Sclerostin promotes the apoptosis of human osteoblastic cells: A novel regulation of bone formation

Bone

Volumn 35, Issue 4, 2004, Pages 828-835

  Sutherland, May Kung ^a   Geoghegan, James C ^a   Yu, Changpu ^a   Turcott, Eileen ^a   Skonier, John E ^a   Winkler, David G ^a   Latham, John A ^a,b  

^a Celltech R and D Inc   (United States)

^b WA 98119 ^*  (United States)

Author keywords

Apoptosis; BMP antagonists; Bone morphogenetic protein (BMP); Caspase; Osteoblast; Sclerostin

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 6; CASPASE; CASPASE 3 INHIBITOR; CASPASE INHIBITOR; CHORDIN; DNA FRAGMENT; GENE PRODUCT; HISTONE; INTERLEUKIN 1BETA CONVERTING ENZYME; NOGGIN; SCLEROSTIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BONE CELL; CELL DIFFERENTIATION; CELL FUNCTION; CONTROLLED STUDY; DNA HISTONE INTERACTION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GASTRULATION; HUMAN; HUMAN CELL; MESENCHYME CELL; NICK END LABELING; OSSIFICATION; OSTEOBLAST; PROTEIN ANALYSIS; PROTEIN FUNCTION;

ALKALINE PHOSPHATASE; APOPTOSIS; BONE MORPHOGENETIC PROTEINS; CASPASES; CELLS, CULTURED; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GENETIC MARKERS; HUMANS; OSTEOBLASTS; OSTEOGENESIS;

EID: 5344234448     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2004.05.023     Document Type: Article

References (42)

1. Balemans W., Ebeling M., Patel N., VanHul E., Olson P., Dioszegi M., et al. Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST). Hum. Mol. Genet. 10:2001;537-543
2. Brunkow M.E., Gardner J.C., VanNess J., Paeper B.W., Kovacevich B.R., Proll S., et al. Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. Am. J. Hum. Genet. 68:2001;577-589
3. Winkler D.G., Sutherland M.K., Geoghegan J.C., Yu C., Hayes T., Skonier J.E., et al. Osteocyte control of bone formation via sclerostin, a novel BMP antagonist. EMBO J. 22:2003;6267-6276
4. Boyce B.F., Xing L., Jilka R.L., Bellido T., Weinstein R.S., Parfitt A.M., et al. Apoptosis in bone cells. Bilezekian L. Jr., Rodan G. Principles of Bone Biology. vol. 1:2002;151-168 Academic Press, San Diego
5. Hock J.M., Krishnan V., Onyia J.E., Bidwell J.P., Milas J., Stanislaus D. Osteoblast apoptosis and bone turnover. J. Bone Miner. Res. 16:2001;975-984
6. Jilka R.L., Weinstein R.S., Bellido T., Roberson P., Parfitt A.M., Manolagas S.C. Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone. J. Clin. Invest. 104:1999;439-446
7. Mackie E.J. Osteoblasts: novel roles in orchestration of skeletal architecture. Int. J. Biochem. Cell Biol. 35:2003;1301-1305
8. Weinstein R.S., Manolagas S.C. Apoptosis and osteoporosis. Am. J. Med. 108:2000;153-164
9. Jilka R.L., Weinstein R.S., Bellido T., Parfitt A.M., Manolagas S.C. Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines. J. Bone Miner. Res. 13:1998;793-802
10. Distelhorst C.W. Recent insights into the mechanism of glucocorticosteroid-induced apoptosis. Cell Death Differ. 9:2002;6-19
11. Gilbert L., He X., Farmer P., Boden S., Kozlowski M., Rubin J., et al. Inhibition of osteoblast differentiation by tumor necrosis factor-alpha. Endocrinology. 141:2000;3956-3964
12. Lian J.B., Stein G.S. The developmental stages of osteoblast growth and differentiation exhibit selective responses of genes to growth factors (TGF beta 1) and hormones (vitamin D and glucocorticoids). J. Oral Implantol. 19:1993;95-105. (discussion 36-7)
13. Manolagas S.C. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr. Rev. 21:2000;115-137
14. Marie P.J. Fibroblast growth factor signaling controlling osteoblast differentiation. Gene. 316:2003;23-32
15. Turner P.R., Mefford S., Christakos S., Nissenson R.A. Apoptosis mediated by activation of the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein (PTHrP). Mol. Endocrinol. 14:2000;241-254
16. Long M.W. Osteogenesis and bone marrow-derived cells. Blood Cells, Mol. Dis. 27:2001;677-690
17. Adams C.S., Shapiro I.M. Mechanisms by which extracellular matrix components induce osteoblast apoptosis. Connect. Tissue Res. 44(Suppl. 1):2003;230-239
18. Globus R.K., Doty S.B., Lull J.C., Holmuhamedov E., Humphries M.J., Damsky C.H. Fibronectin is a survival factor for differentiated osteoblasts. J. Cell Sci. 111(Pt. 10):1998;1385-1393
19. Thornberry N.A., Lazebnik Y. Caspases: enemies within. Science. 281:1998;1312-1316
20. Budd R.C. Death receptors couple to both cell proliferation and apoptosis. J. Clin. Invest. 109:2002;437-441
21. Vaughan A.T., Betti C.J., Villalobos M.J. Surviving apoptosis. Apoptosis. 7:2002;173-177
22. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., et al. Multilineage potential of adult human mesenchymal stem cells. Science. 284:1999;143-147
23. Schecroun N., Delloye C. Bone-like nodules formed by human bone marrow stromal cells: comparative study and characterization. Bone. 32:2003;252-260
24. Bu R., Borysenko C.W., Li Y., Cao L., Sabokbar A., Blair H.C. Expression and function of TNF-family proteins and receptors in human osteoblasts. Bone. 33:2003;760-770
25. Kawakami A., Eguchi K., Matsuoka N., Tsuboi M., Koji T., Urayama S., et al. Fas and Fas ligand interaction is necessary for human osteoblast apoptosis. J. Bone Miner. Res. 12:1997;1637-1646
26. Tsuboi M., Kawakami A., Nakashima T., Matsuoka N., Urayama S., Kawabe Y., et al. Tumor necrosis factor-alpha and interleukin-1beta increase the Fas-mediated apoptosis of human osteoblasts. J. Lab. Clin. Med. 134:1999;222-231
27. Gong Y., Slee R.B., Fukai N., Rawadi G., Roman-Roman S., Reginato A.M., et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell. 107:2001;513-523
28. Karsenty G. The genetic transformation of bone biology. Genes Dev. 13:1999;3037-3051
29. Yoshizawa T., Handa Y., Uematsu Y., Takeda S., Sekine K., Yoshihara Y., et al. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat. Genet. 16:1997;391-396
30. Vortkamp A. Interaction of growth factors regulating chondrocyte differentiation in the developing embryo. Osteoarthr. Cartil. 9:2001;S109-S117
31. Weinstein R.S., Jilka R.L., Parfitt A.M., Manolagas S.C. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J. Clin. Invest. 102:1998;274-282
32. Weston A.D., Rosen V., Chandraratna R.A., Underhill T.M. Regulation of skeletal progenitor differentiation by the BMP and retinoid signaling pathways. J. Cell Biol. 148:2000;679-690
33. Hill P.A., Tumber A., Meikle M.C. Multiple extracellular signals promote osteoblast survival and apoptosis. Endocrinology. 138:1997;3849-3858
34. Deveraux Q.L., Schendel S.L., Reed J.C. Antiapoptotic proteins. The bcl-2 and inhibitor of apoptosis protein families. Cardiol. Clin. 19:2001;57-74
35. Green D.R., Reed J.C. Mitochondria and apoptosis. Science. 281:1998;1309-1312
36. Kamada S., Washida M., Hasegawa J., Kusano H., Funahashi Y., Tsujimoto Y. Involvement of caspase-4(-like) protease in Fas-mediated apoptotic pathway. Oncogene. 15:1997;285-290
37. Van Bezooijen R.L., Roelen B.A., Visser A., Van Der Wee-Pals L., De Wilt E., Karperien M., et al. Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist. J. Exp. Med. 199:2004;805-814
38. Sutherland M.K., Geoghegan J.C., Yu C., Winkler D.G., Latham J.A. Unique regulation of SOST, the sclerosteosis gene, by BMPs and steroid hormones in human osteoblasts. Bone. 35:2004;448-454
39. Sevetson B., Taylor S., Pan Y. Cbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST). J. Biol. Chem. 279:2004;13849-13858
40. Hamersma H., Gardner J., Beighton P. The natural history of sclerosteosis. Clin. Genet. 63:2003;192-197
41. Hill S.C., Stein S.A., Dwyer A., Altman J., Dorwart R., Doppman J. Cranial CT findings in sclerosteosis. Am. J. Neuroradiol. 7:1986;505-511
42. Stein S., Witkop C., Hill S., Fallon M., Viernstein L., Gucer G., et al. Sclerosteosis: neurogenetic and pathophysiologic analysis of an American kinship. Neurology. 33:1983;267-277