Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling

Blood

Volumn 122, Issue 9, 2013, Pages 3322-3330

  Hole, Paul S ^a   Zabkiewicz, Joanna ^a   Munje, Chinmay ^a   Newton, Zarabeth ^a   Pearn, Lorna ^a   White, Paul ^a   Marquez, Nuria ^a   Hills, Robert K ^a   Burnett, Alan K ^a   Tonks, Alex ^a   Darley, Richard L ^a  

^a CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; GLUTATHIONE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE P38;

ACUTE MYELOBLASTIC LEUKEMIA; ARTICLE; BONE MARROW BIOPSY; CANCER PATIENT; CELL PROLIFERATION; DNA CONTENT; ELECTRON TRANSPORT; FLOW CYTOMETRY; HEMATOPOIETIC CELL; HOSPITAL PATIENT; HUMAN; HUMAN CELL; MTS ASSAY; MYELOID LEUKEMIA CELL LINE; OXIDATIVE STRESS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; CASE CONTROL STUDY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MONONUCLEAR CELL; PATHOLOGY; PRIMARY CELL CULTURE;

ANTIGENS, CD34; APOPTOSIS; CASE-CONTROL STUDIES; CELL PROLIFERATION; GENE EXPRESSION REGULATION, LEUKEMIC; GLUTATHIONE; HUMANS; HYDROGEN PEROXIDE; LEUKEMIA, MYELOID, ACUTE; LEUKOCYTES, MONONUCLEAR; NADPH OXIDASE; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PRIMARY CELL CULTURE; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84891672388     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-04-491944     Document Type: Article

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