Computational study of culture conditions and nutrient supply in a hollow membrane sheet bioreactor for large-scale bone tissue engineering

Journal of Artificial Organs

Volumn 17, Issue 1, 2014, Pages 69-80

  Khademi, Ramin ^a   Mohebbi Kalhori, Davod ^a   Hadjizadeh, Afra ^b,c  

^a UNIVERSITY OF SISTAN AND BALUCHESTAN   (Iran)

^b ÉCOLE POLYTECHNIQUE DE MONTRÉAL   (Canada)

^c AMIRKABIR UNIVERSITY OF TECHNOLOGY   (Iran)

Author keywords

3D mathematical model; Bioreactor; Bone tissue; Hollow membrane sheet; Scaffold

Indexed keywords

TISSUE SCAFFOLD; OXYGEN;

ARTICLE; BIOREACTOR; BONE TISSUE; CELL DENSITY; CONTROLLED STUDY; CULTURE TECHNIQUE; EQUIPMENT DESIGN; EXTRACELLULAR MATRIX; FINITE ELEMENT ANALYSIS; GEOMETRY; HOLLOW MEMBRANE SHEET BIOREACTOR; HYDRODYNAMICS; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; NUTRIENT SUPPLY; PHYSICAL CHEMISTRY; POROSITY; PREDICTION; PRIORITY JOURNAL; PROCESS DEVELOPMENT; THREE DIMENSIONAL IMAGING; TISSUE ENGINEERING; BIOLOGICAL MODEL; BONE; CELL COUNT; CYTOLOGY; METABOLISM; TISSUE SCAFFOLD;

BIOREACTORS; BONE AND BONES; CELL COUNT; CELL CULTURE TECHNIQUES; FINITE ELEMENT ANALYSIS; HYDRODYNAMICS; MODELS, BIOLOGICAL; OXYGEN; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84896982836     PISSN: 14347229     EISSN: 16190904     Source Type: Journal    
DOI: 10.1007/s10047-013-0732-2     Document Type: Article

References (22)

1. Rauh J, Milan F, Gunther KP, Stiehler M. Bioreactor systems for bone tissue engineering. Tissue Eng Part B Rev. 2011;17:263-80.
2. Hadjizadeh A, Mohebbi-Kalhori D. Porous hollow membrane sheet for tissue engineering applications. J Biomed Mater Res A. 2010;93A:1140-50.
3. Mohebbi-Kalhori D, Behzadmehr A, Doillon C, Hadjizadeh A. Computational modeling of adherent cell growth in a hollow-fiber membrane bioreactor for large-scale 3-D bone tissue engineering. J Artif Organs. 2012;15:250-65.
4. Mohebbi-Kalhori D. A positron emission tomography approach to visualize flow perfusion in hollow-fiber membrane bioreactors. J Artif Organs. 2011;14:318-30.
5. Ellis MJ, Chaudhuri JB. Poly(lactic-co-glycolic acid) hollow fibre membranes for use as a tissue engineering scaffold. Biotechnol Bioeng. 2007;96:177-87. (Pubitemid 46036170)
6. Abdullah NS, Das DB. Modelling nutrient transport in hollow fibre membrane bioreactor for growing bone tissue with consideration of multi-component interactions. Chem Eng Sci. 2007;62:5821-39. (Pubitemid 47484354)
7. Coletti F, Macchietto S, Elvassore N. Mathematical modeling of three-dimensional cell cultures in perfusion bioreactors. Ind Eng Chem Res. 2006;45:8158-69. (Pubitemid 44876453)
8. Galbusera F, Cioffi M, Raimondi MT, Pietrabissa R. Computational modeling of combined cell population dynamics and oxygen transport in engineered tissue subject to interstitial perfusion. Comput Methods Biomech Biomed Eng. 2007;10:279-87.
9. Flaibani M, Magrofuoco E, Elvassore N. Computational modeling of cell growth heterogeneity in a perfused 3D scaffold. Ind Eng Chem Res. 2009;49:859-69.
10. Chung CA, Yang CW, Chen CW. Analysis of cell growth and diffusion in a scaffold for cartilage tissue engineering. Biotechol Bioeng. 2006;94:1138-46. (Pubitemid 44221059)
11. Pierre J, Oddou C. Engineered bone culture in a perfusion bio-reactor: a 2D computational study of stationary mass and momentum transport. Comput Methods Biomech Biomed Eng. 2007;10:429-38.
12. Croll TI, Gentz S, Mueller K, Davidson M, O'Connor AJ, Stevens GW, Cooper-White JJ. Modelling oxygen diffusion and cell growth in a porous, vascularising scaffold for soft tissue engineering applications. Chem Eng Sci. 2005;60:4924-34. (Pubitemid 40792962)
13. Yu P, Lee TS, Zeng Y, Low HT. Fluid dynamics and oxygen transport in a micro-bioreactor with a tissue engineering scaffold. Int J Heat Mass Transf. 2009;52:316-27.
14. Bancroft GN, Sikavitsas VI, Mikos AG. Design of a flow perfusion bioreactor system for bone tissue-engineering applications. Tissue Eng. 2003;9:549-54. (Pubitemid 36736136)
15. Goldstein AS, Juarez TM, Helmke CD, Gustin MC, Mikos AG. Effect of convection on osteoblastic cell growth and function in biodegradable polymer foam scaffolds. Biomaterials. 2001;22:1279-88. (Pubitemid 32409949)
16. Hay PD, Veitch AR, Smith MD, Cousins RB, Gaylor JDS. Oxygen transfer in a diffusion-limited hollow fiber bioartificial liver. Artif Organs. 2000;24:278-88. (Pubitemid 30262362)
17. Sengers BG, Van Donkelaar CC, Oomens CWJ, Baaijens FPT. Computational study of culture conditions and nutrient supply in cartilage tissue engineering. Biotechnol Prog. 2005;21:1252-61. (Pubitemid 41099598)
18. Salim A, Nacamuli RP, Morgan EF, Giaccia AJ, Longaker MT. Transient changes in oxygen tension inhibit osteogenic differentiation and Runx2 expression in osteoblasts. J Biol Chem. 2004;279:40007-16. (Pubitemid 39258275)
19. Cooper JA, Lu HH, Ko FK, Freeman JW, Laurencin CT. Fiber-based tissue-engineered scaffold for ligament replacement: design considerations and in vitro evaluation. Biomaterials. 2005;26:1523-32. (Pubitemid 39441385)
20. Li S, de Wijn JR, Li J, Layrolle P, de Groot K. Macroporous biphasic calcium phosphate scaffold with high permeability/porosity ratio. Tissue Eng. 2003;9:535-48. (Pubitemid 36740496)
21. Agrawal CM, McKinney JS, Lanctot D, Athanasiou KA. Effects of fluid flow on the in vitro degradation kinetics of biodegradable scaffolds for tissue engineering. Biomaterials. 2000;21:2443-52.
22. Komarova SV, Ataullakhanov FI, Globus RK. Bioenergetics and mitochondrial transmembrane potential during differentiation of cultured osteoblasts. Am J Physiol Cell Physiol. 2000;279:C1220-9.