Effect of flow perfusion on the osteogenic differentiation of bone marrow stromal cells cultured on starch-based three-dimensional scaffolds

Journal of Biomedical Materials Research - Part A

Volumn 67, Issue 1, 2003, Pages 87-95

  Gomes, Manuela E ^a,b   Sikavitsas, Vassilios I ^c   Behravesh, Esfandiar ^b   Reis, Rui L ^a   Mikos, Antonios G ^b  

^a UNIVERSITY OF MINHO   (Portugal)

^b Rice University   (United States)

^c Univ of Oklahoma   (United States)

Author keywords

Biodegradable polymers; Bone marrow stromal cells; Bone tissue engineering; Flow perfusion bioreactor; Starch based scaffolds

Indexed keywords

CALCIUM; CELL CULTURE; FLUORESCENCE; SCAFFOLDS; STARCH; TISSUE;

BONE MARROW;

BONE;

ALKALINE PHOSPHATASE; ETHYLENE VINYL ALCOHOL COPOLYMER; POLYCAPROLACTONE; STARCH; TETRACYCLINE;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; ENZYME ACTIVITY; FEMUR; FLOW; FLUORESCENCE; NONHUMAN; OSTEOBLAST; PERFUSION; POROSITY; RAT; TIBIA;

EID: 0344306513     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbm.a.10075     Document Type: Article

References (31)

1. Freed LE, Vunjak-Novakovic G. Culture of organized cell communities. Adv Drug Deliv Rev 1998;33:15-30.
2. Thomson RC, Wake MC, Yaszemski MJ, Mikos AG. Biodegradable polymer scaffolds to regenerate organs. Adv Polym Sci 1995;122:247-274.
3. Langer R. Selected advances in drug delivery and tissue engineering. J Controlled Release 1999;62:7-11.
4. Lu L, Mikos AG. The importance of new processing techniques in tissue engineering. MRS Bull 1996;21:28-32.
5. Langer R, Vacanti JP. Tissue engineering. Science 1993;260: 920-925.
6. Chen G, Ushida T, Tateishi T. Hybrid biomaterials for tissue engineering: a preparative method for PLA or PLGA-collagen hybrid sponges. Adv Mater 2000;12:455-457.
7. Laurencin C, Ambrosio A, Borden M, Cooper J. Tissue engineering: orthopedic applications. Ann Rev Biomed Eng 1999;1:19-46.
8. Mooney D, Mikos AG. Growing new organs. Scientific American 1999;280:38-43.
9. Hutmacher DW, Teoh SH, Zein I, Renawake M, Lau S. Tissue engineering research: the engineer's role. Med Dev Tech 2000; 1:33-39.
10. Middleton JC, Tipton AJ. Synthetic biodegradable polymers as orthopaedic devices. Biomaterials 2000;21:2335-2346.
11. Vacanti CA, Bonassar LJ. An overview of tissue engineered bone. Clin Orthop Rel Res 1999;367S:375-381.
12. Kim BS, Mooney D. Development of biocompatible synthetic extracellular matrices for tissue engineering. TIB TECH 1998; 16:224-230.
13. Chapekar MS. Tissue engineering: challenges and opportunities. J Biomed Mater Res (Appl Biomater) 2000;53:617-620.
14. Thomson RC, Yaszemski MJ, Powers JM, Mikos AG. Fabrication of biodegradable scaffolds to engineer trabecular bone. J Biomater Sci Polym Edn 1995;7:23-38.
15. Hutmacher DW. Scaffolds in tissue engineering bone and cartilage. Biomaterials 2000;21:2529-2543.
16. Freed LE, Vunjak-Novakovic G, Biron R, Eagles D, Lesnoy D, Barlow S, Langer R. Biodegradable polymers scaffolds for tissue engineering. Bio/Technology 1994;12:689-693.
17. Gomes ME, Reis RL, Cunha AM. Alternative tissue engineering scaffolds based on starch: processing methodologies, morphology, degradation behaviour and mechanical properties. Mater Sci Eng C Biomimet Supramolec Syst 2002;20:19-26.
18. Gomes ME, Reis RL, Cunha AM, van Blitterswijk CA, Bruijn JD. Cytocompatibility and response of osteoblastic-like cells to starch-based polymers: effect of several additives and processing conditions. Biomaterials 2001;22:1911-1917.
19. Mendes SC, Bovell YP, Reis RL, Cunha AM, Bruijn JD, van Blitterswijk CA. Biocompatibility testing of novel of starch-based materials with potential application in orthopaedic surgery. Biomaterials 2001;22:2057-2064.
20. Marques AP, Reis RL, Hunt JA. In vitro evaluation of the biocompatibility of novel biodegradable starch-based polymeric and composite materials. Biomaterials 2002;23:1471-1478.
21. Bruder SP, Caplan AI. Bone regeneration through cellular engineering. In: Lanza RP, Langer R, Vacanti JP, editors. Principles of tissue engineering, 2nd ed. New York: Academic Press; 2000. p 683-696.
22. Freed LE, Vunjak-Novakovic G. Tissue engineering bioreactors. In: Lanza RP, Langer R, Vacanti JP, editors. Principles of tissue engineering, 2nd ed. New York: Academic Press; 2000. p 143-156.
23. Sikavitsas VI, Bancroft GN, Mikos AG. Formation of three-dimensional cell/polymer constructs for bone tissue engineering in a spinner flask and a rotating wall vessel bioreactor. J Biomed Mater Res 2002;62:136-148.
24. Botchwey EA, Pollack SR, Levine EM, Laurencin CT. Bone tissue engineering in a rotating bioreactor using a microcarrier matrix system. J Biomed Mater Res 2001;55:242-253.
25. Goldstein AS, Juarez TM, Helmke CD, Gustin MC, Mikos AG. Effect of convection on osteoblastic cell growth and function in biodegradable polymer foam scaffolds. Biomaterials 2001;22: 1279-1288.
26. Bancroft GN, Sikavitsas VI, van den Dolder J, Sheffield TL, Ambrose CG, Jansen JA, Mikos AG. Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner. Proc Natl Acad Sci USA 2002;99:12600-12605.
27. Begley CM, Kleis SJ. The fluid dynamic and shear environment in the NASA/JSC rotating-wall perfused-vessel bioreactor. Biotech Bioeng 2000;70:32-40.
28. Glowacki J, Mizuno S, Greenberger JS. Perfusion enhances functions of bone marrow stromal cells in three-dimensional culture. Cell Transplant 1998;7:319-326.
29. Maniatopoulos C, Sodek JM. Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats. Cell Tissue Res 1988;254:317-330.
30. van den Dolder J, Bancroft GN, Sikavitsas VI, Spauwen PHM, Jansen JA, Mikos AG. Flow perfusion culture of marrow stromal osteoblasts in titanium fiber mesh. J Biomed Mater Res Part A 2003;64A:235-241.
31. Lian JB, Stein GS. Concepts of osteoblast growth and differentiation: basis for modulation of bone cell development and tissue formation. Crit Rev Oral Biol Med 1992;3:269-305.