Cell based advanced therapeutic medicinal products for bone repair: Keep it simple?

Advanced Drug Delivery Reviews

Volumn 84, Issue , 2015, Pages 30-44

  Leijten, J ^a,b   Chai, Y C ^a,b   Papantoniou, I ^a,b   Geris, L ^a,c   Schrooten, J ^a   Luyten, F P ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b SKELETAL BIOLOGY AND ENGINEERING RESEARCH CENTER   (Belgium)

^c UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Enabling technology; Musculoskeletal; Regenerative medicine; Stem cell; Therapy; Tissue engineering

Indexed keywords

BONE; CYTOLOGY; REGENERATIVE MEDICINE; REPAIR; STEM CELLS; TISSUE ENGINEERING;

CLINICAL TREATMENTS; ENABLING TECHNOLOGIES; HEALTH-CARE SYSTEM; INDUSTRIAL MANUFACTURING; MEDICINAL PRODUCTS; MUSCULOSKELETAL; REGULATORY FRAMEWORKS; THERAPY;

CELL ENGINEERING;

ADVANCED THERAPEUTIC MEDICINAL PRODUCT; BIOMATERIAL; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 6; GROWTH FACTOR; OSTEOGENIC PROTEIN 1; STROMAL CELL DERIVED FACTOR 1; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; WNT PROTEIN;

ANGIOGENESIS; BIOREACTOR; BONE ALLOGRAFT; BONE DEFECT; BONE MINERALIZATION; BONE REGENERATION; BONE REMODELING; CELL FATE; CELL THERAPY; COST EFFECTIVENESS ANALYSIS; DRUG COATING; DRUG DELIVERY DEVICE; ENCHONDRAL OSSIFICATION; EXTRACELLULAR MATRIX; FRACTURE; FRACTURE HEALING; HUMAN; INTEGRATED HEALTH CARE SYSTEM; MESENCHYMAL STEM CELL; MICROTECHNOLOGY; MOLECULAR MODEL; NONHUMAN; OSTEOBLAST; PREDICTION; PRIORITY JOURNAL; REGENERATIVE MEDICINE; REVIEW; STEM CELL NICHE; TISSUE ENGINEERING; TREATMENT OUTCOME; BIOLOGICAL THERAPY; BONE; INJURIES; PROCEDURES; SURGERY;

BIOCOMPATIBLE MATERIALS; BONE AND BONES; CELL- AND TISSUE-BASED THERAPY; HUMANS; TISSUE ENGINEERING;

EID: 84929128339     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2014.10.025     Document Type: Review

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