Overlapping hotspots in CDRs are critical sites for V region diversification

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 7, 2015, Pages E728-E737

  Wei, Lirong ^a   Chahwan, Richard ^b   Wang, Shanzhi ^a   Wang, Xiaohua ^a   Pham, Phuong T ^c,d   Goodman, Myron F ^c,d   Bergman, Aviv ^a   Scharff, Matthew D ^a   MacCarthy, Thomas ^e  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF EXETER   (United Kingdom)

^c Department of Biological Sciences ^*  (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^e Stony Brook University   (United States)

Author keywords

AID; Complementarity determining regions; Cytosine deamination; IGHV3 23; Somatic hypermutation

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; CYTOSINE; AICDA (ACTIVATION-INDUCED CYTIDINE DEAMINASE); COMPLEMENTARITY DETERMINING REGION; CYTIDINE DEAMINASE; DNA; IMMUNOGLOBULIN VARIABLE REGION; PRIMER DNA;

ANTIBODY COMBINING SITE; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; BURKITT LYMPHOMA CELL LINE; COMPLEMENTARITY DETERMINING REGION; CRYSTAL STRUCTURE; DEAMINATION; DNA MODIFICATION; DNA SEQUENCE; EXCISION REPAIR; GENE LOCUS; GENE MUTATION; GERMINAL CENTER; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN HEAVY CHAIN GENE; IMMUNOGLOBULIN LIGHT CHAIN GENE; IN VITRO STUDY; IN VIVO STUDY; MEMORY CELL; MUTATION RATE; OVERLAPPING GENE; PRIORITY JOURNAL; PROTEIN MOTIF; SOMATIC HYPERMUTATION; SOMATIC MUTATION; CELL LINE; GENETICS; IMMUNOGLOBULIN VARIABLE REGION; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE;

BASE SEQUENCE; CELL LINE; COMPLEMENTARITY DETERMINING REGIONS; CYTIDINE DEAMINASE; DNA; DNA PRIMERS; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MUTATION;

EID: 84923195015     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1500788112     Document Type: Article

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