Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 1, 2013, Pages 264-269

  Schmidt, Aaron G ^a   Xu, Huafeng ^b   Khan, Amir R ^a,h   O'Donnell, Timothy ^b   Khurana, Surender ^c   King, Lisa R ^c   Manischewitz, Jody ^c   Golding, Hana ^c   Suphaphiphat, Pirada ^d   Carfi, Andrea ^d   Settembre, Ethan C ^d   Dormitzer, Philip R ^d   Kepler, Thomas B ^e   Zhang, Ruijun ^f   Moody, M Anthony ^f   Haynes, Barton F ^f   Liao, Hua Xin ^f   Shaw, David E ^b,g   Harrison, Stephen C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b D E SHAW RESEARCH   (United States)

^c CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^d NOVARTIS VACCINES AND DIAGNOSTICS   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g Columbia University ^*  (United States)

^h TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Antigen recognition; Immunity; X ray crystallography

Indexed keywords

NEUTRALIZING ANTIBODY; NEUTRALIZING INFLUENZA VIRUS ANTIBODY; UNCLASSIFIED DRUG; VIRUS ANTIBODY;

ANTIBODY COMBINING SITE; ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; BINDING KINETICS; CELL LINEAGE; HUMAN; INFLUENZA VIRUS; LAST COMMON ANCESTOR; MOLECULAR DYNAMICS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECEPTOR BINDING; SOMATIC MUTATION;

AMINO ACID SEQUENCE; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; B-LYMPHOCYTES; BINDING SITES, ANTIBODY; CRYSTALLOGRAPHY, X-RAY; EVOLUTION, MOLECULAR; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN VARIABLE REGION; INFLUENZA VACCINES; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; ORTHOMYXOVIRIDAE;

ORTHOMYXOVIRIDAE;

EID: 84871994029     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1218256109     Document Type: Article

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