Rapid development of broadly influenza neutralizing antibodies through redundant mutations

Nature

Volumn 516, Issue 7531, 2014, Pages 418-422

  Pappas, Leontios ^a   Foglierini, Mathilde ^a   Piccoli, Luca ^a   Kallewaard, Nicole L ^b   Turrini, Filippo ^c   Silacci, Chiara ^a   Fernandez Rodriguez, Blanca ^a   Agatic, Gloria ^d   Giacchetto Sasselli, Isabella ^a   Pellicciotta, Gabriele ^c   Sallusto, Federica ^a   Zhu, Qing ^b   Vicenzi, Elisa ^c   Corti, Davide ^a,d   Lanzavecchia, Antonio ^a,e  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

^b MEDIMMUNE   (United States)

^c SAN RAFFAELE HOSPITAL   (Italy)

^d Humabs BioMed SA ^*  (Switzerland)

^e ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; B LYMPHOCYTE RECEPTOR; HEMAGGLUTININ; NEUTRALIZING ANTIBODY; PHENYLALANINE; PROLINE; TYROSINE; COMPLEMENTARITY DETERMINING REGION; HEMAGGLUTININ, HUMAN INFLUENZA A VIRUS; IMMUNOGLOBULIN HEAVY CHAIN; INFLUENZA VIRUS HEMAGGLUTININ; PROTEIN BINDING;

ANTIBODY; ANTIGEN; INFLUENZA; MUTATION; VIRUS;

ALLELE; AMINO ACID SUBSTITUTION; ANTIBODY AFFINITY; ANTIBODY ISOLATION; ANTIBODY RESPONSE; ANTIGEN PRESENTATION; ARTICLE; CONTROLLED STUDY; CROSS REACTION; GENE REARRANGEMENT; HEAVY CHAIN; HUMAN; INFLUENZA A; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H2N2; MEMORY CELL; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMA CELL; PRIORITY JOURNAL; SOMATIC MUTATION; SURFACE PLASMON RESONANCE; VDJ RECOMBINATION; VIRUS NEUTRALIZATION; VIRUS STRAIN; ADULT; AMINO ACID SEQUENCE; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; COMPLEMENTARITY DETERMINING REGION; FEMALE; GENETIC POLYMORPHISM; GENETICS; IMMUNOLOGY; INFLUENZA; MALE; METABOLISM; MIDDLE AGED; MUTATION; ORTHOMYXOVIRIDAE; PROTEIN TERTIARY STRUCTURE; VIROLOGY; YOUNG ADULT;

ORTHOMYXOVIRIDAE;

ADULT; AMINO ACID SEQUENCE; ANTIBODIES, NEUTRALIZING; CELLS, CULTURED; COMPLEMENTARITY DETERMINING REGIONS; FEMALE; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; INFLUENZA, HUMAN; MALE; MIDDLE AGED; MODELS, MOLECULAR; MUTATION; ORTHOMYXOVIRIDAE; POLYMORPHISM, GENETIC; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; YOUNG ADULT;

EID: 84922225958     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13764     Document Type: Article

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