Targeting extracellular ROS signaling of tumor cells

Anticancer Research

Volumn 34, Issue 4, 2014, Pages 1467-1482

  Bauer, Georg ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Apoptosis; Catalase; NOX1; Review; ROS; Superoxide anion; Superoxide dismutase

Indexed keywords

CATALASE; CELL PROTEIN; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; SUPEROXIDE DISMUTASE; ANTINEOPLASTIC AGENT; MEMBRANE PROTEIN;

APOPTOSIS; ARTICLE; CANCER THERAPY; CARCINOGENESIS; CELL MEMBRANE; ELECTRON TRANSPORT; ENZYME ACTIVITY; HUMAN; INTRACELLULAR SIGNALING; LIPID PEROXIDATION; MUTAGENIC ACTIVITY; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSFORMED CELL; TUMOR CELL; CELL TRANSFORMATION; DRUG EFFECT; EXTRACELLULAR SPACE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULARLY TARGETED THERAPY; NEOPLASM; NOX1; PROTEIN BINDING; REVIEW; ROS;

APOPTOSIS; CATALASE; NOX1; REVIEW; ROS; SUPEROXIDE ANION; SUPEROXIDE DISMUTASE;

ANTINEOPLASTIC AGENTS; CATALASE; CELL TRANSFORMATION, NEOPLASTIC; EXTRACELLULAR SPACE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MEMBRANE PROTEINS; MOLECULAR TARGETED THERAPY; NEOPLASMS; PHENOTYPE; PROTEIN BINDING; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE;

EID: 84902267722     PISSN: 02507005     EISSN: 17917530     Source Type: Journal    
DOI: None     Document Type: Article

References (97)

1. Bauer G: Tumor cell-protective catalase as a novel target for rational therapeutic approaches based on specific intercellular ROS signaling. Anticancer Res 32: 2599-2624, 2012.
2. Feig DI, Reid TM and Loeb LA: Reactive oxygen species in tumorigenesis. Cancer Res 54: 1890-1894, 1994.
3. Storz P: Reactive oxygen species in tumor progression. Front Bioscii 10: 1881-1896, 2005.
4. Cerutti PA: Prooxidant states and tumor promotion. Science 227: 375-381, 1985.
5. Irani K, Xia Y, Zweier JL, Sollott SJ, Der CJ, Fearon ER, Sundaresan M, Finkel T and Goldschmidt-Clermont PJ: Mitogenic signalling by oxidants in Ras-transformed fibroblasts. Science 275: 1649-1652, 1997.
6. Irani K and Goldschmidt-Clermont PJ: Ras, Superoxide and Signal Transduction. Biochem Pharmacol 55: 1339-1346, 1998.
7. Suh Y-A, Arnold RS, Lassegue B, Shi J, Xu X, Sorescu D, Chung AB, Griendling KK and Lambeth JD: Cell transformation by the superoxide-generating oxidase Mox1. Nature 401: 79-82, 1999.
8. Bittinger F, Gonzalez-Garcia JL, Lein CL, Brochhausen C, Offner F and Kirkpatrick CJ: Production of superoxide by human malignant melanoma cells. Melanoma Res 8: 381-387, 1998.
9. Yang JQ, Li S, Domann FE, Buettner G and Oberley LW: Superoxide generation in v-Ha-ras-transduced human keratinocyte HaCaT cells. Mol Carcinogenesis 26: 180-188, 1999.
10. Herdener M, Heigold S, Saran M and Bauer G: Target cell-derived superoxide anions cause efficiency and selectivity of intercellular induction of apoptosis. Free Rad Biol Med 29: 1260-1271, 2000.
11. Engelmann I, Dormann S, Saran M and Bauer G: Transformed target cell-derived superoxide anions drive apoptosis induction by myeloperoxidase. Redox Report 5: 207-214, 2000.
12. Schwieger A, Bauer L, Hanusch J, Sers C, Schäfer R and Bauer G: Ras oncogene expression determines sensitivity for intercellular induction of apoptosis. Carcinogenesis 22: 1385-1392, 2001.
13. Ivanovas B and Bauer G: Selective and nonselective apoptosis induction in transformed and nontransformed fibroblasts by exogenous reactive oxygen and nitrogen species. Anticancer Res 22: 841-856, 2002.
14. Brar SS, Kennedy TP, Sturrock AB, HuecksteadtTP, Quinn MT, Whorton AR and Hoidal Jr.: An NADPH oxidase regulates growth and transcription in melanoma cells. Am J Physiol 282: C1212-C1224, 2002.
15. Heigold S, Sers C, Bechtel W, Ivanovas B, Schäfer R and Bauer G: Nitric oxide mediates apoptosis induction selectively in transformed fibroblasts compared to nontransformed fibroblasts. Carcinogenesis 23: 929-941, 2002.
16. Chamulitrat W, Schmidt R, Tomakidi P, Stremmel W, Chunglok W, Kawahara T and Rokutan K: Association of GP91PHOX homolog NOX1 with anchorage-independent growth and MAP kinase activation of transformed human keratinocyte. Oncogene 22: 6045-6053, 2003.
17. Mitsushita J, Lambeth JD and Kamata T: The Superoxide- Generating Oxidase Nox1 is Functionally Required for Ras Oncogenic Transformation. Cancer Res 64: 3580-3585, 2004.
18. Alexandrova AY, Kopnin PB, Vasilev JM and Kopnin PB: Ros up-regulation mediates Ras-induced changes of cell morphology and motility. Exp Cell Res 312: 2066-2073, 2006.
19. Laurent E, McCoy JW, Maccina RA, Liu W, Cheng GJ, Robine S, Papkoff J and Lambeth JD: Nox1 is overexpressed in human colon cancers and correlates with activating mutations in K-Ras. Int J Cancer 123: 100-107, 2008.
20. Ma Q, Cavallin LE, Yan B, Zhu S, Duran EM, Wang H, Hala LP, Dong C, Cesarman E, Mesri EA and Goldschmidt-Clermont PJ: Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma. Proc Natl Acad Sci USA 106: 8683-8688, 2009.
21. Kim E-Y, Seo J-M, Kim C, Lee J-E, Lee K-M and Kim J-H: BLT2 promotes the invasion and metastasis of aggressive bladder cancer through a reactive oxygen species-linked pathway. Free Rad Biol Med 49: 1072-1081, 2010.
22. Du J, Liu J, Smith BJ, Tsao MS and Cullen J: Role of RAC-1- dependent NADPH oxidase in the growth of pancreatic cancer. Cancer Gene Ther 18: 135-143, 2011.
23. Behrend L, Henderson G and Zwacka RM: Reactive oxygen species in oncogenic transformation. Biochem Soc Trans 31: 1441-1444, 2003.
24. Geiszt M and Leto L: The NOX family of NAD(P)H oxidases: Host defense and beyond. J Biol Chem 279: 51715-51718, 2004.
25. Bedard K and Krause KH: The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 87: 245-313, 2007.
26. Lambeth JD: Nox enzymes, ROS, and chronic disease: An example of antagonistic pleiotropy. Free Rad Biol Med 43: 332-347, 2007.
27. Lopez-Lazaro M: Excessive superoxide anion generation plays a key role in carcinogenesis. Int J Cancer 120: 1378-1380, 2007.
28. Kamata T: Roles of Nox1 and other Nox isoforms in cancer development. Cancer Sci 100: 1382-1388, 2009.
29. Weinberg F and Chandel NS: Reactive oxygen species dependent signaling regulates cancer. Cell Mol Life Sci 66: 3663-3673, 2009.
30. Jürgensmeier J, Schmitt CP, Viesel E, Höfler P and Bauer G: TGF- β-treated normal fibroblasts eliminate transformed fibroblasts by induction of apoptosis. Cancer Res 54: 393-398, 1994.
31. Jürgensmeier J, Höfler P and Bauer G: TGF-β-induced elimination of transformed fibroblasts by normal cells: independence of cell-to-cell contact and dependence on reactive oxygen species. Int J Oncology 5: 525-531, 1994.
32. Schaefer D, Jürgensmeier J and Bauer G: Catechol interferes with TGF-β-induced elimination of transformed cells by normal cells: implications for the survival of transformed cells during carcinogenesis. Int J Cancer 60: 520-526, 1995.
33. Langer C, Jürgensmeier JM and Bauer G: Reactive oxygen species act both at TGF-β-dependent and -independent steps during induction of apoptosis of transformed cells by normal cells. Exp Cell Res 222: 117-124, 1996.
34. Hipp M-L and Bauer G: Intercellular induction of apoptosis in transformed cells does not depend on p53. Oncogene 15: 791-797, 1997.
35. Jürgensmeier J and Bauer G: Interference of Bcl-2 with intercellular control of carcinogenesis. Int. J. Cancer 71: 698-704, 1997.
36. Panse J, Hipp M-L and Bauer G: Fibroblasts transformed by chemical carcinogens are sensitive for intercellular induction of apoptosis: Implications for the control of oncogenesis. Carcinogenesis 18: 259-264, 1997.
37. Beck E, Schäfer R and Bauer G: Sensitivity of transformed fibroblasts for intercellular induction of apoptosis is determined by their transformed phenotype. Exp Cell Res 234: 47-56, 1997.
38. Zucker B and Bauer G: Intercellular induction of apoptosis of transformed cells is modulated by their intracellular glutathione concentration. Int J Oncol 10: 141-146, 1997.
39. Eckert S and Bauer G: TGF-β isoforms and fibroblast growth factor exhibit analogous indirect antioncogenic activity through triggering of intercellular induction of apoptosis. Anticancer Res 18: 45-52, 1998.
40. Dormann S and Bauer G: TGF-β and FGF trigger intercellular induction of apoptosis: analogous activity on non-transformed but differential activity on transformed cells. Int J Oncol 13: 1247-1252, 1998.
41. Von Eynatten K and Bauer G: Central and ambivalent role of hydrogen peroxide during intercellular induction of apoptosis. Int J Oncol 18: 1169-1174, 2001.
42. Kundrát P, Bauer G, Jacob P and Friedland W:. Mechanistic modelling suggests that the size of preneoplastic lesions is limited by intercellular induction of apoptosis in oncogenically transformed cells. Carcinogenesis 33: 253-259, 2012.
43. Bauer G: Elimination of transformed cells by normal cells: A novel concept for the control of carcinogenesis. Histol Histopathol 11: 237-255, 1996.
44. Bauer G; Reactive oxygen and nitrogen species: efficient, selective and interactive signals during intercellular induction of apoptosis. Anticancer Res 20: 4115-4140, 2000.
45. Bauer G: Signaling and proapoptotic functions of transformed cell-derived reactive oxygen species. Prostagl Leukotri Essent Fatty Acid 66: 41-56, 2002.
46. Bauer G: Low-dose radiation and intercellular induction of apoptosis: Potential implications for the control of oncogenesis. Int J Radiation Biol 83: 887-902, 2007.
47. Bauer G, Chatgilialoglu C, Gebicki JL, Gebicka L, Gescheidt G, Golding BT, Goldstein S, Kaizer J, Merenyi G, Speier G and Wardman P: Biologically relevant small radicals. Chimia 62: 1-9, 2008.
48. Deichman GI and Vendrov EL: Characteristics of in vitrotransformed cells essential for their in vivo survival, selection and metastatic activity. Int J Cancer 37: 401-409, 1986.
49. Deichman GI, Kluchareva TE, Matveeva VA, Kushlinsky NE, Bassalyk LS and Vendrov EL: Clustering of discrete cell properties essential for tumorigenicity and metastasis. I. Studies of Syrian hamster embryo fibroblasts spontaneously transformed in vitro. Int J Cancer 44: 904-907, 1989.
50. Deichman G, Matveeva VA, Kashkina LM, Dyakova NA, Uvarova EN, Nikiforov MA and Gudkov AV: Cell transforming genes and tumor progression: in vivo unified secondary phenotypic cell changes. Int J Cancer 75: 277-283, 1998.
51. Deichman G: Natural selection and early changes of phenotype of tumor cells in vivo: Acquisition of new defense mechanisms. Biochem 65: 78-94, 2000.
52. Deichman G: Early phenotypic changes of in vitro transformed cells during in vivo progression: Possible role of the host innate immunity. Sem Cancer Biol 12: 317-326, 2002.
53. Bechtel W and Bauer G: Catalase protects tumor cells against apoptosis induction by intercellular ROS signaling. Anticancer Res 29: 4541-4557, 2009
54. Bechtel W and Bauer G: Modulation of intercellular ROS signaling of human tumor cells. Anticancer Res 29: 4559-4570, 2009
55. Heinzelmann S and Bauer G: Multiple protective functions of catalase against intercellular apoptosis-inducing ROS signaling of human tumor cells. Biol Chem 391: 675-693, 2010.
56. Cheng G, Diebold BA, Hughes Y and Lambeth JD: Nox1- dependent Reactive Oxygen Generation is Regulated by Rac1. J Biol Chem 281: 17718-17726, 2006.
57. Arnold RS, Shi J, Murad E, Whalen AM, Sun CQ, Palavarapu R, Parthasarathy S, Petros JA and Lambeth JD: Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1. Proc Natl Acad Sci USA 98: 5550-5555, 2001.
58. Shinohara M, Shang W-H, Kubodera M, Hanada S, Mitsushita J, Kato M, Miyazaki H, Suminoto H and Kamata T: Nox1 Redox Signaling Mediates Oncogenic Ras-induced Disruption of Stress Fibers and Focal Adhesions by Down-regulating Rho. J Biol Chem 282: 17640-17648, 2007.
59. Sadok A, Bourgarel-Rey V, Gattacceca F, Penel C, Lehmann M and Kovacic H: Nox1-dependent superoxide production controls colon adenocarcinoma cell migration. Biochem Biophys Acta 1783: 23-33, 2008.
60. Tominaga K, Kawahara T, Sano t, Toida K, Kuwano Y, Sasaki H and Kawai T: Evidence for cancer-associated expression of NADPH oxidase 1 (Nox1)-based oxidase system in the human stomach. Free Rad Biol Med 43: 1627-1638, 2007.
61. Liu SY, Yen CY, Yang SC anc Chiang WF: Overexpression of Rac-1 small GTPase-binding protein in oral squamous cell carcinoma. J Oral Maxillofac Surg 62: 702-707, 2004.
62. Hwang SL, Hong YR, Sy WD, Lieu AS, Lin CL, Lee KS and Howng SL: Rac1 gene mutations in human brain tumors. Eur J Surg Oncol 30: 68-72, 2004.
63. Arbiser JL, Petros J, Klafter R, Govindajaran B, McLaughlin ER, Brown LF, Cohen C, Moses M, Kilroy S, Arnold RS and Lambeth JD: Reactive oxygen generated by Nox1 triggers the angiogenic switch. Proc Acad Natl Acad Sci USA 99: 715-720, 2002.
64. Blanchetot C and Boonstra J: The ROS-NOX connection in cancer and angiogenesis. Crit Rev Euk Gene Expr 18: 35-45, 2008.
65. Ferraro D, Corso S, Fasano E, Panieri E, Santangelo R, Borrelo S, Giordano S, Pani G and Galeotti T: Pro-metastatic signaling by c-Met through Rac-1 and reactive oxygen species. Oncogene 25: 3689-3698, 2006.
66. Lopez-Lazaro M: Why do tumors metastasize? Cancer Biol Ther 6: 141-144, 2007.
67. Chiera F, Meccia E, Degan P, Aquilina G, Pietraforte D, Minetti M, Lambeth D and Bignami M: Overexpression of human NOX1 complex induces genome instability in mammalian cells. Free Rad Biol Med 44: 332-342, 2008.
68. Steinmann M, Moosmann N, Schimmel M, Gerhardus C and Bauer G: Differential role of extra- and intracellular superoxide anions for nitric oxide-mediated apoptosis induction. In Vivo 18: 293-310, 2004.
69. Steinebach C and Bauer G: An alternative signalling pathway based on nitryl chloride during intercellular induction of apoptosis. In Vitro Appl Mol Toxicol 14: 107-120, 2001.
70. Schimmel M and Bauer G: Proapoptotic and redox state-related signalling of reactive oxygen species generated by transformed fibroblasts. Oncogene 21: 5886-5896, 2002.
71. Engelmann I and Bauer G: How can tumor cells escape intercellular induction of apoptosis? Anticancer Res 20: 2297-2306, 2000.
72. Engelmann I, Eichholtz-Wirth H and Bauer G: Ex vivo tumor cell lines are resistant to intercellular induction of apoptosis and independent of exogenous survival factors. Anticancer Res 20: 2361-2370, 2000.
73. Brunelli L, Yermilov V and Beckman JS. Modulation of catalase peroxidatic and catalatic activity by nitric oxide. Free Rad.Biol Med 30: 709-714, 2001.
74. Kono Y, Yamasaki T, Ueda A and Shibata H: Catalase catalyzes of peroxynitrite-mediated phenolic nitration. Biosci Biotechnol Biochem 62: 448-452, 1998.
75. Gebicka, L. and Didil J: Catalytic scavenging of peroxynitrite by catalase. Int J Inorg Biochem 103: 1375-1379, 2009.
76. Bauer G: HOCl-dependent singlet oxygen and hydroxyl radical generation modulate and induce apoptosis of malignant cells. Anticancer Res 33: 3589-3602, 2013.
77. Turner BJ, Atkin JD, Farg MA, Zang DW, Rembach A, Lopes EC, Patch JD, Hill AF and Cheema SS: Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis. J Neurosc 25: 108-117, 2005.
78. Zelko IN, Mariani TJ and Folz RJ:Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn- SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Radic Biol Med 33: 337-349, 2002.
79. Ischiropoulos H, Zhu L, Chen J, Sai M, Martin JC, Smith CD and Beckman JS: Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase. Arch Biochem Biophys 298: 431-437, 1982.
80. Radi R: Reactions of nitric oxide with metalloproteins. Chem Res Toxicol 9: 828-835, 1996
81. Yim MB, Chock PB and Stadtman ER: Copper, zinc superoxide dismutase catalyzes hydroxyl radical production from hydrogen peroxide. Proc Natl Acad Sci USA 87: 5008-5010, 1990.
82. Offer T, Russo A and Samuni A: The pro-oxidative activity of SOD and nitroxide SOD mimetics. FASEB J 14: 1215-1223, 2000.
83. Murphy ME and Sies H: Reversible conversion of nitroxyl anion to nitric oxide by superoxide dismutase. Proc Natl Acad Sci USA 88: 10860-10864, 1991.
84. Kono Y and Fridovich I: Superoxide radical inhibits catalase. J Biol Chem 257:5751-5754, 1982.
85. Shimizu N, Kobayashi K and Hayashi K: The reaction of superoxide radical with catalase. Mechanism of the inhibition of catalase by superoxide radical. J Biol Chem 259: 4414-4418, 1984.
86. Fridovich I: Biological effects of the superoxide radical. Arch Biochem Biophys 247: 1-11, 1986.
87. Gebicka L, Metodiewa D and Gebicki JL: Pulse radiolysis of catalase in solution. I. Reactions of O2 •- with catalase and its compound I. Int J Rad Biol 55: 45-50, 1989.
88. Pigeolet E, Corbisier P, Houbion A, Lambert D, Michiels C, Raes M, Zachary M-D and Remacle J: Glutathione peroxidase, superoxide dismutase, and catalase inactivation by peroxides and oxygen derived free radicals. Mech Ageing Dev 51: 283-297, 1990.
89. Lardinois OM: Reactions of bovine liver catalase with superoxide radicals and hydrogen peroxide. Free Rad Res 22: 251-274, 1995.
90. Hodgson EK and Fridovich I: The interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide: Inactivation of the enzyme. Biochemistry 14: 5294-5299, 1975.
91. Pelicano H, Carney D and Huang P: ROS stress in cancer cells and therapeutic implications. Drug Resist Updates 7: 97-110, 2004.
92. Trachootham D, Alexandre J and Huang P: Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach? Nature Rev Drug Discov 8: 579-591, 2009.
93. Wondrak GT: Redox-directed cancer therapeutics: Molecular mechanisms and opportunities. Antioxid Redox Signal 11: 3013-3069, 2009.
94. Fang J, Seki T and Maeda H: Therapeutic strategies by modulating oxygen stress in cancer and inflammation. Adv Drug Deliv Rev 61: 290-302, 2009.
95. Gorrini C, Harris IS and Mak TW: Modulation of oxidative stress as an anticancer strategy. Nature Reviews. Drug Discovery 12: 931-947, 2013.
96. Marklund SL: Extracellular superoxide dismutase in human tissues and human cell lines. J Clin Invest 74: 1398-1403, 1984.
97. Bauer G, Bereswill S, Aichele P and Glocker E: Helicobacter pylori protects oncogenically transformed cells from reactive oxygen species-mediated intercellular induction of apoptosis. Carcinogenesis, in press.