Hypoxia Inhibits Hypertrophic Differentiation and Endochondral Ossification in Explanted Tibiae

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Leijten, Jeroen C H ^a   Moreira Teixeira, Liliana S ^a   Landman, Ellie B M ^a   van Blitterswijk, Clemens A ^a   Karperien, Marcel ^a  

^a UNIVERSITY OF TWENTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE 3; DICKKOPF 1 PROTEIN; GELATINASE B; MESSENGER RNA; OXYGEN; TRANSCRIPTION FACTOR RUNX2;

ACAN GENE; ALPL GENE; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CALCIFICATION; CARTILAGE CELL; CELL DIFFERENTIATION; CELL STIMULATION; CHONDROPATHY; COL10A1 GENE; COL2A1 GENE; CONTROLLED STUDY; DKK1 GENE; ENCHONDRAL OSSIFICATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIPHYSIS; EXPLANT; FRZB GENE; GENE; GENE EXPRESSION; GREM1 GENE; GROWTH RATE; HISTOPATHOLOGY; HYALINE CARTILAGE; HYPERTROPHY; HYPOXIA; METABOLIC INHIBITION; MMP13 GENE; MMP9 GENE; MOUSE; NONHUMAN; OXYGEN TENSION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SECRETION; REGULATORY MECHANISM; RUNX2 GENE; SIGNAL TRANSDUCTION; SOX9 GENE; TIBIA;

ANIMALS; ANOXIA; CELL DIFFERENTIATION; CHONDROCYTES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GROWTH PLATE; HYPERTROPHY; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; ORGAN CULTURE TECHNIQUES; OSTEOGENESIS; OXYGEN; SIGNAL TRANSDUCTION; TIBIA;

EID: 84869812683     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0049896     Document Type: Article

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