Engineering parameters in bioreactor's design: A critical aspect in tissue engineering

BioMed Research International

Volumn 2013, Issue , 2013, Pages

  Salehi Nik, Nasim ^a   Amoabediny, Ghassem ^a   Pouran, Behdad ^a   Tabesh, Hadi ^b   Shokrgozar, Mohammad Ali ^c   Haghighipour, Nooshin ^c   Khatibi, Nahid ^a   Anisi, Fatemeh ^a   Mottaghy, Khosrow ^b   Zandieh Doulabi, Behrouz ^d  

^a UNIVERSITY OF TEHRAN   (Iran)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c PASTEUR INSTITUTE OF IRAN   (Iran)

^d NONE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; COLLAGEN; DISSOLVED OXYGEN; GLUCOSE; GLYCOSAMINOGLYCAN; OXYGEN;

BIOREACTOR; CARTILAGE CELL; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; ELECTRIC CURRENT; ELECTROSTIMULATION; EXTRACELLULAR MATRIX; HEART; HUMAN; MATHEMATICAL MODEL; MECHANICAL STIMULATION; NUTRIENT; NUTRIENT SUPPLY; OXYGEN CONSUMPTION; OXYGEN TENSION; REVIEW; SHEAR STRESS; STIMULATION; TISSUE ENGINEERING; BIOLOGICAL MODEL; CELL CULTURE TECHNIQUE; COMPUTER AIDED DESIGN; COMPUTER SIMULATION; DEVICE FAILURE ANALYSIS; DEVICES; EQUIPMENT DESIGN; MALE; MICROFLUIDIC ANALYSIS; CULTURE TECHNIQUE; EQUIPMENT; EQUIPMENT FAILURE;

BIOREACTORS; CELL CULTURE TECHNIQUES; COMPUTER SIMULATION; COMPUTER-AIDED DESIGN; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; HUMANS; MALE; MICROFLUIDIC ANALYTICAL TECHNIQUES; MODELS, BIOLOGICAL; TISSUE ENGINEERING;

EID: 84883185120     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2013/762132     Document Type: Review

References (139)

1. Pörtner R., Nagel-Heyer S., Goepfert C., Adamietz P., Meenen N. M., Bioreactor design for tissue engineering. Journal of Bioscience and Bioengineering 2005 100 3 235 245 2-s2.0-28744433557 10.1263/jbb.100.235
2. Ellis M., Jarman-Smith M., Chaudhuri J. B., Al-Rubeai M., Chaudhuri J. B., Bioreactor systems for tissue engineering: a four-dimensional challenge. Bioreactors For Tissue Engineering: Principles, Design and Operation 2005 Springer 1 18
3. Sengers B. G., Taylor M., Please C. P., Oreffo R. O. C., Computational modelling of cell spreading and tissue regeneration in porous scaffolds. Biomaterials 2007 28 10 1926 1940 2-s2.0-33846330965 10.1016/j.biomaterials. 2006.12.008
4. Radisic M., Park H., Vunjak-Novakovic G., Lanza R., Langer R., Vacanti J. P., Cardiac-tissue engineering. Principles of Tissue Engineering 2008 3rd Academic Press
5. Pancrazio J. J., Wang F., Kelley C. A., Enabling tools for tissue engineering. Biosensors and Bioelectronics 2007 22 12 2803 2811 2-s2.0-34248562943 10.1016/j.bios.2006.12.023
6. Freshney R. I., Obradovic B., Grayson W., Cannizzaro C., Vunjak-Novakovic G., Lanza R., Langer R., Vacanti J. P., Principles of tissue culture and bioreactor design. Principles of Tissue Engineering 2008 3rd Academic Press
7. Yang Y. I., Seol D. L., Kim H. I., Cho M. H., Lee S. J., Continuous perfusion culture for generation of functional tissue-engineered soft tissues. Current Applied Physics 2007 7 1 e80 e84 2-s2.0-33847164834 10.1016/j.cap.2006. 11.021
8. Pörtner R., Giese C., Vunjack-Novakovic G., Ian Freshney R., An overview on bioreactor design, prototyping and process control for reproducible three-dimensional tissue culture. Culture of Cells For Tissue Engineering 2006 John Wiley & Sons 53 78
9. Martin I., Wendt D., Heberer M., The role of bioreactors in tissue engineering. Trends in Biotechnology 2004 22 2 80 86 2-s2.0-1642563967 10.1016/j.tibtech.2003.12.001
10. Martin Y., Vermette P., Bioreactors for tissue mass culture: design, characterization, and recent advances. Biomaterials 2005 26 35 7481 7503 2-s2.0-23644448920 10.1016/j.biomaterials.2005.05.057
11. El Haj A. J., Wood M. A., Thomas P., Yang Y., Controlling cell biomechanics in orthopaedic tissue engineering and repair. Pathologie Biologie 2005 53 10 581 589 2-s2.0-29144502174 10.1016/j.patbio.2004.12.002
12. Bueno E. M., Bilgen B., Carrier R. L., Barabino G. A., Increased rate of chondrocyte aggregation in a wavy-walled bioreactor. Biotechnology and Bioengineering 2004 88 6 767 777 2-s2.0-16644365884 10.1002/bit.20261
13. Chen H.-C., Hu Y.-C., Bioreactors for tissue engineering. Biotechnology Letters 2006 28 18 1415 1423 2-s2.0-33748569155 10.1007/s10529-006-9111-x
14. Tabesh H., Amoabediny G., Nik N. S., Heydari M., Yosefifard M., Siadat S. O. R., Mottaghy K., The role of biodegradable engineered scaffolds seeded with Schwann cells for spinal cord regeneration. Neurochemistry International 2009 54 2 73 83 2-s2.0-60249091457 10.1016/j.neuint.2008.11.002
15. Kannan R. Y., Salacinski H. J., Sales K., Butler P., Seifalian A. M., The roles of tissue engineering and vascularisation in the development of micro-vascular networks: a review. Biomaterials 2005 26 14 1857 1875 2-s2.0-9644255525 10.1016/j.biomaterials.2004.07.006
16. Lawrence B. J., Devarapalli M., Madihally S. V., Flow dynamics in bioreactors containing tissue engineering scaffolds. Biotechnology and Bioengineering 2009 102 3 935 947 2-s2.0-60349087986 10.1002/bit.22106
17. Wendt D., Timmins N., Malda J., Janssen F., Ratcliffe A., Vunjak-Novakovic G., van Blitterswijk C., Thomsen P., Hubbell J., Cancedda R., de Bruijn J. D., Lindahl A., Bioreactors for tissue engineering. Tissue Engineering 2008 484 506
18. Rolfe P., Sensing in tissue bioreactors. Measurement Science and Technology 2006 17 3 578 583 2-s2.0-31644434493 10.1088/0957-0233/17/3/S20
19. Muschler G. F., Nakamoto C., Griffith L. G., Engineering principles of clinical cell-based tissue engineering. Journal of Bone and Joint Surgery A 2004 86 7 1541 1558 2-s2.0-3042778829
20. Wang S. J., Zhong J. J., Yang S. T., Bioreactor engineering. Bioprocessing For Value-Added Products From Renewable Resources 2007 Elsevier
21. Depprich R., Handschel J., Wiesmann H.-P., Jäsche-Meyer J., Meyer U., Use of bioreactors in maxillofacial tissue engineering. British Journal of Oral and Maxillofacial Surgery 2008 46 5 349 354 2-s2.0-44849103006 10.1016/j.bjoms.2008.01.012
22. Eibl R., Eibl D., Portner R., Catapano G., Czermak P., Cell and Tissue Reaction Engineering 2008 New York, NY, USA Springer
23. Rivera-Solorio I., Kleis S. J., Model of the mass transport to the surface of animal cells cultured in a rotating bioreactor operated in micro gravity. Biotechnology and Bioengineering 2006 94 3 495 504 2-s2.0-33745200972 10.1002/bit.20864
24. Malda J., Radisic M., Levenberg S., Woodfield T., Oomens C., Baaijens F., Svalander P., Vunjak-Novakovic G., van Blitterswijk C., Thomsen P., Hubbell J., Cancedda R., Bruijn J. D., Lindahl A., Sohier J., Williams D., Cell nutrition. Tissue Engineering 2008 328 362
25. Garcia-Ochoa F., Gomez E., Bioreactor scale-up and oxygen transfer rate in microbial processes: an overview. Biotechnology Advances 2009 27 2 153 176 2-s2.0-58149473705 10.1016/j.biotechadv.2008.10.006
26. Hermann R., Lehmann M., Büchs J., Characterization of gas-liquid mass transfer phenomena in microtiter plates. Biotechnology and Bioengineering 2003 81 2 178 186 2-s2.0-0037454635 10.1002/bit.10456
27. Suresh S., Srivastava V. C., Mishra I. M., Techniques for oxygen transfer measurement in bioreactors: a review. Journal of Chemical Technology and Biotechnology 2009 84 1091 1103
28. Marques D. A. V., Torres B. R., Porto A. L. F., Pessoa-Júnior A., Converti A., Comparison of oxygen mass transfer coefficient in simple and extractive fermentation systems. Biochemical Engineering Journal 2009 47 1-3 122 126 2-s2.0-69549123870 10.1016/j.bej.2009.07.015
29. Tabesh H., Amoabediny G., Salehi-Nik N., Esfahani K., Derakhshanfar H., Zandieh Doulabi B., Use of computerized simulation of engineering parameters in tissue-engineering bioreactors. European Spine Journal 2010 19 1408
30. Yeatts A. B., Fisher J. P., Bone tissue engineering bioreactors: dynamic culture and the influence of shear stress. Bone 2011 48 2 171 181 2-s2.0-78650976757 10.1016/j.bone.2010.09.138
31. Sakamoto N., Saito N., Han X., Ohashi T., Sato M., Effect of spatial gradient in fluid shear stress on morphological changes in endothelial cells in response to flow. Biochemical and Biophysical Research Communications 2010 395 2 264 269 2-s2.0-77951622707 10.1016/j.bbrc.2010.04.002
32. Simmers M. B., Pryor A. W., Blackman B. R., Arterial shear stress regulates endothelial cell-directed migration, polarity, and morphology in confluent monolayers. The American Journal of Physiology 2007 293 3 H1937 H1946 2-s2.0-34548412647 10.1152/ajpheart.00534.2007
33. McCoy R. J., O'Brien F. J., Influence of shear stress in perfusion bioreactor cultures for the development of three-dimensional bone tissue constructs: a review. Tissue Engineering B 2010 16 6 587 601 2-s2.0-78649859752 10.1089/ten.teb.2010.0370
34. Waldman S. D., Couto D. C., Grynpas M. D., Pilliar R. M., Kandel R. A., Multi-axial mechanical stimulation of tissue engineered cartilage: review. European Cells and Materials 2007 13 66 73 2-s2.0-34248137928
35. Bacabac R. G., Smit T. H., Van Loon J. J. W. A., Doulabi B. Z., Helder M., Klein-Nulend J., Bone cell responses to high-frequency vibration stress: does the nucleus oscillate within the cytoplasm? FASEB Journal 2006 20 7 858 864 2-s2.0-33744462626 10.1096/fj.05-4966.com
36. Lemon G., King J. R., Byrne H. M., Jensen O. E., Shakesheff K. M., Mathematical modelling of engineered tissue growth using a multiphase porous flow mixture theory. Journal of Mathematical Biology 2006 52 5 571 594 2-s2.0-33645957316 10.1007/s00285-005-0363-1
37. Vatsa A., Smit T. H., Klein-Nulend J., Extracellular NO signalling from a mechanically stimulated osteocyte. Journal of Biomechanics 2007 40 1 S89 S95 2-s2.0-34249885105 10.1016/j.jbiomech.2007.02.015
38. Bacabac R. G., Mizuno D., Schmidt C. F., MacKintosh F. C., Van Loon J. J. W. A., Klein-Nulend J., Smit T. H., Round versus flat: bone cell morphology, elasticity, and mechanosensing. Journal of Biomechanics 2008 41 1590 1598 2-s2.0-49449104054 10.1016/j.jbiomech.2008.01.031
39. Henzler H. J., Particle stress in bioreactors. Advances in Biochemical Engineering/Biotechnology 2000 67 35 82 2-s2.0-0033644296
40. Zoro B. J. H., Owen S., Drake R. A. L., Hoare M., The impact of process stress on suspended anchorage-dependent mammalian cells as an indicator of likely challenges for regenerative medicines. Biotechnology and Bioengineering 2008 99 2 468 474 2-s2.0-38449114747 10.1002/bit.21544
41. Bayati V., Sadeghi Y., Shokrgozar M. A., Haghighipour N., Azadmanesh K., Amanzadeh A., Azari S., The evaluation of cyclic uniaxial strain on myogenic differentiation of adipose-derived stem cells. Tissue and Cell 2011 43 6 359 366 2-s2.0-82455212861 10.1016/j.tice.2011.07.004
42. Hatami J., Tafazzoli-Shadpour M., Haghighipour N., Shokrgozar M. A., Evaluation of Effects of cyclic loading on structural properties of cultured endothelial cell. Modares Journal of Medical Sciences 2010 12 4 19 30
43. Haghighipour N., Tafazzoli-Shadpour M., Shokrgozar M. A., Amini S., Amanzadeh A., Khorasani M. T., Topological remodeling of cultured endothelial cells by characterized cyclic strains. MCB Molecular and Cellular Biomechanics 2007 4 4 189 199 2-s2.0-41949102233
44. Haghighipour N., Tafazzoli-Shadpour M., Avolio A., Residual stress distribution in a lamellar model of the arterial wall. Journal of Medical Engineering and Technology 2010 34 7-8 422 428 2-s2.0-77958504517 10.3109/03091902.2010.514974
45. Haghighipour N., Tafazzoli-Shadpour M., Shokrgozar M. A., Amini S., Effects of cyclic stretch waveform on endothelial cell morphology using fractal analysis. Artificial Organs 2010 34 6 481 490 2-s2.0-77953212318 10.1111/j.1525-1594.2010.01003.x
46. Safshekan F., Tafazzoli Shadpour M., Shokrgozar M. A., Haghighipour N., Mahdian R., Hemmati A., Intermittent hydrostatic pressure enhances growth factor-induced chondroinduction of human adipose-derived mesenchymal stem cells. Artificial Organs 2012 36 12 1065 1071
47. Bakker A. D., Soejima K., Klein-Nulend J., Burger E. H., The production of nitric oxide and prostaglandin E2 by primary bone cells is shear stress dependent. Journal of Biomechanics 2001 34 5 671 677 2-s2.0-0035059024 10.1016/S0021-9290(00)00231-1
48. ] Kaur H., Carriveau R., Mutus B., A simple parallel plate flow chamber to study effects of shear stress on endothelial cells. The American Journal of Biomedical Sciences 2012 4 1 70 78
49. Kang H., Fan Y., Deng X., Vascular smooth muscle cell glycocalyx modulates shear-induced proliferation, migration, and NO production responses. The American Journal of Physiology 2011 300 1 H76 H83 2-s2.0-78651326880 10.1152/ajpheart.00905.2010
50. Isenberg B. C., Williams C., Tranquillo R. T., Small-diameter artificial arteries engineered in vitro. Circulation Research 2006 98 1 25 35 2-s2.0-33644846787 10.1161/01.RES.0000196867.12470.84
51. Diamantouros S. E., Hurtado-Aguilar L. G., Schmitz-Rode T., Mela P., Jockenhoevel S., Pulsatile perfusion bioreactor system for durability testing and compliance estimation of tissue engineered vascular grafts. Annals of Biomedical Engineering 2013 10.1007/s10439-013-0823-5
52. Hahn M. S., McHale M. K., Wang E., Schmedlen R. H., West J. L., Physiologic pulsatile flow bioreactor conditioning of poly(ethylene glycol)-based tissue engineered vascular grafts. Annals of Biomedical Engineering 2007 35 2 190 200 2-s2.0-33846297021 10.1007/s10439-006-9099-3
53. Zaucha M. T., Raykin J., Wan W., Gauvin R., Auger F. A., Germain L., Michaels T. E., Gleason R. L. Jr., A novel cylindrical biaxial computer-controlled bioreactor and biomechanical testing device for vascular tissue engineering. Tissue Engineering A 2009 15 11 3331 3340 2-s2.0-72649096640 10.1089/ten.tea.2008.0369
54. Haghighipour N., Heidarian S., Shokrgozar M. A., Amirizadeh N., Differential effects of cyclic uniaxial stretch on human mesenchymal stem cell into skeletal muscle cell. Cell Biology International 2012 36 7 669 675
55. Petrović M., Mitraković D., Bugarski B., Vonwil D., Martin I., Obradović B., A novel bioreactor with mechanical stimulation for skeletal tissue engineering. Chemical Industry and Chemical Engineering Quarterly 2009 15 1 41 44 2-s2.0-74049103091 10.2298/CICEQ0901041P
56. Tandon N., Marsano A., Maidhof R., Numata K., Montouri-Sorrentino C., Cannizzaro C., Voldman J., Vunjak-Novakovic G., Surface-patterned electrode bioreactor for electrical stimulation. Lab on a Chip 2010 10 6 692 700 2-s2.0-77949419996 10.1039/b917743d
57. Tandon N., Marsano A., Cannizzaro C., Voldman J., Vunjak-Novakovic G., Design of electrical stimulation bioreactors for cardiac tissue engineering. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2008 2008 3594 3597 2-s2.0-65349135394
58. Radisic M., Park H., Shing H., Consi T., Schoen F. J., Langer R., Freed L. E., Vunjak-Novakovic G., Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds. Proceedings of the National Academy of Sciences of the United States of America 2004 101 52 18129 18134 2-s2.0-11144248959 10.1073/pnas.0407817101
59. Tandon N., Marsano A., Maidhof R., Wan L., Park H., Vunjak-Novakovic G., Optimization of electrical stimulation parameters for cardiac tissue engineering. Journal of Tissue Engineering and Regenerative Medicine 2011 5 6 e115 e125 2-s2.0-79956276332 10.1002/term.377
60. Liao I. C., Liu J. B., Bursac N., Leong K. W., Effect of electromechanical stimulation on the maturationofmyotubes on aligned electrospun fibers. Cellular and Molecular Bioengineering 2008 1 133 145
61. Malda J., Woodfield T. B. F., van der Vloodt F., Wilson C., Martens D. E., Tramper J., Van Blitterswijk C. A., Riesle J., The effect of PEGT/PBT scaffold architecture on the composition of tissue engineered cartilage. Biomaterials 2005 26 1 63 72 2-s2.0-2942592809 10.1016/j.biomaterials.2004.02. 046
62. Fernandes-Platzgummer A., Diogo M. M., Baptista R. P., Silva C. L. D., Cabral J. M. S., Scale-up of mouse embryonic stem cell expansion in stirred bioreactors. Biotechnology Progress 2011 27 5 1421 1432 2-s2.0-80053909366 10.1002/btpr.658
63. Partap S., Plunkett N. A., O' Brien F. J., Eberli D., Bioreactors in tissue engineering. Tissue Engineering 2010 323 337
64. Yeatts A. B., Fisher J. P., Bone tissue engineering bioreactors: dynamic culture and the influence of shear stress. Bone 2011 48 2 171 181 2-s2.0-78650976757 10.1016/j.bone.2010.09.138
65. Oragui E., Nannaparaju M., Khan W. S., The role of bioreactors in tissue engineering for musculoskeletal applications. The Open Orthopaedics Journal 2011 5 267 270
66. Zhang X., Bürki C.-A., Stettler M., De Sanctis D., Perrone M., Discacciati M., Parolini N., DeJesus M., Hacker D. L., Quarteroni A., Wurm F. M., Efficient oxygen transfer by surface aeration in shaken cylindrical containers for mammalian cell cultivation at volumetric scales up to 1000 L. Biochemical Engineering Journal 2009 45 1 41 47 2-s2.0-62849118682 10.1016/j.bej.2009.02.003
67. Belfiore L. A., Bonani W., Leoni M., Belfiore C. J., Pressure-sensitive nutrient consumption via dynamic normal stress in rotational bioreactors. Biophysical Chemistry 2009 140 1-3 99 107 2-s2.0-58549102718 10.1016/j.bpc.2008.11.015
68. Nesic D., Whiteside R., Brittberg M., Wendt D., Martin I., Mainil-Varlet P., Cartilage tissue engineering for degenerative joint disease. Advanced Drug Delivery Reviews 2006 58 2 300 322 2-s2.0-33646482909 10.1016/j.addr.2006.01.012
69. Khetani S. R., Bhatia S. N., Engineering tissues for in vitro applications. Current Opinion in Biotechnology 2006 17 5 524 531 2-s2.0-33748980058 10.1016/j.copbio.2006.08.009
70. Yu X., Botchwey E. A., Levine E. M., Pollack S. R., Laurencin C. T., Bioreactor-based bone tissue engineering: the influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization. Proceedings of the National Academy of Sciences of the United States of America 2004 101 31 11203 11208 2-s2.0-3843112154 10.1073/pnas.0402532101
71. Zhang Z.-Y., Teoh S. H., Chong W.-S., Foo T.-T., Chng Y.-C., Choolani M., Chan J., A biaxial rotating bioreactor for the culture of fetal mesenchymal stem cells for bone tissue engineering. Biomaterials 2009 30 14 2694 2704 2-s2.0-61849156328 10.1016/j.biomaterials.2009.01.028
72. Lotter S., Büchs J., Utilization of specific power input measurements for optimization of culture conditions in shaking flasks. Biochemical Engineering Journal 2004 17 3 195 203 2-s2.0-1042264071 10.1016/S1369-703X(03)00178-5
73. Anderlei T., Zang W., Papaspyrou M., Büchs J., Online respiration activity measurement (OTR, CTR, RQ) in shake flasks. Biochemical Engineering Journal 2004 17 3 187 194 2-s2.0-1042287173 10.1016/S1369-703X(03)00181-5
74. Freyer S. A., König M., Künkel A., Validating shaking flasks as representative screening systems. Biochemical Engineering Journal 2004 17 3 169 173 2-s2.0-1042298884 10.1016/S1369-703X(03)00175-X
75. Akgün A., Müller C., Engmann R., Büchs J., Application of an improved continuous parallel shaken bioreactor system for three microbial model systems. Bioprocess and Biosystems Engineering 2008 31 3 193 205 2-s2.0-41049117760 10.1007/s00449-007-0183-3
76. Jamnongwong M., Loubiere K., Dietrich N., Hébrard G., Experimental study of oxygen diffusion coefficients in clean water containing salt, glucose or surfactant: consequences on the liquid-side mass transfer coefficients. Chemical Engineering Journal 2010 165 3 758 768 2-s2.0-78649450522 10.1016/j.cej.2010.09.040
77. Bellucci J. J., Hamaker K. H., Evaluation of oxygen transfer rates in stirred-tank bioreactors for clinical manufacturing. Biotechnology Progress 2011 27 2 368 376 2-s2.0-79953846049 10.1002/btpr.540
78. Duetz W. A., Witholt B., Oxygen transfer by orbital shaking of square vessels and deepwell microtiter plates of various dimensions. Biochemical Engineering Journal 2004 17 3 181 185 2-s2.0-1042275653 10.1016/S1369-703X(03) 00177-3
79. Doig S. D., Pickering S. C. R., Lye G. J., Baganz F., Modelling surface aeration rates in shaken microtitre plates using dimensionless groups. Chemical Engineering Science 2005 60 10 2741 2750 2-s2.0-15344339338 10.1016/j.ces.2004. 12.025
80. Therning P., Rasmuson A., Mass transfer measurements in a non-isothermal bubble column using the uncatalyzed oxidation of sulphite to sulphate. Chemical Engineering Journal 2006 116 2 97 103 2-s2.0-29744466066 10.1016/j.cej.2005.11. 001
81. Cascaval D., Galaction A.-I., Folescu E., Turnea M., Comparative study on the effects of n-dodecane addition on oxygen transfer in stirred bioreactors for simulated, bacterial and yeasts broths. Biochemical Engineering Journal 2006 31 1 56 66 2-s2.0-33747117582 10.1016/j.bej.2006.05.019
82. Puthli M. S., Rathod V. K., Pandit A. B., Gas-liquid mass transfer studies with triple impeller system on a laboratory scale bioreactor. Biochemical Engineering Journal 2005 23 1 25 30 2-s2.0-11844299073 10.1016/j.bej.2004.10.006
83. Seletzky J. M., Noack U., Fricke J., Hahn S., Büchs J., Metabolic activity of Corynebacterium glutamicum grown on L-lactic acid under stress. Applied Microbiology and Biotechnology 2006 72 6 1297 1307 2-s2.0-33749860135 10.1007/s00253-006-0436-0
84. 2 sensitivity of micro-organisms in shaken bioreactors. II. Novel online monitoring method. Biotechnology and Applied Biochemistry 2010 57 4 167 175 2-s2.0-79955065009 10.1042/BA20100212
85. 2 sensitivity of micro-organisms in shaken bioreactors. I. Novel method based on the resistance of sterile closure. Biotechnology and Applied Biochemistry 2010 57 4 157 166 2-s2.0-79955067759 10.1042/BA20100211
86. Seletzky J. M., Noack U., Hahn S., Knoll A., Amoabediny G., Büchs J., An experimental comparison of respiration measuring techniques in fermenters and shake flasks: exhaust gas analyzer vs. RAMOS device vs. respirometer. Journal of Industrial Microbiology and Biotechnology 2007 34 2 123 130 2-s2.0-33846406935 10.1007/s10295-006-0176-2
87. Peña C., Peter C. P., Büchs J., Galindo E., Evolution of the specific power consumption and oxygen transfer rate in alginate-producing cultures of Azotobacter vinelandii conducted in shake flasks. Biochemical Engineering Journal 2007 36 2 73 80 2-s2.0-34547961282 10.1016/j.bej.2007.02.019
88. Scheidle M., Klinger J., Büchs J., Combination of on-line pH and oxygen transfer rate measurement in shake flasks by fiber optical technique and respiration activity monitoring system (RAMOS). Sensors 2007 7 3472 3480
89. Ortigara A. R. C., Foladori P., Andreottola G., Kinetics of heterotrophic biomass and storage mechanism in wetland cores measured by respirometry. Water Science and Technology 2011 64 2 409 415 2-s2.0-79961121589 10.2166/wst.2011.547
90. Liovic P., Šutalo I. D., Stewart R., Glattauer V., Meagher L., Fluid flow and stresses on microcarriers in spinner flask bioreactors. Proceedings of the 9th International Conference on CFD in the Minerals and Process Industries 2012 Melbourne, VIC, Australia
91. Rossi M., Lindken R., Hierck B P., Westerweel J., Microfluidic system for the study of mechanical and biochemical response of endothelial cells to flow-induced mechanical stimuli. Proceedings of the 12th Conference on Miniaturized Systems for Chemistry and Life Sciences 2008
92. Leong Ch M., Voorhees A., Nackman T Wei G. B., Flow bioreactor design for quantitative measurements over endothelial cells using micro-particle image velocimetry. Review of Scientific Instruments 2013 84 10 045109
93. Nguyen C. V., Carberry J., Fouras A., Volumetric-correlation PIV to measure particle concentration and velocity of microflows. Experiments in Fluids 2011 52 3 636 677 2-s2.0-79954583982 10.1007/s00348-011-1087-1
94. Higgins S. P. A., Samarage C. R., Paganin D. M., Fouras A., Holographic Correlation Velocimetry. Proceedings of the 9th international symposium on particle image velocimetry 2011 Kobe, Japan
95. Ismadi M. Z., Higgins S., Samarage C. R., Paganin D., Hourigan K., Optimisation of a stirred bioreactor through the use of a novel holographic correlation velocimetry flow measurement technique. Plos ONE 2013 8 6 14 e65714
96. Ooms T., Koek W., Westerweel J., Digital holographic particle image velocimetry: eliminating a sign-ambiguity error and a bias error from the measured particle field displacement. Measurement Science and Technology 2008 19 7 2-s2.0-46749095568 10.1088/0957-0233/19/7/074003 074003
97. Deen N. G., Hjertager B. H., Solberg T., Comparison of PIV and LDA measurement methods applied to the gas-liquid flow in a bubble column. Proceedings of the10th International Symposium on Applications of Laser Techniques to Fluid Mechanics 2000 Lisbon, Portugal
98. Feng Y., Goree J., Liu B., Errors in particle tracking velocimetry with high-speed cameras. Review of Scientific Instruments 2011 82 5 2-s2.0-79958038188 10.1063/1.3589267 053707
99. Chara Z., Matousek V., Comparative study of ADV and LDA measuring techniques. Proceedings of the 6th International Symposium on Ultrasonic Doppler Methods for Fluid Mechanics and Fluid Engineering
100. Chanson H., Trevethan M., Aoki S. I., Acoustic Doppler velocimetry (ADV) in a small estuarine system. IIAHR Congress 2005 Republic of Korea
101. Abousleiman R. I., Sikavitsas V. I., Bioreactors for tissues of the musculoskeletal system. Advances in Experimental Medicine and Biology 2006 585 243 259 2-s2.0-34447248951 10.1007/978-0-387-34133-0-17
102. Cimetta E., Flaibani M., Mella M., Serena E., Boldrin L., De Coopi P., Elvassore N., Enhancement of viability of muscle precursor cells on 3D scaffold in a perfusion bioreactor. International Journal of Artificial Organs 2007 30 5 415 428 2-s2.0-34447523918
103. Kim S. S., Penkala R., Abrahimi P., A perfusion bioreactor for intestinal tissue engineering. Journal of Surgical Research 2007 142 2 327 331 2-s2.0-34548670519 10.1016/j.jss.2007.03.039
104. Sikavitsas V. I., Bancroft G. N., Lemoine J. J., Liebschner M. A. K., Dauner M., Mikos A. G., Flow perfusion enhances the calcified matrix deposition of marrow stromal cells in biodegradable nonwoven fiber mesh scaffolds. Annals of Biomedical Engineering 2005 33 1 63 70 2-s2.0-17044418448 10.1007/s10439-005-8963-x
105. Lovett M., Rockwood D., Baryshyan A., Kaplan D. L., Simple modular bioreactors for tissue engineering: a system for characterization of oxygen gradients, human mesenchymal stem cell differentiation, and prevascularization. Tissue Engineering C 2010 16 6 1565 1573 2-s2.0-78649643876 10.1089/ten.tec. 2010.0241
106. Lee C., Grad S., Wimmer M., Alini M., Ashammakhi N., Reis R. L., The influence of mechanical stimuli on articular cartilage tissue engineering. Topics in Tissue Engineering 2005 2 1 32
107. Cerulli J., Perfusion Bioreactor for the Development of Tissue-Engineered Blood Vessels [Bachelor thesis] 2011 Worcester polytechnic Institute
108. Radisic M., Marsano A., Maidhof R., Wang Y., Vunjak-Novakovic G., Cardiac tissue engineering using perfusion bioreactor systems. Nature Protocols 2008 3 4 719 738 2-s2.0-42049121079 10.1038/nprot.2008.40
109. Meyer U., Büchter A., Nazer N., Wiesmann H. P., Design and performance of a bioreactor system for mechanically promoted three-dimensional tissue engineering. British Journal of Oral and Maxillofacial Surgery 2006 44 2 134 140 2-s2.0-33644650212 10.1016/j.bjoms.2005.05.001
110. Chung C. A., Chen C. P., Lin T. H., Tseng C. S., A compact computational model for cell construct development in perfusion culture. Biotechnology and Bioengineering 2008 99 6 1535 1541 2-s2.0-41049102178 10.1002/bit.21701
111. Chung C. A., Yang C. W., Chen C. W., Analysis of cell growth and diffusion in a scaffold for cartilage tissue engineering. Biotechnology and Bioengineering 2006 94 6 1138 1146 2-s2.0-33747140795 10.1002/bit.20944
112. Lewis M. C., MacArthur B. D., Malda J., Pettet G., Please C. P., Heterogeneous proliferation within engineered cartilaginous tissue: the role of oxygen tension. Biotechnology and Bioengineering 2005 91 5 607 615 2-s2.0-25144444761 10.1002/bit.20508
113. Malda J., Rouwkema J., Martens D. E., Le Comte E. P., Kooy F. K., Tramper J., Van Blitterswijk C. A., Riesle J., Oxygen gradients in tissue-engineered PEGT/PBT cartilaginous constructs: measurement and modeling. Biotechnology and Bioengineering 2004 86 1 9 18 2-s2.0-1542510685 10.1002/bit.20038
114. Yan X., Bergstrom D. J., Chen X. B., Modeling of cell cultures in perfusion bioreactors. IEEE Transactions on Biomedical Engineering 2012 59 9 2568 2575
115. O'Dea R. D., Waters S. L., Byrne H. M., A two-fluid model for tissue growth within a dynamic flow environment. European Journal of Applied Mathematics 2008 19 6 607 634 2-s2.0-54049114651 10.1017/S0956792508007687
116. Shi Y., Numerical simulation of global hydro-dynamics in a pulsatile bioreactor for cardiovascular tissue engineering. Journal of Biomechanics 2008 41 5 953 959 2-s2.0-40249102978 10.1016/j.jbiomech.2008.01.001
117. Sucosky P., Osorio D. F., Brown J. B., Neitzel G. P., Fluid mechanics of a spinner-flask bioreactor. Biotechnology and Bioengineering 2004 85 1 34 46 2-s2.0-0345869732 10.1002/bit.10788
118. Shakeel M., Continuum modelling of cell growth andnutrient transport in a perfusion bioreactor [Ph.D. thesis] 2011 University of Nottingham
119. Sengers B. G., van Donkelaar C. C., Oomens C. W. J., Baaijens F. P. T., Computational study of culture conditions and nutrient supply in cartilage tissue engineering. Biotechnology Progress 2005 21 4 1252 1261 2-s2.0-23244457579 10.1021/bp0500157
120. Chung C. A., Chen C. W., Chen C. P., Tseng C. S., Enhancement of cell growth in tissue-engineering constructs under direct perfusion: modeling and simulation. Biotechnology and Bioengineering 2007 97 6 1603 1616 2-s2.0-34547613758 10.1002/bit.21378
121. Coletti F., Macchietto S., Elvassore N., Mathematical modeling of three-dimensional cell cultures in perfusion bioreactors. Industrial and Engineering Chemistry Research 2006 45 24 8158 8169 2-s2.0-33845335851 10.1021/ie051144v
122. Whittaker R. J., Booth R., Dyson R., Bailey C., Parsons Chini L., Naire S., Payvandi S., Rong Z., Woollard H., Cummings L. J., Waters S. L., Mawasse L., Chaudhuri J. B., Ellis M. J., Michael V., Kuiper N. J., Cartmell S., Mathematical modelling of fibre-enhanced perfusion inside a tissue-engineering bioreactor. Journal of Theoretical Biology 2009 256 4 533 546 2-s2.0-58749086882 10.1016/j.jtbi.2008.10.013
123. Amoabediny G., Büchs J., Modelling and advanced understanding of unsteady-state gas transfer in shaking bioreactors. Biotechnology and Applied Biochemistry 2007 46 1 57 67 2-s2.0-33846216759 10.1042/BA20060120
124. Anderlei T., Mrotzek C., Bartsch S., Amoabediny G., Peter C. P., Büchs J., New method to determine the mass transfer resistance of sterile closures for shaken bioreactors. Biotechnology and Bioengineering 2007 98 5 999 1007 2-s2.0-36749065017 10.1002/bit.21490
125. Pisu M., Lai N., Cincotti A., Concas A., Cao G., Modeling of engineered cartilage growth in rotating bioreactors. Chemical Engineering Science 2004 59 22-23 5035 5040 2-s2.0-10044286056 10.1016/j.ces.2004.07.101
126. Abdullah N. S., Das D. B., Modelling nutrient transport in hollow fibre membrane bioreactor for growing bone tissue with consideration of multi-component interactions. Chemical Engineering Science 2007 62 21 5821 5839 2-s2.0-34748812486 10.1016/j.ces.2007.06.024
127. Yu P., Lee T. S., Zeng Y., Low H. T., A 3D analysis of oxygen transfer in a low-cost micro-bioreactor for animal cell suspension culture. Computer Methods and Programs in Biomedicine 2007 85 1 59 68 2-s2.0-37849188661 10.1016/j.cmpb.2006.09.008
128. Cioffi M., Boschetti F., Raimondi M. T., Dubini G., Modeling evaluation of the fluid-dynamic microenvironment in tissue-engineered constructs: a micro-CT based model. Biotechnology and Bioengineering 2006 93 3 500 510 2-s2.0-32544432849 10.1002/bit.20740
129. Hutmacher D. W., Singh H., Computational fluid dynamics for improved bioreactor design and 3D culture. Trends in Biotechnology 2008 26 4 166 172 2-s2.0-40849112959 10.1016/j.tibtech.2007.11.012
130. Porter B., Zauel R., Stockman H., Guldberg R., Fyhrie D., 3-D computational modeling of media flow through scaffolds in a perfusion bioreactor. Journal of Biomechanics 2005 38 3 543 549 2-s2.0-12344284982 10.1016/j.jbiomech.2004.04.011
131. Dubey H., Das S. K., Panda T., Numerical simulation of a fully baffled biological reactor: the differential circumferential averaging mixing plane approach. Biotechnology and Bioengineering 2006 95 4 754 766 2-s2.0-33750546024 10.1002/bit.21030
132. Singh H., Eng S. A., Lim T. T., Hutmacher D. W., Flow modeling in a novel non-perfusion conical bioreactor. Biotechnology and Bioengineering 2007 97 5 1291 1299 2-s2.0-34547592483 10.1002/bit.21327
133. Zeng Y., Lee T.-S., Yu P., Roy P., Low H.-T., Mass transport and shear stress in a microchannel bioreactor: numerical simulation and dynamic similarity. Journal of Biomechanical Engineering 2006 128 2 185 193 2-s2.0-33645960134 10.1115/1.2170118
134. Provin C., Takano K., Sakai Y., Fujii T., Shirakashi R., A method for the design of 3D scaffolds for high-density cell attachment and determination of optimum perfusion culture conditions. Journal of Biomechanics 2008 41 7 1436 1449 2-s2.0-42749086051 10.1016/j.jbiomech.2008.02.025
135. Boschetti F., Raimondi M. T., Migliavacca F., Dubini G., Prediction of the micro-fluid dynamic environment imposed to three-dimensional engineered cell systems in bioreactors. Journal of Biomechanics 2006 39 3 418 425 2-s2.0-29744456039 10.1016/j.jbiomech.2004.12.022
136. Pouran B., Amoabediny G., Saghafinia S., Haji Abbas M. P., Characterization of interfacial hydrodynamics in a single cell of shaken microtiter plate bioreactors applying computational fluid dynamics technique. Procedia Engineering 2012 42 924 930
137. Yu P., Lee T. S., Zeng Y., Low H. T., Fluid dynamics of a micro-bioreactor for tissue engineering. Fluid Dynamics and Materials Processing 2005 1 235 246
138. Bilgen B., Barabino G. A., Location of scaffolds in bioreactors modulates the hydrodynamic environment experienced by engineered tissues. Biotechnology and Bioengineering 2007 98 1 282 294 2-s2.0-34548251103 10.1002/bit.21385
139. Tabrizi H. O., Amoabediny G., Moshiri B., Haji Abbas M. P., Pouran B., Imenipour E., Rashedi H., Büchs J., Novel dynamic model for aerated shaking bioreactors. Biotechnology and Applied Biochemistry 2011 58 2 128 137 2-s2.0-79955058412 10.1002/bab.18