Quantifying the mechanical micro-environment during three-dimensional cell expansion on microbeads by means of individual cell-based modelling

Computer Methods in Biomechanics and Biomedical Engineering

Volumn 16, Issue 10, 2013, Pages 1071-1084

  Smeets, Bart ^a   Odenthal, Tim ^a   Tijskens, Engelbert ^a   Ramon, Herman ^a   van Oosterwyck, Hans ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

discrete element method; individual cell based models; mechanical micro environment; mechanical stress heterogeneity; microcarriers; three dimensional cell expansion

Indexed keywords

CELL EXPANSION; INDIVIDUAL CELL-BASED MODELS; MECHANICAL STRESS; MICROCARRIERS; MICROENVIRONMENTS;

CELL ADHESION; CELLS; FINITE DIFFERENCE METHOD; MECHANICAL PROPERTIES; STRESSES; THREE DIMENSIONAL;

BIOMECHANICS;

MICROBEAD; POLYMER; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CELL BASED MODELLING; CELL CYCLE; CELL EXPANSION; CELL PROLIFERATION; INDIVIDUAL CELL BASED MODEL; MATHEMATICAL COMPUTING; MECHANICAL STRESS; MECHANICS; MICROCARRIER CULTURE; MODEL; OSTEOPROGENITOR CELL; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SIMULATION;

CELL ADHESION; CELL CULTURE TECHNIQUES; CELL CYCLE; CELL PROLIFERATION; MICROSPHERES; MODELS, BIOLOGICAL; STRESS, MECHANICAL;

EID: 84886379963     PISSN: 10255842     EISSN: 14768259     Source Type: Journal    
DOI: 10.1080/10255842.2013.829461     Document Type: Article

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