Allelic variants of glutathione S-transferase P1-1 differentially mediate the peroxidase function of peroxiredoxin VI and alter membrane lipid peroxidation

Free Radical Biology and Medicine

Volumn 54, Issue , 2013, Pages 62-70

  Manevich, Y ^a   Hutchens, S ^a   Tew, K D ^a   Townsend, D M ^b  

^a Department of Cell and Molecular Pharmacology and Experimental Therapeutics ^*  (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Allelic variants; Free radicals; Glutathione; Glutathione S transferase; Lipid peroxidation; Peroxidase function; Peroxiredoxin VI; Protein protein interactions

Indexed keywords

ALANINE; FLUORESCENT DYE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE P1; GLUTATHIONE TRANSFERASE P1 1; GLUTATHIONE TRANSFERASE P1 1A; GLUTATHIONE TRANSFERASE P1 1B; GLUTATHIONE TRANSFERASE P1 1C; GLUTATHIONE TRANSFERASE P1 1D; HYDROXYL RADICAL; ISOLEUCINE; PEROXIDASE; PEROXIREDOXIN 6; PHENYLALANINE; PHOSPHOLIPID; PHOSPHOLIPID HYDROPEROXIDASE; RECOMBINANT PEROXIREDOXIN 6; RECOMBINANT PROTEIN; TYROSINE; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; BINDING AFFINITY; CATALYSIS; CELL DEATH; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELL STRAIN MCF 7; CELL SURVIVAL; COMPUTER MODEL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; FLUORESCENCE IMAGING; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETIC TRANSFECTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LABELING INDEX; LIPID PEROXIDATION; MEDIATOR; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; APOPTOSIS; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CYTOPROTECTION; GLUTATHIONE TRANSFERASE; HUMANS; LIPID PEROXIDATION; MCF-7 CELLS; MUTATION; OXIDATIVE STRESS; PEROXIREDOXIN VI; POLYMORPHISM, GENETIC; PROTEIN BINDING; TRANSGENES;

EID: 84870312437     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.10.556     Document Type: Article

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