Bone healing in the rat and dog with nonglycosylated BMP-2 demonstrating low solubility in fibrin matrices

Journal of Orthopaedic Research

Volumn 22, Issue 2, 2004, Pages 376-381

  Schmoekel, Hugo ^a,b   Schense, Jason C ^a,c   Weber, Franz E ^a,d   Grätz, Klaus W ^a,d   Gnägi, Dania ^a,d   Müller, Ralph ^a   Hubbell, Jeffrey A ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c Kuros Therapeutics AG   (Switzerland)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

BMP 2; Bone defect; Controlled release; Fibrin; Glycosylation; Precipitation

Indexed keywords

FIBRIN GLUE; GLYCOSYLATED PROTEIN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRODESIS; ARTICLE; BONE GRAFT; BONE MATRIX; BONE RADIOGRAPHY; CALVARIA; CANCELLOUS BONE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOG; FRACTURE HEALING; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; RAT; SOLUBILITY;

ANIMALS; ARTHRODESIS; BONE MORPHOGENETIC PROTEINS; CARPUS, ANIMAL; DISEASE MODELS, ANIMAL; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FIBRIN; FRACTURE HEALING; GLYCOSYLATION; OSSEOINTEGRATION; PROSPECTIVE STUDIES; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SKULL; SOLUBILITY; TRANSFORMING GROWTH FACTOR BETA;

EID: 0742319022     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0736-0266(03)00188-8     Document Type: Article

References (32)

1. Brekke J. Toth J.M. Principles of tissue engineering applied to programmable osteogenesis J. Biomed. Mater. Res. 43 1998 365-373
2. Brinker W. Permattei D. Flo G. Handbook of small animal orthopedics and fracture treatment 1990 WB Saunders Company Philadelphia p. 534-35
3. Chang C. Werb Z. The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis Trends Cell Biol. 11 2001 S37-S43
4. Cook S.D. Rueger D.C. Osteogenic protein-1: biology and applications Clin. Orthop. Rel. Res. 324 1996 29-38
5. European-Agency-for-the-Evaluation-of-Medicinal-Products: Cpmp/0393/01, 2001. Available: www.eudra.org/humandocs/humans/epar/osteogenicprot1/ osteogenicprot1.htm.
6. Fischgrund J.S. James S.B. Chabot M.C. Hankin R. Herkowitz H.N. Wozney J.M. et al. Augmentation of autograft using rhBMP-2 and different carrier media in the canine spinal fusion model J. Spinal Disord. 10 1997 467-472
7. Friedlaender G.E. Perry C.R. Cole J.D. Cook S.D. Cierny G. Muschler G.F. et al. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions - a prospective, randomized clinical trial comparing rhOP-1 with fresh bone autograft J. Bone Joint Surg.-Am. 83A 2001 S151-S158
8. Hecht B.P. Fischgrund J.S. Herkowitz H.N. Penman L. Toth J.M. Shirkhoda A. The use of recombinant human bone morphogenetic protein 2 (rhBMP-2) to promote spinal fusion in a nonhuman primate anterior interbody fusion model Spine 25 2000 107S-114S
9. Hollinger J. Schmitt J. Buck D. Shannon R. Joh S. Zegzula H. et al. Recombinant human bone morphogenetic protein-2 and collagen for bone regeneration J. Biomed. Mater. Res. 43 1998 356-364
10. Hollinger J.O. Kleinschmidt J.C. The critical size defect as an experimental model to test bone repair materials J. Craniofac. Surg. 1 1990 60-68
11. Isobe M. Yamazaki Y. Mori M. Amagasa T. Bone regeneration produced in rat femur defects by polymer capsules containing recombinant human bone morphogenetic protein-2 J. Oral Maxillofac. Surg. 57 1999 695-698
12. Isobe M. Yamazaki Y. Mori M. Ishihara K. Nakabayashi N. Amagasa T. The role of recombinant human bone morphogenetic protein-2 in plga capsules at an extraskeletal site of the rat J. Biomed. Mater. Res. 45 1999 36-41
13. Kandziora F. Bail H. Schmidmaier G. Schollmeier G. Scholz M. Knispel C. et al. Bone morphogenetic protein-2 application by a poly(D,L-lactide)-coated interbody cage: in vivo results of a new carrier for growth factors J. Neurosurg. 97 2002 40-48
14. Kenley R. Marden L. Turek T. Jin L. Ron E. Hollinger J.O. Osseous regeneration in the rat calvarium using novel delivery systems for recombinant human bone morphogenetic protein-2 (rhBMP-2) J. Biomed. Mater. Res. 28 1994 1139-1147
15. Magin M.N. Delling G. Improved lumbar vertebral interbody fusion using rhOP-1 - a comparison of autogenous bone graft, bovine hydroxylapatite (Bio-Oss), and BMP-7 (rhOP-1) in sheep Spine 26 2001 469-478
16. Marden L.J. Hollinger J.O. Chaudhari A. Turek T. Schaub R.G. Ron E. Recombinant human bone morphogenetic protein-2 is superior to demineralized bone-matrix in repairing craniotomy defects in rats J. Biomed. Mater. Res. 28 1994 1127-1138
17. Mayer M. Hollinger J. Ron E. Wozney J. Maxillary alveolar cleft repair in dogs using recombinant human bone morphogenetic protein-2 and a polymer carrier Plast. Reconstr. Surg. 98 1996 247-259
18. Michal U. Flueckiger M. Schmoekel H. Healing of dorsal pancarpal arthrodesis in the dog J. Small Anim. Pract. 44 2003 109-112
19. Muller R. Van Campenhout H. Van Damme B. Van Der Perre G. Dequeker J. Hildebrand T. et al. Morphometric analysis of human bone biopsies: a quantitative structural comparison of histological sections and micro-computed tomography Bone 23 1998 59-66
20. Murphy G. Gavrilovic J. Proteolysis and cell migration: creating a path? Curr. Opin. Cell Biol. 11 1999 614-621
21. Reddi A.H. Morphogenetic messages are in the extracellular matrix: biotechnology from bench to bedside Biochem. Soc. Trans. 28 2000 345-349
22. Ripamonti U. Ramoshebi L.N. Matsaba T. Tasker J. Crooks J. Teare J. Bone induction by BMPs/OPs and related family members in primates - the critical role of delivery systems J. Bone Joint Surg.-Am. 83A 2001 S116-S127
23. Ruppert R. Hoffmann E. Sebald W. Human bone morphogenetic protein 2 contains a heparin-binding site which modifies its biological activity Eur. J. Biochem. 237 1996 295-302
24. Sampath T.K. Coughlin J.E. Whetstone R.M. Banach D. Corbett C. Ridge R.J. et al. Bovine osteogenic protein is composed of dimers of op-1 and BMP-2a, two members of the transforming growth factor-beta superfamily J. Biol. Chem. 265 1990 13198-13205
25. Schense J.C. Bloch J. Aebischer P. Hubbell J.A. Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension Nat. Biotechnol. 18 2000 415-419
26. Sieron A.L. Louneva N. Fertala A. Site-specific interaction of bone morphogenetic protein 2 with procollagen II Cytokine 18 2002 214-221-
27. Weber F. Eyrich G. Gratz K. Thomas R. Maly F. Sailer H. Disulfide bridge conformers of mature BMP are inhibitors for heterotopic ossification Biochem. Biophys. Res. Commun. 286 2001 554-558
28. Weber F.E. Eyrich G. Gratz K.W. Maly F.E. Sailer H.F. Slow and continuous application of human recombinant bone morphogenetic protein via biodegradable poly(lactide-co-glycolide) foamspheres Int. J. Oral Maxillofac. Surg. 31 2002 60-65
29. Woo B.H. Fink B.F. Page R. Schrier J.A. Jo Y.W. Jiang G. et al. Enhancement of bone growth by sustained delivery of recombinant human bone morphogenetic protein-2 in a polymeric matrix Pharm. Res. 18 2001 1747-1753
30. Wozney J.M. The potential role of bone morphogenetic proteins in periodontal reconstruction J. Periodont. 66 1995 506-510
31. Wozney J.M. Overview of bone morphogenetic proteins Spine 27 2002 S2-S8
32. Zhu G. Mallery S.R. Schwendeman S.P. Stabilization of proteins encapsulated in injectable poly(lactide-co-glycolide) Nat. Biotechnol. 18 2000 52-57