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Volumn 26, Issue 6, 2013, Pages 617-625

Stem cell therapy for acute cerebral injury: What do we know and what will the future bring?

Author keywords

Neural repair; Recovery; Stem cell therapy; Stroke; Traumatic brain injury

Indexed keywords

ALLOGENIC BONE MARROW TRANSPLANTATION; BONE MARROW CELL; CANCER RISK; CELL HOMING; CEREBROVASCULAR ACCIDENT; COGNITION; CORD BLOOD STEM CELL TRANSPLANTATION; EMBRYONAL CARCINOMA STEM CELL; EMBRYONIC STEM CELL; FETAL STEM CELL; FETUS CELL; FOLLOW UP; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INTRAARTERIAL DRUG ADMINISTRATION; INTRACEREBRAL DRUG ADMINISTRATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRATHECAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MESENCHYMAL STEM CELL TRANSPLANTATION; MONONUCLEAR CELL; NEURAL STEM CELL; NEURAL STEM CELL TRANSPLANTATION; NEUROPROTECTION; NONHUMAN; OUTCOME ASSESSMENT; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PLURIPOTENT STEM CELL; REVIEW; STEM CELL RESEARCH; STEM CELL TRANSPLANTATION; TRAUMATIC BRAIN INJURY; BRAIN INJURIES; PHYSIOLOGY; PROCEDURES; STEM CELL;

EID: 84892374506     PISSN: 13507540     EISSN: 14736551     Source Type: Journal    
DOI: 10.1097/WCO.0000000000000023     Document Type: Review
Times cited : (46)

References (80)
  • 1
    • 84855396777 scopus 로고    scopus 로고
    • Executive summary: Heart disease and stroke statistics: 2012 update - A report from the american heart association
    • Roger VL, Go AS, Lloyd-Jones DM, et al. Executive summary: heart disease and stroke statistics: 2012 update - A report from the American Heart Association. Circulation 2012; 125:188-197.
    • (2012) Circulation , vol.125 , pp. 188-197
    • Roger, V.L.1    Go, A.S.2    Lloyd-Jones, D.M.3
  • 2
    • 66849089771 scopus 로고    scopus 로고
    • Treatment time-specific number needed to treat estimates for tissue plasminogen activator therapy in acute stroke based on shifts over the entire range of the modified Rankin Scale
    • Lansberg MG, Schrooten M, Bluhmki E, et al. Treatment time-specific number needed to treat estimates for tissue plasminogen activator therapy in acute stroke based on shifts over the entire range of the modified Rankin Scale. Stroke 2009; 40:2079-2084.
    • (2009) Stroke , vol.40 , pp. 2079-2084
    • Lansberg, M.G.1    Schrooten, M.2    Bluhmki, E.3
  • 3
    • 70349168002 scopus 로고    scopus 로고
    • Reducing prehospital delay in acute stroke
    • Bouckaert M, Lemmens R, Thijs V. Reducing prehospital delay in acute stroke. Nat Rev Neurol 2009; 5:477-483.
    • (2009) Nat Rev Neurol , vol.5 , pp. 477-483
    • Bouckaert, M.1    Lemmens, R.2    Thijs, V.3
  • 4
    • 0029794598 scopus 로고    scopus 로고
    • Lifetime cost of stroke in the United States
    • Taylor TN, Davis PH, Torner JC, et al. Lifetime cost of stroke in the United States. Stroke 1996; 27:1459-1466.
    • (1996) Stroke , vol.27 , pp. 1459-1466
    • Taylor, T.N.1    Davis, P.H.2    Torner, J.C.3
  • 5
    • 46849094295 scopus 로고    scopus 로고
    • Moderate and severe traumatic brain injury in adults
    • Maas AI, Stocchetti N, Bullock R. Moderate and severe traumatic brain injury in adults. Lancet Neurol 2008; 7:728-741.
    • (2008) Lancet Neurol , vol.7 , pp. 728-741
    • Maas, A.I.1    Stocchetti, N.2    Bullock, R.3
  • 6
    • 33745601099 scopus 로고    scopus 로고
    • Stem cells for the treatment of neurological disorders
    • Lindvall O, Kokaia Z. Stem cells for the treatment of neurological disorders. Nature 2006; 441:1094-1096.
    • (2006) Nature , vol.441 , pp. 1094-1096
    • Lindvall, O.1    Kokaia, Z.2
  • 7
    • 80051725785 scopus 로고    scopus 로고
    • Stem cells and bioactive scaffolds as a treatment for traumatic brain injury
    • Stabenfeldt SE, Irons HR, Laplaca MC. Stem cells and bioactive scaffolds as a treatment for traumatic brain injury. Curr Stem Cell Res Ther 2011; 6:208- 220.
    • (2011) Curr Stem Cell Res Ther , vol.6 , pp. 208-220
    • Stabenfeldt, S.E.1    Irons, H.R.2    Laplaca, M.C.3
  • 8
    • 33846705350 scopus 로고    scopus 로고
    • Cell transplantation therapy for stroke
    • Bliss T, Guzman R, Daadi M, et al. Cell transplantation therapy for stroke. Stroke 2007; 38 (2 Suppl):817-826.
    • (2007) Stroke , vol.38 , Issue.2 SUPPL. , pp. 817-826
    • Bliss, T.1    Guzman, R.2    Daadi, M.3
  • 9
    • 79957814267 scopus 로고    scopus 로고
    • Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain
    • Andres RH, Horie N, Slikker W, et al. Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain. Brain 2011; 134 (Pt 6):1777-1789.
    • (2011) Brain , vol.134 , Issue.PART 6 , pp. 1777-1789
    • Andres, R.H.1    Horie, N.2    Slikker, W.3
  • 10
    • 45749113333 scopus 로고    scopus 로고
    • Adherent self-renewable human embryonic stem cell-derived neural stem cell line: Functional engraftment in experimental stroke model
    • Daadi MM, Maag AL, Steinberg GK. Adherent self-renewable human embryonic stem cell-derived neural stem cell line: functional engraftment in experimental stroke model. PLoS One 2008; 3:e1644.
    • (2008) PLoS One , vol.3
    • Daadi, M.M.1    Maag, A.L.2    Steinberg, G.K.3
  • 11
    • 59149083670 scopus 로고    scopus 로고
    • Transplantation of human embryonic stem cell-derived neural precursor cells and enriched environment after cortical stroke in rats: Cell survival and functional recovery
    • Hicks AU, Lappalainen RS, Narkilahti S, et al. Transplantation of human embryonic stem cell-derived neural precursor cells and enriched environment after cortical stroke in rats: Cell survival and functional recovery. Eur J Neurosci 2009; 29:562-574.
    • (2009) Eur J Neurosci , vol.29 , pp. 562-574
    • Hicks, A.U.1    Lappalainen, R.S.2    Narkilahti, S.3
  • 12
    • 4744367348 scopus 로고    scopus 로고
    • Human neural stem/progenitor cells, expanded in long-term neurosphere culture, promote functional recovery after focal ischemia in Mongolian gerbils
    • Ishibashi S, Sakaguchi M, Kuroiwa T, et al. Human neural stem/progenitor cells, expanded in long-term neurosphere culture, promote functional recovery after focal ischemia in Mongolian gerbils. J Neurosci Res 2004; 78:215- 223.
    • (2004) J Neurosci Res , vol.78 , pp. 215-223
    • Ishibashi, S.1    Sakaguchi, M.2    Kuroiwa, T.3
  • 13
    • 74049146111 scopus 로고    scopus 로고
    • The postischemic environment differentially impacts teratoma or tumor formation after transplantation of human embryonic stem cell-derived neural progenitors
    • Seminatore C, Polentes J, Ellman D, et al. The postischemic environment differentially impacts teratoma or tumor formation after transplantation of human embryonic stem cell-derived neural progenitors. Stroke 2010; 41: 153-159.
    • (2010) Stroke , vol.41 , pp. 153-159
    • Seminatore, C.1    Polentes, J.2    Ellman, D.3
  • 14
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126:663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 15
    • 84861903354 scopus 로고    scopus 로고
    • Human-induced pluripotent stem cells form functional neurons and improve recovery after grafting in stroke-damaged brain
    • .Oki K, Tatarishvili J, Wood J, et al. Human-induced pluripotent stem cells form functional neurons and improve recovery after grafting in stroke-damaged brain. Stem Cells 2012; 30:1120-1133.
    • (2012) Stem Cells , vol.30 , pp. 1120-1133
    • Oki, K.1    Tatarishvili, J.2    Wood, J.3
  • 16
    • 33845325474 scopus 로고    scopus 로고
    • Neuronal differentiation of transplanted embryonic stem cell-derived precursors in stroke lesions of adult rats
    • Buhnemann C, Scholz A, Bernreuther C, et al. Neuronal differentiation of transplanted embryonic stem cell-derived precursors in stroke lesions of adult rats. Brain 2006; 129 (Pt 12):3238-3248.
    • (2006) Brain , vol.129 , Issue.PART 12 , pp. 3238-3248
    • Buhnemann, C.1    Scholz, A.2    Bernreuther, C.3
  • 17
    • 67649856579 scopus 로고    scopus 로고
    • Molecular and magnetic resonance imaging of human embryonic stem cell-derived neural stem cell grafts in ischemic rat brain
    • Daadi MM, Li Z, Arac A, et al. Molecular and magnetic resonance imaging of human embryonic stem cell-derived neural stem cell grafts in ischemic rat brain. Mol Ther 2009; 17:1282-1291.
    • (2009) Mol Ther , vol.17 , pp. 1282-1291
    • Daadi, M.M.1    Li, Z.2    Arac, A.3
  • 18
    • 84873282055 scopus 로고    scopus 로고
    • Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo
    • Espuny-Camacho I, Michelsen KA, Gall D, et al. Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo. Neuron 2013; 77:440-456.
    • (2013) Neuron , vol.77 , pp. 440-456
    • Espuny-Camacho, I.1    Michelsen, K.A.2    Gall, D.3
  • 19
    • 84892370783 scopus 로고    scopus 로고
    • Hyaluronan, neural stem cells and tissue reconstruction after acute ischemic stroke
    • Epub ahead of print
    • Moshayedi P, Carmichael ST. Hyaluronan, neural stem cells and tissue reconstruction after acute ischemic stroke. Biomatter 2013. [Epub ahead of print]
    • (2013) Biomatter
    • Moshayedi, P.1    Carmichael, S.T.2
  • 20
    • 79952164901 scopus 로고    scopus 로고
    • Transplanted stem cell-secreted vascular endothelial growth factor effects poststroke recovery, inflammation, and vascular repair
    • Horie N, Pereira MP, Niizuma K, et al. Transplanted stem cell-secreted vascular endothelial growth factor effects poststroke recovery, inflammation, and vascular repair. Stem Cells 2011; 29:274-285.
    • (2011) Stem Cells , vol.29 , pp. 274-285
    • Horie, N.1    Pereira, M.P.2    Niizuma, K.3
  • 21
    • 34447274187 scopus 로고    scopus 로고
    • Human neural stem cells over-expressing VEGF provide neuroprotection, angiogenesis and functional recovery in mouse stroke model
    • Lee HJ, Kim KS, Park IH, et al. Human neural stem cells over-expressing VEGF provide neuroprotection, angiogenesis and functional recovery in mouse stroke model. PLoS One 2007; 2:e156.
    • (2007) PLoS One , vol.2
    • Lee, H.J.1    Kim, K.S.2    Park, I.H.3
  • 22
    • 39749109431 scopus 로고    scopus 로고
    • Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke
    • Lee ST, Chu K, Jung KH, et al. Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke. Brain 2008; 131 (Pt 3):616-629.
    • (2008) Brain , vol.131 , Issue.PART 3 , pp. 616-629
    • Lee, S.T.1    Chu, K.2    Jung, K.H.3
  • 23
    • 68649120817 scopus 로고    scopus 로고
    • The neural stem cell line CTX0E03 promotes behavioral recovery and endogenous neurogenesis after experimental stroke in a dose-dependent fashion
    • Stroemer P, Patel S, Hope A, et al. The neural stem cell line CTX0E03 promotes behavioral recovery and endogenous neurogenesis after experimental stroke in a dose-dependent fashion. Neurorehabil Neural Repair 2009; 23:895-909.
    • (2009) Neurorehabil Neural Repair , vol.23 , pp. 895-909
    • Stroemer, P.1    Patel, S.2    Hope, A.3
  • 24
    • 84864449051 scopus 로고    scopus 로고
    • Cross-talk between neural stem cells and immune cells: The key to better brain repair?
    • .Kokaia Z, Martino G, Schwartz M, et al. Cross-talk between neural stem cells and immune cells: The key to better brain repair? Nat Neurosci 2012; 15:1078-1087.
    • (2012) Nat Neurosci , vol.15 , pp. 1078-1087
    • Kokaia, Z.1    Martino, G.2    Schwartz, M.3
  • 25
    • 43449092523 scopus 로고    scopus 로고
    • Human adult bone marrow-derived somatic cell therapy results in functional recovery and axonal plasticity following stroke in the rat
    • Andrews EM, Tsai SY, Johnson SC, et al. Human adult bone marrow-derived somatic cell therapy results in functional recovery and axonal plasticity following stroke in the rat. Exp Neurol 2008; 211:588-592.
    • (2008) Exp Neurol , vol.211 , pp. 588-592
    • Andrews, E.M.1    Tsai, S.Y.2    Johnson, S.C.3
  • 26
    • 78650517407 scopus 로고    scopus 로고
    • Transplantation of human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and endogenous neurogenesis after cerebral ischemia in rats
    • Bao X, Wei J, Feng M, et al. Transplantation of human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and endogenous neurogenesis after cerebral ischemia in rats. Brain Res 2011; 1367:103- 113.
    • (2011) Brain Res , vol.1367 , pp. 103-113
    • Bao, X.1    Wei, J.2    Feng, M.3
  • 27
    • 0037418936 scopus 로고    scopus 로고
    • Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats
    • Chen J, Zhang ZG, Li Y, et al. Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ Res 2003; 92:692-699.
    • (2003) Circ Res , vol.92 , pp. 692-699
    • Chen, J.1    Zhang, Z.G.2    Li, Y.3
  • 28
    • 0037183512 scopus 로고    scopus 로고
    • Human marrow stromal cell therapy for stroke in rat: Neurotrophins and functional recovery
    • Li Y, Chen J, Chen XG, et al. Human marrow stromal cell therapy for stroke in rat: neurotrophins and functional recovery. Neurology 2002; 59:514-523.
    • (2002) Neurology , vol.59 , pp. 514-523
    • Li, Y.1    Chen, J.2    Chen, X.G.3
  • 29
    • 4744341332 scopus 로고    scopus 로고
    • Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume
    • Vendrame M, Cassady J, Newcomb J, et al. Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume. Stroke 2004; 35:2390-2395.
    • (2004) Stroke , vol.35 , pp. 2390-2395
    • Vendrame, M.1    Cassady, J.2    Newcomb, J.3
  • 30
    • 77950179422 scopus 로고    scopus 로고
    • Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model
    • Wakabayashi K, Nagai A, Sheikh AM, et al. Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model. J Neurosci Res 2010; 88:1017-1025.
    • (2010) J Neurosci Res , vol.88 , pp. 1017-1025
    • Wakabayashi, K.1    Nagai, A.2    Sheikh, A.M.3
  • 31
    • 34648839855 scopus 로고    scopus 로고
    • Angiopoietin1/Tie2 and VEGF/Flk1 induced by MSC treatment amplifies angiogenesis and vascular stabilization after stroke
    • Zacharek A, Chen J, Cui X, et al. Angiopoietin1/Tie2 and VEGF/Flk1 induced by MSC treatment amplifies angiogenesis and vascular stabilization after stroke. J Cereb Blood Flow Metab 2007; 27:1684-1691.
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 1684-1691
    • Zacharek, A.1    Chen, J.2    Cui, X.3
  • 32
    • 79955467425 scopus 로고    scopus 로고
    • Delayed administration of human umbilical tissue-derived cells improved neurological functional recovery in a rodent model of focal ischemia
    • Zhang L, Li Y, Zhang C, et al. Delayed administration of human umbilical tissue-derived cells improved neurological functional recovery in a rodent model of focal ischemia. Stroke 2011; 42:1437-1444.
    • (2011) Stroke , vol.42 , pp. 1437-1444
    • Zhang, L.1    Li, Y.2    Zhang, C.3
  • 33
    • 84865639336 scopus 로고    scopus 로고
    • Therapeutic effects of hMAPC and hMSC transplantation after stroke in mice
    • Mora-Lee S, Sirerol-Piquer MS, Gutierrez-Perez M, et al. Therapeutic effects of hMAPC and hMSC transplantation after stroke in mice. PLoS One 2012; 7:e43683.
    • (2012) PLoS One , vol.7
    • Mora-Lee, S.1    Sirerol-Piquer, M.S.2    Gutierrez-Perez, M.3
  • 34
    • 63949087266 scopus 로고    scopus 로고
    • Neuroprotective effects of mesenchymal stem cells derived from human embryonic stem cells in transient focal cerebral ischemia in rats
    • Liu YP, Seckin H, Izci Y, et al. Neuroprotective effects of mesenchymal stem cells derived from human embryonic stem cells in transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab 2009; 29:780-791.
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 780-791
    • Liu, Y.P.1    Seckin, H.2    Izci, Y.3
  • 35
    • 75349097509 scopus 로고    scopus 로고
    • Transplantation of placenta-derived mesenchymal stromal cells upon experimental stroke in rats
    • Kranz A, Wagner DC, Kamprad M, et al. Transplantation of placenta-derived mesenchymal stromal cells upon experimental stroke in rats. Brain Res 2010; 1315:128-136.
    • (2010) Brain Res , vol.1315 , pp. 128-136
    • Kranz, A.1    Wagner, D.C.2    Kamprad, M.3
  • 36
    • 50149096420 scopus 로고    scopus 로고
    • Use of bone marrow mesenchymal (stromal) stem cells in experimental ischemic stroke in rats
    • Skvortsova VI, Gubskiy LV, Tairova RT, et al. Use of bone marrow mesenchymal (stromal) stem cells in experimental ischemic stroke in rats. Bull Exp Biol Med 2008; 145:122-128.
    • (2008) Bull Exp Biol Med , vol.145 , pp. 122-128
    • Skvortsova, V.I.1    Gubskiy, L.V.2    Tairova, R.T.3
  • 37
    • 0032006347 scopus 로고    scopus 로고
    • Transplantation of cryopreserved human embryonal carcinoma-derived neurons (NT2N cells) promotes functional recovery in ischemic rats
    • Borlongan CV, Tajima Y, Trojanowski JQ, et al. Transplantation of cryopreserved human embryonal carcinoma-derived neurons (NT2N cells) promotes functional recovery in ischemic rats. Exp Neurol 1998; 149:310-321.
    • (1998) Exp Neurol , vol.149 , pp. 310-321
    • Borlongan, C.V.1    Tajima, Y.2    Trojanowski, J.Q.3
  • 38
    • 38449088280 scopus 로고    scopus 로고
    • Development of a human neural stem cell line for use in recovery from disability after stroke
    • Stroemer P, Hope A, Patel S, et al. Development of a human neural stem cell line for use in recovery from disability after stroke. Front Biosci 2008; 13:2290-2292.
    • (2008) Front Biosci , vol.13 , pp. 2290-2292
    • Stroemer, P.1    Hope, A.2    Patel, S.3
  • 39
    • 33748423523 scopus 로고    scopus 로고
    • Transplantation of primed human fetal neural stem cells improves cognitive function in rats after traumatic brain injury
    • Gao J, Prough DS, McAdoo DJ, et al. Transplantation of primed human fetal neural stem cells improves cognitive function in rats after traumatic brain injury. Exp Neurol 2006; 201:281-292.
    • (2006) Exp Neurol , vol.201 , pp. 281-292
    • Gao, J.1    Prough, D.S.2    McAdoo, D.J.3
  • 40
    • 84858123362 scopus 로고    scopus 로고
    • Targeted intra-arterial transplantation of stem cells to the injured CNS is more effective than intravenous administration: Engraftment is dependent on cell type and adhesion molecule expression
    • Lundberg J, Sodersten E, Sundstrom E, et al. Targeted intra-arterial transplantation of stem cells to the injured CNS is more effective than intravenous administration: engraftment is dependent on cell type and adhesion molecule expression. Cell Transplant 2012; 21:333-343.
    • (2012) Cell Transplant , vol.21 , pp. 333-343
    • Lundberg, J.1    Sodersten, E.2    Sundstrom, E.3
  • 41
    • 79952773178 scopus 로고    scopus 로고
    • Long-term benefit of human fetal neuronal progenitor cell transplantation in a clinically adapted model after traumatic brain injury
    • Skardelly M, Gaber K, Burdack S, et al. Long-term benefit of human fetal neuronal progenitor cell transplantation in a clinically adapted model after traumatic brain injury. J Neurotrauma 2011; 28:401-414.
    • (2011) J Neurotrauma , vol.28 , pp. 401-414
    • Skardelly, M.1    Gaber, K.2    Burdack, S.3
  • 42
    • 0347624005 scopus 로고    scopus 로고
    • Proliferation, migration, and differentiation of human neural stem/progenitor cells after transplantation into a rat model of traumatic brain injury
    • Wennersten A, Meier X, Holmin S, et al. Proliferation, migration, and differentiation of human neural stem/progenitor cells after transplantation into a rat model of traumatic brain injury. J Neurosurg 2004; 100:88-96.
    • (2004) J Neurosurg , vol.100 , pp. 88-96
    • Wennersten, A.1    Meier, X.2    Holmin, S.3
  • 43
    • 0036820999 scopus 로고    scopus 로고
    • Transplanted neural stem cells survive, differentiate, and improve neurological motor function after experimental traumatic brain injury
    • discussion 1052-1044
    • Riess P, Zhang C, Saatman KE, et al. Transplanted neural stem cells survive, differentiate, and improve neurological motor function after experimental traumatic brain injury. Neurosurgery 2002; 51:1043-1052; discussion 1052-1044.
    • (2002) Neurosurgery , vol.51 , pp. 1043-1052
    • Riess, P.1    Zhang, C.2    Saatman, K.E.3
  • 44
    • 84876194713 scopus 로고    scopus 로고
    • Neural stem-like cells derived from human amnion tissue are effective in treating traumatic brain injury in rat
    • Yan ZJ, Zhang P, Hu YQ, et al. Neural stem-like cells derived from human amnion tissue are effective in treating traumatic brain injury in rat. Neurochem Res 2013; 38:1022-1033.
    • (2013) Neurochem Res , vol.38 , pp. 1022-1033
    • Yan, Z.J.1    Zhang, P.2    Hu, Y.Q.3
  • 45
    • 75449087711 scopus 로고    scopus 로고
    • Human amnion-derived multipotent progenitor cell treatment alleviates traumatic brain injury-induced axonal degeneration
    • Chen Z, Tortella FC, Dave JR, et al. Human amnion-derived multipotent progenitor cell treatment alleviates traumatic brain injury-induced axonal degeneration. J Neurotrauma 2009; 26:1987-1997.
    • (2009) J Neurotrauma , vol.26 , pp. 1987-1997
    • Chen, Z.1    Tortella, F.C.2    Dave, J.R.3
  • 46
    • 80755136558 scopus 로고    scopus 로고
    • Comparison of transdifferentiated and untransdifferentiated human umbilical mesenchymal stem cells in rats after traumatic brain injury
    • Hong SQ, Zhang HT, You J, et al. Comparison of transdifferentiated and untransdifferentiated human umbilical mesenchymal stem cells in rats after traumatic brain injury. Neurochem Res 2011; 36:2391-2400.
    • (2011) Neurochem Res , vol.36 , pp. 2391-2400
    • Hong, S.Q.1    Zhang, H.T.2    You, J.3
  • 47
    • 76349100524 scopus 로고    scopus 로고
    • Therapeutic effects of human mesenchymal stem cells on traumatic brain injury in rats: Secretion of neurotrophic factors and inhibition of apoptosis
    • Kim HJ, Lee JH, Kim SH. Therapeutic effects of human mesenchymal stem cells on traumatic brain injury in rats: secretion of neurotrophic factors and inhibition of apoptosis. J Neurotrauma 2010; 27:131-138.
    • (2010) J Neurotrauma , vol.27 , pp. 131-138
    • Kim, H.J.1    Lee, J.H.2    Kim, S.H.3
  • 48
    • 0035998729 scopus 로고    scopus 로고
    • Intravenous administration of human umbilical cord blood reduces neurological deficit in the rat after traumatic brain injury
    • Lu D, Sanberg PR, Mahmood A, et al. Intravenous administration of human umbilical cord blood reduces neurological deficit in the rat after traumatic brain injury. Cell Transplant 2002; 11:275-281.
    • (2002) Cell Transplant , vol.11 , pp. 275-281
    • Lu, D.1    Sanberg, P.R.2    Mahmood, A.3
  • 49
    • 84873651187 scopus 로고    scopus 로고
    • Neurogenic and neuro-protective potential of a novel subpopulation of peripheral blood-derived CD133+ ABCG2+CXCR4+ mesenchymal stem cells: Development of autologous cell-based therapeutics for traumatic brain injury
    • Nichols JE, Niles JA, Dewitt D, et al. Neurogenic and neuro-protective potential of a novel subpopulation of peripheral blood-derived CD133+ ABCG2+CXCR4+ mesenchymal stem cells: development of autologous cell-based therapeutics for traumatic brain injury. StemCell Res Ther 2013; 4:3.
    • (2013) StemCell Res Ther , vol.4 , pp. 3
    • Nichols, J.E.1    Niles, J.A.2    Dewitt, D.3
  • 50
    • 0345829915 scopus 로고    scopus 로고
    • Genetically modified NT2N human neuronal cells mediate long-term gene expression as CNS grafts in vivo and improve functional cognitive outcome following experimental traumatic brain injury
    • Watson DJ, Longhi L, Lee EB, et al. Genetically modified NT2N human neuronal cells mediate long-term gene expression as CNS grafts in vivo and improve functional cognitive outcome following experimental traumatic brain injury. J Neuropathol Exp Neurol 2003; 62:368-380.
    • (2003) J Neuropathol Exp Neurol , vol.62 , pp. 368-380
    • Watson, D.J.1    Longhi, L.2    Lee, E.B.3
  • 51
    • 33745187411 scopus 로고    scopus 로고
    • Intravenous infusion of immortalized human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat
    • Honma T, Honmou O, Iihoshi S, et al. Intravenous infusion of immortalized human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat. Exp Neurol 2006; 199:56-66.
    • (2006) Exp Neurol , vol.199 , pp. 56-66
    • Honma, T.1    Honmou, O.2    Iihoshi, S.3
  • 52
    • 84866273598 scopus 로고    scopus 로고
    • Stem cell-based therapy for experimental stroke: A systematic review and meta-analysis
    • .Lees JS, Sena ES, Egan KJ, et al. Stem cell-based therapy for experimental stroke: A systematic review and meta-analysis. Int J Stroke 2012; 7:582-588.
    • (2012) Int J Stroke , vol.7 , pp. 582-588
    • Lees, J.S.1    Sena, E.S.2    Egan, K.J.3
  • 53
    • 79960828040 scopus 로고    scopus 로고
    • Effects of duplicate administration of human neural stem cell after focal cerebral ischemia in the rat
    • Song M, Kim YJ, Kim YH, et al. Effects of duplicate administration of human neural stem cell after focal cerebral ischemia in the rat. Int J Neurosci 2011; 121:457-461.
    • (2011) Int J Neurosci , vol.121 , pp. 457-461
    • Song, M.1    Kim, Y.J.2    Kim, Y.H.3
  • 54
    • 78649804099 scopus 로고    scopus 로고
    • Changes in host blood factors and brain glia accompanying the functional recovery after systemic administration of bone marrow stem cells in ischemic stroke rats
    • Yang M, Wei X, Li J, et al. Changes in host blood factors and brain glia accompanying the functional recovery after systemic administration of bone marrow stem cells in ischemic stroke rats. Cell Transplant 2010; 19:1073- 1084.
    • (2010) Cell Transplant , vol.19 , pp. 1073-1084
    • Yang, M.1    Wei, X.2    Li, J.3
  • 55
    • 84875606564 scopus 로고    scopus 로고
    • Injection time-dependent effect of adult human bone marrow stromal cell transplantation in a rat model of severe traumatic brain injury
    • Han EY, Chun MH, Kim ST, et al. Injection time-dependent effect of adult human bone marrow stromal cell transplantation in a rat model of severe traumatic brain injury. Curr Stem Cell Res Ther 2013; 8:172-181.
    • (2013) Curr Stem Cell Res Ther , vol.8 , pp. 172-181
    • Han, E.Y.1    Chun, M.H.2    Kim, S.T.3
  • 56
    • 84866285333 scopus 로고    scopus 로고
    • Getting neurorehabilitation right: What can be learned from animal models?
    • Krakauer JW, Carmichael ST, Corbett D, et al. Getting neurorehabilitation right: what can be learned from animal models? Neurorehabil Neural Repair 2012; 26:923-931.
    • (2012) Neurorehabil Neural Repair , vol.26 , pp. 923-931
    • Krakauer, J.W.1    Carmichael, S.T.2    Corbett, D.3
  • 57
    • 15944397267 scopus 로고    scopus 로고
    • Comparison of ischemia-directed migration of neural precursor cells after intrastriatal, intraventricular, or intravenous transplantation in the rat
    • Jin K, Sun Y, Xie L, et al. Comparison of ischemia-directed migration of neural precursor cells after intrastriatal, intraventricular, or intravenous transplantation in the rat. Neurobiol Dis 2005; 18:366-374.
    • (2005) Neurobiol Dis , vol.18 , pp. 366-374
    • Jin, K.1    Sun, Y.2    Xie, L.3
  • 58
    • 84858743385 scopus 로고    scopus 로고
    • Intravenous and intra-arterial administration of bone marrow mononuclear cells after focal cerebral ischemia: Is there a difference in biodistribution and efficacy?
    • Vasconcelos-dos-Santos A, Rosado-de-Castro PH, Lopes de Souza SA, et al. Intravenous and intra-arterial administration of bone marrow mononuclear cells after focal cerebral ischemia: Is there a difference in biodistribution and efficacy? Stem Cell Res 2012; 9:1-8.
    • (2012) Stem Cell Res , vol.9 , pp. 1-8
    • Vasconcelos-Dos-Santos, A.1    Rosado-De-Castro, P.H.2    Lopes De Souza, S.A.3
  • 59
    • 0033845975 scopus 로고    scopus 로고
    • Transplantation of cultured human neuronal cells for patients with stroke
    • Kondziolka D, Wechsler L, Goldstein S, et al. Transplantation of cultured human neuronal cells for patients with stroke. Neurology 2000; 55:565-569.
    • (2000) Neurology , vol.55 , pp. 565-569
    • Kondziolka, D.1    Wechsler, L.2    Goldstein, S.3
  • 60
    • 24944466539 scopus 로고    scopus 로고
    • Neurotransplantation for patients with subcortical motor stroke: A phase 2 randomized trial
    • Kondziolka D, Steinberg GK, Wechsler L, et al. Neurotransplantation for patients with subcortical motor stroke: A phase 2 randomized trial. J Neurosurg 2005; 103:38-45.
    • (2005) J Neurosurg , vol.103 , pp. 38-45
    • Kondziolka, D.1    Steinberg, G.K.2    Wechsler, L.3
  • 61
    • 23844487540 scopus 로고    scopus 로고
    • Neurotransplantation of fetal porcine cells in patients with basal ganglia infarcts: A preliminary safety and feasibility study
    • Savitz SI, Dinsmore J, Wu J, et al. Neurotransplantation of fetal porcine cells in patients with basal ganglia infarcts: A preliminary safety and feasibility study. Cerebrovasc Dis 2005; 20:101-107.
    • (2005) Cerebrovasc Dis , vol.20 , pp. 101-107
    • Savitz, S.I.1    Dinsmore, J.2    Wu, J.3
  • 64
    • 72749123129 scopus 로고    scopus 로고
    • Migration and homing of bone-marrow mononuclear cells in chronic ischemic stroke after intra-arterial injection
    • Barbosa da Fonseca LM, Gutfilen B, Rosado de Castro PH, et al. Migration and homing of bone-marrow mononuclear cells in chronic ischemic stroke after intra-arterial injection. Exp Neurol 2010; 221:122-128.
    • (2010) Exp Neurol , vol.221 , pp. 122-128
    • Barbosa Da Fonseca, L.M.1    Gutfilen, B.2    Rosado De Castro, P.H.3
  • 65
    • 20444419744 scopus 로고    scopus 로고
    • Autologous mesenchymal stem cell transplantation in stroke patients
    • Bang OY, Lee JS, Lee PH, et al. Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol 2005; 57:874-882.
    • (2005) Ann Neurol , vol.57 , pp. 874-882
    • Bang, O.Y.1    Lee, J.S.2    Lee, P.H.3
  • 66
    • 77956638921 scopus 로고    scopus 로고
    • A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke
    • Lee JS, Hong JM, Moon GJ, et al. A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke. Stem Cells 2010; 28:1099-1106.
    • (2010) Stem Cells , vol.28 , pp. 1099-1106
    • Lee, J.S.1    Hong, J.M.2    Moon, G.J.3
  • 67
    • 78650668601 scopus 로고    scopus 로고
    • Safety of autologous bone marrow mononuclear cell transplantation in patients with nonacute ischemic stroke
    • Battistella V, de Freitas GR, da Fonseca LM, et al. Safety of autologous bone marrow mononuclear cell transplantation in patients with nonacute ischemic stroke. Regen Med 2011; 6:45-52.
    • (2011) Regen Med , vol.6 , pp. 45-52
    • Battistella, V.1    De Freitas, G.R.2    Da Fonseca, L.M.3
  • 68
    • 79960826161 scopus 로고    scopus 로고
    • Intravenous autologous bone marrow mononuclear cells for ischemic stroke
    • Savitz SI, Misra V, Kasam M, et al. Intravenous autologous bone marrow mononuclear cells for ischemic stroke. Ann Neurol 2011; 70:59-69.
    • (2011) Ann Neurol , vol.70 , pp. 59-69
    • Savitz, S.I.1    Misra, V.2    Kasam, M.3
  • 69
    • 79957796744 scopus 로고    scopus 로고
    • Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke
    • Honmou O, Houkin K, Matsunaga T, et al. Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke. Brain 2011; 134 (Pt 6):1790-1807.
    • (2011) Brain , vol.134 , Issue.PART 6 , pp. 1790-1807
    • Honmou, O.1    Houkin, K.2    Matsunaga, T.3
  • 72
    • 84866744900 scopus 로고    scopus 로고
    • Autologous intravenous bone marrow mononuclear cell therapy for patients with subacute ischaemic stroke: A pilot study
    • Prasad K, Mohanty S, Bhatia R, et al. Autologous intravenous bone marrow mononuclear cell therapy for patients with subacute ischaemic stroke: A pilot study. Indian J Med Res 2012; 136:221-228.
    • (2012) Indian J Med Res , vol.136 , pp. 221-228
    • Prasad, K.1    Mohanty, S.2    Bhatia, R.3
  • 73
    • 84864284648 scopus 로고    scopus 로고
    • Intra-arterial bone marrow mononuclear cells in ischemic stroke: A pilot clinical trial
    • .Moniche F, Gonzalez A, Gonzalez-Marcos JR, et al. Intra-arterial bone marrow mononuclear cells in ischemic stroke: A pilot clinical trial. Stroke 2012; 43:2242-2244.
    • (2012) Stroke , vol.43 , pp. 2242-2244
    • Moniche, F.1    Gonzalez, A.2    Gonzalez-Marcos, J.R.3
  • 74
    • 84876076089 scopus 로고    scopus 로고
    • Autologous bone marrow mesenchymal stem cell therapy in the subacute stage of traumatic brain injury by lumbar puncture
    • .Tian C, Wang X, Wang L, et al. Autologous bone marrow mesenchymal stem cell therapy in the subacute stage of traumatic brain injury by lumbar puncture. Exp Clin Transplant 2013; 11:176-181.
    • (2013) Exp Clin Transplant , vol.11 , pp. 176-181
    • Tian, C.1    Wang, X.2    Wang, L.3
  • 75
    • 5344247965 scopus 로고    scopus 로고
    • Changes in cognitive function after neuronal cell transplantation for basal ganglia stroke
    • Stilley CS, Ryan CM, Kondziolka D, et al. Changes in cognitive function after neuronal cell transplantation for basal ganglia stroke. Neurology 2004; 63:1320-1322.
    • (2004) Neurology , vol.63 , pp. 1320-1322
    • Stilley, C.S.1    Ryan, C.M.2    Kondziolka, D.3
  • 76
    • 79958256926 scopus 로고    scopus 로고
    • Effects of neural progenitor cells on sensorimotor recovery and endogenous repair mechanisms after photothrombotic stroke
    • Minnerup J, Kim JB, Schmidt A, et al. Effects of neural progenitor cells on sensorimotor recovery and endogenous repair mechanisms after photothrombotic stroke. Stroke 2011; 42:1757-1763.
    • (2011) Stroke , vol.42 , pp. 1757-1763
    • Minnerup, J.1    Kim, J.B.2    Schmidt, A.3
  • 77
    • 84892369529 scopus 로고    scopus 로고
    • Press Release 28 May 2013. Available at, Accessed 30 September 2013
    • ReNeuron. Press release, 28 May 2013. Available at http://www.reneuron. com/press-release/interim-data-from-clinical-trial-of-reneuron-s-stem- celltherapy-for-stroke-to-be-presented-at-leading-stroke-conference-longer- termdata-continue-to-show-good-safety-profile-and-evidence-of-sustained- reductions-in-neurologica. [Accessed 30 September 2013]
    • ReNeuron
  • 78
    • 78751580257 scopus 로고    scopus 로고
    • Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): A randomised placebo-controlled trial
    • Chollet F, Tardy J, Albucher JF, et al. Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): A randomised placebo-controlled trial. Lancet Neurol 2011; 10:123-130.
    • (2011) Lancet Neurol , vol.10 , pp. 123-130
    • Chollet, F.1    Tardy, J.2    Albucher, J.F.3
  • 79
    • 72749121996 scopus 로고    scopus 로고
    • Optimizing the success of cell transplantation therapy for stroke
    • Bliss TM, Andres RH, Steinberg GK. Optimizing the success of cell transplantation therapy for stroke. Neurobiol Dis 2010; 37:275-283.
    • (2010) Neurobiol Dis , vol.37 , pp. 275-283
    • Bliss, T.M.1    Andres, R.H.2    Steinberg, G.K.3
  • 80
    • 84867539057 scopus 로고    scopus 로고
    • Tracking stem cells for cellular therapy in stroke
    • Manley NC, Steinberg GK. Tracking stem cells for cellular therapy in stroke. Curr Pharm Des 2012; 18:3685-3693.
    • (2012) Curr Pharm Des , vol.18 , pp. 3685-3693
    • Manley, N.C.1    Steinberg, G.K.2


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