메뉴 건너뛰기




Volumn 49, Issue 3, 2011, Pages 319-327

Unraveling the role of FoxOs in bone-Insights from mouse models

Author keywords

Aging; Osteoblasts; Osteoclasts; Reactive oxygen species; Wnt signaling

Indexed keywords

GROWTH FACTOR; INSULIN; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTION FACTOR FOXO4; UNCLASSIFIED DRUG;

EID: 79960575561     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2011.05.023     Document Type: Review
Times cited : (68)

References (140)
  • 1
    • 27844497945 scopus 로고    scopus 로고
    • FOXO transcription factors at the interface between longevity and tumor suppression
    • Greer E.L., Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 2005, 24:7410-7425.
    • (2005) Oncogene , vol.24 , pp. 7410-7425
    • Greer, E.L.1    Brunet, A.2
  • 2
  • 3
    • 41849087003 scopus 로고    scopus 로고
    • FOXO animal models reveal a variety of diverse roles for FOXO transcription factors
    • Arden K.C. FOXO animal models reveal a variety of diverse roles for FOXO transcription factors. Oncogene 2008, 27:2345-2350.
    • (2008) Oncogene , vol.27 , pp. 2345-2350
    • Arden, K.C.1
  • 4
    • 79251583486 scopus 로고    scopus 로고
    • Understanding forkhead box class O function: lessons from Drosophila melanogaster
    • Puig O., Mattila J. Understanding forkhead box class O function: lessons from Drosophila melanogaster. Antioxid Redox Signal 2011, 14:635-647.
    • (2011) Antioxid Redox Signal , vol.14 , pp. 635-647
    • Puig, O.1    Mattila, J.2
  • 5
    • 41849136901 scopus 로고    scopus 로고
    • Forkhead transcription factors and ageing
    • Partridge L., Bruning J.C. Forkhead transcription factors and ageing. Oncogene 2008, 27:2351-2363.
    • (2008) Oncogene , vol.27 , pp. 2351-2363
    • Partridge, L.1    Bruning, J.C.2
  • 6
    • 77950265945 scopus 로고    scopus 로고
    • Linking functional decline of telomeres, mitochondria and stem cells during ageing
    • Sahin E., DePinho R.A. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature 2010, 464:520-528.
    • (2010) Nature , vol.464 , pp. 520-528
    • Sahin, E.1    DePinho, R.A.2
  • 7
    • 77049308856 scopus 로고
    • Aging: a theory based on free radical and radiation chemistry
    • Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956, 11:298-300.
    • (1956) J Gerontol , vol.11 , pp. 298-300
    • Harman, D.1
  • 10
    • 0034626735 scopus 로고    scopus 로고
    • Oxidants, oxidative stress and the biology of ageing
    • Finkel T., Holbrook N.J. Oxidants, oxidative stress and the biology of ageing. Nature 2000, 408:239-247.
    • (2000) Nature , vol.408 , pp. 239-247
    • Finkel, T.1    Holbrook, N.J.2
  • 11
    • 0035917440 scopus 로고    scopus 로고
    • A conserved regulatory system for aging
    • Kenyon C. A conserved regulatory system for aging. Cell 2001, 105:165-168.
    • (2001) Cell , vol.105 , pp. 165-168
    • Kenyon, C.1
  • 12
    • 34848878406 scopus 로고    scopus 로고
    • Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids
    • Almeida M., Han L., Martin-Millan M., Plotkin L.I., Stewart S.A., Roberson P.K., et al. Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J Biol Chem 2007, 282:27285-27297.
    • (2007) J Biol Chem , vol.282 , pp. 27285-27297
    • Almeida, M.1    Han, L.2    Martin-Millan, M.3    Plotkin, L.I.4    Stewart, S.A.5    Roberson, P.K.6
  • 13
    • 78349252031 scopus 로고    scopus 로고
    • Effects of chronic estrogen treatment on modulating age-related bone loss in female mice
    • Syed F.A., Modder U.I., Roforth M., Hensen I., Fraser D.G., Peterson J.M., et al. Effects of chronic estrogen treatment on modulating age-related bone loss in female mice. J Bone Miner Res 2010, 25:2438-2446.
    • (2010) J Bone Miner Res , vol.25 , pp. 2438-2446
    • Syed, F.A.1    Modder, U.I.2    Roforth, M.3    Hensen, I.4    Fraser, D.G.5    Peterson, J.M.6
  • 15
    • 0036372060 scopus 로고    scopus 로고
    • Age-related changes in bone mineral density, cross-sectional area and strength at different skeletal sites in male rats
    • Iida H., Fukuda S. Age-related changes in bone mineral density, cross-sectional area and strength at different skeletal sites in male rats. J Vet Med Sci 2002, 64:29-34.
    • (2002) J Vet Med Sci , vol.64 , pp. 29-34
    • Iida, H.1    Fukuda, S.2
  • 16
    • 78349266526 scopus 로고    scopus 로고
    • Decreased oxidative stress and greater bone anabolism in the aged, as compared to the young, murine skeleton by parathyroid hormone
    • Jilka R.L., Almeida M., Ambrogini E., Han L., Roberson P.K., Weinstein R.S., et al. Decreased oxidative stress and greater bone anabolism in the aged, as compared to the young, murine skeleton by parathyroid hormone. Aging Cell 2010, 9:851-867.
    • (2010) Aging Cell , vol.9 , pp. 851-867
    • Jilka, R.L.1    Almeida, M.2    Ambrogini, E.3    Han, L.4    Roberson, P.K.5    Weinstein, R.S.6
  • 18
    • 11144248825 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha mediates osteopenia caused by depletion of antioxidants
    • Jagger C.J., Lean J.M., Davies J.T., Chambers T.J. Tumor necrosis factor-alpha mediates osteopenia caused by depletion of antioxidants. Endocrinology 2005, 146:113-118.
    • (2005) Endocrinology , vol.146 , pp. 113-118
    • Jagger, C.J.1    Lean, J.M.2    Davies, J.T.3    Chambers, T.J.4
  • 21
    • 75149146587 scopus 로고    scopus 로고
    • FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice
    • Ambrogini E., Almeida M., Martin-Millan M., Paik J., dePinho R., Han L., et al. FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. Cell Metab 2010, 11:136-146.
    • (2010) Cell Metab , vol.11 , pp. 136-146
    • Ambrogini, E.1    Almeida, M.2    Martin-Millan, M.3    Paik, J.4    dePinho, R.5    Han, L.6
  • 22
    • 75149115329 scopus 로고    scopus 로고
    • FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts
    • Rached M.T., Kode A., Xu L., Yoshikawa Y., Paik J.H., DePinho R.A., et al. FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts. Cell Metab 2010, 11:147-160.
    • (2010) Cell Metab , vol.11 , pp. 147-160
    • Rached, M.T.1    Kode, A.2    Xu, L.3    Yoshikawa, Y.4    Paik, J.H.5    DePinho, R.A.6
  • 23
    • 0034643331 scopus 로고    scopus 로고
    • AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
    • Medema R.H., Kops G.J., Bos J.L., Burgering B.M. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 2000, 404:782-787.
    • (2000) Nature , vol.404 , pp. 782-787
    • Medema, R.H.1    Kops, G.J.2    Bos, J.L.3    Burgering, B.M.4
  • 24
    • 0037134040 scopus 로고    scopus 로고
    • DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein
    • Tran H., Brunet A., Grenier J.M., Datta S.R., Fornace A.J., DiStefano P.S., et al. DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 2002, 296:530-534.
    • (2002) Science , vol.296 , pp. 530-534
    • Tran, H.1    Brunet, A.2    Grenier, J.M.3    Datta, S.R.4    Fornace, A.J.5    DiStefano, P.S.6
  • 25
    • 0036651790 scopus 로고    scopus 로고
    • A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR
    • Ramaswamy S., Nakamura N., Sansal I., Bergeron L., Sellers W.R. A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Cancer Cell 2002, 2:81-91.
    • (2002) Cancer Cell , vol.2 , pp. 81-91
    • Ramaswamy, S.1    Nakamura, N.2    Sansal, I.3    Bergeron, L.4    Sellers, W.R.5
  • 26
    • 0037136563 scopus 로고    scopus 로고
    • Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
    • Kops G.J., Dansen T.B., Polderman P.E., Saarloos I., Wirtz K.W., Coffer P.J., et al. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 2002, 419:316-321.
    • (2002) Nature , vol.419 , pp. 316-321
    • Kops, G.J.1    Dansen, T.B.2    Polderman, P.E.3    Saarloos, I.4    Wirtz, K.W.5    Coffer, P.J.6
  • 27
    • 0037192473 scopus 로고    scopus 로고
    • Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway
    • Nemoto S., Finkel T. Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science 2002, 295:2450-2452.
    • (2002) Science , vol.295 , pp. 2450-2452
    • Nemoto, S.1    Finkel, T.2
  • 28
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    • Brunet A., Bonni A., Zigmond M.J., Lin M.Z., Juo P., Hu L.S., et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999, 96:857-868.
    • (1999) Cell , vol.96 , pp. 857-868
    • Brunet, A.1    Bonni, A.2    Zigmond, M.J.3    Lin, M.Z.4    Juo, P.5    Hu, L.S.6
  • 29
    • 0034609737 scopus 로고    scopus 로고
    • Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
    • Dijkers P.F., Medema R.H., Lammers J.W., Koenderman L., Coffer P.J. Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr Biol 2000, 10:1201-1204.
    • (2000) Curr Biol , vol.10 , pp. 1201-1204
    • Dijkers, P.F.1    Medema, R.H.2    Lammers, J.W.3    Koenderman, L.4    Coffer, P.J.5
  • 30
    • 37349096366 scopus 로고    scopus 로고
    • FOXO transcription factors in ageing and cancer
    • Greer E.L., Brunet A. FOXO transcription factors in ageing and cancer. Acta Physiol (Oxf) 2008, 192:19-28.
    • (2008) Acta Physiol (Oxf) , vol.192 , pp. 19-28
    • Greer, E.L.1    Brunet, A.2
  • 31
    • 41849128523 scopus 로고    scopus 로고
    • The FoxO code
    • Calnan D.R., Brunet A. The FoxO code. Oncogene 2008, 27:2276-2288.
    • (2008) Oncogene , vol.27 , pp. 2276-2288
    • Calnan, D.R.1    Brunet, A.2
  • 32
    • 79951887419 scopus 로고    scopus 로고
    • FOXO as a sensor, mediator and regulator of redox signaling
    • de Keizer P., Burgering B., Dansen T.B. FOXO as a sensor, mediator and regulator of redox signaling. Antioxid Redox Signal 2010, 14(6):1093-1106.
    • (2010) Antioxid Redox Signal , vol.14 , Issue.6 , pp. 1093-1106
    • de Keizer, P.1    Burgering, B.2    Dansen, T.B.3
  • 33
    • 80052964810 scopus 로고    scopus 로고
    • Structural basis for DNA recognition by FOXO proteins
    • [Epub ahead of print]
    • Obsil T., Obsilova V. Structural basis for DNA recognition by FOXO proteins. Biochim Biophys Acta 2010, [Epub ahead of print]. 10.1016/j.bbamcr.2010.11.025.
    • (2010) Biochim Biophys Acta
    • Obsil, T.1    Obsilova, V.2
  • 34
    • 80052968161 scopus 로고    scopus 로고
    • Regulation of FOXO protein stability via ubiquitination and proteasome degradation
    • Epub ahead of print
    • Huang H., Tindall D.J. Regulation of FOXO protein stability via ubiquitination and proteasome degradation. Biochim Biophys Acta 2011, Epub ahead of print. 10.1016/j.bbamcr.2011.01.007.
    • (2011) Biochim Biophys Acta
    • Huang, H.1    Tindall, D.J.2
  • 35
    • 33846208251 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1
    • Asada S., Daitoku H., Matsuzaki H., Saito T., Sudo T., Mukai H., et al. Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1. Cell Signal 2007, 19:519-527.
    • (2007) Cell Signal , vol.19 , pp. 519-527
    • Asada, S.1    Daitoku, H.2    Matsuzaki, H.3    Saito, T.4    Sudo, T.5    Mukai, H.6
  • 36
    • 38849139580 scopus 로고    scopus 로고
    • ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
    • Yang J.Y., Zong C.S., Xia W., Yamaguchi H., Ding Q., Xie X., et al. ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat Cell Biol 2008, 10:138-148.
    • (2008) Nat Cell Biol , vol.10 , pp. 138-148
    • Yang, J.Y.1    Zong, C.S.2    Xia, W.3    Yamaguchi, H.4    Ding, Q.5    Xie, X.6
  • 37
    • 77949434499 scopus 로고    scopus 로고
    • Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT
    • Singh A., Ye M., Bucur O., Zhu S., Tanya S.M., Rabinovitz I., et al. Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT. Mol Biol Cell 2010, 21:1140-1152.
    • (2010) Mol Biol Cell , vol.21 , pp. 1140-1152
    • Singh, A.1    Ye, M.2    Bucur, O.3    Zhu, S.4    Tanya, S.M.5    Rabinovitz, I.6
  • 39
    • 34249281690 scopus 로고    scopus 로고
    • Stressing the role of FoxO proteins in lifespan and disease
    • van der H.A., Burgering B.M. Stressing the role of FoxO proteins in lifespan and disease. Nat Rev Mol Cell Biol 2007, 8:440-450.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 440-450
    • van der, H.A.1    Burgering, B.M.2
  • 40
    • 11244320393 scopus 로고    scopus 로고
    • FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK
    • Essers M.A., Weijzen S., Vries-Smits A.M., Saarloos I., de Ruiter N.D., Bos J.L., et al. FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J 2004, 23:4802-4812.
    • (2004) EMBO J , vol.23 , pp. 4802-4812
    • Essers, M.A.1    Weijzen, S.2    Vries-Smits, A.M.3    Saarloos, I.4    de Ruiter, N.D.5    Bos, J.L.6
  • 41
    • 33646934067 scopus 로고    scopus 로고
    • A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
    • Lehtinen M.K., Yuan Z., Boag P.R., Yang Y., Villen J., Becker E.B., et al. A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 2006, 125:987-1001.
    • (2006) Cell , vol.125 , pp. 987-1001
    • Lehtinen, M.K.1    Yuan, Z.2    Boag, P.R.3    Yang, Y.4    Villen, J.5    Becker, E.B.6
  • 42
    • 17044408768 scopus 로고    scopus 로고
    • JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling
    • Wang M.C., Bohmann D., Jasper H. JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell 2005, 121:115-125.
    • (2005) Cell , vol.121 , pp. 115-125
    • Wang, M.C.1    Bohmann, D.2    Jasper, H.3
  • 43
    • 15444371989 scopus 로고    scopus 로고
    • JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16
    • Oh S.W., Mukhopadhyay A., Svrzikapa N., Jiang F., Davis R.J., Tissenbaum H.A. JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci U S A 2005, 102:4494-4499.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 4494-4499
    • Oh, S.W.1    Mukhopadhyay, A.2    Svrzikapa, N.3    Jiang, F.4    Davis, R.J.5    Tissenbaum, H.A.6
  • 44
    • 22944479314 scopus 로고    scopus 로고
    • JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3
    • Sunayama J., Tsuruta F., Masuyama N., Gotoh Y. JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3. J Cell Biol 2005, 170:295-304.
    • (2005) J Cell Biol , vol.170 , pp. 295-304
    • Sunayama, J.1    Tsuruta, F.2    Masuyama, N.3    Gotoh, Y.4
  • 45
    • 0037474274 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade
    • Lee Y.H., Giraud J., Davis R.J., White M.F. c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J Biol Chem 2003, 278:2896-2902.
    • (2003) J Biol Chem , vol.278 , pp. 2896-2902
    • Lee, Y.H.1    Giraud, J.2    Davis, R.J.3    White, M.F.4
  • 46
    • 77949909616 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase enhances MST1-mediated pro-apoptotic signaling through phosphorylation at serine 82
    • Bi W., Xiao L., Jia Y., Wu J., Xie Q., Ren J., et al. c-Jun N-terminal kinase enhances MST1-mediated pro-apoptotic signaling through phosphorylation at serine 82. J Biol Chem 2010, 285:6259-6264.
    • (2010) J Biol Chem , vol.285 , pp. 6259-6264
    • Bi, W.1    Xiao, L.2    Jia, Y.3    Wu, J.4    Xie, Q.5    Ren, J.6
  • 47
    • 71049155850 scopus 로고    scopus 로고
    • Mst1-FoxO signaling protects naive T lymphocytes from cellular oxidative stress in mice
    • Choi J., Oh S., Lee D., Oh H.J., Park J.Y., Lee S.B., et al. Mst1-FoxO signaling protects naive T lymphocytes from cellular oxidative stress in mice. PLoS One 2009, 4:e8011.
    • (2009) PLoS One , vol.4
    • Choi, J.1    Oh, S.2    Lee, D.3    Oh, H.J.4    Park, J.Y.5    Lee, S.B.6
  • 48
    • 12144290563 scopus 로고    scopus 로고
    • Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    • Brunet A., Sweeney L.B., Sturgill J.F., Chua K.F., Greer P.L., Lin Y., et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004, 303:2011-2015.
    • (2004) Science , vol.303 , pp. 2011-2015
    • Brunet, A.1    Sweeney, L.B.2    Sturgill, J.F.3    Chua, K.F.4    Greer, P.L.5    Lin, Y.6
  • 51
    • 20144365700 scopus 로고    scopus 로고
    • Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes
    • Frescas D., Valenti L., Accili D. Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. J Biol Chem 2005, 280:20589-20595.
    • (2005) J Biol Chem , vol.280 , pp. 20589-20595
    • Frescas, D.1    Valenti, L.2    Accili, D.3
  • 52
    • 27744518040 scopus 로고    scopus 로고
    • FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction
    • Kitamura Y.I., Kitamura T., Kruse J.P., Raum J.C., Stein R., Gu W., et al. FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab 2005, 2:153-163.
    • (2005) Cell Metab , vol.2 , pp. 153-163
    • Kitamura, Y.I.1    Kitamura, T.2    Kruse, J.P.3    Raum, J.C.4    Stein, R.5    Gu, W.6
  • 53
    • 77954225200 scopus 로고    scopus 로고
    • Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity
    • Zhao Y., Yang J., Liao W., Liu X., Zhang H., Wang S., et al. Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat Cell Biol 2010, 12:665-675.
    • (2010) Nat Cell Biol , vol.12 , pp. 665-675
    • Zhao, Y.1    Yang, J.2    Liao, W.3    Liu, X.4    Zhang, H.5    Wang, S.6
  • 56
    • 41849086320 scopus 로고    scopus 로고
    • FOXO-binding partners: it takes two to tango
    • van der Vos K.E., Coffer P.J. FOXO-binding partners: it takes two to tango. Oncogene 2008, 27:2289-2299.
    • (2008) Oncogene , vol.27 , pp. 2289-2299
    • van der Vos, K.E.1    Coffer, P.J.2
  • 57
    • 1642332084 scopus 로고    scopus 로고
    • Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
    • Seoane J., Le H.V., Shen L., Anderson S.A., Massague J. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 2004, 117:211-223.
    • (2004) Cell , vol.117 , pp. 211-223
    • Seoane, J.1    Le, H.V.2    Shen, L.3    Anderson, S.A.4    Massague, J.5
  • 59
    • 0242580872 scopus 로고    scopus 로고
    • Convergence of peroxisome proliferator-activated receptor gamma and Foxo1 signaling pathways
    • Dowell P., Otto T.C., Adi S., Lane M.D. Convergence of peroxisome proliferator-activated receptor gamma and Foxo1 signaling pathways. J Biol Chem 2003, 278:45485-45491.
    • (2003) J Biol Chem , vol.278 , pp. 45485-45491
    • Dowell, P.1    Otto, T.C.2    Adi, S.3    Lane, M.D.4
  • 60
    • 33746017379 scopus 로고    scopus 로고
    • FOXO1 represses peroxisome proliferator-activated receptor-gamma1 and -gamma2 gene promoters in primary adipocytes. A novel paradigm to increase insulin sensitivity
    • Armoni M., Harel C., Karni S., Chen H., Bar-Yoseph F., Ver M.R., et al. FOXO1 represses peroxisome proliferator-activated receptor-gamma1 and -gamma2 gene promoters in primary adipocytes. A novel paradigm to increase insulin sensitivity. J Biol Chem 2006, 281:19881-19891.
    • (2006) J Biol Chem , vol.281 , pp. 19881-19891
    • Armoni, M.1    Harel, C.2    Karni, S.3    Chen, H.4    Bar-Yoseph, F.5    Ver, M.R.6
  • 61
    • 0037237279 scopus 로고    scopus 로고
    • The forkhead transcription factor Foxo1 regulates adipocyte differentiation
    • Nakae J., Kitamura T., Kitamura Y., Biggs W.H., Arden K.C., Accili D. The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev Cell 2003, 4:119-129.
    • (2003) Dev Cell , vol.4 , pp. 119-129
    • Nakae, J.1    Kitamura, T.2    Kitamura, Y.3    Biggs, W.H.4    Arden, K.C.5    Accili, D.6
  • 62
    • 0037216526 scopus 로고    scopus 로고
    • AKT-independent protection of prostate cancer cells from apoptosis mediated through complex formation between the androgen receptor and FKHR
    • Li P., Lee H., Guo S., Unterman T.G., Jenster G., Bai W. AKT-independent protection of prostate cancer cells from apoptosis mediated through complex formation between the androgen receptor and FKHR. Mol Cell Biol 2003, 23:104-118.
    • (2003) Mol Cell Biol , vol.23 , pp. 104-118
    • Li, P.1    Lee, H.2    Guo, S.3    Unterman, T.G.4    Jenster, G.5    Bai, W.6
  • 63
    • 34147101043 scopus 로고    scopus 로고
    • Insulin-like growth factor 1/insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen receptor
    • Fan W., Yanase T., Morinaga H., Okabe T., Nomura M., Daitoku H., et al. Insulin-like growth factor 1/insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen receptor. J Biol Chem 2007, 282:7329-7338.
    • (2007) J Biol Chem , vol.282 , pp. 7329-7338
    • Fan, W.1    Yanase, T.2    Morinaga, H.3    Okabe, T.4    Nomura, M.5    Daitoku, H.6
  • 64
    • 1842690558 scopus 로고    scopus 로고
    • Androgens negatively regulate forkhead transcription factor FKHR (FOXO1) through a proteolytic mechanism in prostate cancer cells
    • Huang H., Muddiman D.C., Tindall D.J. Androgens negatively regulate forkhead transcription factor FKHR (FOXO1) through a proteolytic mechanism in prostate cancer cells. J Biol Chem 2004, 279:13866-13877.
    • (2004) J Biol Chem , vol.279 , pp. 13866-13877
    • Huang, H.1    Muddiman, D.C.2    Tindall, D.J.3
  • 65
    • 0030669765 scopus 로고    scopus 로고
    • Interaction between the amino- and carboxyl-terminal regions of the rat androgen receptor modulates transcriptional activity and is influenced by nuclear receptor coactivators
    • Ikonen T., Palvimo J.J., Janne O.A. Interaction between the amino- and carboxyl-terminal regions of the rat androgen receptor modulates transcriptional activity and is influenced by nuclear receptor coactivators. J Biol Chem 1997, 272:29821-29828.
    • (1997) J Biol Chem , vol.272 , pp. 29821-29828
    • Ikonen, T.1    Palvimo, J.J.2    Janne, O.A.3
  • 66
    • 58849127943 scopus 로고    scopus 로고
    • FoxO1 mediates PTEN suppression of androgen receptor N- and C-terminal interactions and coactivator recruitment
    • Ma Q., Fu W., Li P., Nicosia S.V., Jenster G., Zhang X., et al. FoxO1 mediates PTEN suppression of androgen receptor N- and C-terminal interactions and coactivator recruitment. Mol Endocrinol 2009, 23:213-225.
    • (2009) Mol Endocrinol , vol.23 , pp. 213-225
    • Ma, Q.1    Fu, W.2    Li, P.3    Nicosia, S.V.4    Jenster, G.5    Zhang, X.6
  • 67
    • 0035823576 scopus 로고    scopus 로고
    • Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family
    • Schuur E.R., Loktev A.V., Sharma M., Sun Z., Roth R.A., Weigel R.J. Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family. J Biol Chem 2001, 276:33554-33560.
    • (2001) J Biol Chem , vol.276 , pp. 33554-33560
    • Schuur, E.R.1    Loktev, A.V.2    Sharma, M.3    Sun, Z.4    Roth, R.A.5    Weigel, R.J.6
  • 68
    • 0035958853 scopus 로고    scopus 로고
    • Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-interacting protein with both coactivator and corepressor functions
    • Zhao H.H., Herrera R.E., Coronado-Heinsohn E., Yang M.C., Ludes-Meyers J.H., Seybold-Tilson K.J., et al. Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-interacting protein with both coactivator and corepressor functions. J Biol Chem 2001, 276:27907-27912.
    • (2001) J Biol Chem , vol.276 , pp. 27907-27912
    • Zhao, H.H.1    Herrera, R.E.2    Coronado-Heinsohn, E.3    Yang, M.C.4    Ludes-Meyers, J.H.5    Seybold-Tilson, K.J.6
  • 69
    • 44849127978 scopus 로고    scopus 로고
    • Forkhead box transcription factor FOXO3a suppresses estrogen-dependent breast cancer cell proliferation and tumorigenesis
    • Zou Y., Tsai W.B., Cheng C.J., Hsu C., Chung Y.M., Li P.C., et al. Forkhead box transcription factor FOXO3a suppresses estrogen-dependent breast cancer cell proliferation and tumorigenesis. Breast Cancer Res 2008, 10:R21.
    • (2008) Breast Cancer Res , vol.10
    • Zou, Y.1    Tsai, W.B.2    Cheng, C.J.3    Hsu, C.4    Chung, Y.M.5    Li, P.C.6
  • 70
    • 75149198825 scopus 로고    scopus 로고
    • Akt2 inhibition enables the forkhead transcription factor FoxO3a to have a repressive role in estrogen receptor alpha transcriptional activity in breast cancer cells
    • Morelli C., Lanzino M., Garofalo C., Maris P., Brunelli E., Casaburi I., et al. Akt2 inhibition enables the forkhead transcription factor FoxO3a to have a repressive role in estrogen receptor alpha transcriptional activity in breast cancer cells. Mol Cell Biol 2010, 30:857-870.
    • (2010) Mol Cell Biol , vol.30 , pp. 857-870
    • Morelli, C.1    Lanzino, M.2    Garofalo, C.3    Maris, P.4    Brunelli, E.5    Casaburi, I.6
  • 71
    • 79956311528 scopus 로고    scopus 로고
    • FOXO1 mediates IGF1/insulin regulation of osteocalcin expression by antagonizing RUNX2 in osteoblasts
    • [Epub ahead of print]
    • Yang S., Xu H., Yu S., Cao H., Fan J., Ge C., et al. FOXO1 mediates IGF1/insulin regulation of osteocalcin expression by antagonizing RUNX2 in osteoblasts. J Biol Chem 2011, [Epub ahead of print]. 10.1074/jbc.M110.197905.
    • (2011) J Biol Chem
    • Yang, S.1    Xu, H.2    Yu, S.3    Cao, H.4    Fan, J.5    Ge, C.6
  • 72
    • 77957258122 scopus 로고    scopus 로고
    • Foxo1, a novel regulator of osteoblast differentiation and skeletogenesis
    • Teixeira C.C., Liu Y., Thant L.M., Pang J., Palmer G., Alikhani M. Foxo1, a novel regulator of osteoblast differentiation and skeletogenesis. J Biol Chem 2010, 285:31055-31065.
    • (2010) J Biol Chem , vol.285 , pp. 31055-31065
    • Teixeira, C.C.1    Liu, Y.2    Thant, L.M.3    Pang, J.4    Palmer, G.5    Alikhani, M.6
  • 73
    • 79955520485 scopus 로고    scopus 로고
    • FOXO1 Inhibits Runx2 transcriptional activity and prostate cancer cell migration and invasion
    • Zhang H., Pan Y., Zheng L., Choe C., Lindgren B., Jensen E.D., et al. FOXO1 Inhibits Runx2 transcriptional activity and prostate cancer cell migration and invasion. Cancer Res 2011, 71:3257-3267.
    • (2011) Cancer Res , vol.71 , pp. 3257-3267
    • Zhang, H.1    Pan, Y.2    Zheng, L.3    Choe, C.4    Lindgren, B.5    Jensen, E.D.6
  • 75
    • 34848814178 scopus 로고    scopus 로고
    • Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription
    • Almeida M., Han L., Martin-Millan M., O'Brien C.A., Manolagas S.C. Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription. J Biol Chem 2007, 282:27298-27305.
    • (2007) J Biol Chem , vol.282 , pp. 27298-27305
    • Almeida, M.1    Han, L.2    Martin-Millan, M.3    O'Brien, C.A.4    Manolagas, S.C.5
  • 77
    • 1542267804 scopus 로고    scopus 로고
    • Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
    • Hosaka T., Biggs W.H., Tieu D., Boyer A.D., Varki N.M., Cavenee W.K., et al. Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc Natl Acad Sci U S A 2004, 101:2975-2980.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 2975-2980
    • Hosaka, T.1    Biggs, W.H.2    Tieu, D.3    Boyer, A.D.4    Varki, N.M.5    Cavenee, W.K.6
  • 78
    • 79251557845 scopus 로고    scopus 로고
    • Targeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models
    • Cheng Z., White M.F. Targeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models. Antioxid Redox Signal 2011, 14:649-661.
    • (2011) Antioxid Redox Signal , vol.14 , pp. 649-661
    • Cheng, Z.1    White, M.F.2
  • 79
    • 33745234081 scopus 로고    scopus 로고
    • Diabetes, glucose toxicity, and oxidative stress: a case of double jeopardy for the pancreatic islet beta cell
    • Robertson R.P., Harmon J.S. Diabetes, glucose toxicity, and oxidative stress: a case of double jeopardy for the pancreatic islet beta cell. Free Radic Biol Med 2006, 41:177-184.
    • (2006) Free Radic Biol Med , vol.41 , pp. 177-184
    • Robertson, R.P.1    Harmon, J.S.2
  • 80
  • 82
    • 41849104205 scopus 로고    scopus 로고
    • Structure/function relationships underlying regulation of FOXO transcription factors
    • Obsil T., Obsilova V. Structure/function relationships underlying regulation of FOXO transcription factors. Oncogene 2008, 27:2263-2275.
    • (2008) Oncogene , vol.27 , pp. 2263-2275
    • Obsil, T.1    Obsilova, V.2
  • 83
    • 33846419112 scopus 로고    scopus 로고
    • FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
    • Tothova Z., Kollipara R., Huntly B.J., Lee B.H., Castrillon D.H., Cullen D.E., et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 2007, 128:325-339.
    • (2007) Cell , vol.128 , pp. 325-339
    • Tothova, Z.1    Kollipara, R.2    Huntly, B.J.3    Lee, B.H.4    Castrillon, D.H.5    Cullen, D.E.6
  • 84
    • 33846295218 scopus 로고    scopus 로고
    • FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
    • Paik J.H., Kollipara R., Chu G., Ji H., Xiao Y., Ding Z., et al. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 2007, 128:309-323.
    • (2007) Cell , vol.128 , pp. 309-323
    • Paik, J.H.1    Kollipara, R.2    Chu, G.3    Ji, H.4    Xiao, Y.5    Ding, Z.6
  • 85
    • 70350497348 scopus 로고    scopus 로고
    • FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis
    • Paik J.H., Ding Z., Narurkar R., Ramkissoon S., Muller F., Kamoun W.S., et al. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 2009, 5:540-553.
    • (2009) Cell Stem Cell , vol.5 , pp. 540-553
    • Paik, J.H.1    Ding, Z.2    Narurkar, R.3    Ramkissoon, S.4    Muller, F.5    Kamoun, W.S.6
  • 87
    • 79953186624 scopus 로고    scopus 로고
    • FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress
    • Sengupta A., Molkentin J.D., Paik J.H., DePinho R.A., Yutzey K.E. FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress. J Biol Chem 2011, 286:7468-7478.
    • (2011) J Biol Chem , vol.286 , pp. 7468-7478
    • Sengupta, A.1    Molkentin, J.D.2    Paik, J.H.3    DePinho, R.A.4    Yutzey, K.E.5
  • 88
    • 78650172708 scopus 로고    scopus 로고
    • Silent information regulator 1 protects the heart from ischemia/reperfusion
    • Hsu C.P., Zhai P., Yamamoto T., Maejima Y., Matsushima S., Hariharan N., et al. Silent information regulator 1 protects the heart from ischemia/reperfusion. Circulation 2010, 122:2170-2182.
    • (2010) Circulation , vol.122 , pp. 2170-2182
    • Hsu, C.P.1    Zhai, P.2    Yamamoto, T.3    Maejima, Y.4    Matsushima, S.5    Hariharan, N.6
  • 89
    • 70349208608 scopus 로고    scopus 로고
    • Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice
    • Sundaresan N.R., Gupta M., Kim G., Rajamohan S.B., Isbatan A., Gupta M.P. Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. J Clin Invest 2009, 119:2758-2771.
    • (2009) J Clin Invest , vol.119 , pp. 2758-2771
    • Sundaresan, N.R.1    Gupta, M.2    Kim, G.3    Rajamohan, S.B.4    Isbatan, A.5    Gupta, M.P.6
  • 90
    • 22744447211 scopus 로고    scopus 로고
    • Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis
    • Giorgio M., Migliaccio E., Orsini F., Paolucci D., Moroni M., Contursi C., et al. Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell 2005, 122:221-233.
    • (2005) Cell , vol.122 , pp. 221-233
    • Giorgio, M.1    Migliaccio, E.2    Orsini, F.3    Paolucci, D.4    Moroni, M.5    Contursi, C.6
  • 91
    • 0033581704 scopus 로고    scopus 로고
    • The p66shc adaptor protein controls oxidative stress response and life span in mammals
    • Migliaccio E., Giorgio M., Mele S., Pelicci G., Reboldi P., Pandolfi P.P., et al. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 1999, 402:309-313.
    • (1999) Nature , vol.402 , pp. 309-313
    • Migliaccio, E.1    Giorgio, M.2    Mele, S.3    Pelicci, G.4    Reboldi, P.5    Pandolfi, P.P.6
  • 93
    • 77957364479 scopus 로고    scopus 로고
    • Oxidative stress stimulates apoptosis and activates NF-kappaB in osteoblastic cells via a PKCbeta/p66shc signaling cascade: counter regulation by estrogens or androgens
    • Almeida M., Han L., Ambrogini E., Bartell S.M., Manolagas S.C. Oxidative stress stimulates apoptosis and activates NF-kappaB in osteoblastic cells via a PKCbeta/p66shc signaling cascade: counter regulation by estrogens or androgens. Mol Endocrinol 2010, 24:2030-2037.
    • (2010) Mol Endocrinol , vol.24 , pp. 2030-2037
    • Almeida, M.1    Han, L.2    Ambrogini, E.3    Bartell, S.M.4    Manolagas, S.C.5
  • 94
    • 34547660196 scopus 로고    scopus 로고
    • FoxO transcription factors and stem cell homeostasis: insights from the hematopoietic system
    • Tothova Z., Gilliland D.G. FoxO transcription factors and stem cell homeostasis: insights from the hematopoietic system. Cell Stem Cell 2007, 1:140-152.
    • (2007) Cell Stem Cell , vol.1 , pp. 140-152
    • Tothova, Z.1    Gilliland, D.G.2
  • 95
    • 34547101264 scopus 로고    scopus 로고
    • FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle
    • Southgate R.J., Neill B., Prelovsek O., El Osta A., Kamei Y., Miura S., et al. FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle. J Biol Chem 2007, 282:21176-21186.
    • (2007) J Biol Chem , vol.282 , pp. 21176-21186
    • Southgate, R.J.1    Neill, B.2    Prelovsek, O.3    El Osta, A.4    Kamei, Y.5    Miura, S.6
  • 96
    • 74949089660 scopus 로고    scopus 로고
    • FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice
    • Rached M.T., Kode A., Silva B.C., Jung D.Y., Gray S., Ong H., et al. FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. J Clin Invest 2010, 120:357-368.
    • (2010) J Clin Invest , vol.120 , pp. 357-368
    • Rached, M.T.1    Kode, A.2    Silva, B.C.3    Jung, D.Y.4    Gray, S.5    Ong, H.6
  • 97
    • 79953038259 scopus 로고    scopus 로고
    • The osteoblast: an insulin target cell controlling glucose homeostasis
    • Clemens T.L., Karsenty G. The osteoblast: an insulin target cell controlling glucose homeostasis. J Bone Miner Res 2010, 26:677-680.
    • (2010) J Bone Miner Res , vol.26 , pp. 677-680
    • Clemens, T.L.1    Karsenty, G.2
  • 98
    • 48349144852 scopus 로고    scopus 로고
    • Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
    • Pearson K.J., Baur J.A., Lewis K.N., Peshkin L., Price N.L., Labinskyy N., et al. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab 2008, 8:157-168.
    • (2008) Cell Metab , vol.8 , pp. 157-168
    • Pearson, K.J.1    Baur, J.A.2    Lewis, K.N.3    Peshkin, L.4    Price, N.L.5    Labinskyy, N.6
  • 99
    • 33745514431 scopus 로고    scopus 로고
    • Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells
    • Backesjo C.M., Li Y., Lindgren U., Haldosen L.A. Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells. J Bone Miner Res 2006, 21:993-1002.
    • (2006) J Bone Miner Res , vol.21 , pp. 993-1002
    • Backesjo, C.M.1    Li, Y.2    Lindgren, U.3    Haldosen, L.A.4
  • 100
    • 0032583546 scopus 로고    scopus 로고
    • Resveratrol stimulates the proliferation and differentiation of osteoblastic MC3T3-E1 cells
    • Mizutani K., Ikeda K., Kawai Y., Yamori Y. Resveratrol stimulates the proliferation and differentiation of osteoblastic MC3T3-E1 cells. Biochem Biophys Res Commun 1998, 253:859-863.
    • (1998) Biochem Biophys Res Commun , vol.253 , pp. 859-863
    • Mizutani, K.1    Ikeda, K.2    Kawai, Y.3    Yamori, Y.4
  • 102
    • 37249009271 scopus 로고    scopus 로고
    • Motif module map reveals enforcement of aging by continual NF-kappaB activity
    • Adler A.S., Sinha S., Kawahara T.L., Zhang J.Y., Segal E., Chang H.Y. Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes Dev 2007, 21:3244-3257.
    • (2007) Genes Dev , vol.21 , pp. 3244-3257
    • Adler, A.S.1    Sinha, S.2    Kawahara, T.L.3    Zhang, J.Y.4    Segal, E.5    Chang, H.Y.6
  • 103
    • 33750475959 scopus 로고    scopus 로고
    • Cross-talk between nuclear receptors and nuclear factor kappaB
    • De Bosscher K., Vanden Berghe W., Haegeman G. Cross-talk between nuclear receptors and nuclear factor kappaB. Oncogene 2006, 25:6868-6886.
    • (2006) Oncogene , vol.25 , pp. 6868-6886
    • De Bosscher, K.1    Vanden Berghe, W.2    Haegeman, G.3
  • 105
    • 11144357466 scopus 로고    scopus 로고
    • IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
    • Hu M.C., Lee D.F., Xia W., Golfman L.S., Ou-Yang F., Yang J.Y., et al. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 2004, 117:225-237.
    • (2004) Cell , vol.117 , pp. 225-237
    • Hu, M.C.1    Lee, D.F.2    Xia, W.3    Golfman, L.S.4    Ou-Yang, F.5    Yang, J.Y.6
  • 108
    • 47049095632 scopus 로고    scopus 로고
    • Routes to 4-hydroxynonenal: fundamental issues in the mechanisms of lipid peroxidation
    • Schneider C., Porter N.A., Brash A.R. Routes to 4-hydroxynonenal: fundamental issues in the mechanisms of lipid peroxidation. J Biol Chem 2008, 283:15539-15543.
    • (2008) J Biol Chem , vol.283 , pp. 15539-15543
    • Schneider, C.1    Porter, N.A.2    Brash, A.R.3
  • 109
    • 70350451479 scopus 로고    scopus 로고
    • Increased lipid oxidation causes oxidative stress, increased PPAR{gamma} expression and diminished pro-osteogenic Wnt signaling in the skeleton
    • Almeida M., Ambrogini E., Han L., Manolagas S.C., Jilka R.L. Increased lipid oxidation causes oxidative stress, increased PPAR{gamma} expression and diminished pro-osteogenic Wnt signaling in the skeleton. J Biol Chem 2009, 284:27438-27448.
    • (2009) J Biol Chem , vol.284 , pp. 27438-27448
    • Almeida, M.1    Ambrogini, E.2    Han, L.3    Manolagas, S.C.4    Jilka, R.L.5
  • 110
    • 34347235843 scopus 로고    scopus 로고
    • Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein α and peroxisome proliferator-activated receptor γ
    • Kang S., Bennett C.N., Gerin I., Rapp L.A., Hankenson K.D., MacDougald O.A. Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein α and peroxisome proliferator-activated receptor γ. J Biol Chem 2007, 282:14515-14524.
    • (2007) J Biol Chem , vol.282 , pp. 14515-14524
    • Kang, S.1    Bennett, C.N.2    Gerin, I.3    Rapp, L.A.4    Hankenson, K.D.5    MacDougald, O.A.6
  • 111
    • 65249138877 scopus 로고    scopus 로고
    • COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis
    • Okamura M., Kudo H., Wakabayashi K., Tanaka T., Nonaka A., Uchida A., et al. COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis. Proc Natl Acad Sci U S A 2009, 106:5819-5824.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 5819-5824
    • Okamura, M.1    Kudo, H.2    Wakabayashi, K.3    Tanaka, T.4    Nonaka, A.5    Uchida, A.6
  • 112
    • 4143065010 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma activation can regulate beta-catenin levels via a proteasome-mediated and adenomatous polyposis coli-independent pathway
    • Sharma C., Pradeep A., Wong L., Rana A., Rana B. Peroxisome proliferator-activated receptor gamma activation can regulate beta-catenin levels via a proteasome-mediated and adenomatous polyposis coli-independent pathway. J Biol Chem 2004, 279:35583-35594.
    • (2004) J Biol Chem , vol.279 , pp. 35583-35594
    • Sharma, C.1    Pradeep, A.2    Wong, L.3    Rana, A.4    Rana, B.5
  • 116
    • 50649097541 scopus 로고    scopus 로고
    • Fat and beyond: the diverse biology of PPARgamma
    • Tontonoz P., Spiegelman B.M. Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem 2008, 77:289-312.
    • (2008) Annu Rev Biochem , vol.77 , pp. 289-312
    • Tontonoz, P.1    Spiegelman, B.M.2
  • 117
    • 2142652189 scopus 로고    scopus 로고
    • PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
    • Akune T., Ohba S., Kamekura S., Yamaguchi M., Chung U.I., Kubota N., et al. PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest 2004, 113:846-855.
    • (2004) J Clin Invest , vol.113 , pp. 846-855
    • Akune, T.1    Ohba, S.2    Kamekura, S.3    Yamaguchi, M.4    Chung, U.I.5    Kubota, N.6
  • 118
    • 1542406446 scopus 로고    scopus 로고
    • NOX enzymes and the biology of reactive oxygen
    • Lambeth J.D. NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol 2004, 4:181-189.
    • (2004) Nat Rev Immunol , vol.4 , pp. 181-189
    • Lambeth, J.D.1
  • 119
    • 76749102420 scopus 로고    scopus 로고
    • Inactivation of peroxiredoxin I by phosphorylation allows localized H(2)O(2) accumulation for cell signaling
    • Woo H.A., Yim S.H., Shin D.H., Kang D., Yu D.Y., Rhee S.G. Inactivation of peroxiredoxin I by phosphorylation allows localized H(2)O(2) accumulation for cell signaling. Cell 2010, 140:517-528.
    • (2010) Cell , vol.140 , pp. 517-528
    • Woo, H.A.1    Yim, S.H.2    Shin, D.H.3    Kang, D.4    Yu, D.Y.5    Rhee, S.G.6
  • 120
    • 0025236484 scopus 로고
    • Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo
    • Garrett I.R., Boyce B.F., Oreffo R.O., Bonewald L., Poser J., Mundy G.R. Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest 1990, 85:632-639.
    • (1990) J Clin Invest , vol.85 , pp. 632-639
    • Garrett, I.R.1    Boyce, B.F.2    Oreffo, R.O.3    Bonewald, L.4    Poser, J.5    Mundy, G.R.6
  • 122
    • 20444474124 scopus 로고    scopus 로고
    • Reactive oxygen species stimulates receptor activator of NF-kappaB ligand expression in osteoblast
    • Bai X.C., Lu D., Liu A.L., Zhang Z.M., Li X.M., Zou Z.P., et al. Reactive oxygen species stimulates receptor activator of NF-kappaB ligand expression in osteoblast. J Biol Chem 2005, 280:17497-17506.
    • (2005) J Biol Chem , vol.280 , pp. 17497-17506
    • Bai, X.C.1    Lu, D.2    Liu, A.L.3    Zhang, Z.M.4    Li, X.M.5    Zou, Z.P.6
  • 123
    • 12344281693 scopus 로고    scopus 로고
    • Hydrogen peroxide is essential for estrogen-deficiency bone loss and osteoclast formation
    • Lean J.M., Jagger C.J., Kirstein B., Fuller K., Chambers T.J. Hydrogen peroxide is essential for estrogen-deficiency bone loss and osteoclast formation. Endocrinology 2005, 146:728-735.
    • (2005) Endocrinology , vol.146 , pp. 728-735
    • Lean, J.M.1    Jagger, C.J.2    Kirstein, B.3    Fuller, K.4    Chambers, T.J.5
  • 124
    • 8644225111 scopus 로고    scopus 로고
    • Reactive oxygen species mediate RANK signaling in osteoclasts
    • Ha H., Kwak H.B., Lee S.W., Jin H.M., Kim H.M., Kim H.H., et al. Reactive oxygen species mediate RANK signaling in osteoclasts. Exp Cell Res 2004, 301:119-127.
    • (2004) Exp Cell Res , vol.301 , pp. 119-127
    • Ha, H.1    Kwak, H.B.2    Lee, S.W.3    Jin, H.M.4    Kim, H.M.5    Kim, H.H.6
  • 125
    • 22144457305 scopus 로고    scopus 로고
    • A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation
    • Lee N.K., Choi Y.G., Baik J.Y., Han S.Y., Jeong D.W., Bae Y.S., et al. A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation. Blood 2005, 106:852-859.
    • (2005) Blood , vol.106 , pp. 852-859
    • Lee, N.K.1    Choi, Y.G.2    Baik, J.Y.3    Han, S.Y.4    Jeong, D.W.5    Bae, Y.S.6
  • 126
    • 62049085382 scopus 로고    scopus 로고
    • Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation
    • Ishii K.A., Fumoto T., Iwai K., Takeshita S., Ito M., Shimohata N., et al. Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation. Nat Med 2009, 15:259-266.
    • (2009) Nat Med , vol.15 , pp. 259-266
    • Ishii, K.A.1    Fumoto, T.2    Iwai, K.3    Takeshita, S.4    Ito, M.5    Shimohata, N.6
  • 129
    • 13544249982 scopus 로고    scopus 로고
    • Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors
    • Sugatani T., Hruska K.A. Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors. J Biol Chem 2005, 280:3583-3589.
    • (2005) J Biol Chem , vol.280 , pp. 3583-3589
    • Sugatani, T.1    Hruska, K.A.2
  • 131
    • 0033393957 scopus 로고    scopus 로고
    • TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src
    • Wong B.R., Besser D., Kim N., Arron J.R., Vologodskaia M., Hanafusa H., et al. TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src. Mol Cell 1999, 4:1041-1049.
    • (1999) Mol Cell , vol.4 , pp. 1041-1049
    • Wong, B.R.1    Besser, D.2    Kim, N.3    Arron, J.R.4    Vologodskaia, M.5    Hanafusa, H.6
  • 132
    • 0033520927 scopus 로고    scopus 로고
    • Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase
    • Reszka A.A., Halasy-Nagy J.M., Masarachia P.J., Rodan G.A. Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase. J Biol Chem 1999, 274:34967-34973.
    • (1999) J Biol Chem , vol.274 , pp. 34967-34973
    • Reszka, A.A.1    Halasy-Nagy, J.M.2    Masarachia, P.J.3    Rodan, G.A.4
  • 133
    • 35649004861 scopus 로고    scopus 로고
    • Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation
    • Jang S.W., Yang S.J., Srinivasan S., Ye K. Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation. J Biol Chem 2007, 282:30836-30844.
    • (2007) J Biol Chem , vol.282 , pp. 30836-30844
    • Jang, S.W.1    Yang, S.J.2    Srinivasan, S.3    Ye, K.4
  • 134
    • 27544495989 scopus 로고    scopus 로고
    • Resveratrol inhibits myeloma cell growth, prevents osteoclast formation, and promotes osteoblast differentiation
    • Boissy P., Andersen T.L., Abdallah B.M., Kassem M., Plesner T., Delaisse J.M. Resveratrol inhibits myeloma cell growth, prevents osteoclast formation, and promotes osteoblast differentiation. Cancer Res 2005, 65:9943-9952.
    • (2005) Cancer Res , vol.65 , pp. 9943-9952
    • Boissy, P.1    Andersen, T.L.2    Abdallah, B.M.3    Kassem, M.4    Plesner, T.5    Delaisse, J.M.6
  • 135
    • 77958153014 scopus 로고    scopus 로고
    • Resveratrol prevents RANKL-induced osteoclast differentiation of murine osteoclast progenitor RAW 264.7 cells through inhibition of ROS production
    • He X., Andersson G., Lindgren U., Li Y. Resveratrol prevents RANKL-induced osteoclast differentiation of murine osteoclast progenitor RAW 264.7 cells through inhibition of ROS production. Biochem Biophys Res Commun 2010, 401:356-362.
    • (2010) Biochem Biophys Res Commun , vol.401 , pp. 356-362
    • He, X.1    Andersson, G.2    Lindgren, U.3    Li, Y.4
  • 136
    • 79953191835 scopus 로고    scopus 로고
    • Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-{kappa}B ligand (RANKL) activation of NF-{kappa}B signaling and inhibit osteoclastogenesis in bone-derived cells
    • Shakibaei M., Buhrmann C., Mobasheri A. Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-{kappa}B ligand (RANKL) activation of NF-{kappa}B signaling and inhibit osteoclastogenesis in bone-derived cells. J Biol Chem 2011, 286:11492-11505.
    • (2011) J Biol Chem , vol.286 , pp. 11492-11505
    • Shakibaei, M.1    Buhrmann, C.2    Mobasheri, A.3
  • 137
    • 34547107359 scopus 로고    scopus 로고
    • Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol
    • Su J.L., Yang C.Y., Zhao M., Kuo M.L., Yen M.L. Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. J Biol Chem 2007, 282:19385-19398.
    • (2007) J Biol Chem , vol.282 , pp. 19385-19398
    • Su, J.L.1    Yang, C.Y.2    Zhao, M.3    Kuo, M.L.4    Yen, M.L.5
  • 138
    • 20244373613 scopus 로고    scopus 로고
    • Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation
    • Glass D.A., Bialek P., Ahn J.D., Starbuck M., Patel M.S., Clevers H., et al. Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell 2005, 8:751-764.
    • (2005) Dev Cell , vol.8 , pp. 751-764
    • Glass, D.A.1    Bialek, P.2    Ahn, J.D.3    Starbuck, M.4    Patel, M.S.5    Clevers, H.6
  • 140
    • 77955035304 scopus 로고    scopus 로고
    • Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism
    • Ferron M., Wei J., Yoshizawa T., Del Fattore A., DePinho R.A., Teti A., et al. Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell 2010, 142:296-308.
    • (2010) Cell , vol.142 , pp. 296-308
    • Ferron, M.1    Wei, J.2    Yoshizawa, T.3    Del Fattore, A.4    DePinho, R.A.5    Teti, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.