Effects of medium supplements on proliferation, differentiation potential, and in vitro expansion of mesenchymal stem cells

Stem Cells Translational Medicine

Volumn 1, Issue 11, 2012, Pages 771-782

  Gharibi, Borzo ^a   Hughes, Francis J ^a  

^a GUY S HOSPITAL   (United Kingdom)

Author keywords

Adult stem cells; Cell culture; Differentiation; Self renewal

Indexed keywords

ALKALINE PHOSPHATASE; ASCORBIC ACID; CD146 ANTIGEN; CD71 ANTIGEN; CELL SURFACE MARKER; CYCLIN D; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN E; CYTOKINE; ENDOGLIN; EPIDERMAL GROWTH FACTOR; FATTY ACID BINDING PROTEIN 4; FIBROBLAST GROWTH FACTOR 2; GROWTH FACTOR; HERMES ANTIGEN; KRUPPEL LIKE FACTOR 4; LIPOPROTEIN LIPASE; OCTAMER TRANSCRIPTION FACTOR 4; PLATELET DERIVED GROWTH FACTOR BB; THY 1 ANTIGEN; TRANSCRIPTION FACTOR NANOG; TRANSFERRIN; WNT3A PROTEIN; CELL SURFACE RECEPTOR; ENG PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; PLATELET DERIVED GROWTH FACTOR B; PLATELET-DERIVED GROWTH FACTOR BB; TRANSFERRIN RECEPTOR;

ARTICLE; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL RENEWAL; CULTURE MEDIUM; DNA REPAIR; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; PHENOTYPE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL EXPANSION; ADULT; CELL AGING; CELL CULTURE; CELL DIVISION; CULTURE TECHNIQUE; CYTOLOGY; DRUG EFFECT; FEMALE; MALE; MESENCHYMAL STROMA CELL; METABOLISM; PHYSIOLOGY;

ADULT; ALKALINE PHOSPHATASE; ANTIGENS, CD; ANTIGENS, CD146; ANTIGENS, CD44; ANTIGENS, THY-1; ASCORBIC ACID; CELL AGING; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL DIVISION; CELL PROLIFERATION; CELLS, CULTURED; CULTURE MEDIA; DNA REPAIR; EPIDERMAL GROWTH FACTOR; FEMALE; FIBROBLAST GROWTH FACTOR 2; HUMANS; MALE; MESENCHYMAL STROMAL CELLS; PROTO-ONCOGENE PROTEINS C-SIS; RECEPTORS, CELL SURFACE; RECEPTORS, TRANSFERRIN;

EID: 84873038745     PISSN: 21576564     EISSN: 21576580     Source Type: Journal    
DOI: 10.5966/sctm.2010-0031     Document Type: Article

References (37)

1. Pittenger MF, Mackay AM, Beck SC et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-147.
2. Horwitz EM, Gordon PL, Koo WK et al. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone. Proc Natl Acad Sci USA 2002;99:8932-8937.
3. Quarto R, Mastrogiacomo M, Cancedda R et al. Repair of large bone defects with the use of autologous bone marrow stromal cells. N Engl J Med 2001;344:385-386.
4. Hernigou P, Poignard A, Beaujean F et al. Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells. J Bone Joint Surg Am 2005;87:1430-1437.
5. Lee J, Sung HM, Jang JD et al. Successful reconstruction of 15-cm segmental defects by bone marrow stem cells and resected autogenous bone graft in central hemangioma. J Oral Maxillofac Surg 2010;68:188-194.
6. Mesimäki K, Lindroos B, Törnwall J et al. Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells. Int J Oral Maxillofac Surg 2009;38:201-209.
7. Le Blanc K, Frassoni F, Ball L et al. Mesenchymal stem cells for treatment of steroidresistant, severe, acute graft-versus-host disease: A phase II study. Lancet 2008;371: 1579-1586.
8. Behre G, Theurich S, Weber T et al. Reply to "The correlation between cotransplantation of mesenchymal stem cells, higher recurrence rates in hematologic malignancy patients: Outcome of a pilot clinical study" by Ning et al. Leukemia 2009;21579-15793:178.
9. Timmers L, Lim SK, Hoefer IE et al. Human mesenchymal stem cell-conditioned medium improves cardiac function following myocar- dial infarction. Stem Cell Res 2011;6:206-214.
10. Amado LC, Saliaris AP, Schuleri KH et al. Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc Natl Acad Sci USA 2005;102:11474-11479.
11. Kharaziha P, Hellström PM, Noorinayer B et al. Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: A phase I-II clinical trial. Eur J Gastroenterol Hepatol 2009;21:1199-1205.
12. Tfilin M, Sudai E, Merenlender A et al. Mesenchymal stem cells increase hippocampal neurogenesis and counteract depressive-like behavior. Mol Psychiatry 2010;15:1164-1175.
13. Dwyer RM, Khan S, Barry FP et al. Advances in mesenchymal stem cell-mediated gene therapy for cancer. Stem Cell Res Ther 2010;1:25.
14. Bernardo ME, Avanzini MA, Perotti C et al. Optimization of in vitro expansion of human multipotent mesenchymal stromal cells for cell-therapy approaches: Further insights in the search for a fetal calf serum substitute. J Cell Physiol 2007;211:121-130.
15. Sotiropoulou PA, Perez SA, Salagianni M et al. Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cells. STEM CELLS 2006; 24:462-471.
16. Both SK, van der Muijsenberg AJ, van Blitterswijk CA et al. A rapid and efficient method for expansion of human mesenchymal stem cells. Tissue Eng 2007;13:3-9.
17. Tsutsumi S, Shimazu A, Miyazaki K et al. Retention of multilineage differentiation potential of mesenchymal cells during proliferation in response to FGF. Biochem Biophys Res Commun 2001;288:413-419.
18. Solchaga LA, Penick K, Porter JD et al. FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells. J Cell Physiol 2005;203:398-409.
19. Martin I, Muraglia A, Campanile G et al. Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow. Endocrinology 1997;138:4456-4462.
20. Bianchi G, Banfi A, Mastrogiacomo M et al. Ex vivo enrichment of mesenchymal cell progenitors by fibroblast growth factor 2. Exp Cell Res 2003;287:98-105.
21. Tamama K, Fan VH, Griffith LG et al. Epidermal growth factor as a candidate for ex vivo expansion of bone marrow- derived mesenchymal stem cells. STEM CELLS 2006;24:686-695.
22. Pricola KL, Kuhn NZ, Haleem-Smith H et al. Interleukin-6 maintains bone marrow-derived mesenchymal stem cell stemness by an ERK1/2-dependent mechanism. J Cell Biochem 2009;108:577-588.
23. Kumar A, Salimath BP, Stark GB et al. Platelet-derived growth factor receptor signaling is not involved in osteogenic differentiation of human mesenchymal stem cells. Tissue Eng Part A 2010;16:983-993.
24. Gharibi B, Abraham AA, Ham J et al. Adenosine receptor subtype expression and activation influence the differentiation of mesenchymal stem cells to osteoblasts and adipocytes. J Bone Miner Res 2011;26:2112-2124.
25. Neubauer M, Fischbach C, Bauer-Kreisel P et al. Basic fibroblast growth factor enhances PPARgamma ligand-induced adipogenesis of mesenchymal stem cells. FEBS Lett 2004;577: 277-283.
26. Ito T, Sawada R, Fujiwara Y et al. FGF-2 increases osteogenic and chondrogenic differentiation potentials of human mesenchymal stem cells by inactivation of TGF- signaling. Cytotechnology 2008;56:1-7.
27. Lai W-T, Krishnappa V, Phinney DG. Fibroblast growth factor 2 (Fgf2) inhibits differentiation of mesenchymal stem cells by inducing Twist2 and Spry4, blocking extracellular regulated kinase activation, and altering Fgf receptor expression levels. STEM CELLS 2011;29: 1102-1111.
28. Osathanon T, Nowwarote N, Pavasant P. Basic fibroblast growth factor inhibits mineralization but induces neuronal differentiation by human dental pulp stem cells through a FGFR and PLC signaling pathway. J Cell Biochem 2011;112:1807-1816.
29. Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res 1961;25:585-621.
30. Bonab MM, Alimoghaddam K, Talebian F et al. Aging of mesenchymal stem cell in vitro. BMC Cell Biol 2006;7:14.
31. Alves H, Munoz-Najar U, De Wit J et al. A link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cells. J Cell Mol Med 2010;14: 2729-2738.
32. Galderisi U, Helmbold H, Squillaro T et al. In vitro senescence of rat mesenchymal stem cells is accompanied by downregulation of stemness-related and DNA damage repair genes. Stem Cells Dev 2009;18:1033-1042.
33. Cheng H, Qiu L, Ma J et al. Replicative senescence of human bone marrow and umbilical cord derived mesenchymal stem cells and their differentiation to adipocytes and osteoblasts. Mol Biol Rep 2011;38:5161-5168.
34. Chamberlain G, Fox J, Ashton B et al. Concise review: Mesenchymal stem cells: Their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 2007;25:2739-2749.
35. Dominici M, Le Blanc K, Mueller I et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006;8:315-317.
36. Flores-Torales E, Orozco-Barocio A, Gonzalez-Ramella OR et al. The CD271 expression could be alone for establisher phenotypic marker in bone marrow derived mesenchymal stem cells. Folia Histochem Cytobiol 2010;48: 682-686.
37. Sacchetti B, Funari A, Michienzi S et al. Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell 2007;131:324-336.