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Volumn 15, Issue 4, 2009, Pages 395-422

Developmental engineering: A new paradigm for the design and manufacturing of cell-based products. Part II. from genes to networks: Tissue engineering from the viewpoint of systems biology and network science

Author keywords

[No Author keywords available]

Indexed keywords

ARTIFICIAL TISSUES; BIOLOGICAL CONTROLS; BIOLOGICAL NETWORKS; BIOLOGICAL PROCESS; BIOMIMETIC PROCESS; CELL-BASED; COMPLEX INTERACTION; COMPUTATIONAL APPROACH; COMPUTATIONAL DESIGN; DESIGN PARAMETERS; DESIGN RULES; DEVELOPMENTAL BIOLOGY; EMPIRICAL CONCEPTS; EXPERIMENTAL DATA; IN-VITRO; IN-VIVO; MANUFACTURING PROCESS; MATHEMATICAL METHOD; NETWORK SCIENCE; NEW CONCEPT; RECENT PROGRESS; SYSTEMS BIOLOGY; TECHNOLOGY-BASED; THEORETICAL FRAMEWORK; TISSUE DEVELOPMENT; TISSUE FUNCTION;

EID: 71849118757     PISSN: 19373368     EISSN: None     Source Type: Journal    
DOI: 10.1089/ten.teb.2009.0461     Document Type: Review
Times cited : (97)

References (110)
  • 1
    • 71849086405 scopus 로고    scopus 로고
    • Developmental engineering: A new paradigm for the design and manufacturing of cell-based products. Part I: From three-dimensional cell growth to biomimetics of in vivo development
    • Lenas, P., Moos, M., and Luyten, F.P. Developmental engineering: a new paradigm for the design and manufacturing of cell-based products. Part I: from three-dimensional cell growth to biomimetics of in vivo development. Tissue Eng 15B, 381, 2009.
    • (2009) Tissue Eng , vol.15 B , pp. 381
    • Lenas, P.1    Moos, M.2    Luyten, F.P.3
  • 4
    • 0345827521 scopus 로고    scopus 로고
    • Failure of in vitro-differentiated mesenchymal stem cells from the synovial membrane to form ectopic stable cartilage in vivo
    • de Bari, C., Dell'accio, F., and Luyten, F.P. Failure of in vitro-differentiated mesenchymal stem cells from the synovial membrane to form ectopic stable cartilage in vivo. Arthritis Rheum 50, 142, 2004.
    • (2004) Arthritis Rheum , vol.50 , pp. 142
    • De Bari, C.1    Dell'Accio, F.2    Luyten, F.P.3
  • 5
    • 0029683307 scopus 로고    scopus 로고
    • Genetic architecture of common multifactorial diseases
    • Sing, C.F., Haviland, M.B., and Reilly, S.L. Genetic architecture of common multifactorial diseases. Ciba Found Symp 197, 211, 1996.
    • (1996) Ciba Found Symp , vol.197 , pp. 211
    • Sing, C.F.1    Haviland, M.B.2    Reilly, S.L.3
  • 6
    • 0029790351 scopus 로고    scopus 로고
    • Ultrasensitivity in the mitogen-activated protein cascade
    • Huang, C.Y., and Ferrell, J.E., Jr. Ultrasensitivity in the mitogen-activated protein cascade. Proc Natl Acad Sci USA 93, 10078, 1996.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 10078
    • Huang, C.Y.1    Ferrell Jr, J.E.2
  • 7
    • 0000870544 scopus 로고
    • Die Kinetik der In-vertinwirking
    • Michaelis, L., and Menten, M. Die Kinetik der In-vertinwirking. Biochem Z 49, 333, 1913.
    • (1913) Biochem Z , vol.49 , pp. 333
    • Michaelis, L.1    Menten, M.2
  • 8
    • 0031092897 scopus 로고    scopus 로고
    • The coming Kuhnian revolution in biology-commentary
    • Strohman, R.C. The coming Kuhnian revolution in biology-commentary. Nat Biotechnol 15, 194, 1997.
    • (1997) Nat Biotechnol , vol.15 , pp. 194
    • Strohman, R.C.1
  • 9
    • 33745104130 scopus 로고    scopus 로고
    • The impact of systems biology and biosi-mulation on drug discovery and development
    • Michelson, S. The impact of systems biology and biosi-mulation on drug discovery and development. Mol Biosyst 2, 288, 2006.
    • (2006) Mol Biosyst , vol.2 , pp. 288
    • Michelson, S.1
  • 13
    • 67349231375 scopus 로고    scopus 로고
    • Systems and synthetic biology: Tackling genetic networks and complex diseases
    • Cuccato, G., Della Gatta, G., and di Bernardo, D. Systems and synthetic biology: tackling genetic networks and complex diseases. Heredity 102, 527, 2009.
    • (2009) Heredity , vol.102 , pp. 527
    • Cuccato, G.1    Della Gatta, G.2    Di Bernardo, D.3
  • 14
    • 18344369425 scopus 로고    scopus 로고
    • Anonymous. in pursuit of systems
    • Anonymous. In pursuit of systems. Nature 435, 1, 2005.
    • (2005) Nature , vol.435 , pp. 1
  • 15
    • 0029750190 scopus 로고    scopus 로고
    • Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
    • Vortkamp, A., Lee, K., Lanske, B., Segre, G.V., Kronenberg, H.M., and Tabin, C.J. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 273, 613, 1996.
    • (1996) Science , vol.273 , pp. 613
    • Vortkamp, A.1    Lee, K.2    Lanske, B.3    Segre, G.V.4    Kronenberg, H.M.5    Tabin, C.J.6
  • 16
    • 0023149819 scopus 로고
    • Metabolic zonation of liver parenchyma: Significance for the regulation of glycogen metabolism, gluconeogenesis, and glycolysis
    • Jungermann, K. Metabolic zonation of liver parenchyma: significance for the regulation of glycogen metabolism, gluconeogenesis, and glycolysis. Diabetes Metab Rev 3, 269, 1987.
    • (1987) Diabetes Metab Rev , vol.3 , pp. 269
    • Jungermann, K.1
  • 17
    • 0030666202 scopus 로고    scopus 로고
    • Individual beta cells within the intact islet differentially respond to glucose
    • deVargas, L.M., Sobolewski, J., Siegel, R., and Moss, L.G. Individual beta cells within the intact islet differentially respond to glucose. J Biol Chem 272, 26573, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 26573
    • Devargas, M.L.1    Sobolewski, J.2    Siegel, R.3    Moss, G.L.4
  • 18
    • 0028095283 scopus 로고
    • Physiological relevance of heterogeneity in the pancreatic beta-cell population
    • Pipeleers, D., Kiekens, R., Ling, Z., Wilikens, A., and Schuit, F. Physiological relevance of heterogeneity in the pancreatic beta-cell population. Diabetologia 37, S57, 1994.
    • (1994) Diabetologia , vol.37
    • Pipeleers, D.1    Kiekens, R.2    Ling, Z.3    Wilikens, A.4    Schuit, F.5
  • 19
    • 0028245445 scopus 로고
    • A measure for brain complexity-relating functional segregation and integration in the nervous-system
    • Tononi, G., Sporns, O., and Edelman, G.M. A measure for brain complexity-relating functional segregation and integration in the nervous-system. Proc Natl Acad Sci USA 91, 5033, 1994.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 5033
    • Tononi, G.1    Sporns, O.2    Edelman, G.M.3
  • 20
    • 21044443402 scopus 로고    scopus 로고
    • Search for organising principles: Understanding in systems biology
    • Mesarovic, M.D., Sreenath, S.N., and Keene, J.D. Search for organising principles: understanding in systems biology. Syst Biol (Stevenage) 1, 19, 2004.
    • (2004) Syst Biol (Stevenage) , vol.1 , pp. 19
    • Mesarovic, M.D.1    Sreenath, S.N.2    Keene, J.D.3
  • 21
    • 0037452576 scopus 로고    scopus 로고
    • Regulatory gene networks and the properties of the developmental process
    • Davidson, E.H., Mccay, D.R., and Hood, L. Regulatory gene networks and the properties of the developmental process. Proc Natl Acad Sci USA 100, 1475, 2003.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 1475
    • Davidson, E.H.1    McCay, D.R.2    Hood, L.3
  • 22
    • 45849102001 scopus 로고    scopus 로고
    • A gene regulatory network orchestrates neural crest formation
    • Sauka-Spengler, T., and Bronner-Fraser, M. A gene regulatory network orchestrates neural crest formation. Nat Rev Mol Cell Biol 9, 557, 2008.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 557
    • Sauka-Spengler, T.1    Bronner-Fraser, M.2
  • 23
    • 36048980877 scopus 로고    scopus 로고
    • Robustness of embryonic spatial patterning in Drosophila melano-gaster
    • Umulis, D., O'Connor, M.B., and Othmert, H.G. Robustness of embryonic spatial patterning in Drosophila melano-gaster. Curr Top Dev Biol 81, 65, 2008.
    • (2008) Curr Top Dev Biol , vol.81 , pp. 65
    • Umulis, D.1    O'Connor, M.B.2    Othmert, H.G.3
  • 24
    • 46249114829 scopus 로고    scopus 로고
    • Scaling of the BMP activation gradient in Xenopus embryos
    • Ben Zvi, D., Shilo, B.Z., Fainsod, A., and Barkai, N. Scaling of the BMP activation gradient in Xenopus embryos. Nature 453, 1205, 2008.
    • (2008) Nature , vol.453 , pp. 1205
    • Ben Zvi, D.1    Shilo, B.Z.2    Fainsod, A.3    Barkai, N.4
  • 25
  • 26
    • 0034644270 scopus 로고    scopus 로고
    • The segment polarity network is a robust development module
    • von Dassow, G., Meir, E., Munro, E.M., and Odell, G.M. The segment polarity network is a robust development module. Nature 406, 188, 2000.
    • (2000) Nature , vol.406 , pp. 188
    • Von Dassow, G.1    Meir, E.2    Munro, E.M.3    Odell, G.M.4
  • 27
    • 0037108607 scopus 로고    scopus 로고
    • Design and constraints of the Drosophila segment polarity module: Robust spatial patterning emerges from intertwined cell state switches
    • von Dassow, G., and Odell, G.M. Design and constraints of the Drosophila segment polarity module: robust spatial patterning emerges from intertwined cell state switches. J Exp Zool 294, 179, 2002.
    • (2002) J Exp Zool , vol.294 , pp. 179
    • Von Dassow, G.1    Odell, G.M.2
  • 28
    • 0014489272 scopus 로고
    • Metabolic stability and epigenesis in randomly constructed genetic nets
    • Kauffman, S.A. Metabolic stability and epigenesis in randomly constructed genetic nets. J Theor Biol 22, 437, 1969.
    • (1969) J Theor Biol , vol.22 , pp. 437
    • Kauffman, S.A.1
  • 30
    • 0014671878 scopus 로고
    • Homeostasis and differentiation in random genetic control networks
    • Kauffman, S.A. Homeostasis and differentiation in random genetic control networks. Nature 224, 177, 1969.
    • (1969) Nature , vol.224 , pp. 177
    • Kauffman, S.A.1
  • 31
    • 84882291057 scopus 로고    scopus 로고
    • Multistability and multicellularity: Cell fates as high-dimensional attractors of gene regulatory networks
    • Kriete, A., and Eils, R., (Eds.) New York: Elsevier Academic Press
    • Wang, S. Multistability and multicellularity: cell fates as high-dimensional attractors of gene regulatory networks. In: Kriete, A., and Eils, R., (Eds.), Computational Systems Biology. New York: Elsevier Academic Press, pp. 293-326, 2005.
    • (2005) Computational Systems Biology , pp. 293-326
    • Wang, S.1
  • 32
    • 0037686112 scopus 로고    scopus 로고
    • The topology of the regulatory interactions predicts the expression pattern of the segment polarity genes in Drosophila melanogaster
    • Albert, R., and Othmer, H.G. The topology of the regulatory interactions predicts the expression pattern of the segment polarity genes in Drosophila melanogaster. J Theor Biol 223, 1, 2003.
    • (2003) J Theor Biol , vol.223 , pp. 1
    • Albert, R.1    Othmer, H.G.2
  • 33
    • 0037136555 scopus 로고    scopus 로고
    • Robustness of the BMP morphogen gradient in Drosophila embryonic patterning
    • Eldar, A., Dorfman, R., Weiss, D., Ashe, H., Shilo, B.Z., and Barkai, N. Robustness of the BMP morphogen gradient in Drosophila embryonic patterning. Nature 419, 304, 2002.
    • (2002) Nature , vol.419 , pp. 304
    • Eldar, A.1    Dorfman, R.2    Weiss, D.3    Ashe, H.4    Shilo, B.Z.5    Barkai, N.6
  • 34
    • 3042881964 scopus 로고
    • Developmental horizons in human embryos (fourth issue). A review of the histogenesis of cartilage and bone
    • Streeter, G.L. Developmental horizons in human embryos (fourth issue). A review of the histogenesis of cartilage and bone. Contrib Embryol 220, 151, 1949.
    • (1949) Contrib Embryol , vol.220 , pp. 151
    • Streeter, G.L.1
  • 35
    • 0001305966 scopus 로고
    • Row formation and other types of arrangement of cartilage cells in endochondral ossification
    • Dodds, G.S. Row formation and other types of arrangement of cartilage cells in endochondral ossification. Anat Rec 46, 385, 1930.
    • (1930) Anat Rec , vol.46 , pp. 385
    • Dodds, G.S.1
  • 36
    • 0030921044 scopus 로고    scopus 로고
    • Three-dimensional culture of bovine chondrocytes in rotating-wall vessels
    • Baker, T.L., and Goodwin, T.J. Three-dimensional culture of bovine chondrocytes in rotating-wall vessels. In Vitro Cell Dev Biol Anim 33, 358, 1997.
    • (1997) In Vitro Cell Dev Biol Anim , vol.33 , pp. 358
    • Baker, T.L.1    Goodwin, T.J.2
  • 38
    • 0031442990 scopus 로고    scopus 로고
    • Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide
    • Schipani, E., Lanske, B., Hunzelman, J., Luz, A., Kovacs, C.S., Lee, K., Pirro, A., Kronenberg, H.M., and Juppner, H. Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide. Proc Natl Acad Sci USA 94, 13689, 1997.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13689
    • Schipani, E.1    Lanske, B.2    Hunzelman, J.3    Luz, A.4    Kovacs, C.S.5    Lee, K.6    Pirro, A.7    Kronenberg, H.M.8    Juppner, H.9
  • 39
    • 0034755005 scopus 로고    scopus 로고
    • Vascular regression is required for mesenchymal condensation and chondrogenesis in the developing limb
    • Yin, M., and Pacifici, M. Vascular regression is required for mesenchymal condensation and chondrogenesis in the developing limb. Dev Dyn 222, 522, 2001.
    • (2001) Dev Dyn , vol.222 , pp. 522
    • Yin, M.1    Pacifici, M.2
  • 40
    • 0029811142 scopus 로고    scopus 로고
    • Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation
    • Weir, E.C., Philbrick, W.M., Amling, M., Neff, L.A., Baron, R., and Broadus, A.E. Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation. Proc Natl Acad Sci USA 93, 10240, 1996.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 10240
    • Weir, E.C.1    Philbrick, W.M.2    Amling, M.3    Neff, L.A.4    Baron, R.5    Broadus, A.E.6
  • 41
    • 0025990014 scopus 로고
    • Reduced amounts of cartilage collagen fibrils and growth plate anomalies in transgenic mice harboring a glycine-to-cysteine mutation in the mouse type-Ii procollagen alpha-1-chain gene
    • Garofalo, S., Vuorio, E., Metsaranta, M., Rosati, R., Toman, D., Vaughan, J., Lozano, G., Mayne, R., Ellard, J., Horton, W., and Decrombrugghe, B. Reduced amounts of cartilage collagen fibrils and growth plate anomalies in transgenic mice harboring a glycine-to-cysteine mutation in the mouse type-Ii procollagen alpha-1-chain gene. Proc Natl Acad Sci USA 88, 9648, 1991.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 9648
    • Garofalo, S.1    Vuorio, E.2    Metsaranta, M.3    Rosati, R.4    Toman, D.5    Vaughan, J.6    Lozano, G.7    Mayne, R.8    Ellard, J.9    Horton, W.10    Decrombrugghe, B.11
  • 42
    • 0032573058 scopus 로고    scopus 로고
    • The parathyroid hormone parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation
    • Chung, U.I., Lanske, B., Lee, K.C., Li, E., and Kronenberg, H. The parathyroid hormone parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation. Proc Natl Acad Sci USA 95, 13030, 1998.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13030
    • Chung, U.I.1    Lanske, B.2    Lee, K.C.3    Li, E.4    Kronenberg, H.5
  • 43
    • 0035691559 scopus 로고    scopus 로고
    • Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation
    • Long, F.X., Zhang, X.Y.M., Karp, S., Yang, Y.Z., and McMahon, A.P. Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development 128, 5099, 2001.
    • (2001) Development , vol.128 , pp. 5099
    • Long, F.X.1    Zhang, X.Y.M.2    Karp, S.3    Yang, Y.Z.4    McMahon, A.P.5
  • 44
    • 0034747252 scopus 로고    scopus 로고
    • BMP and Ihh=PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation
    • Minina, E., Wenzel, H.M., Kreschel, C., Karp, S., Gaffield, W., McMahon, A.P., and Vortkamp, A. BMP and Ihh=PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation. Development 128, 4523, 2001.
    • (2001) Development , vol.128 , pp. 4523
    • Minina, E.1    Wenzel, H.M.2    Kreschel, C.3    Karp, S.4    Gaffield, W.5    McMahon, A.P.6    Vortkamp, A.7
  • 45
    • 0034078012 scopus 로고    scopus 로고
    • Expression of Indian hedgehog, parathyroid hormone-related protein, and their receptors in the postnatal growth plate of the rat: Evidence for a locally acting growth restraining feedback loop after birth
    • van der Eerden, B.C.J., Karperien, M., Gevers, E.F., Lowik, C.W.G.M., and Wit, J.M. Expression of Indian hedgehog, parathyroid hormone-related protein, and their receptors in the postnatal growth plate of the rat: evidence for a locally acting growth restraining feedback loop after birth. J Bone Mine Res 15, 1045, 2000.
    • (2000) J Bone Mine Res , vol.15 , pp. 1045
    • Van Der Eerden, B.C.J.1    Karperien, M.2    Gevers, E.F.3    Lowik, C.W.G.M.4    Wit, J.M.5
  • 46
    • 23244459215 scopus 로고    scopus 로고
    • Determining diffusion coefficients in inhomogeneous tissues using fluorescence recovery after photobleaching
    • Sniekers, Y.H., and van Donkelaar, C.C. Determining diffusion coefficients in inhomogeneous tissues using fluorescence recovery after photobleaching. Biophys J 89, 1302, 2005.
    • (2005) Biophys J , vol.89 , pp. 1302
    • Sniekers, Y.H.1    Van Donkelaar, C.C.2
  • 47
    • 34547681709 scopus 로고    scopus 로고
    • Solute transport in growth plate cartilage: In vitro and in vivo
    • Williams, R.M., Zipfel, W.R., Tinsley, M.L., and Farnum, C.E. Solute transport in growth plate cartilage: in vitro and in vivo. Biophys J 93, 1039, 2007.
    • (2007) Biophys J , vol.93 , pp. 1039
    • Williams, R.M.1    Zipfel, W.R.2    Tinsley, M.L.3    Farnum, C.E.4
  • 48
    • 0036203870 scopus 로고    scopus 로고
    • Volume increase in growth plate chondrocytes during hypertrophy: The contribution of organic osmolytes
    • Farnum, C.E., Lee, R., O'Hara, K., and Urban, J.P.G. Volume increase in growth plate chondrocytes during hypertrophy: the contribution of organic osmolytes. Bone 30, 574, 2002.
    • (2002) Bone , vol.30 , pp. 574
    • Farnum, C.E.1    Lee, R.2    O'Hara, K.3    Urban, J.P.G.4
  • 49
    • 0027457447 scopus 로고
    • Determination of prolif-erative characteristics of growth plate chondrocytes by labeling with bromodeoxyuridine
    • Farnum, C.E., and Wilsman, N.J. Determination of prolif-erative characteristics of growth plate chondrocytes by labeling with bromodeoxyuridine. Calcif Tissue Int 52, 110, 1993.
    • (1993) Calcif Tissue Int , vol.52 , pp. 110
    • Farnum, C.E.1    Wilsman, N.J.2
  • 50
    • 0030483252 scopus 로고    scopus 로고
    • Differential growth by growth plates as a function of multiple parameters of chondrocytic kinetics
    • Wilsman, N.J., Farnum, C.E., Leiferman, E.M., Fry, M., and Barreto, C. Differential growth by growth plates as a function of multiple parameters of chondrocytic kinetics. J Orthop Res 14, 927, 1996.
    • (1996) J Orthop Res , vol.14 , pp. 927
    • Wilsman, N.J.1    Farnum, C.E.2    Leiferman, E.M.3    Fry, M.4    Barreto, C.5
  • 51
    • 0032055031 scopus 로고    scopus 로고
    • Kinetic studies on epiphyseal growth cartilage in the normal mouse
    • Vanky, P., Brockstedt, U., Hjerpe, A., and Wikstrom, B. Kinetic studies on epiphyseal growth cartilage in the normal mouse. Bone 22, 331, 1998.
    • (1998) Bone , vol.22 , pp. 331
    • Vanky, P.1    Brockstedt, U.2    Hjerpe, A.3    Wikstrom, B.4
  • 52
    • 34247348274 scopus 로고    scopus 로고
    • Gradients in bone morphogenetic protein-related gene expression across the growth plate
    • Nilsson, O., Parker, E.A., Hegde, A., Chau, M., Barnes, K.M., and Baron, J. Gradients in bone morphogenetic protein-related gene expression across the growth plate. J En-docrinol 193, 75, 2007.
    • (2007) J En-docrinol , vol.193 , pp. 75
    • Nilsson, O.1    Parker, E.A.2    Hegde, A.3    Chau, M.4    Barnes, K.M.5    Baron, J.6
  • 53
    • 13844315153 scopus 로고    scopus 로고
    • Microarray analysis of proliferative and hypertrophic growth plate zones identifies differentiation markers and signal pathways
    • Yan, W., Middleton, F., Horton, J.A., Reichel, L., Farnum, C.E., and Damron, T.A. Microarray analysis of proliferative and hypertrophic growth plate zones identifies differentiation markers and signal pathways. Bone 35, 1273, 2004.
    • (2004) Bone , vol.35 , pp. 1273
    • Yan, W.1    Middleton, F.2    Horton, J.A.3    Reichel, L.4    Farnum, C.E.5    Damron, T.A.6
  • 54
    • 0037108539 scopus 로고    scopus 로고
    • A versatile tool for reconstituting genetic networks, with examples from the segment polarity network
    • Meir, E., Munro, E.M., Odell, G.M., and von Dassow, G. Ingeneue: a versatile tool for reconstituting genetic networks, with examples from the segment polarity network. J Exp Zool 294, 216, 2002.
    • (2002) J Exp Zool , vol.294 , pp. 216
    • Meir, E.1    Munro, E.M.2    Odell, G.M.3    Dassow, G.4
  • 56
    • 3042548087 scopus 로고    scopus 로고
    • Modeling the interactions between osteoblast and os-teoclast activities in bone remodeling
    • Lemaire, V., Tobin, F.L., Greller, L.D., Cho, C.R., and Suva, L.J. Modeling the interactions between osteoblast and os-teoclast activities in bone remodeling. J Theor Biol 229, 293, 2004.
    • (2004) J Theor Biol , vol.229 , pp. 293
    • Lemaire, V.1    Tobin, F.L.2    Greller, L.D.3    Cho, C.R.4    Suva, L.J.5
  • 57
    • 0031630211 scopus 로고    scopus 로고
    • Genomic regulation modeled as a network with basins of attraction
    • Wuensche, A. Genomic regulation modeled as a network with basins of attraction. Pac Symp Biocomput 89, 1998.
    • (1998) Pac Symp Biocomput , vol.89
    • Wuensche, A.1
  • 62
    • 18144408736 scopus 로고    scopus 로고
    • Cell fates as high-dimensional attractor states of a complex gene regulatory network
    • Huang, S., Eichler, G., Bar-Yam, Y., and Ingber, D.E. Cell fates as high-dimensional attractor states of a complex gene regulatory network. Phys Rev Lett 94, 128701, 2005.
    • (2005) Phys Rev Lett , vol.94 , pp. 128701
    • Huang, S.1    Eichler, G.2    Bar-Yam, Y.3    Ingber, D.E.4
  • 63
    • 0035923604 scopus 로고    scopus 로고
    • Degeneracy and complexity in biological systems
    • Edelman, G.M., and Gally, J.A. Degeneracy and complexity in biological systems. Proc Natl Acad Sci USA 98, 13763, 2001.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 13763
    • Edelman, G.M.1    Gally, J.A.2
  • 64
    • 0033001953 scopus 로고    scopus 로고
    • Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes
    • Fambrough, D., McClure, K., Kazlauskas, A., and Lander, E.S. Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell 97, 727, 1999.
    • (1999) Cell , vol.97 , pp. 727
    • Fambrough, D.1    McClure, K.2    Kazlauskas, A.3    Lander, E.S.4
  • 65
    • 44349162752 scopus 로고    scopus 로고
    • Transcriptome-wide noise controls lineage choice in mammalian progenitor cells
    • Chang, H.H., Hemberg, M., Barahona, M., Ingber, D.E., and Huang, S. Transcriptome-wide noise controls lineage choice in mammalian progenitor cells. Nature 453, 544, 2008.
    • (2008) Nature , vol.453 , pp. 544
    • Chang, H.H.1    Hemberg, M.2    Barahona, M.3    Ingber, D.E.4    Huang, S.5
  • 66
    • 35348903141 scopus 로고    scopus 로고
    • Mechanistic exploration of phthalimide neovascular factor 1 using network analysis tools
    • Wieghaus, K.A., Gianchandani, E.P., Brown, M.L., Papin, J.A., and Botchwey, E.A. Mechanistic exploration of phthalimide neovascular factor 1 using network analysis tools. Tissue Eng 13, 2561, 2007.
    • (2007) Tissue Eng , vol.13 , pp. 2561
    • Wieghaus, K.A.1    Gianchandani, E.P.2    Brown, M.L.3    Papin, J.A.4    Botchwey, E.A.5
  • 69
    • 33645097646 scopus 로고    scopus 로고
    • Multi-stable and multistep dynamics in neutrophil differentiation
    • Chang, H.H., Oh, P.Y., Ingber, D.E., and Huang, S. Multi-stable and multistep dynamics in neutrophil differentiation. BMC Cell Biol 7, 11, 2006.
    • (2006) BMC Cell Biol , vol.7 , pp. 11
    • Chang, H.H.1    Oh, P.Y.2    Ingber, D.E.3    Huang, S.4
  • 70
  • 71
    • 0042847336 scopus 로고    scopus 로고
    • Pancreas specification: A budding question
    • Kumar, M., and Melton, D. Pancreas specification: a budding question. Curr Opin Genet Dev 13, 401, 2003.
    • (2003) Curr Opin Genet Dev , vol.13 , pp. 401
    • Kumar, M.1    Melton, D.2
  • 72
    • 0034352167 scopus 로고    scopus 로고
    • From genome to physiome: Integrative models of cardiac excitation
    • Rudy, Y. From genome to physiome: integrative models of cardiac excitation. Ann Biomed Eng 28, 945, 2000.
    • (2000) Ann Biomed Eng , vol.28 , pp. 945
    • Rudy, Y.1
  • 73
    • 0036499997 scopus 로고    scopus 로고
    • Modeling the heart-from genes to cells to the whole organ
    • Noble, D. Modeling the heart-from genes to cells to the whole organ. Science 295, 1678, 2002.
    • (2002) Science , vol.295 , pp. 1678
    • Noble, D.1
  • 74
    • 43449106475 scopus 로고    scopus 로고
    • Cell biology: The cellular hullabaloo
    • Pearson, H. Cell biology: the cellular hullabaloo. Nature 453, 150, 2008.
    • (2008) Nature , vol.453 , pp. 150
    • Pearson, H.1
  • 75
    • 0033151624 scopus 로고    scopus 로고
    • Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: Functional antagonism in erythroid cells
    • Rekhtman, N., Radparvar, F., Evans, T., and Skoultchi, A.I. Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells. Gene Dev 13, 1398, 1999.
    • (1999) Gene Dev , vol.13 , pp. 1398
    • Rekhtman, N.1    Radparvar, F.2    Evans, T.3    Skoultchi, A.I.4
  • 79
    • 0038483826 scopus 로고    scopus 로고
    • Emergence of scaling in random networks
    • Barabasi, A.L., and Albert, R. Emergence of scaling in random networks. Science 286, 509, 1999.
    • (1999) Science , vol.286 , pp. 509
    • Barabasi, A.L.1    Albert, R.2
  • 80
    • 0034029892 scopus 로고    scopus 로고
    • Robustness against mutations in genetic networks of yeast
    • Wagner, A. Robustness against mutations in genetic networks of yeast. Nat Genet 24, 355, 2000.
    • (2000) Nat Genet , vol.24 , pp. 355
    • Wagner, A.1
  • 81
    • 0742305866 scopus 로고    scopus 로고
    • Network biology: Understanding the cell's functional organization
    • Barabasi, A.L., and Oltvai, Z.N. Network biology: understanding the cell's functional organization. Nat Rev Genet 5, 101, 2004.
    • (2004) Nat Rev Genet , vol.5 , pp. 101
    • Barabasi, A.L.1    Oltvai, Z.N.2
  • 82
    • 0034721164 scopus 로고    scopus 로고
    • Error and attack tolerance of complex networks
    • Albert, R., Jeong, H., and Barabasi, A.L. Error and attack tolerance of complex networks. Nature 406, 378, 2000.
    • (2000) Nature , vol.406 , pp. 378
    • Albert, R.1    Jeong, H.2    Barabasi, A.L.3
  • 83
    • 1542288938 scopus 로고    scopus 로고
    • Global organization of metabolic fluxes in the bacterium Escherichia coli
    • Almaas, E., Kovacs, B., Vicsek, T., Oltvai, Z.N., and Bar-abasi, A.L. Global organization of metabolic fluxes in the bacterium Escherichia coli. Nature 427, 839, 2004.
    • (2004) Nature , vol.427 , pp. 839
    • Almaas, E.1    Kovacs, B.2    Vicsek, T.3    Oltvai, Z.N.4    Bar-Abasi, A.L.5
  • 84
    • 40749104852 scopus 로고    scopus 로고
    • An extended transcriptional network for pluripotency of embryonic stem cells
    • Kim, J., Chu, J.L., Shen, X.H., Wang, J.L., and Orkin, S.H. An extended transcriptional network for pluripotency of embryonic stem cells. Cell 132, 1049, 2008.
    • (2008) Cell , vol.132 , pp. 1049
    • Kim, J.1    Chu, J.L.2    Shen, X.H.3    Wang, J.L.4    Orkin, S.H.5
  • 86
  • 87
    • 1842580761 scopus 로고    scopus 로고
    • Functional and topological characterization of protein interaction networks
    • Yook, S.H., Oltvai, Z.N., and Barabasi, A.L. Functional and topological characterization of protein interaction networks. Proteomics 4, 928, 2004.
    • (2004) Proteomics , vol.4 , pp. 928
    • Yook, S.H.1    Oltvai, Z.N.2    Barabasi, A.L.3
  • 89
    • 0141483011 scopus 로고    scopus 로고
    • Redirecting tyrosine kinase signaling to an ap-optotic caspase pathway through chimeric adaptor proteins
    • Howard, P.L., Chia, M.C., Del Rizzo, S., Liu, F.F., and Pawson, T. Redirecting tyrosine kinase signaling to an ap-optotic caspase pathway through chimeric adaptor proteins. Proc Natl Acad Sci USA 100, 11267, 2003.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11267
    • Howard, P.L.1    Chia, M.C.2    Del Rizzo, S.3    Liu, F.F.4    Pawson, T.5
  • 91
    • 0037706944 scopus 로고    scopus 로고
    • Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate
    • Kumar, M., Jordan, N., Melton, D., and Grapin-Botton, A. Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate. Dev Biol 259, 109, 2003.
    • (2003) Dev Biol , vol.259 , pp. 109
    • Kumar, M.1    Jordan, N.2    Melton, D.3    Grapin-Botton, A.4
  • 92
    • 0035072545 scopus 로고    scopus 로고
    • A bipotential precursor population for pancreas and liver within the embryonic endoderm
    • Deutsch, G., Jung, J.N., Zheng, M.H., Lora, J., and Zaret, K.S. A bipotential precursor population for pancreas and liver within the embryonic endoderm. Development 128, 871, 2001.
    • (2001) Development , vol.128 , pp. 871
    • Deutsch, G.1    Jung, J.N.2    Zheng, M.H.3    Lora, J.4    Zaret, K.S.5
  • 95
    • 0032995893 scopus 로고    scopus 로고
    • Formation of a primitive ectoderm like cell population, EPL cells, from ES cells in response to biologically derived factors
    • Rathjen, J., Lake, J.A., Bettess, M.D., Washington, J.M., Chapman, G., and Rathjen, P.D. Formation of a primitive ectoderm like cell population, EPL cells, from ES cells in response to biologically derived factors. J Cell Sci 112, 601, 1999.
    • (1999) J Cell Sci , vol.112 , pp. 601
    • Rathjen, J.1    Lake, J.A.2    Bettess, M.D.3    Washington, J.M.4    Chapman, G.5    Rathjen, P.D.6
  • 96
    • 0033998971 scopus 로고    scopus 로고
    • Reversible programming of pluripotent cell differentiation
    • Lake, J.A., Rathjen, J., Remiszewski, J., and Rathjen, P.D. Reversible programming of pluripotent cell differentiation. J Cell Sci 113, 555, 2000.
    • (2000) J Cell Sci , vol.113 , pp. 555
    • Lake, J.A.1    Rathjen, J.2    Remiszewski, J.3    Rathjen, P.D.4
  • 98
    • 1642474003 scopus 로고    scopus 로고
    • Global expression analysis of gene regulatory pathways during endocrine pancreatic development
    • Gu, G.Q., Wells, J.M., Dombkowski, D., Preffer, F., Ar-onow, B., and Melton, D.A. Global expression analysis of gene regulatory pathways during endocrine pancreatic development. Development 131, 165, 2004.
    • (2004) Development , vol.131 , pp. 165
    • Gu, G.Q.1    Wells, J.M.2    Dombkowski, D.3    Preffer, F.4    Ar-Onow, B.5    Melton, D.A.6
  • 99
    • 6244256053 scopus 로고
    • Bmpr encodes a type i bone morphogenetic protein receptor that is essential for gastrulation during mouse em-bryogenesis
    • Mishina, Y., Suzuki, A., Ueno, N., and Behringer, R.R. Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse em-bryogenesis. Gene Dev 9, 3027, 1995.
    • (1995) Gene Dev , vol.9 , pp. 3027
    • Mishina, Y.1    Suzuki, A.2    Ueno, N.3    Behringer, R.R.4
  • 101
    • 0037941585 scopus 로고    scopus 로고
    • Module networks: Identifying regulatory modules and their condition-specific regulators from gene expression data
    • Segal, E., Shapira, M., Regev, A., Pe'er, D., Botstein, D., Koller, D., and Friedman, N. Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data. Nat Genet 34, 166, 2003.
    • (2003) Nat Genet , vol.34 , pp. 166
    • Segal, E.1    Shapira, M.2    Regev, A.3    Pe'Er, D.4    Botstein, D.5    Koller, D.6    Friedman, N.7
  • 103
    • 0035112448 scopus 로고    scopus 로고
    • Key events of pancreas formation are triggered in gut endo-derm by ectopic expression of pancreatic regulatory genes
    • Grapin-Botton, A., Majithia, A.R., and Melton, D.A. Key events of pancreas formation are triggered in gut endo-derm by ectopic expression of pancreatic regulatory genes. Gene Dev 15, 444, 2001.
    • (2001) Gene Dev , vol.15 , pp. 444
    • Grapin-Botton, A.1    Majithia, A.R.2    Melton, D.A.3
  • 104
    • 0035913986 scopus 로고    scopus 로고
    • Induction of pancreatic differentiation by signals from blood vessels
    • Lammert, E., Cleaver, O., and Melton, D. Induction of pancreatic differentiation by signals from blood vessels. Science 294, 564, 2001.
    • (2001) Science , vol.294 , pp. 564
    • Lammert, E.1    Cleaver, O.2    Melton, D.3
  • 105
    • 1342263524 scopus 로고    scopus 로고
    • Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a
    • Yoshitomi, H., and Zaret, K.S. Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a. Development 131, 807, 2004.
    • (2004) Development , vol.131 , pp. 807
    • Yoshitomi, H.1    Zaret, K.S.2
  • 106
    • 0028245030 scopus 로고
    • 2+ and insulin release in glucose-stimulated pancreatic-islets
    • Bergsten, P., Grapengiesser, E., Gylfe, E., Tengholm, A., and Hellman, B. Synchronous oscillations of cytoplasmic Ca2+ and insulin release in glucose-stimulated pancreatic-islets. J Biol Chem 269, 8749, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 8749
    • Bergsten, P.1    Grapengiesser, E.2    Gylfe, E.3    Tengholm, A.4    Hellman, B.5
  • 108
    • 71849110175 scopus 로고    scopus 로고
    • Modularity in development and why it matters to devo-evo
    • Bolker, J.A. Modularity in development and why it matters to devo-evo. Am Zool 39, 108A, 1999.
    • (1999) Am Zool , vol.39 A , pp. 108
    • Bolker, J.A.1
  • 110
    • 0012651592 scopus 로고
    • Technological paradigms and technological trajectories-a suggested interpretation of the determinants and directions of technical change
    • Dosi, G. Technological paradigms and technological trajectories-a suggested interpretation of the determinants and directions of technical change. Res Pol 11, 147, 1982.
    • (1982) Res Pol , vol.11 , pp. 147
    • Dosi, G.1


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