Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 21, 2014, Pages 7849-7854

  Ro, Seung Hyun ^a   Nam, Myeongjin ^a,b   Jang, Insook ^a   Park, Hwan Woo ^a   Park, Haeli ^a   Semple, Ian A ^a   Kim, Myungjin ^a   Kim, Jeong Sig ^a,c   Park, Haewon ^a   Einat, Paz ^d   Damari, Golda ^d,e   Golikov, Maya ^d   Feinstein, Elena ^d   Lee, Jun Hee ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b Gachon University College of Medicine   (South Korea)

^c Soonchunhyang University   (South Korea)

^d QBI Enterprises Ltd   (Israel)

^e WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Aging; Homeostasis; Mouse; adrenergic signaling

Indexed keywords

ACETYLCYSTEINE; BUTYLATED HYDROXYANISOLE; CYCLIC AMP; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN; REACTIVE OXYGEN METABOLITE; SESTRIN 2 PROTEIN; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BROWN ADIPOSE TISSUE; CELL DIFFERENTIATION; COLD EXPOSURE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GENE OVEREXPRESSION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIPID STORAGE; MALE; MEDIATOR; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION UNCOUPLING; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THERMOGENESIS; TISSUE METABOLISM; TRANSCRIPTION INITIATION;

AGING; HOMEOSTASIS; MOUSE; Β-ADRENERGIC SIGNALING;

ADIPOCYTES; ANIMALS; AZO COMPOUNDS; FATTY ACIDS, NONESTERIFIED; GENE EXPRESSION REGULATION; HUMANS; IMMUNOBLOTTING; ION CHANNELS; MICE; MICE, TRANSGENIC; MITOCHONDRIAL PROTEINS; NUCLEAR PROTEINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84901684204     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1401787111     Document Type: Article

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