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Volumn 48, Issue 2, 2011, Pages 171-181

Bone tissue engineering bioreactors: Dynamic culture and the influence of shear stress

Author keywords

Bioreactor; Perfusion; Rotating wall; Shear stress; Spinner flask; Tissue engineering

Indexed keywords

TISSUE SCAFFOLD;

EID: 78650976757     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2010.09.138     Document Type: Review
Times cited : (247)

References (99)
  • 2
    • 0036278406 scopus 로고    scopus 로고
    • What's new in orthopaedic surgery
    • Gitelis S., Saiz P. What's new in orthopaedic surgery. J Am Coll Surg 2002, 194:788-791.
    • (2002) J Am Coll Surg , vol.194 , pp. 788-791
    • Gitelis, S.1    Saiz, P.2
  • 3
    • 21244472361 scopus 로고    scopus 로고
    • Tissue engineering strategies for bone regeneration
    • Mistry A.S., Mikos A.G. Tissue engineering strategies for bone regeneration. Adv Biochem Eng Biotechnol 2005, 94:1-22.
    • (2005) Adv Biochem Eng Biotechnol , vol.94 , pp. 1-22
    • Mistry, A.S.1    Mikos, A.G.2
  • 4
    • 0033649024 scopus 로고    scopus 로고
    • Tissue engineering
    • Langer R. Tissue engineering. Mol Ther 2000, 1:12-15.
    • (2000) Mol Ther , vol.1 , pp. 12-15
    • Langer, R.1
  • 6
    • 34848863384 scopus 로고    scopus 로고
    • Adult mesenchymal stem cells for tissue engineering versus regenerative medicine
    • Caplan A.I. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J Cell Physiol 2007, 213:341-347.
    • (2007) J Cell Physiol , vol.213 , pp. 341-347
    • Caplan, A.I.1
  • 7
    • 33847262631 scopus 로고    scopus 로고
    • Flow perfusion improves seeding of tissue engineering scaffolds with different architectures
    • Alvarez-Barreto J.F., Linehan S.M., Shambaugh R.L., Sikavitsas V.I. Flow perfusion improves seeding of tissue engineering scaffolds with different architectures. Ann Biomed Eng 2007, 35:429-442.
    • (2007) Ann Biomed Eng , vol.35 , pp. 429-442
    • Alvarez-Barreto, J.F.1    Linehan, S.M.2    Shambaugh, R.L.3    Sikavitsas, V.I.4
  • 8
    • 34547943045 scopus 로고    scopus 로고
    • Improved mesenchymal stem cell seeding on RGD-modified poly(l-lactic acid) scaffolds using flow perfusion
    • Alvarez-Barreto J.F., Sikavitsas V.I. Improved mesenchymal stem cell seeding on RGD-modified poly(l-lactic acid) scaffolds using flow perfusion. Macromol Biosci 2007, 7:579-588.
    • (2007) Macromol Biosci , vol.7 , pp. 579-588
    • Alvarez-Barreto, J.F.1    Sikavitsas, V.I.2
  • 9
    • 0141596127 scopus 로고    scopus 로고
    • Oscillating perfusion of cell suspensions through three-dimensional scaffolds enhances cell seeding efficiency and uniformity
    • Wendt D., Marsano A., Jakob M., Heberer M., Martin I. Oscillating perfusion of cell suspensions through three-dimensional scaffolds enhances cell seeding efficiency and uniformity. Biotechnol Bioeng 2003, 84:205-214.
    • (2003) Biotechnol Bioeng , vol.84 , pp. 205-214
    • Wendt, D.1    Marsano, A.2    Jakob, M.3    Heberer, M.4    Martin, I.5
  • 10
    • 54949104711 scopus 로고    scopus 로고
    • Effects of initial seeding density and fluid perfusion rate on formation of tissue-engineered bone
    • Grayson W.L., Bhumiratana S., Cannizzaro C., Chao P.H.G., Lennon D.P., Caplan A.I., et al. Effects of initial seeding density and fluid perfusion rate on formation of tissue-engineered bone. Tissue Eng A 2008, 14:1809-1820.
    • (2008) Tissue Eng A , vol.14 , pp. 1809-1820
    • Grayson, W.L.1    Bhumiratana, S.2    Cannizzaro, C.3    Chao, P.H.G.4    Lennon, D.P.5    Caplan, A.I.6
  • 11
    • 33751327351 scopus 로고    scopus 로고
    • Mesenchymal stem cell ingrowth and differentiation on coralline hydroxyapatite scaffolds
    • Mygind T., Stiehler M., Baatrup A., Li H., Zoua X., Flyvbjerg A., et al. Mesenchymal stem cell ingrowth and differentiation on coralline hydroxyapatite scaffolds. Biomaterials 2007, 28:1036-1047.
    • (2007) Biomaterials , vol.28 , pp. 1036-1047
    • Mygind, T.1    Stiehler, M.2    Baatrup, A.3    Li, H.4    Zoua, X.5    Flyvbjerg, A.6
  • 12
    • 1042301245 scopus 로고    scopus 로고
    • In vivo bone tissue engineering using mesenchymal stem cells on a novel electrospun nanofibrous scaffold
    • Shin M., Yoshimoto H., Vacanti J.P. In vivo bone tissue engineering using mesenchymal stem cells on a novel electrospun nanofibrous scaffold. Tissue Eng 2004, 10:33-41.
    • (2004) Tissue Eng , vol.10 , pp. 33-41
    • Shin, M.1    Yoshimoto, H.2    Vacanti, J.P.3
  • 13
    • 75749099718 scopus 로고    scopus 로고
    • Proliferation and osteogenesis of immortalized bone marrow-derived mesenchymal stem cells in porous polylactic glycolic acid scaffolds under perfusion culture
    • Yang J.F., Cao C., Wang W., Tong X.M., Shi D.Y., Wu F.B., et al. Proliferation and osteogenesis of immortalized bone marrow-derived mesenchymal stem cells in porous polylactic glycolic acid scaffolds under perfusion culture. J Biomed Mater Res A 2010, 92A:817-829.
    • (2010) J Biomed Mater Res A , vol.92 A , pp. 817-829
    • Yang, J.F.1    Cao, C.2    Wang, W.3    Tong, X.M.4    Shi, D.Y.5    Wu, F.B.6
  • 14
    • 0036791972 scopus 로고    scopus 로고
    • Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteloblasts in a dose-dependent manner
    • Bancroft G.N., Sikavitsast V.I., van den Dolder J., Sheffield T.L., Ambrose C.G., Jansen J.A., et al. Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteloblasts in a dose-dependent manner. Proc Natl Acad Sci U S A 2002, 99:12600-12605.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 12600-12605
    • Bancroft, G.N.1    Sikavitsast, V.I.2    van den Dolder, J.3    Sheffield, T.L.4    Ambrose, C.G.5    Jansen, J.A.6
  • 15
    • 33644517215 scopus 로고    scopus 로고
    • In vitro generated extracellular matrix and fluid shear stress synergistically enhance 3D osteoblastic differentiation
    • Datta N., Pham Q.P., Sharma U., Sikavitsas V.I., Jansen J.A., Mikos A.G. In vitro generated extracellular matrix and fluid shear stress synergistically enhance 3D osteoblastic differentiation. Proc Natl Acad Sci U S A 2006, 103:2488-2493.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 2488-2493
    • Datta, N.1    Pham, Q.P.2    Sharma, U.3    Sikavitsas, V.I.4    Jansen, J.A.5    Mikos, A.G.6
  • 18
    • 0345598939 scopus 로고    scopus 로고
    • Mineralized matrix deposition by marrow stromal osteoblasts in 3D perfusion culture increases with increasing fluid shear forces
    • Sikavitsas V.I., Bancroft G.N., Holtorf H.L., Jansen J.A., Mikos A.G. Mineralized matrix deposition by marrow stromal osteoblasts in 3D perfusion culture increases with increasing fluid shear forces. Proc Natl Acad Sci U S A 2003, 100:14683-14688.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 14683-14688
    • Sikavitsas, V.I.1    Bancroft, G.N.2    Holtorf, H.L.3    Jansen, J.A.4    Mikos, A.G.5
  • 19
    • 17044418448 scopus 로고    scopus 로고
    • Flow perfusion enhances the calcified matrix deposition of marrow stromal cells in biodegradable nonwoven fiber mesh scaffolds
    • Sikavitsas V.I., Bancroft G.N., Lemoine J.J., Liebschner M.A.K., Dauner M., Mikos A.G. Flow perfusion enhances the calcified matrix deposition of marrow stromal cells in biodegradable nonwoven fiber mesh scaffolds. Ann Biomed Eng 2005, 33:63-70.
    • (2005) Ann Biomed Eng , vol.33 , pp. 63-70
    • Sikavitsas, V.I.1    Bancroft, G.N.2    Lemoine, J.J.3    Liebschner, M.A.K.4    Dauner, M.5    Mikos, A.G.6
  • 20
    • 31844451096 scopus 로고    scopus 로고
    • Uniform tissues engineered by seeding and culturing cells in 3D scaffolds under perfusion at defined oxygen tensions
    • Wendt D., Stroebel S., Jakob M., John G.T., Martin I. Uniform tissues engineered by seeding and culturing cells in 3D scaffolds under perfusion at defined oxygen tensions. Biorheology 2006, 43:481-488.
    • (2006) Biorheology , vol.43 , pp. 481-488
    • Wendt, D.1    Stroebel, S.2    Jakob, M.3    John, G.T.4    Martin, I.5
  • 22
    • 2942588974 scopus 로고    scopus 로고
    • Bone tissue engineering using human mesenchymal stem cells: effects of scaffold material and medium flow
    • Meinel L., Karageorgiou V., Fajardo R., Snyder B., Shinde-Patil V., Zichner L., et al. Bone tissue engineering using human mesenchymal stem cells: effects of scaffold material and medium flow. Ann Biomed Eng 2004, 32:112-122.
    • (2004) Ann Biomed Eng , vol.32 , pp. 112-122
    • Meinel, L.1    Karageorgiou, V.2    Fajardo, R.3    Snyder, B.4    Shinde-Patil, V.5    Zichner, L.6
  • 23
    • 62249103678 scopus 로고    scopus 로고
    • Effect of dynamic 3-D culture on proliferation, distribution, and osteogenic differentiation of human mesenchymal stem cells
    • Stiehler M., Bunger C., Baatrup A., Lind M., Kassem M., Mygind T. Effect of dynamic 3-D culture on proliferation, distribution, and osteogenic differentiation of human mesenchymal stem cells. J Biomed Mater Res A 2009, 89A:96-107.
    • (2009) J Biomed Mater Res A , vol.89 A , pp. 96-107
    • Stiehler, M.1    Bunger, C.2    Baatrup, A.3    Lind, M.4    Kassem, M.5    Mygind, T.6
  • 24
    • 60349102755 scopus 로고    scopus 로고
    • Regulation of adult human mesenchymal stem cells into osteogenic and chondrogenic lineages by different bioreactor systems
    • Wang T.W., Wu H.C., Wang H.Y., Lin F.H., Sun J.S. Regulation of adult human mesenchymal stem cells into osteogenic and chondrogenic lineages by different bioreactor systems. J Biomed Mater Res A 2009, 88A:935-946.
    • (2009) J Biomed Mater Res A , vol.88 A , pp. 935-946
    • Wang, T.W.1    Wu, H.C.2    Wang, H.Y.3    Lin, F.H.4    Sun, J.S.5
  • 25
    • 3843112154 scopus 로고    scopus 로고
    • Bioreactor-based bone tissue engineering: the influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization
    • Yu X.J., Botchwey E.A., Levine E.M., Pollack S.R., Laurencin C.T. Bioreactor-based bone tissue engineering: the influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization. Proc Natl Acad Sci U S A 2004, 101:11203-11208.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 11203-11208
    • Yu, X.J.1    Botchwey, E.A.2    Levine, E.M.3    Pollack, S.R.4    Laurencin, C.T.5
  • 26
    • 61849156328 scopus 로고    scopus 로고
    • A biaxial rotating bioreactor for the culture of fetal mesenchymal stem cells for bone tissue engineering
    • Zhang Z.Y., Teoh S.H., Chong W.S., Foo T.T., Chng Y.C., Choolani M., et al. A biaxial rotating bioreactor for the culture of fetal mesenchymal stem cells for bone tissue engineering. Biomaterials 2009, 30:2694-2704.
    • (2009) Biomaterials , vol.30 , pp. 2694-2704
    • Zhang, Z.Y.1    Teoh, S.H.2    Chong, W.S.3    Foo, T.T.4    Chng, Y.C.5    Choolani, M.6
  • 27
    • 0037937606 scopus 로고    scopus 로고
    • Design of a flow perfusion bioreactor system for bone tissue-engineering applications
    • Bancroft G.N., Sikavitsas V.I., Mikos A.G. Design of a flow perfusion bioreactor system for bone tissue-engineering applications. Tissue Eng 2003, 9:549-554.
    • (2003) Tissue Eng , vol.9 , pp. 549-554
    • Bancroft, G.N.1    Sikavitsas, V.I.2    Mikos, A.G.3
  • 28
    • 0344306513 scopus 로고    scopus 로고
    • Effect of flow perfusion on the osteogenic differentiation of bone marrow stromal cells cultured on starch-based three-dimensional scaffolds
    • Gomes M.E., Sikavitsas V.I., Behravesh E., Reis R.L., Mikos A.G. Effect of flow perfusion on the osteogenic differentiation of bone marrow stromal cells cultured on starch-based three-dimensional scaffolds. J Biomed Mater Res A 2003, 67A:87-95.
    • (2003) J Biomed Mater Res A , vol.67 A , pp. 87-95
    • Gomes, M.E.1    Sikavitsas, V.I.2    Behravesh, E.3    Reis, R.L.4    Mikos, A.G.5
  • 29
    • 13944270566 scopus 로고    scopus 로고
    • Flow perfusion culture induces the osteoblastic differentiation of marrow stromal cell-scaffold constructs in the absence of dexamethasone
    • Holtorf H.L., Jansen J.A., Mikos A.G. Flow perfusion culture induces the osteoblastic differentiation of marrow stromal cell-scaffold constructs in the absence of dexamethasone. J Biomed Mater Res A 2005, 72A:326-334.
    • (2005) J Biomed Mater Res A , vol.72 A , pp. 326-334
    • Holtorf, H.L.1    Jansen, J.A.2    Mikos, A.G.3
  • 30
    • 26844480409 scopus 로고    scopus 로고
    • A perfusion bioreactor system capable of producing clinically relevant volumes of tissue-engineered bone: in vivo bone formation showing proof of concept
    • Janssen F.W., Oostra J., van Oorschot A., van Blitterswijk C.A. A perfusion bioreactor system capable of producing clinically relevant volumes of tissue-engineered bone: in vivo bone formation showing proof of concept. Biomaterials 2006, 27:315-323.
    • (2006) Biomaterials , vol.27 , pp. 315-323
    • Janssen, F.W.1    Oostra, J.2    van Oorschot, A.3    van Blitterswijk, C.A.4
  • 31
    • 33846928754 scopus 로고    scopus 로고
    • Effects of shear stress on 3-D human mesenchymal stem cell construct development in a perfusion bioreactor system: experiments and hydrodynamic modeling
    • Zhao F., Chella R., Ma T. Effects of shear stress on 3-D human mesenchymal stem cell construct development in a perfusion bioreactor system: experiments and hydrodynamic modeling. Biotechnol Bioeng 2007, 96:584-595.
    • (2007) Biotechnol Bioeng , vol.96 , pp. 584-595
    • Zhao, F.1    Chella, R.2    Ma, T.3
  • 32
    • 33750937779 scopus 로고    scopus 로고
    • Bioreactors for tissue engineering: focus on mechanical constraints. A comparative review
    • Bilodeau K., Mantovani D. Bioreactors for tissue engineering: focus on mechanical constraints. A comparative review. Tissue Eng 2006, 12:2367-2383.
    • (2006) Tissue Eng , vol.12 , pp. 2367-2383
    • Bilodeau, K.1    Mantovani, D.2
  • 34
    • 33344455592 scopus 로고    scopus 로고
    • Molecular pathways mediating mechanical signaling in bone
    • Rubin J., Rubin C., Jacobs C.R. Molecular pathways mediating mechanical signaling in bone. Gene 2006, 367:1-16.
    • (2006) Gene , vol.367 , pp. 1-16
    • Rubin, J.1    Rubin, C.2    Jacobs, C.R.3
  • 35
    • 0028386524 scopus 로고
    • A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses
    • Weinbaum S., Cowin S.C., Zeng Y. A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses. J Biomech 1994, 27:339-360.
    • (1994) J Biomech , vol.27 , pp. 339-360
    • Weinbaum, S.1    Cowin, S.C.2    Zeng, Y.3
  • 37
    • 0037345529 scopus 로고    scopus 로고
    • Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways
    • Kapur S., Baylink D.J., Lau K.H.W. Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways. Bone 2003, 32:241-251.
    • (2003) Bone , vol.32 , pp. 241-251
    • Kapur, S.1    Baylink, D.J.2    Lau, K.H.W.3
  • 38
    • 20444389065 scopus 로고    scopus 로고
    • Fluid flow stimulates expression of osteopontin and bone sialoprotein by bone marrow stromal cells in a temporally dependent manner
    • Kreke M.R., Huckle W.R., Goldstein A.S. Fluid flow stimulates expression of osteopontin and bone sialoprotein by bone marrow stromal cells in a temporally dependent manner. Bone 2005, 36:1047-1055.
    • (2005) Bone , vol.36 , pp. 1047-1055
    • Kreke, M.R.1    Huckle, W.R.2    Goldstein, A.S.3
  • 39
    • 42049100497 scopus 로고    scopus 로고
    • Effect of intermittent shear stress on mechanotransductive signaling and osteoblastic differentiation of bone marrow stromal cells
    • Kreke M.R., Sharp L.A., Lee Y.W., Goldstein A.S. Effect of intermittent shear stress on mechanotransductive signaling and osteoblastic differentiation of bone marrow stromal cells. Tissue Eng A 2008, 14:529-537.
    • (2008) Tissue Eng A , vol.14 , pp. 529-537
    • Kreke, M.R.1    Sharp, L.A.2    Lee, Y.W.3    Goldstein, A.S.4
  • 40
    • 41549164762 scopus 로고    scopus 로고
    • Design of bioreactors for mesenchymal stem cell tissue engineering
    • Godara P., McFarland C.D., Nordon R.E. Design of bioreactors for mesenchymal stem cell tissue engineering. J Chem Technol Biotechnol 2008, 83:408-420.
    • (2008) J Chem Technol Biotechnol , vol.83 , pp. 408-420
    • Godara, P.1    McFarland, C.D.2    Nordon, R.E.3
  • 41
    • 0036323143 scopus 로고    scopus 로고
    • Formation of three-dimensional cell/polymer constructs for bone tissue engineering in a spinner flask and a rotating wall vessel bioreactor
    • Sikavitsas V.I., Bancroft G.N., Mikos A.G. Formation of three-dimensional cell/polymer constructs for bone tissue engineering in a spinner flask and a rotating wall vessel bioreactor. J Biomed Mater Res 2002, 62:136-148.
    • (2002) J Biomed Mater Res , vol.62 , pp. 136-148
    • Sikavitsas, V.I.1    Bancroft, G.N.2    Mikos, A.G.3
  • 43
    • 38349179178 scopus 로고    scopus 로고
    • Proliferation, osteogenic differentiation, and distribution of rat bone marrow stromal cells in nonwoven fabrics by different culture methods
    • Ichinohe N., Takamoto T., Tabata Y. Proliferation, osteogenic differentiation, and distribution of rat bone marrow stromal cells in nonwoven fabrics by different culture methods. Tissue Eng A 2008, 14:107-116.
    • (2008) Tissue Eng A , vol.14 , pp. 107-116
    • Ichinohe, N.1    Takamoto, T.2    Tabata, Y.3
  • 44
    • 27744502341 scopus 로고    scopus 로고
    • Perfusion culture enhances osteogenic differentiation of rat mesenchymal stem cells in collagen sponge reinforced with poly( glycolic acid) fiber
    • Hosseinkhani H., Inatsugu Y., Hiraoka Y., Inoue S., Tabata Y. Perfusion culture enhances osteogenic differentiation of rat mesenchymal stem cells in collagen sponge reinforced with poly( glycolic acid) fiber. Tissue Eng 2005, 11:1476-1488.
    • (2005) Tissue Eng , vol.11 , pp. 1476-1488
    • Hosseinkhani, H.1    Inatsugu, Y.2    Hiraoka, Y.3    Inoue, S.4    Tabata, Y.5
  • 45
    • 0035372005 scopus 로고    scopus 로고
    • Effect of convection on osteoblastic cell growth and function in biodegradable polymer foam scaffolds
    • Goldstein A.S., Juarez T.M., Helmke C.D., Gustin M.C., Mikos A.G. Effect of convection on osteoblastic cell growth and function in biodegradable polymer foam scaffolds. Biomaterials 2001, 22:1279-1288.
    • (2001) Biomaterials , vol.22 , pp. 1279-1288
    • Goldstein, A.S.1    Juarez, T.M.2    Helmke, C.D.3    Gustin, M.C.4    Mikos, A.G.5
  • 46
    • 0035089668 scopus 로고    scopus 로고
    • Bone tissue engineering in a rotating bioreactor using a microcarrier matrix system
    • Botchwey E.A., Pollack S.R., Levine E.M., Laurencin C.T. Bone tissue engineering in a rotating bioreactor using a microcarrier matrix system. J Biomed Mater Res 2001, 55:242-253.
    • (2001) J Biomed Mater Res , vol.55 , pp. 242-253
    • Botchwey, E.A.1    Pollack, S.R.2    Levine, E.M.3    Laurencin, C.T.4
  • 48
    • 1842629581 scopus 로고    scopus 로고
    • Quantitative analysis of three-dimensional fluid flow in rotating bioreactors for tissue engineering
    • Botchwey E.A., Pollack S.R., Levine E.M., Johnston E.D., Laurencin C.T. Quantitative analysis of three-dimensional fluid flow in rotating bioreactors for tissue engineering. J Biomed Mater Res A 2004, 69A:205-215.
    • (2004) J Biomed Mater Res A , vol.69 A , pp. 205-215
    • Botchwey, E.A.1    Pollack, S.R.2    Levine, E.M.3    Johnston, E.D.4    Laurencin, C.T.5
  • 49
    • 0037205360 scopus 로고    scopus 로고
    • In vitro engineering of bone using a rotational oxygen-permeable bioreactor system
    • Terai H., Hannouche D., Ochoa E., Yamano Y., Vacanti J.P. In vitro engineering of bone using a rotational oxygen-permeable bioreactor system. Mater Sci Eng 2002, 20:3-8.
    • (2002) Mater Sci Eng , vol.20 , pp. 3-8
    • Terai, H.1    Hannouche, D.2    Ochoa, E.3    Yamano, Y.4    Vacanti, J.P.5
  • 50
    • 0037400540 scopus 로고    scopus 로고
    • A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering
    • Yoshimoto H., Shin Y.M., Terai H., Vacanti J.P. A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. Biomaterials 2003, 24:2077-2082.
    • (2003) Biomaterials , vol.24 , pp. 2077-2082
    • Yoshimoto, H.1    Shin, Y.M.2    Terai, H.3    Vacanti, J.P.4
  • 51
    • 47049105384 scopus 로고    scopus 로고
    • Three-dimensional fabrication of engineered bone with human bio-derived bone scaffolds in a rotating wall vessel bioreactor
    • Song K.D., Liu T.Q., Cui Z.F., Li X.Q., Ma X.H. Three-dimensional fabrication of engineered bone with human bio-derived bone scaffolds in a rotating wall vessel bioreactor. J Biomed Mater Res A 2008, 86A:323-332.
    • (2008) J Biomed Mater Res A , vol.86 A , pp. 323-332
    • Song, K.D.1    Liu, T.Q.2    Cui, Z.F.3    Li, X.Q.4    Ma, X.H.5
  • 52
    • 0345015415 scopus 로고    scopus 로고
    • Effects of medium perfusion rate on cell-seeded three-dimensional bone constructs in vitro
    • Cartmell S.H., Porter B.D., Garcia A.J., Guldberg R.E. Effects of medium perfusion rate on cell-seeded three-dimensional bone constructs in vitro. Tissue Eng 2003, 9:1197-1203.
    • (2003) Tissue Eng , vol.9 , pp. 1197-1203
    • Cartmell, S.H.1    Porter, B.D.2    Garcia, A.J.3    Guldberg, R.E.4
  • 53
    • 33745288735 scopus 로고    scopus 로고
    • Ectopic bone formation in collagen sponge self-assembled peptide-amphiphile nanofibers hybrid scaffold in a perfusion culture bioreactor
    • Hosseinkhani H., Hosseinkhani M., Tian F., Kobayashi H., Tabata Y. Ectopic bone formation in collagen sponge self-assembled peptide-amphiphile nanofibers hybrid scaffold in a perfusion culture bioreactor. Biomaterials 2006, 27:5089-5098.
    • (2006) Biomaterials , vol.27 , pp. 5089-5098
    • Hosseinkhani, H.1    Hosseinkhani, M.2    Tian, F.3    Kobayashi, H.4    Tabata, Y.5
  • 54
    • 27744545675 scopus 로고    scopus 로고
    • Impregnation of plasmid DNA into three-dimensional scaffolds and medium perfusion enhance in vitro DNA expression of mesenchymal stem cells
    • Hosseinkhani H., Inatsugu Y., Hiraoka Y., Inoue S., Shimokawa H., Tabata Y. Impregnation of plasmid DNA into three-dimensional scaffolds and medium perfusion enhance in vitro DNA expression of mesenchymal stem cells. Tissue Eng 2005, 11:1459-1475.
    • (2005) Tissue Eng , vol.11 , pp. 1459-1475
    • Hosseinkhani, H.1    Inatsugu, Y.2    Hiraoka, Y.3    Inoue, S.4    Shimokawa, H.5    Tabata, Y.6
  • 55
    • 28444487378 scopus 로고    scopus 로고
    • Enhanced ectopic bone formation using a combination of plasmid DNA impregnation into 3-D scaffold and bioreactor perfusion culture
    • Hosseinkhani H., Yamamoto M., Inatsugu Y., Hiraoka Y., Inoue S., Shimokawa H., et al. Enhanced ectopic bone formation using a combination of plasmid DNA impregnation into 3-D scaffold and bioreactor perfusion culture. Biomaterials 2006, 27:1387-1398.
    • (2006) Biomaterials , vol.27 , pp. 1387-1398
    • Hosseinkhani, H.1    Yamamoto, M.2    Inatsugu, Y.3    Hiraoka, Y.4    Inoue, S.5    Shimokawa, H.6
  • 56
    • 0036791972 scopus 로고    scopus 로고
    • Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner
    • Bancroft G.N., Sikavitsas V.I., van den Dolder J., Sheffield T.L., Ambrose C.G., Jansen J.A., et al. Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner. Proc Natl Acad Sci U S A 2002, 99:12600-12605.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 12600-12605
    • Bancroft, G.N.1    Sikavitsas, V.I.2    van den Dolder, J.3    Sheffield, T.L.4    Ambrose, C.G.5    Jansen, J.A.6
  • 57
    • 33646558911 scopus 로고    scopus 로고
    • Influence of the porosity of starch-based fiber mesh scaffolds on the proliferation and osteogenic differentiation of bone marrow stromal cells cultured in a flow perfusion bioreactor
    • Gomes M.E., Holtorf H.L., Reis R.L., Mikos A.G. Influence of the porosity of starch-based fiber mesh scaffolds on the proliferation and osteogenic differentiation of bone marrow stromal cells cultured in a flow perfusion bioreactor. Tissue Eng 2006, 12:801-809.
    • (2006) Tissue Eng , vol.12 , pp. 801-809
    • Gomes, M.E.1    Holtorf, H.L.2    Reis, R.L.3    Mikos, A.G.4
  • 58
    • 24144472548 scopus 로고    scopus 로고
    • Flow perfusion culture of marrow stromal cells seeded on porous biphasic calcium phosphate ceramics
    • Holtorf H.L., Sheffield T.L., Ambrose C.G., Jansen J.A., Mikos A.G. Flow perfusion culture of marrow stromal cells seeded on porous biphasic calcium phosphate ceramics. Ann Biomed Eng 2005, 33:1238-1248.
    • (2005) Ann Biomed Eng , vol.33 , pp. 1238-1248
    • Holtorf, H.L.1    Sheffield, T.L.2    Ambrose, C.G.3    Jansen, J.A.4    Mikos, A.G.5
  • 59
    • 41849128809 scopus 로고    scopus 로고
    • Flow perfusion culture of human mesenchymal stem cells on silicate-substituted tricalcium phosphate scaffolds
    • Bjerre L., Bunger C.E., Kassem M., Mygind T. Flow perfusion culture of human mesenchymal stem cells on silicate-substituted tricalcium phosphate scaffolds. Biomaterials 2008, 29:2616-2627.
    • (2008) Biomaterials , vol.29 , pp. 2616-2627
    • Bjerre, L.1    Bunger, C.E.2    Kassem, M.3    Mygind, T.4
  • 60
    • 34249945567 scopus 로고    scopus 로고
    • Bone tissue engineering constructs based on starch scaffolds and bone marrow cells cultured in a flow perfusion bioreactor
    • Gomes M.E., Reis R.L., Mikos A.G. Bone tissue engineering constructs based on starch scaffolds and bone marrow cells cultured in a flow perfusion bioreactor. Advanced Materials Forum Iii, Pts 1 and 2 2006, 514-516:980-984.
    • (2006) Advanced Materials Forum Iii, Pts 1 and 2 , vol.514-516 , pp. 980-984
    • Gomes, M.E.1    Reis, R.L.2    Mikos, A.G.3
  • 61
    • 77957309354 scopus 로고    scopus 로고
    • Stereolithographic bone scaffold design parameters: osteogenic differentiation and signal expression
    • Kim K, Yeatts A, Dean D, Fisher JP. Stereolithographic bone scaffold design parameters: osteogenic differentiation and signal expression. Tissue Eng B Rev 2010;16:523-39.
    • (2010) Tissue Eng B Rev , vol.16 , pp. 523-39
    • Kim, K.1    Yeatts, A.2    Dean, D.3    Fisher, J.P.4
  • 62
    • 17844400927 scopus 로고    scopus 로고
    • Porosity of 3D biornaterial scaffolds and osteogenesis
    • Karageorgiou V., Kaplan D. Porosity of 3D biornaterial scaffolds and osteogenesis. Biomaterials 2005, 26:5474-5491.
    • (2005) Biomaterials , vol.26 , pp. 5474-5491
    • Karageorgiou, V.1    Kaplan, D.2
  • 63
    • 33644907150 scopus 로고    scopus 로고
    • In vitro localization of bone growth factors in constructs of biodegradable scaffolds seeded with marrow stromal cells and cultured in a flow perfusion bioreactor
    • Gomes M.E., Bossano C.M., Johnston C.M., Reis R.L., Mikos A.G. In vitro localization of bone growth factors in constructs of biodegradable scaffolds seeded with marrow stromal cells and cultured in a flow perfusion bioreactor. Tissue Eng 2006, 12:177-188.
    • (2006) Tissue Eng , vol.12 , pp. 177-188
    • Gomes, M.E.1    Bossano, C.M.2    Johnston, C.M.3    Reis, R.L.4    Mikos, A.G.5
  • 64
    • 9644255525 scopus 로고    scopus 로고
    • The roles of tissue engineering and vascularisation in the development of micro-vascular networks: a review
    • Kannan R.Y., Salacinski H.J., Sales K., Butler P., Seifalian A.M. The roles of tissue engineering and vascularisation in the development of micro-vascular networks: a review. Biomaterials 2005, 26:1857-1875.
    • (2005) Biomaterials , vol.26 , pp. 1857-1875
    • Kannan, R.Y.1    Salacinski, H.J.2    Sales, K.3    Butler, P.4    Seifalian, A.M.5
  • 66
    • 49349090133 scopus 로고    scopus 로고
    • Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery)
    • Bessa P.C., Casal M., Reis R.L. Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery). J Tissue Eng Regen Med 2008, 2:81-96.
    • (2008) J Tissue Eng Regen Med , vol.2 , pp. 81-96
    • Bessa, P.C.1    Casal, M.2    Reis, R.L.3
  • 67
    • 43949090746 scopus 로고    scopus 로고
    • Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts)
    • Bessa P.C., Casal M., Reis R.L. Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts). J Tissue Eng Regen Med 2008, 2:1-13.
    • (2008) J Tissue Eng Regen Med , vol.2 , pp. 1-13
    • Bessa, P.C.1    Casal, M.2    Reis, R.L.3
  • 72
    • 0035679092 scopus 로고    scopus 로고
    • Extracellular matrix mineralization and osteoblast gene expression by human adipose tissue-derived stromal cells
    • Halvorsen Y.D.C., Franklin D., Bond A.L., Hitt D.C., Auchter C., Boskey A.L., et al. Extracellular matrix mineralization and osteoblast gene expression by human adipose tissue-derived stromal cells. Tissue Eng 2001, 7:729-741.
    • (2001) Tissue Eng , vol.7 , pp. 729-741
    • Halvorsen, Y.D.C.1    Franklin, D.2    Bond, A.L.3    Hitt, D.C.4    Auchter, C.5    Boskey, A.L.6
  • 74
    • 0035067539 scopus 로고    scopus 로고
    • Multilineage cells from human adipose tissue: Implications for cell-based therapies
    • Zuk P.A., Zhu M., Mizuno H., Huang J., Futrell J.W., Katz A.J., et al. Multilineage cells from human adipose tissue: Implications for cell-based therapies. Tissue Eng 2001, 7:211-228.
    • (2001) Tissue Eng , vol.7 , pp. 211-228
    • Zuk, P.A.1    Zhu, M.2    Mizuno, H.3    Huang, J.4    Futrell, J.W.5    Katz, A.J.6
  • 75
    • 33750482958 scopus 로고    scopus 로고
    • Online measurement of oxygen consumption by goat bone marrow stromal cells in a combined cell-seeding and proliferation perfusion bioreactor
    • Janssen F.W., Hofland I., van Oorschot A., Oostra J., Peters H., van Blitterswijk C.A. Online measurement of oxygen consumption by goat bone marrow stromal cells in a combined cell-seeding and proliferation perfusion bioreactor. J Biomed Mater Res A 2006, 79A:338-348.
    • (2006) J Biomed Mater Res A , vol.79 A , pp. 338-348
    • Janssen, F.W.1    Hofland, I.2    van Oorschot, A.3    Oostra, J.4    Peters, H.5    van Blitterswijk, C.A.6
  • 76
    • 25444435416 scopus 로고    scopus 로고
    • Three-dimensional perfusion culture of human bone marrow cells and generation of osteoinductive grafts
    • Braccini A., Wendt D., Jaquiery C., Jakob M., Heberer M., Kenins L., et al. Three-dimensional perfusion culture of human bone marrow cells and generation of osteoinductive grafts. Stem Cells 2005, 23:1066-1072.
    • (2005) Stem Cells , vol.23 , pp. 1066-1072
    • Braccini, A.1    Wendt, D.2    Jaquiery, C.3    Jakob, M.4    Heberer, M.5    Kenins, L.6
  • 77
    • 34548087011 scopus 로고    scopus 로고
    • Three-dimensional cell culture and tissue engineering in a T-CUP (tissue culture under perfusion)
    • Timmins N.E., Scherberich A., Fruh J.A., Heberer M., Martin I., Jakob M. Three-dimensional cell culture and tissue engineering in a T-CUP (tissue culture under perfusion). Tissue Eng 2007, 13:2021-2028.
    • (2007) Tissue Eng , vol.13 , pp. 2021-2028
    • Timmins, N.E.1    Scherberich, A.2    Fruh, J.A.3    Heberer, M.4    Martin, I.5    Jakob, M.6
  • 78
    • 0348015827 scopus 로고    scopus 로고
    • Influence of the in vitro culture period on the in vivo performance of cell/titanium bone tissue-engineered constructs using a rat cranial critical size defect model
    • Sikavitsas V.I., van den Dolder J., Bancroft G.N., Jansen J.A., Mikos A.G. Influence of the in vitro culture period on the in vivo performance of cell/titanium bone tissue-engineered constructs using a rat cranial critical size defect model. J Biomed Mater Res A 2003, 67A:944-951.
    • (2003) J Biomed Mater Res A , vol.67 A , pp. 944-951
    • Sikavitsas, V.I.1    van den Dolder, J.2    Bancroft, G.N.3    Jansen, J.A.4    Mikos, A.G.5
  • 79
    • 47049084249 scopus 로고    scopus 로고
    • Effects of fluid flow and calcium phosphate coating on human bone marrow stromal cells cultured in a defined 2D model system
    • Scaglione S., Wendt D., Miggino S., Papadimitropoulos A., Fato M., Quarto R., et al. Effects of fluid flow and calcium phosphate coating on human bone marrow stromal cells cultured in a defined 2D model system. J Biomed Mater Res A 2008, 86A:411-419.
    • (2008) J Biomed Mater Res A , vol.86 A , pp. 411-419
    • Scaglione, S.1    Wendt, D.2    Miggino, S.3    Papadimitropoulos, A.4    Fato, M.5    Quarto, R.6
  • 80
    • 64549142058 scopus 로고    scopus 로고
    • Can shear stress direct stem cell fate?
    • Stolberg S., McCloskey K.E. Can shear stress direct stem cell fate?. Biotechnol Prog 2009, 25:10-19.
    • (2009) Biotechnol Prog , vol.25 , pp. 10-19
    • Stolberg, S.1    McCloskey, K.E.2
  • 81
    • 53749103124 scopus 로고    scopus 로고
    • Effects of dextran on proliferation and osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells
    • Li D., Dai K., Tang T. Effects of dextran on proliferation and osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells. Cytotherapy 2008, 10:587-596.
    • (2008) Cytotherapy , vol.10 , pp. 587-596
    • Li, D.1    Dai, K.2    Tang, T.3
  • 82
    • 33845947864 scopus 로고    scopus 로고
    • Three-dimensional flow perfusion culture system for stem cell proliferation inside the critical-size beta-tricalcium phosphate scaffold
    • Xie Y.Z., Hardouin P., Zhu Z.N., Tang T.T., Dai K.R., Lu J.X. Three-dimensional flow perfusion culture system for stem cell proliferation inside the critical-size beta-tricalcium phosphate scaffold. Tissue Eng 2006, 12:3535-3543.
    • (2006) Tissue Eng , vol.12 , pp. 3535-3543
    • Xie, Y.Z.1    Hardouin, P.2    Zhu, Z.N.3    Tang, T.T.4    Dai, K.R.5    Lu, J.X.6
  • 83
    • 73349136774 scopus 로고    scopus 로고
    • Effects of flow shear stress and mass transport on the construction of a large-scale tissue-engineered bone in a perfusion bioreactor
    • Li D., Tang T., Lu J., Dai K. Effects of flow shear stress and mass transport on the construction of a large-scale tissue-engineered bone in a perfusion bioreactor. Tissue Eng A 2009, 15:2773-2783.
    • (2009) Tissue Eng A , vol.15 , pp. 2773-2783
    • Li, D.1    Tang, T.2    Lu, J.3    Dai, K.4
  • 84
    • 33847644129 scopus 로고    scopus 로고
    • Noninvasive image analysis of 3D construct mineralization in a perfusion bioreactor
    • Porter B.D., Lin A.S.P., Peister A., Hutmacher D., Guldberg R.E. Noninvasive image analysis of 3D construct mineralization in a perfusion bioreactor. Biomaterials 2007, 28:2525-2533.
    • (2007) Biomaterials , vol.28 , pp. 2525-2533
    • Porter, B.D.1    Lin, A.S.P.2    Peister, A.3    Hutmacher, D.4    Guldberg, R.E.5
  • 85
    • 62149127776 scopus 로고    scopus 로고
    • Perfusion affects the tissue developmental patterns of human mesenchymal stem cells in 3D scaffolds
    • Zhao F., Grayson W.L., Ma T., Irsigler A. Perfusion affects the tissue developmental patterns of human mesenchymal stem cells in 3D scaffolds. J Cell Physiol 2009, 219:421-429.
    • (2009) J Cell Physiol , vol.219 , pp. 421-429
    • Zhao, F.1    Grayson, W.L.2    Ma, T.3    Irsigler, A.4
  • 86
    • 23244452726 scopus 로고    scopus 로고
    • Perfusion bioreactor system for human mesenchymal stem cell tissue engineering: dynamic cell seeding and construct development
    • Zhao F., Ma T. Perfusion bioreactor system for human mesenchymal stem cell tissue engineering: dynamic cell seeding and construct development. Biotechnol Bioeng 2005, 91:482-493.
    • (2005) Biotechnol Bioeng , vol.91 , pp. 482-493
    • Zhao, F.1    Ma, T.2
  • 87
    • 23244434168 scopus 로고    scopus 로고
    • Effects of oxygen transport on 3-D human mesenchymal stem cell metabolic activity in perfusion and static cultures: experiments and mathematical model
    • Zhao F., Pathi P., Grayson W., Xing Q., Locke B.R., Ma T. Effects of oxygen transport on 3-D human mesenchymal stem cell metabolic activity in perfusion and static cultures: experiments and mathematical model. Biotechnol Prog 2005, 21:1269-1280.
    • (2005) Biotechnol Prog , vol.21 , pp. 1269-1280
    • Zhao, F.1    Pathi, P.2    Grayson, W.3    Xing, Q.4    Locke, B.R.5    Ma, T.6
  • 88
    • 0034798881 scopus 로고    scopus 로고
    • Effects of filtration seeding on cell density, spatial distribution, and proliferation in nonwoven fibrous matrices
    • Li Y., Ma T., Kniss D.A., Lasky L.C., Yang S.T. Effects of filtration seeding on cell density, spatial distribution, and proliferation in nonwoven fibrous matrices. Biotechnol Prog 2001, 17:935-944.
    • (2001) Biotechnol Prog , vol.17 , pp. 935-944
    • Li, Y.1    Ma, T.2    Kniss, D.A.3    Lasky, L.C.4    Yang, S.T.5
  • 89
    • 33646052289 scopus 로고    scopus 로고
    • Three-dimensional cell seeding and growth in radial-flow perfusion bioreactor for in vitro tissue reconstruction
    • Kitagawa T., Yamaoka T., Iwase R., Murakami A. Three-dimensional cell seeding and growth in radial-flow perfusion bioreactor for in vitro tissue reconstruction. Biotechnol Bioeng 2006, 93:947-954.
    • (2006) Biotechnol Bioeng , vol.93 , pp. 947-954
    • Kitagawa, T.1    Yamaoka, T.2    Iwase, R.3    Murakami, A.4
  • 92
    • 40849141369 scopus 로고    scopus 로고
    • 3D-cultivation of bone marrow stromal cells on hydroxyapatite scaffolds fabricated by dispense-plotting and negative mould technique
    • Detsch R., Uhl F., Deisinger U., Ziegler G. 3D-cultivation of bone marrow stromal cells on hydroxyapatite scaffolds fabricated by dispense-plotting and negative mould technique. J Mater Sci Mater Med 2008, 19:1491-1496.
    • (2008) J Mater Sci Mater Med , vol.19 , pp. 1491-1496
    • Detsch, R.1    Uhl, F.2    Deisinger, U.3    Ziegler, G.4
  • 95
    • 0037409773 scopus 로고    scopus 로고
    • Transplantation of cultured bone cells using combinations of scaffolds and culture techniques
    • Uemura T., Dong J., Wang Y.C., Kojima H., Saito T., Iejima D., et al. Transplantation of cultured bone cells using combinations of scaffolds and culture techniques. Biomaterials 2003, 24:2277-2286.
    • (2003) Biomaterials , vol.24 , pp. 2277-2286
    • Uemura, T.1    Dong, J.2    Wang, Y.C.3    Kojima, H.4    Saito, T.5    Iejima, D.6
  • 96
    • 0344152914 scopus 로고    scopus 로고
    • Application of perfusion culture system improves in vitro and in vivo osteogenesis of bone marrow-derived osteoblastic cells in porous ceramic materials
    • Wang Y.C., Uemura T., Dong R., Kojima H., Tanaka J., Tateishi T. Application of perfusion culture system improves in vitro and in vivo osteogenesis of bone marrow-derived osteoblastic cells in porous ceramic materials. Tissue Eng 2003, 9:1205-1214.
    • (2003) Tissue Eng , vol.9 , pp. 1205-1214
    • Wang, Y.C.1    Uemura, T.2    Dong, R.3    Kojima, H.4    Tanaka, J.5    Tateishi, T.6
  • 97
    • 34249889846 scopus 로고    scopus 로고
    • Influence of in vitro cultivation on the integration of cell-matrix constructs after subcutaneous implantation
    • Seitz S., Ern K., Lamper G., Docheva D., Drosse I., Milz S., et al. Influence of in vitro cultivation on the integration of cell-matrix constructs after subcutaneous implantation. Tissue Eng 2007, 13:1059-1067.
    • (2007) Tissue Eng , vol.13 , pp. 1059-1067
    • Seitz, S.1    Ern, K.2    Lamper, G.3    Docheva, D.4    Drosse, I.5    Milz, S.6
  • 98
    • 33749188522 scopus 로고    scopus 로고
    • Bioreactor expansion of human adult bone marrow-derived mesenchymal stem cells
    • Chen X., Xu H., Wan C., McCaigue M., Li G. Bioreactor expansion of human adult bone marrow-derived mesenchymal stem cells. Stem Cells 2006, 24:2052-2059.
    • (2006) Stem Cells , vol.24 , pp. 2052-2059
    • Chen, X.1    Xu, H.2    Wan, C.3    McCaigue, M.4    Li, G.5
  • 99
    • 33748973572 scopus 로고    scopus 로고
    • Bone and cartilage tissue constructs grown using human bone marrow stromal cells, silk scaffolds and rotating bioreactors
    • Marolt D., Augst A., Freed L.E., Vepari C., Fajardo R., Patel N., et al. Bone and cartilage tissue constructs grown using human bone marrow stromal cells, silk scaffolds and rotating bioreactors. Biomaterials 2006, 27:6138-6149.
    • (2006) Biomaterials , vol.27 , pp. 6138-6149
    • Marolt, D.1    Augst, A.2    Freed, L.E.3    Vepari, C.4    Fajardo, R.5    Patel, N.6


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