myc is a critical target for C/EBPα in granulopoiesis
    • Johansen, L. M. et al. C-myc is a critical target for C/EBPα in granulopoiesis. Mol. Cell. Biol. 21, 3789-3806 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3789-3806
    • Johansen, L.M.1
  • 43
    • 0035913913 scopus 로고    scopus 로고
    • E2F repression by C/EBPα is required for adipogenesis and granulopoiesis in vivo
    • Porse, B. T. et al. E2F repression by C/EBPα is required for adipogenesis and granulopoiesis in vivo. Cell 107, 247-258 (2001). Shows the important link between the ability of C/EBPα to inhibit the cell-cycle-promoting gene E2F and the ability to induce granulocytic differentiation.
    • (2001) Cell , vol.107 , pp. 247-258
    • Porse, B.T.1
  • 44
    • 0025786584 scopus 로고
    • Activation of the erythropoietin receptor promoter by transcription factor GATA-1
    • Zon, L. I., Youssoufian, H., Mather, C., Lodish, H. F. & Orkin, S. H. Activation of the erythropoietin receptor promoter by transcription factor GATA-1. Proc. Natl Acad. Sci. USA 88, 10638-10641 (1991).
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 10638-10641
    • Zon, L.I.1    Youssoufian, H.2    Mather, C.3    Lodish, H.F.4    Orkin, S.H.5
  • 45
    • 0028798816 scopus 로고
    • Autoregulation of the human C/EBPα gene by stimulation of upstream stimulatory factor binding
    • Timchenko, N. et al. Autoregulation of the human C/EBPα gene by stimulation of upstream stimulatory factor binding. Mol. Cell. Biol. 15, 1192-1202 (1995).
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1192-1202
    • Timchenko, N.1
  • 46
    • 0028826488 scopus 로고
    • PU.1 (Spi-1) autoregulates its expression in myeloid cells
    • Chen, H. M. et al. PU.1 (Spi-1) autoregulates its expression in myeloid cells. Oncogene 11, 1549-1560 (1995).
    • (1995) Oncogene , vol.11 , pp. 1549-1560
    • Chen, H.M.1
  • 47
    • 0035892121 scopus 로고    scopus 로고
    • Regulation of the PU.1 gene by distal elements
    • Li, Y. et al. Regulation of the PU.1 gene by distal elements. Blood 98, 2958-2965 (2001).
    • (2001) Blood , vol.98 , pp. 2958-2965
    • Li, Y.1
  • 48
    • 0035529053 scopus 로고    scopus 로고
    • Cooperation between C/EBPα TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation
    • Pedersen, T. A., Kowenz-Leutz, E., Leutz, A. & Nerlov, C. Cooperation between C/EBPα TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation. Genes Dev. 15, 3208-3216 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 3208-3216
    • Pedersen, T.A.1    Kowenz-Leutz, E.2    Leutz, A.3    Nerlov, C.4
  • 49
    • 0032555932 scopus 로고    scopus 로고
    • Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein α (C/EBPα) is critical for granulopoiesis
    • Zhang, P. et al. Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein α (C/EBPα) is critical for granulopoiesis. J. Exp. Med. 188, 1173-1184 (1998).
    • (1998) J. Exp. Med. , vol.188 , pp. 1173-1184
    • Zhang, P.1
  • 50
    • 0035798414 scopus 로고    scopus 로고
    • McBindall: A better name for CCAAT/enhancer binding proteins?
    • McKnight, S. L. McBindall: a better name for CCAAT/enhancer binding proteins? Cell 107, 259-261 (2001).
    • (2001) Cell , vol.107 , pp. 259-261
    • McKnight, S.L.1
  • 51
    • 0033180211 scopus 로고    scopus 로고
    • Reversible tumorigenesis by MYC in hematopoietic lineages
    • Felsher, D. W. & Bishop, J. M. Reversible tumorigenesis by MYC in hematopoietic lineages. Mol. Cell 4, 199-207 (1999).
    • (1999) Mol. Cell , vol.4 , pp. 199-207
    • Felsher, D.W.1    Bishop, J.M.2
  • 52
    • 0037438380 scopus 로고    scopus 로고
    • The effects of Bcr-Abl on C/EBP transcription-factor regulation and neutrophilic differentiation are reversed by the Abl kinase inhibitor imatinib mesylate
    • Schuster, C. et al. The effects of Bcr-Abl on C/EBP transcription-factor regulation and neutrophilic differentiation are reversed by the Abl kinase inhibitor imatinib mesylate. Blood 101, 655-663 (2003).
    • (2003) Blood , vol.101 , pp. 655-663
    • Schuster, C.1
  • 53
    • 0026716011 scopus 로고
    • Cell cycle-dependent initiation and lineage-dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors
    • Sposi, N. M. et al. Cell cycle-dependent initiation and lineage-dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors. Proc. Natl Acad. Sci. USA 89, 6353-6357 (1992).
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 6353-6357
    • Sposi, N.M.1
  • 54
    • 0034603080 scopus 로고    scopus 로고
    • Expression of the AML-1 oncogene shortens the G(1) phase of the cell cycle
    • Strom, D. K. et al. Expression of the AML-1 oncogene shortens the G(1) phase of the cell cycle. J. Biol. Chem. 275, 3438-3445 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 3438-3445
    • Strom, D.K.1
  • 55
    • 85047696566 scopus 로고    scopus 로고
    • AML1 stimulates G1 to S progression via its transactivation domain
    • Bernardin, F. & Friedman, A. D. AML1 stimulates G1 to S progression via its transactivation domain. Oncogene 21, 3247-3252 (2002).
    • (2002) Oncogene , vol.21 , pp. 3247-3252
    • Bernardin, F.1    Friedman, A.D.2
  • 56
    • 0028954304 scopus 로고
    • Analysis of hematopoiesis in max 41 transgenic mice that exhibit sustained elevations of blood granulocytes and monocytes
    • Metcalf, D., Lindeman, G. J. & Nicola, N. A. Analysis of hematopoiesis in max 41 transgenic mice that exhibit sustained elevations of blood granulocytes and monocytes. Blood 85, 2364-2370 (1995).
    • (1995) Blood , vol.85 , pp. 2364-2370
    • Metcalf, D.1    Lindeman, G.J.2    Nicola, N.A.3
  • 58
    • 0027136259 scopus 로고
    • Hematopoietic regulators: Redundancy or subtlety
    • Metcalf, D. Hematopoietic regulators: redundancy or subtlety. Blood 82, 3515-3523 (1993).
    • (1993) Blood , vol.82 , pp. 3515-3523
    • Metcalf, D.1
  • 59
    • 0023928595 scopus 로고
    • Heparan sulphate bound growth factors: A mechanism for stromal cell mediated haemopoiesis
    • Roberts, R. et al. Heparan sulphate bound growth factors: a mechanism for stromal cell mediated haemopoiesis. Nature 332, 376-378 (1988).
    • (1988) Nature , vol.332 , pp. 376-378
    • Roberts, R.1
  • 60
    • 0027261321 scopus 로고
    • Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors
    • Fairbairn, L. J., Cowling, G. J., Reipert, B. M. & Dexter, T. M. Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors. Cell 74, 823-832 (1993).
    • (1993) Cell , vol.74 , pp. 823-832
    • Fairbairn, L.J.1    Cowling, G.J.2    Reipert, B.M.3    Dexter, T.M.4
  • 61
    • 0027738701 scopus 로고
    • Upregulation of lineage specific receptors and ligands in multipotential prognitor cells is part of an endogenous program of differentiation
    • Just, U. et al. Upregulation of lineage specific receptors and ligands in multipotential prognitor cells is part of an endogenous program of differentiation. Growth Factors 9, 291-300 (1993).
    • (1993) Growth Factors , vol.9 , pp. 291-300
    • Just, U.1
  • 62
    • 0028021829 scopus 로고
    • Inhibition of hemetopoiesis by competitive binding of the transcription factor PU.1
    • Vaso, M. T. et al. Inhibition of hemetopoiesis by competitive binding of the transcription factor PU.1. Proc. Natl Acad. Sci. USA 91, 7932-7936 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 7932-7936
    • Vaso, M.T.1
  • 63
    • 0030954167 scopus 로고    scopus 로고
    • Multilineage gene expression precedes commitment in the hematopoietic system
    • Hu, M. et al. Multilineage gene expression precedes commitment in the hematopoietic system. Genes Dev. 11, 774-785 (1997).
    • (1997) Genes Dev. , vol.11 , pp. 774-785
    • Hu, M.1
  • 64
    • 0034667672 scopus 로고    scopus 로고
    • PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding
    • Zhang, P. et al. PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding. Blood 96, 2641-2648 (2000).
    • (2000) Blood , vol.96 , pp. 2641-2648
    • Zhang, P.1
  • 65
    • 0017162163 scopus 로고
    • Proposals for the classification of the acute leukaemias. French-American-British (FAB) cooperative group
    • Bennett, J. M. et al. Proposals for the classification of the acute leukaemias. French-American-British (FAB) cooperative group. Br. J. Haematol 33, 451-458 (1976). A landmark paper that established a classification system of AML on the basis of differentiation status.
    • (1976) Br. J. Haematol. , vol.33 , pp. 451-458
    • Bennett, J.M.1
  • 66
    • 0036234659 scopus 로고    scopus 로고
    • Unique molecular and cellular features of acute myelogenous leukemia stem cells
    • Jordan, C. T. Unique molecular and cellular features of acute myelogenous leukemia stem cells. Leukemia 16, 559-562 (2002).
    • (2002) Leukemia , vol.16 , pp. 559-562
    • Jordan, C.T.1
  • 67
    • 0034525530 scopus 로고    scopus 로고
    • Proliferative status of primitive hematopoietic progenitors from patients with acute myelogenous leukemia (AML)
    • Guan, Y. & Hogge, D. E. Proliferative status of primitive hematopoietic progenitors from patients with acute myelogenous leukemia (AML). Leukemia 14, 2135-2141 (2000).
    • (2000) Leukemia , vol.14 , pp. 2135-2141
    • Guan, Y.1    Hogge, D.E.2
  • 68
    • 0036340784 scopus 로고    scopus 로고
    • BCR-ABL suppresses C/EBPα expression through inhibitory activity of hnRNP E2
    • Perrotti, D. et al. BCR-ABL suppresses C/EBPα expression through inhibitory activity of hnRNP E2. Nature Genet. 30, 48-58 (2001). Describes yet another mechanism of inactivation of C/EBPα in AML - that involving the downregulation of C/EBPα through post-transcriptional mechanisms as the chronic (proliferative) phase transforms to acute leukaemia.
    • (2001) Nature Genet. , vol.30 , pp. 48-58
    • Perrotti, D.1
  • 69
    • 0032188805 scopus 로고    scopus 로고
    • The importance of diagnostic cytogenetics on outcome in AML: Analysis of 1,612 patients entered into the MRC AML 10 trial
    • The Medical Research Council Adult and Children's Leukaemia Working Parties
    • Grimwade, D. et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood 92, 2322-2333 (1998).
    • (1998) Blood , vol.92 , pp. 2322-2333
    • Grimwade, D.1
  • 70
    • 0037108111 scopus 로고    scopus 로고
    • Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: A study from the Acute Leukemia French Association (ALFA)
    • Preudhomme, C. et al. Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA). Blood 100, 2717-2723 (2002). Relates the status of C/EBPα mutations, with and without FLT3-ITD, to prognosis, and proposes a new classification of AML based on C/EBPα mutation status.
    • (2002) Blood , vol.100 , pp. 2717-2723
    • Preudhomme, C.1
  • 71
    • 0025746321 scopus 로고
    • t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1
    • Miyoshi, H. et al. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc. Natl Acad. Sci. USA 88, 10431-10434 (1991).
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 10431-10434
    • Miyoshi, H.1
  • 72
    • 0032830638 scopus 로고    scopus 로고
    • Haploinsuficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia
    • Song, W. J. et al. Haploinsuficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nature Genet. 23, 166-175 (1999). Reports the haploinsufficiency of an important haematopoietic transcription factor that leads to a propensity to develop AML.
    • (1999) Nature Genet. , vol.23 , pp. 166-175
    • Song, W.J.1
  • 73
    • 0033559746 scopus 로고    scopus 로고
    • Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2αB gene associated with myeloblastic leukemias
    • Osato, M. et al. Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2αB gene associated with myeloblastic leukemias. Blood 93, 1817-1824 (1999). This study, along with reference 74, shows that AML1 could be involved in the pathogenesis of AML through a mechanism other than translocation, and that AML1 mutations were associated with a distinct differentiation subtype of AML.
    • (1999) Blood , vol.93 , pp. 1817-1824
    • Osato, M.1
  • 74
    • 0034667690 scopus 로고    scopus 로고
    • o acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21
    • o acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21. Blood 98, 2862-2869 (2000).
    • (2000) Blood , vol.98 , pp. 2862-2869
    • Preudhomme, C.1
  • 75
    • 0037082499 scopus 로고    scopus 로고
    • In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia (FPD/AML): Implications for mechanisms of pathogenesis
    • Michaud, J. et al. In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia (FPD/AML): implications for mechanisms of pathogenesis. Blood 99, 1364-1372 (2002).
    • (2002) Blood , vol.99 , pp. 1364-1372
    • Michaud, J.1
  • 76
    • 0037702768 scopus 로고    scopus 로고
    • AML1 is required for megakaryocytic maturation in adult hematopoiesis
    • Ichikawa, H. et al. AML1 is required for megakaryocytic maturation in adult hematopoiesis. Blood 100, 130a (2003).
    • (2003) Blood , vol.100
    • Ichikawa, H.1
  • 77
    • 0037092550 scopus 로고    scopus 로고
    • Unlike AML1, CBFβ is not deregulated by point mutations in acute myeloid leukemia and in myelodysplastic syndromes
    • Leroy, H. et al. Unlike AML1, CBFβ is not deregulated by point mutations in acute myeloid leukemia and in myelodysplastic syndromes. Blood 99, 3848-3850 (2002).
    • (2002) Blood , vol.99 , pp. 3848-3850
    • Leroy, H.1
  • 78
    • 0030588487 scopus 로고    scopus 로고
    • The CBFβ subunit is essential for CBFα2 (AML1) function in vivo
    • Wang, Q. et al. The CBFβ subunit is essential for CBFα2 (AML1) function in vivo Cell 87, 697-708 (1996).
    • (1996) Cell , vol.87 , pp. 697-708
    • Wang, Q.1
  • 79
    • 0029973591 scopus 로고    scopus 로고
    • Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta
    • Sasaki, K. et al. Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta. Proc. Natl Acad. Sci. USA 93, 12359-12363 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 12359-12363
    • Sasaki, K.1
  • 80
    • 18344372734 scopus 로고    scopus 로고
    • C/EBP-β C/EBP-δ, PU.1, AML1 genes: Mutational analysis in 381 samples of hematopoietic and solid malignancies
    • Vegesna, V. et al. C/EBP-β C/EBP-δ, PU.1, AML1 genes: mutational analysis in 381 samples of hematopoietic and solid malignancies. Leuk. Res. 26, 451-457 (2002).
    • (2002) Leuk. Res. , vol.26 , pp. 451-457
    • Vegesna, V.1
  • 81
    • 0036682473 scopus 로고    scopus 로고
    • PU.1 mutations are associated with acute myeloid leukemia
    • Mueller, B. U. et al. PU.1 mutations are associated with acute myeloid leukemia. Blood 100, 998-1007 (2002).
    • (2002) Blood , vol.100 , pp. 998-1007
    • Mueller, B.U.1
  • 82
    • 0035353165 scopus 로고    scopus 로고
    • PU.1 exhibits partial functional redundancy with Spi-B, but not with Ets-1 or Elf-1
    • Garrett-Sinha, L. A., Dahl, R., Rao, S., Barton, K. P. & Simon, M. C. PU.1 exhibits partial functional redundancy with Spi-B, but not with Ets-1 or Elf-1. Blood 97, 2908-2912 (2001).
    • (2001) Blood , vol.97 , pp. 2908-2912
    • Garrett-Sinha, L.A.1    Dahl, R.2    Rao, S.3    Barton, K.P.4    Simon, M.C.5
  • 83
    • 0031972701 scopus 로고    scopus 로고
    • The t(8:21) fusion product, AML-1-ETO, associates with C/EBP-α, inhibits C/EBP-α-dependent transcription, and blocks granulocytic differentiation
    • Westendorf, J. J. et al. The t(8:21) fusion product, AML-1-ETO, associates with C/EBP-α, inhibits C/EBP-α-dependent transcription, and blocks granulocytic differentiation. Mol. Cell. Biol. 18, 322-333 (1998). Established that the mechanism of differentiation block induced by AML1-ETO involved inhibition of C/EBPα that is required for granulocyte differentiation.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 322-333
    • Westendorf, J.J.1
  • 84
    • 0037222293 scopus 로고    scopus 로고
    • The myeloid master regulator PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia
    • Vangala, R. K. et al. The myeloid master regulator PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia. Blood 101, 270-277 (2002).
    • (2002) Blood , vol.101 , pp. 270-277
    • Vangala, R.K.1
  • 85
    • 0035093813 scopus 로고    scopus 로고
    • Dominant negative mutations of CEBPα, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia
    • Pabst, T. et al. Dominant negative mutations of CEBPα, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia. Nature Genet. 27, 263-270 (2001). The first report of C/EBPα mutations in AML, this also describes a dominant-negative mechanism that could explain how mutation of one allele could inhibit the differentiation function of the other (wild-type) allele.
    • (2001) Nature Genet. , vol.27 , pp. 263-270
    • Pabst, T.1
  • 86
    • 0037082508 scopus 로고    scopus 로고
    • Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein-α in myelodysplastic syndromes and acute myeloid leukemias
    • Gombart, A. F. et al. Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein-α in myelodysplastic syndromes and acute myeloid leukemias. Blood 99, 1332-1340 (2002).
    • (2002) Blood , vol.99 , pp. 1332-1340
    • Gombart, A.F.1
  • 87
    • 0036727413 scopus 로고    scopus 로고
    • Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down Syndrome
    • Wechsler, J. M. M. A., Anastasi, J., Karp, J. E., LeBeau, M. M. & Crispino, J. D. Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down Syndrome. Nature Genet. 32, 148-152 (2002).
    • (2002) Nature Genet. , vol.32 , pp. 148-152
    • Wechsler, J.M.M.A.1    Anastasi, J.2    Karp, J.E.3    LeBeau, M.M.4    Crispino, J.D.5
  • 88
    • 0028894781 scopus 로고
    • The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line
    • Visvader, J. E., Crossley, M., Hill, J., Orkin, S. H. & Adams, J. M. The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line. Mol. Cell. Biol. 15, 634-641 (1995).
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 634-641
    • Visvader, J.E.1    Crossley, M.2    Hill, J.3    Orkin, S.H.4    Adams, J.M.5
  • 89
    • 0031024994 scopus 로고    scopus 로고
    • Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line
    • Weiss, M. J., Yu, C. & Orkin, S. H. Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. Mol. Cell. Biol. 17, 1642-1651 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1642-1651
    • Weiss, M.J.1    Yu, C.2    Orkin, S.H.3
  • 90
    • 0035903475 scopus 로고    scopus 로고
    • In vivo requirements for GATA-1 functional domains during primitive and definitive erythropoiesis
    • Shimizu, R., Takahashi, S., Ohneda, K., Engel, J. D. & Yamamoto, M. In vivo requirements for GATA-1 functional domains during primitive and definitive erythropoiesis. EMBO J. 20, 5250-5260 (2001).
    • (2001) EMBO J. , vol.20 , pp. 5250-5260
    • Shimizu, R.1    Takahashi, S.2    Ohneda, K.3    Engel, J.D.4    Yamamoto, M.5
  • 91
    • 0035047652 scopus 로고    scopus 로고
    • AML1-ETO downregulates the granulocytic differentiation factor C/EBPα in t(8;21) myeloid leukemia
    • Pabst, T., Mueller, B. U., Harakawa, N., Zhang, D.-E. & Tenen, D. G. AML1-ETO downregulates the granulocytic differentiation factor C/EBPα in t(8;21) myeloid leukemia. Nature Med. 7, 444-451 (2001).
    • (2001) Nature Med. , vol.7 , pp. 444-451
    • Pabst, T.1    Mueller, B.U.2    Harakawa, N.3    Zhang, D.-E.4    Tenen, D.G.5
  • 92
    • 0033569406 scopus 로고    scopus 로고
    • Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
    • Golub, T. R. et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 286, 531-537 (1999).
    • (1999) Science , vol.286 , pp. 531-537
    • Golub, T.R.1
  • 93
    • 0032694990 scopus 로고    scopus 로고
    • CCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment
    • Park, D. J. et al. CCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment. J. Clin. Invest. 103, 1399-1408 (1999).
    • (1999) J. Clin. Invest. , vol.103 , pp. 1399-1408
    • Park, D.J.1
  • 94
    • 0037307675 scopus 로고    scopus 로고
    • CCAAT/enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia
    • Truong, B. T. H. et al. CCAAT/enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia. Blood 101, 1141-1148 (2003).
    • (2003) Blood , vol.101 , pp. 1141-1148
    • Truong, B.T.H.1
  • 95
    • 79960971614 scopus 로고    scopus 로고
    • C/EBPβ is an important target of PML-RARA during ATRA induced differentiation of APL cells
    • Duprez, E. A., Koch, H. & Tenen, D. G. C/EBPβ is an important target of PML-RARA during ATRA induced differentiation of APL cells. Blood 98, 833a (2001).
    • (2001) Blood , vol.98
    • Duprez, E.A.1    Koch, H.2    Tenen, D.G.3
  • 96
    • 0035500922 scopus 로고    scopus 로고
    • Loss of PU.1 expression following inhibition of histone deacetylases
    • Laribee, R. N. & Klemsz, M. J. Loss of PU.1 expression following inhibition of histone deacetylases. J. Immunol. 167, 5160-5166 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 5160-5166
    • Laribee, R.N.1    Klemsz, M.J.2
  • 97
    • 0037081084 scopus 로고    scopus 로고
    • Down-regulation and antiproliferative role of C/EBPα in lung cancer
    • Halmos, B. et al. Down-regulation and antiproliferative role of C/EBPα in lung cancer. Cancer Res. 62, 528-534 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 528-534
    • Halmos, B.1
  • 99
    • 0031471203 scopus 로고    scopus 로고
    • Intercellular trafficking and protein delivery by a herpesvirus structural protein
    • Elliott, G. & O'Hare, P. Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell 88, 223-233 (1997).
    • (1997) Cell , vol.88 , pp. 223-233
    • Elliott, G.1    O'Hare, P.2
  • 100
    • 0033520487 scopus 로고    scopus 로고
    • In vivo protein transduction: Delivery of a biologically active protein into the mouse
    • Schwarze, S. R., Ho, A., Vocero-Akbani, A. & Dowdy, S. F. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 285, 1569-1572 (1999).
    • (1999) Science , vol.285 , pp. 1569-1572
    • Schwarze, S.R.1    Ho, A.2    Vocero-Akbani, A.3    Dowdy, S.F.4
  • 101
    • 0035893252 scopus 로고    scopus 로고
    • Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-Ras
    • Jackson, E. L. et al. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-Ras. Genes Dev. 15, 3243-3248 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 3243-3248
    • Jackson, E.L.1
  • 102
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet, D. & Dick, J. E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nature Med. 3, 730-737 (1997).
    • (1997) Nature Med. , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 103
    • 0034691092 scopus 로고    scopus 로고
    • AML1-ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8; 21 chromosomal translocation
    • Miyamoto, T., Weissman, I. L. & Akashi, K. AML1-ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation. Proc. Natl Acad. Sci. USA 97, 7521-7526 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 7521-7526
    • Miyamoto, T.1    Weissman, I.L.2    Akashi, K.3
  • 104
    • 0035889155 scopus 로고    scopus 로고
    • Multipotent hematopoietic cell lines derived from C/EBPα (-/-) knock out mice display macrophage-colony-stimulating factor, granulocyte-colony-stimulating factor, and retinoic acid-induced granulocytic differentiation
    • Collins, S. J., Ulmer, J. Purton, L. E. & Darlington, G. Multipotent hematopoietic cell lines derived from C/EBPα (-/-) knock out mice display macrophage-colony-stimulating factor, granulocyte-colony-stimulating factor, and retinoic acid-induced granulocytic differentiation. Blood 98, 2382-2388 (2001).
    • (2001) Blood , vol.98 , pp. 2382-2388
    • Collins, S.J.1    Ulmer, J.2    Purton, L.E.3    Darlington, G.4
  • 105
    • 0037097736 scopus 로고    scopus 로고
    • Induction of granulocytic differentiation by two pathways
    • Zhang, P. et al. Induction of granulocytic differentiation by two pathways. Blood 99, 4406-4412 (2002).
    • (2002) Blood , vol.99 , pp. 4406-4412
    • Zhang, P.1
  • 106
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler, K. W. & Vogelstein, B. Lessons from hereditary colorectal cancer. Cell 87, 159-170 (1996).
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 107
    • 0036463950 scopus 로고    scopus 로고
    • Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia
    • Higuchi, M. et al. Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia. Cancer Cell 1, 75-87 (2002).
    • (2002) Cancer Cell , vol.1 , pp. 75-87
    • Higuchi, M.1
  • 108
    • 0032126364 scopus 로고    scopus 로고
    • Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia
    • Traver, D., Akashi, K., Weissman, I. L. & Lagasse, E. Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia. Immunity 9, 47-57 (1998).
    • (1998) Immunity , vol.9 , pp. 47-57
    • Traver, D.1    Akashi, K.2    Weissman, I.L.3    Lagasse, E.4
  • 109
    • 0035886024 scopus 로고    scopus 로고
    • Nuclear factor-κB is constitutively activated in primitive human acute myelogenous leukemia cells
    • Guzman, M. L. et al. Nuclear factor-κB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood 98, 2301-2307 (2001).
    • (2001) Blood , vol.98 , pp. 2301-2307
    • Guzman, M.L.1
  • 110
    • 0035910748 scopus 로고    scopus 로고
    • BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PML-RARα) to block neutrophil differentiation and initiate acute leukemia
    • Kogan, S. C. et al. BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PML-RARα) to block neutrophil differentiation and initiate acute leukemia. J. Exp. Med. 193, 531-543 (2001).
    • (2001) J. Exp. Med. , vol.193 , pp. 531-543
    • Kogan, S.C.1
  • 111
    • 0035895056 scopus 로고    scopus 로고
    • Receptor- and mitochondrial-mediated apoptosis in acute leukemia: A translational view
    • Schimmer, A. D., Hedley, D. W., Penn, L. Z. & Minden, M. D. Receptor- and mitochondrial-mediated apoptosis in acute leukemia: a translational view. Blood 98, 3541-3553 (2001).
    • (2001) Blood , vol.98 , pp. 3541-3553
    • Schimmer, A.D.1    Hedley, D.W.2    Penn, L.Z.3    Minden, M.D.4
  • 112
    • 0034052854 scopus 로고    scopus 로고
    • Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1
    • Nichols, K. E. et al. Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1. Nature Genet. 24, 266-270 (2000).
    • (2000) Nature Genet. , vol.24 , pp. 266-270
    • Nichols, K.E.1
  • 113
    • 0033582475 scopus 로고    scopus 로고
    • C-Jun is a JNK-independent coactivator of the PU.1 transcription factor
    • Behre, G. et al. C-Jun is a JNK-independent coactivator of the PU.1 transcription factor. J. Biol. Chem. 274, 4939-4946 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 4939-4946
    • Behre, G.1
  • 114
    • 0037197968 scopus 로고    scopus 로고
    • Differential regulation of the human and murine CD 34 genes in hematopoietic stem cells
    • Okuno, Y. et al. Differential regulation of the human and murine CD34 genes in hematopoietic stem cells. Proc. Natl Acad. Sci. USA 99, 6246-6251 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 6246-6251
    • Okuno, Y.1
  • 115
    • 0026029709 scopus 로고
    • CCAAT/enhancer binding protein gene promoter: Binding of nuclear factors during differentiation of 3T3-L1 preadipocytes
    • Christy, R. J., Kaestner, K. H., Geiman, D. E. & Lane, M. D. CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes. Proc. Natl Acad. Sci. USA 88, 2593-2597 (1991).
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 2593-2597
    • Christy, R.J.1    Kaestner, K.H.2    Geiman, D.E.3    Lane, M.D.4
  • 116
    • 0027276292 scopus 로고
    • High level activity of the mouse CCAAT/enhancer binding protein (C/EBPα) gene promoter involves autoregulation and several ubiquitous transcription factors
    • Legraverend, C., Antonson, P., Flodby P. & Xanthopoulos, K. G. High level activity of the mouse CCAAT/enhancer binding protein (C/EBPα) gene promoter involves autoregulation and several ubiquitous transcription factors. Nucl. Acids Res. 21, 1735-1742 (1993).
    • (1993) Nucl. Acids Res. , vol.21 , pp. 1735-1742
    • Legraverend, C.1    Antonson, P.2    Flodby, P.3    Xanthopoulos, K.G.4
  • 117
    • 0034970803 scopus 로고    scopus 로고
    • AML1 and AML1 fusion protein AML1-ETO in myeloid gene regulation and leukemogenesis
    • Zhang, D.-E., Burel, S. A., Zhou, L., Hethenngton, C. J. & Yuan, Y. AML1 and AML1 fusion protein AML1-ETO in myeloid gene regulation and leukemogenesis. Blood Cells Mol. Dis. 27, 368-376 (2001).
    • (2001) Blood Cells Mol. Dis. , vol.27 , pp. 368-376
    • Zhang, D.-E.1    Burel, S.A.2    Zhou, L.3    Hethenngton, C.J.4    Yuan, Y.5
  • 118
    • 0029045087 scopus 로고
    • The t(12;21) of acute lymphoblastic leukemia results in a TEL-AML1 gene fusion
    • Romana, S. P. et al. The t(12;21) of acute lymphoblastic leukemia results in a TEL-AML1 gene fusion. Blood 85, 3662-3670 (1995).
    • (1995) Blood , vol.85 , pp. 3662-3670
    • Romana, S.P.1
  • 119
    • 0029004541 scopus 로고
    • Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia
    • Golub, T. R. et al. Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc. Natl Acad. Sci. USA 92, 4917-4921 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4917-4921
    • Golub, T.R.1
  • 120
    • 18344389720 scopus 로고    scopus 로고
    • Causal relationship between the loss of RUNX3 expression and gastric cancer
    • Li, Q. L. et al. Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell 109, 113-124 (2002).
    • (2002) Cell , vol.109 , pp. 113-124
    • Li, Q.L.1
  • 121
    • 0029746172 scopus 로고    scopus 로고
    • Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein-α
    • Flodby, P., Barlow, C., Kylefjord, H., Ahrlund-Richter, L. & Xanthopoulos, K. G. Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein-α. J. Biol. Chem. 271, 24753-24760 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 24753-24760
    • Flodby, P.1    Barlow, C.2    Kylefjord, H.3    Ahrlund-Richter, L.4    Xanthopoulos, K.G.5
  • 122
    • 0032525340 scopus 로고    scopus 로고
    • C/EBPβ but not C/EBPα, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland
    • Seagroves, T. N. et al. C/EBPβ but not C/EBPα, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland. Genes Dev. 12, 1917-1928 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 1917-1928
    • Seagroves, T.N.1
  • 123
    • 0031283125 scopus 로고    scopus 로고
    • Overexpression of C/EBPβ-LIP, a naturally occurring, dominant-negative transcription factor, in human breast cancer
    • Zahnow, C. A., Younes, P., Laucirica, R. & Rosen, J. M. Overexpression of C/EBPβ-LIP, a naturally occurring, dominant-negative transcription factor, in human breast cancer. J. Natl Cancer Inst. 89, 1887-1891 (1997).
    • (1997) J. Natl. Cancer Inst. , vol.89 , pp. 1887-1891
    • Zahnow, C.A.1    Younes, P.2    Laucirica, R.3    Rosen, J.M.4
  • 124
    • 0029156782 scopus 로고
    • CCAAT/enhancer binding protein-alpha amino acid motifs with dual TBP and TFIIB binding ability co-operate to activate transcription in both yeast and mammalian cells
    • Nerlov, C. & Ziff, E. B. CCAAT/enhancer binding protein-alpha amino acid motifs with dual TBP and TFIIB binding ability co-operate to activate transcription in both yeast and mammalian cells. EMBO J. 14, 4318-4328 (1995).
    • (1995) EMBO J. , vol.14 , pp. 4318-4328
    • Nerlov, C.1    Ziff, E.B.2
  • 125
    • 0025131536 scopus 로고
    • Identification of two polypeptide segments of CCAAT/enhancer binding protein required for transcriptional activation of the serum albumin gene
    • Friedman, A. D. & McKnight, S. L. Identification of two polypeptide segments of CCAAT/enhancer binding protein required for transcriptional activation of the serum albumin gene. Genes Dev. 4, 1416-1426 (1990).
    • (1990) Genes Dev. , vol.4 , pp. 1416-1426
    • Friedman, A.D.1    McKnight, S.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.