-
1
-
-
0023107028
-
Patterns of somatic mutations in immunoglobulin variable genes
-
Golding, G. B., P. J. Gearhart, and B. W. Glickman. 1987. Patterns of somatic mutations in immunoglobulin variable genes. Genetics 115: 169-176.
-
(1987)
Genetics
, vol.115
, pp. 169-176
-
-
Golding, G.B.1
Gearhart, P.J.2
Glickman, B.W.3
-
2
-
-
0027499308
-
Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: Clustering, polarity, and specific hot spots
-
Betz, A. G., C. Rada, R. Pannell, C. Milstein, and M. S. Neuberger. 1993. Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. Proc. Natl. Acad. Sci. USA 90: 2385-2388.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 2385-2388
-
-
Betz, A.G.1
Rada, C.2
Pannell, R.3
Milstein, C.4
Neuberger, M.S.5
-
3
-
-
0032101611
-
Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein
-
Phung, Q. H., D.B. Winter, A. Cranston, R. E. Tarone, V. A. Bohr, R. Fishel, and P. J. Gearhart. 1998. Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein. J. Exp. Med. 187: 1745-1751.
-
(1998)
J. Exp. Med.
, vol.187
, pp. 1745-1751
-
-
Phung, Q.H.1
Winter, D.B.2
Cranston, A.3
Tarone, R.E.4
Bohr, V.A.5
Fishel, R.6
Gearhart, P.J.7
-
5
-
-
0032031498
-
Base-specific sequences that bias somatic hypermutation deduced by analysis of out of frame genes
-
Dunn-Walters, D. K., A. Dogan, L. Boursier, C. M. MacDonald, and J. Spencer. 1998. Base-specific sequences that bias somatic hypermutation deduced by analysis of out of frame genes. J. Immunol 160: 2360-2364.
-
(1998)
J. Immunol.
, vol.160
, pp. 2360-2364
-
-
Dunn-Walters, D.K.1
Dogan, A.2
Boursier, L.3
MacDonald, C.M.4
Spencer, J.5
-
6
-
-
0032127804
-
Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting
-
Rada, C., M. R. Ehrenstein, M. S. Neuberger, and C. Milstein. 1998. Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity 9: 135-141.
-
(1998)
Immunity
, vol.9
, pp. 135-141
-
-
Rada, C.1
Ehrenstein, M.R.2
Neuberger, M.S.3
Milstein, C.4
-
7
-
-
0041474807
-
Activation-induced cytidine deaminase: A dual role in class-switch recombination and somatic hypermutation
-
Durandy, A. 2003. Activation-induced cytidine deaminase: a dual role in class-switch recombination and somatic hypermutation. Eur. J. Immunol. 33: 2069-2073.
-
(2003)
Eur. J. Immunol.
, vol.33
, pp. 2069-2073
-
-
Durandy, A.1
-
9
-
-
0037926476
-
Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
-
Pham, P., R. Bransteitter, J. Petruska, and M. F. Goodman. 2003. Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation. Nature 424: 103-107.
-
(2003)
Nature
, vol.424
, pp. 103-107
-
-
Pham, P.1
Bransteitter, R.2
Petruska, J.3
Goodman, M.F.4
-
10
-
-
0037108463
-
Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
-
Rada, C., G. T. Williams, H. Nilsen, D. E. Barnes, T. Lindahl, and M. S. Neuberger. 2002. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr. Biol. 12: 1748-1755.
-
(2002)
Curr. Biol.
, vol.12
, pp. 1748-1755
-
-
Rada, C.1
Williams, G.T.2
Nilsen, H.3
Barnes, D.E.4
Lindahl, T.5
Neuberger, M.S.6
-
11
-
-
0142092610
-
Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination
-
Imai, K., G. Slupphaug, W. I. Lee, P. Revy, S. Nonoyama, N. Catalan, L. Yel, M. Forveille, B. Kavli, H. E. Krokan, et al. 2003. Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination. Nat. Immunol. 4: 1023-1028.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 1023-1028
-
-
Imai, K.1
Slupphaug, G.2
Lee, W.I.3
Revy, P.4
Nonoyama, S.5
Catalan, N.6
Yel, L.7
Forveille, M.8
Kavli, B.9
Krokan, H.E.10
-
12
-
-
1142299546
-
Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1 mutant mice
-
Bardwell, P. D., C. J. Woo, K. Wei, Z. Li, A. Martin, S. Z. Sack, T. Parris, W. Edelmann, and M. D. Scharff. 2004. Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1 mutant mice. Nat. Immunol. 5: 224-229.
-
(2004)
Nat. Immunol.
, vol.5
, pp. 224-229
-
-
Bardwell, P.D.1
Woo, C.J.2
Wei, K.3
Li, Z.4
Martin, A.5
Sack, S.Z.6
Parris, T.7
Edelmann, W.8
Scharff, M.D.9
-
13
-
-
6344256944
-
Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation
-
Rada, C., J. M. Di Nola, and M. S. Neuberger. 2004. Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation. Mol. Cell 16: 163-171.
-
(2004)
Mol. Cell
, vol.16
, pp. 163-171
-
-
Rada, C.1
Di Nola, J.M.2
Neuberger, M.S.3
-
14
-
-
0035377269
-
DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes
-
Zeng, X., D. B. Winter, C. Kasmer, K. H. Kraemer, A. R. Lehmann, and P. J. Gearhart. 2001. DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes. Nat. Immunol. 2: 537-541.
-
(2001)
Nat. Immunol.
, vol.2
, pp. 537-541
-
-
Zeng, X.1
Winter, D.B.2
Kasmer, C.3
Kraemer, K.H.4
Lehmann, A.R.5
Gearhart, P.J.6
-
15
-
-
0036786471
-
The role of polymerase η in somatic hypermutation determined by analysis of mutations in a patient with XPV
-
Yavuz, S., A. S. Yavuz, K. H. Kraemer, and P. E. Lipsky. 2002. The role of polymerase η in somatic hypermutation determined by analysis of mutations in a patient with XPV. J. Immunol. 169: 3825-3830.
-
(2002)
J. Immunol.
, vol.169
, pp. 3825-3830
-
-
Yavuz, S.1
Yavuz, A.S.2
Kraemer, K.H.3
Lipsky, P.E.4
-
16
-
-
0035860310
-
Error rate and specificity of human and murine DNA polymerase η
-
Matsuda, T., K. Bebenek, C. Masutani, I. B. Rogozin, F. Hanaoka, and T. A. Kunkel. 2001. Error rate and specificity of human and murine DNA polymerase η. J. Mol. Biol. 312: 335-346.
-
(2001)
J. Mol. Biol.
, vol.312
, pp. 335-346
-
-
Matsuda, T.1
Bebenek, K.2
Masutani, C.3
Rogozin, I.B.4
Hanaoka, F.5
Kunkel, T.A.6
-
17
-
-
0035379581
-
Somatic mutation hotspots correlate with DNA polymerase η error spectrum
-
Rogozin, I. B., Y. I. Pavlov, K. Bebenek, T. Matsuda, and T. A. Kunkel. 2001. Somatic mutation hotspots correlate with DNA polymerase η error spectrum. Nat. Immunol. 2: 530-536.
-
(2001)
Nat. Immunol.
, vol.2
, pp. 530-536
-
-
Rogozin, I.B.1
Pavlov, Y.I.2
Bebenek, K.3
Matsuda, T.4
Kunkel, T.A.5
-
18
-
-
0037162552
-
Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase η during copying of a mouse immunoglobulin κ light chain transgene
-
Pavlov, Y. I., I. B. Rogozin, A. P. Galkin, A. Y. Aksenova, F. Hanaoka, C. Rada, and T. A. Kunkel. 2002. Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase η during copying of a mouse immunoglobulin κ light chain transgene. Proc. Natl. Acad. Sci. USA 99: 9954-9959.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 9954-9959
-
-
Pavlov, Y.I.1
Rogozin, I.B.2
Galkin, A.P.3
Aksenova, A.Y.4
Hanaoka, F.5
Rada, C.6
Kunkel, T.A.7
-
19
-
-
0035399804
-
Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase zeta
-
Diaz, M., L. K. Verkoczy, M. F. Flajnik, and N. R. Klinman. 2001. Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase zeta. J. Immunol. 167: 327-335.
-
(2001)
J. Immunol.
, vol.167
, pp. 327-335
-
-
Diaz, M.1
Verkoczy, L.K.2
Flajnik, M.F.3
Klinman, N.R.4
-
20
-
-
0035005241
-
The translesion DNA polymerase zeta plays a major role in Ig and Bcl-6 somatic hypermutation
-
Zan, H., A. Komori, Z. Li, A. Cerutti, A. Schaffer, M. F. Flajnik, M. Diaz, and P. Casali. 2001. The translesion DNA polymerase zeta plays a major role in Ig and Bcl-6 somatic hypermutation. Immunity 14: 643-653.
-
(2001)
Immunity
, vol.14
, pp. 643-653
-
-
Zan, H.1
Komori, A.2
Li, Z.3
Cerutti, A.4
Schaffer, A.5
Flajnik, M.F.6
Diaz, M.7
Casali, P.8
-
21
-
-
0037206851
-
Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase ι
-
Faili, A., S. Aoufouchi, E. Flatter, Q. Gueranger, C. A. Reynaud, and J. C. Weill. 2002. Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase ι. Nature 419: 944-947.
-
(2002)
Nature
, vol.419
, pp. 944-947
-
-
Faili, A.1
Aoufouchi, S.2
Flatter, E.3
Gueranger, Q.4
Reynaud, C.A.5
Weill, J.C.6
-
22
-
-
7444228703
-
Overexpression of human polymerase mu (Pol μ) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate
-
Ruiz, J. F., D. Lucas, E. Garcia-Palomero, A. I. Saez, M. A. Gonzalez, M. A. Piris, A. Bernad, and L. Blanco. 2004. Overexpression of human polymerase mu (Pol μ) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate. Nucleic Acids Res. 32: 5861-5873.
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. 5861-5873
-
-
Ruiz, J.F.1
Lucas, D.2
Garcia-Palomero, E.3
Saez, A.I.4
Gonzalez, M.A.5
Piris, M.A.6
Bernad, A.7
Blanco, L.8
-
23
-
-
18844412639
-
Polymerase mu is up-regulated during the T cell-dependent immune response and its deficiency alters developmental dynamics of spleen centroblasts
-
Lucas, D., T. Lain de Lera, M. A. Gonzalez, J. F. Ruiz, O. Dominguez, J. C. Casanova, C. Martinez-A, L. Blanco, and A. Bernad. 2005. Polymerase mu is up-regulated during the T cell-dependent immune response and its deficiency alters developmental dynamics of spleen centroblasts. Eur. J. Immunol. 35: 1601-1611.
-
(2005)
Eur. J. Immunol.
, vol.35
, pp. 1601-1611
-
-
Lucas, D.1
Lain De Lera, T.2
Gonzalez, M.A.3
Ruiz, J.F.4
Dominguez, O.5
Casanova, J.C.6
Martinez-A, C.7
Blanco, L.8
Bernad, A.9
-
24
-
-
1142297508
-
Analysis of strand biased 'G' C hypermutation in human immunoglobulin V(λ) gene segments suggests that both DNA strands are targets for deamination by activation-induced cytidine deaminase
-
Boursier, L., W. Su, and J. Spencer. 2004. Analysis of strand biased 'G' C hypermutation in human immunoglobulin V(λ) gene segments suggests that both DNA strands are targets for deamination by activation-induced cytidine deaminase. Mol. Immunol. 40: 1273-1278.
-
(2004)
Mol. Immunol.
, vol.40
, pp. 1273-1278
-
-
Boursier, L.1
Su, W.2
Spencer, J.3
-
25
-
-
0036169650
-
Effects of sequence and structure on the hypermutability of immunoglobulin genes
-
Michael, N., T. E. Martin, D. Nicolae, N. Kim, K. Padjen, P. Zhan, H. Nguyen, C. Pinkert, and U. Storb. 2002. Effects of sequence and structure on the hypermutability of immunoglobulin genes. Immunity 16: 123-134.
-
(2002)
Immunity
, vol.16
, pp. 123-134
-
-
Michael, N.1
Martin, T.E.2
Nicolae, D.3
Kim, N.4
Padjen, K.5
Zhan, P.6
Nguyen, H.7
Pinkert, C.8
Storb, U.9
-
26
-
-
20444427642
-
DNA polymerase η contributes to strand bias of mutations of A versus T in immunoglobulin genes
-
Mayorov, V. I., I. B. Rogozin, L. R. Adkinson, and P. J. Gearhart. 2005. DNA polymerase η contributes to strand bias of mutations of A versus T in immunoglobulin genes. J. Immunol. 174: 7781-7786.
-
(2005)
J. Immunol.
, vol.174
, pp. 7781-7786
-
-
Mayorov, V.I.1
Rogozin, I.B.2
Adkinson, L.R.3
Gearhart, P.J.4
-
27
-
-
18244401095
-
Contribution of DNA polymerase η to immunoglobulin gene hypermutation in the mouse
-
Delbos, F., A. De Smet, A. Faili, S. Aoufouchi, J.-C. Weill, and C.-A. Reynaud. 2005. Contribution of DNA polymerase η to immunoglobulin gene hypermutation in the mouse. J. Exp. Med. 201: 1191-1196.
-
(2005)
J. Exp. Med.
, vol.201
, pp. 1191-1196
-
-
Delbos, F.1
De Smet, A.2
Faili, A.3
Aoufouchi, S.4
Weill, J.-C.5
Reynaud, C.-A.6
-
28
-
-
0033168638
-
Predicting regional mutability in antibody V genes based solely on di- and trinucleotide sequence composition
-
Shapiro, G. S., K. Aviszus, D. Ikle, and L. J. Wysocki. 1999. Predicting regional mutability in antibody V genes based solely on di- and trinucleotide sequence composition. J. Immunol. 163: 259-268.
-
(1999)
J. Immunol.
, vol.163
, pp. 259-268
-
-
Shapiro, G.S.1
Aviszus, K.2
Ikle, D.3
Wysocki, L.J.4
-
29
-
-
0031569118
-
Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes
-
Dorner, T., H. P. Brezinschek, R. I. Brezinschek, S. J. Foster, R. Domiati-Saad, and P. E. Lipsky. 1997. Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes. J. Immunol. 158: 2779-2789.
-
(1997)
J. Immunol.
, vol.158
, pp. 2779-2789
-
-
Dorner, T.1
Brezinschek, H.P.2
Brezinschek, R.I.3
Foster, S.J.4
Domiati-Saad, R.5
Lipsky, P.E.6
-
30
-
-
0036012782
-
The "A" rule re-visited: Polymerases as determinants of mutational specificity
-
Strauss, B. S. 2002. The "A" rule re-visited: polymerases as determinants of mutational specificity. DNA Repair. 1: 125-135.
-
(2002)
DNA Repair
, vol.1
, pp. 125-135
-
-
Strauss, B.S.1
-
31
-
-
14244250387
-
MSH2-MSH6 stimulates DNA polymerase η, suggesting a role for A:T mutations in antibody genes
-
Wilson, T. M., A. Vaisman, S. A. Martomo, P. Sullivan, L. Lan, F. Hanaoka, A. Yasui, R. Woodgate, and P. J. Gearhart. 2005. MSH2-MSH6 stimulates DNA polymerase η, suggesting a role for A:T mutations in antibody genes. J. Exp. Med. 201: 637-645.
-
(2005)
J. Exp. Med.
, vol.201
, pp. 637-645
-
-
Wilson, T.M.1
Vaisman, A.2
Martomo, S.A.3
Sullivan, P.4
Lan, L.5
Hanaoka, F.6
Yasui, A.7
Woodgate, R.8
Gearhart, P.J.9
-
32
-
-
0037415391
-
Functions of human DNA polymerases η, κ and i suggested by their properties, including fidelity with undamaged DNA templates
-
Kunkel, T. A., Y. I. Pavlov, and K. Bebenek. 2003. Functions of human DNA polymerases η, κ and i suggested by their properties, including fidelity with undamaged DNA templates. DNA Repair 2: 135-149.
-
(2003)
DNA Repair
, vol.2
, pp. 135-149
-
-
Kunkel, T.A.1
Pavlov, Y.I.2
Bebenek, K.3
-
33
-
-
0034652015
-
The nucleotide-replacement spectrum under somatic hypermutation exhibits microsequence dependence that is strand-symmetric and distinct from that under germline mutation
-
Cowell, L. G., and T. B. Kepler. 2000. The nucleotide-replacement spectrum under somatic hypermutation exhibits microsequence dependence that is strand-symmetric and distinct from that under germline mutation. J. Immunol. 164: 1971-1976.
-
(2000)
J. Immunol.
, vol.164
, pp. 1971-1976
-
-
Cowell, L.G.1
Kepler, T.B.2
|