메뉴 건너뛰기




Volumn 188, Issue 11, 1998, Pages 2151-2162

The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus

Author keywords

Antibody repertoire; DNA duplication; ImmunogIobulin gene; Phylogenetic tree; Physical map

Indexed keywords

COMPLEMENTARY DNA; IMMUNOGLOBULIN HEAVY CHAIN; MESSENGER RNA;

EID: 0031775443     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.11.2151     Document Type: Article
Times cited : (322)

References (57)
  • 1
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • Tonegawa, S. 1983. Somatic generation of antibody diversity. Nature. 302:505-581.
    • (1983) Nature , vol.302 , pp. 505-581
    • Tonegawa, S.1
  • 2
    • 0022271336 scopus 로고
    • Origin of immune diversity: Genetic variation and selection
    • Honjo, T., and S. Habu. 1985. Origin of immune diversity: genetic variation and selection. Annu. Rev. Biochem. 54:803-830.
    • (1985) Annu. Rev. Biochem. , vol.54 , pp. 803-830
    • Honjo, T.1    Habu, S.2
  • 3
    • 0025325169 scopus 로고
    • T cell receptor gene diversity and selection
    • Davis, M.M. 1990. T cell receptor gene diversity and selection. Annu. Rev. Biochem. 59:475-496.
    • (1990) Annu. Rev. Biochem. , vol.59 , pp. 475-496
    • Davis, M.M.1
  • 4
    • 1842365099 scopus 로고
    • Localization of human immunoglobulin kappa light chain variable region genes to the short arm of chromosome 2 by in situ hybridization
    • Malcolm, S., P. Barton, C. Murphy, M.A. Ferguson-Smith, D.L. Bentley, and T.H. Rabbitts. 1982. Localization of human immunoglobulin kappa light chain variable region genes to the short arm of chromosome 2 by in situ hybridization. Proc. Natl. Acad. Sci. USA. 79:4957-4961.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 4957-4961
    • Malcolm, S.1    Barton, P.2    Murphy, C.3    Ferguson-Smith, M.A.4    Bentley, D.L.5    Rabbitts, T.H.6
  • 5
    • 0020079869 scopus 로고
    • Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes
    • McBride, O.W., P.A. Hieter, G.F. Hollis, D. Swan, M.C. Otey, and P. Leder. 1982. Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes. J. Exp. Med. 155:1480-1490.
    • (1982) J. Exp. Med. , vol.155 , pp. 1480-1490
    • McBride, O.W.1    Hieter, P.A.2    Hollis, G.F.3    Swan, D.4    Otey, M.C.5    Leder, P.6
  • 6
    • 0019800094 scopus 로고
    • Assignment of the genes for human λ immunoglobulin chains to chromosome 22
    • Erikson, J., J. Martinis, and C.M. Croce. 1981. Assignment of the genes for human λ immunoglobulin chains to chromosome 22. Nature. 294:173-175.
    • (1981) Nature , vol.294 , pp. 173-175
    • Erikson, J.1    Martinis, J.2    Croce, C.M.3
  • 10
    • 0002960871 scopus 로고
    • The human immunoglobulin κ genes
    • T. Honjo and F.W. Alt, editors. Academic Press, London.
    • Zachau, H. 1995. The human immunoglobulin κ genes. In Immunoglobulin Genes. 2nd ed. T. Honjo and F.W. Alt, editors. Academic Press, London. 173-192.
    • (1995) Immunoglobulin Genes. 2nd Ed. , pp. 173-192
    • Zachau, H.1
  • 13
    • 0030483540 scopus 로고    scopus 로고
    • Receptor editing, immune diversification, and self-tolerance
    • Radic, M.Z., and M. Zouali. 1996. Receptor editing, immune diversification, and self-tolerance. Immunity. 5:505-511.
    • (1996) Immunity , vol.5 , pp. 505-511
    • Radic, M.Z.1    Zouali, M.2
  • 14
    • 0030764978 scopus 로고    scopus 로고
    • V(D)J recombination activity in a subset of germinal center B lymphocytes
    • Han, S., S.R. Dillon, B. Zheng, M. Shimoda, M.S. Schissel, and G. Kelsoe. 1997. V(D)J recombination activity in a subset of germinal center B lymphocytes. Science. 278:301-306.
    • (1997) Science , vol.278 , pp. 301-306
    • Han, S.1    Dillon, S.R.2    Zheng, B.3    Shimoda, M.4    Schissel, M.S.5    Kelsoe, G.6
  • 16
    • 0028100960 scopus 로고
    • Recent translocation of variable and diversity (D) segment of the human immunoglobulin heavy chain from chromosome 14 to chromosomes 15 and 16
    • Nagaoka, H., K. Ozawa, F. Matsuda, H. Hayashida, R. Matsumura, M. Haino, E.K. Shin, Y. Fukita, T. Imai, R. Anand, et al. 1994. Recent translocation of variable and diversity (D) segment of the human immunoglobulin heavy chain from chromosome 14 to chromosomes 15 and 16. Genomics. 22: 189-197.
    • (1994) Genomics , vol.22 , pp. 189-197
    • Nagaoka, H.1    Ozawa, K.2    Matsuda, F.3    Hayashida, H.4    Matsumura, R.5    Haino, M.6    Shin, E.K.7    Fukita, Y.8    Imai, T.9    Anand, R.10
  • 18
    • 0028129394 scopus 로고
    • Comparison and evolution of human immunoglobulin VH segments located in the 3′ 0.8-megabase region: Evidence for unidirectional transfer of segmental gene sequences
    • Haino, M., H. Hayashida, T. Miyata, E.K. Shin, F. Matsuda, H. Nagaoka, R. Matsumura, S. Taka-ishi, Y. Fukita, J. Fujikura, and T. Honjo. 1994. Comparison and evolution of human immunoglobulin VH segments located in the 3′ 0.8-megabase region: evidence for unidirectional transfer of segmental gene sequences. J. Biol. Chem. 269:2619-2626.
    • (1994) J. Biol. Chem. , vol.269 , pp. 2619-2626
    • Haino, M.1    Hayashida, H.2    Miyata, T.3    Shin, E.K.4    Matsuda, F.5    Nagaoka, H.6    Matsumura, R.7    Taka-ishi, S.8    Fukita, Y.9    Fujikura, J.10    Honjo, T.11
  • 19
    • 0022450491 scopus 로고
    • Organization and evolution of variable region genes of the human immunoglobulin heavy chain
    • Kodaira, M., T. Kinashi, I. Umemura, F. Matsuda, T. Noma, Y. Ono, and T. Honjo. 1986. Organization and evolution of variable region genes of the human immunoglobulin heavy chain. J. Mol. Biol. 190:529-541.
    • (1986) J. Mol. Biol. , vol.190 , pp. 529-541
    • Kodaira, M.1    Kinashi, T.2    Umemura, I.3    Matsuda, F.4    Noma, T.5    Ono, Y.6    Honjo, T.7
  • 20
    • 0025897085 scopus 로고
    • Yeast artificial chromosome libraries containing large inserts from mouse and human DNA
    • Larin, Z., A.P. Monaco, and H. Lehrach. 1991. Yeast artificial chromosome libraries containing large inserts from mouse and human DNA. Proc. Natl. Acad. Sci. USA. 88:4123-4127.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 4123-4127
    • Larin, Z.1    Monaco, A.P.2    Lehrach, H.3
  • 21
    • 3743151547 scopus 로고
    • Physical mapping of vanable region gene locus of human immunoglobulin heavy chain
    • K. Adolph, editor. Academic Press, Orlando, FL.
    • Matsuda, F., and T. Honjo. 1993. Physical mapping of vanable region gene locus of human immunoglobulin heavy chain. In Methods in Molecular Genetics. Vol. 2. K. Adolph, editor. Academic Press, Orlando, FL. 226-245.
    • (1993) Methods in Molecular Genetics , vol.2 , pp. 226-245
    • Matsuda, F.1    Honjo, T.2
  • 24
    • 0030094146 scopus 로고    scopus 로고
    • CENSOR - A program for identification and elimination of repetitive elements from DNa sequences
    • Jurka, J., P. Klonowski, V. Dagman, and P. Pelton. 1996. CENSOR - a program for identification and elimination of repetitive elements from DNA sequences. Comput. Chem. 20: 119-121.
    • (1996) Comput. Chem. , vol.20 , pp. 119-121
    • Jurka, J.1    Klonowski, P.2    Dagman, V.3    Pelton, P.4
  • 25
    • 0000732090 scopus 로고
    • Evolution of protein molecules
    • H.N. Munro, editor. Academic Press, New York.
    • Jukes, T.H., and C.R. Cantor. 1969. Evolution of protein molecules. In Mammalian Protein Metabolism III. H.N. Munro, editor. Academic Press, New York. 21-132.
    • (1969) Mammalian Protein Metabolism III. , pp. 21-132
    • Jukes, T.H.1    Cantor, C.R.2
  • 26
    • 0023375195 scopus 로고
    • The neighbor-joining method: A new method for reconstructing phylogenetic trees
    • Saitou, N., and M. Nei. 1987. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol. Biol. Evol. 4:406-425.
    • (1987) Mol. Biol. Evol. , vol.4 , pp. 406-425
    • Saitou, N.1    Nei, M.2
  • 27
    • 0014757386 scopus 로고
    • A general method applicable to the search for similarities in the amino acid sequence of two proteins
    • Needleman, S.B., and C.D. Wunsch. 1970. A general method applicable to the search for similarities in the amino acid sequence of two proteins. J. Mol. Biol. 48:443-453.
    • (1970) J. Mol. Biol. , vol.48 , pp. 443-453
    • Needleman, S.B.1    Wunsch, C.D.2
  • 28
    • 0026009526 scopus 로고
    • A novel randomized iterative strategy for aligning multiple protein sequences
    • Berger, M.P., and P.J. Munson. 1991. A novel randomized iterative strategy for aligning multiple protein sequences. Comput. Appl. Biosci. 7:479-484.
    • (1991) Comput. Appl. Biosci. , vol.7 , pp. 479-484
    • Berger, M.P.1    Munson, P.J.2
  • 29
    • 0019850678 scopus 로고
    • Human immunoglobulin D segments encoded in tandem multigenic families
    • Siebenlist, U., J.Y. Ravetch, S. Korsmeyer, T. Waldmann, and P. Leder. 1981. Human immunoglobulin D segments encoded in tandem multigenic families. Nature. 294:631-635.
    • (1981) Nature , vol.294 , pp. 631-635
    • Siebenlist, U.1    Ravetch, J.Y.2    Korsmeyer, S.3    Waldmann, T.4    Leder, P.5
  • 30
    • 0024293529 scopus 로고
    • Organization of human immunoglobulin heavy chain diversity gene loci
    • Ichihara, Y., H. Matsuoka, and Y. Kurosawa. 1988. Organization of human immunoglobulin heavy chain diversity gene loci. EMBO (Eur. Mol. Biol. Organ.) J. 7:4141-4150.
    • (1988) EMBO (Eur. Mol. Biol. Organ.) J. , vol.7 , pp. 4141-4150
    • Ichihara, Y.1    Matsuoka, H.2    Kurosawa, Y.3
  • 31
    • 0031586221 scopus 로고    scopus 로고
    • Sequence of the human immunoglobulin diversity (D) segment locus: A systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination
    • Corbett, S.J., I.M. Tomlinson, E.L.L. Sonnhammer, D. Buck, and G. Winter. 1997. Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination. J. Mol. Biol. 270:587-597.
    • (1997) J. Mol. Biol. , vol.270 , pp. 587-597
    • Corbett, S.J.1    Tomlinson, I.M.2    Sonnhammer, E.L.L.3    Buck, D.4    Winter, G.5
  • 32
    • 0019846077 scopus 로고
    • Structure of the immunoglobulin m locus: Characterization of embryonic and rearranged J and D genes
    • Ravetch, J.V., U. Siebenlist, S. Korsmeyer, T. Waldmann, and P. Leder. 1981. Structure of the immunoglobulin m locus: characterization of embryonic and rearranged J and D genes. Cell. 27:583-591.
    • (1981) Cell. , vol.27 , pp. 583-591
    • Ravetch, J.V.1    Siebenlist, U.2    Korsmeyer, S.3    Waldmann, T.4    Leder, P.5
  • 33
    • 0029941262 scopus 로고    scopus 로고
    • Organization of the human immunoglobulin heavy-chain locus
    • Matsuda, F., and T. Honjo. 1996. Organization of the human immunoglobulin heavy-chain locus. Adv. Immunol. 62:1-29.
    • (1996) Adv. Immunol. , vol.62 , pp. 1-29
    • Matsuda, F.1    Honjo, T.2
  • 34
    • 0030017526 scopus 로고    scopus 로고
    • The complete 685-kilobase DNA sequence of the human β T cell receptor locus
    • Rowen, L., B.F. Koop, and L. Hood. 1996. The complete 685-kilobase DNA sequence of the human β T cell receptor locus. Science. 272:1755-1762.
    • (1996) Science , vol.272 , pp. 1755-1762
    • Rowen, L.1    Koop, B.F.2    Hood, L.3
  • 35
    • 0021165918 scopus 로고
    • Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elements
    • Falkner, F.G., and H.G. Zachau. 1984. Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elements. Nature. 310:71-74.
    • (1984) Nature , vol.310 , pp. 71-74
    • Falkner, F.G.1    Zachau, H.G.2
  • 36
    • 0023449819 scopus 로고
    • Multiple DNA sequence elements are necessary for the function of an immunoglobulin heavy chain promoter
    • Eaton, S., and K. Calame. 1987. Multiple DNA sequence elements are necessary for the function of an immunoglobulin heavy chain promoter. Prof. Natl. Acad. Sci. USA. 84:7634-7638.
    • (1987) Prof. Natl. Acad. Sci. USA , vol.84 , pp. 7634-7638
    • Eaton, S.1    Calame, K.2
  • 37
    • 0029891597 scopus 로고    scopus 로고
    • Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage
    • Ramsden, D.A., J.F. McBlane, D.C. van Gent, and M. Gellert. 1996. Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage. EMBO (Eur. Mol. Biol. Organ.) J. 15:3197-3206.
    • (1996) EMBO (Eur. Mol. Biol. Organ.) J. , vol.15 , pp. 3197-3206
    • Ramsden, D.A.1    McBlane, J.F.2    Van Gent, D.C.3    Gellert, M.4
  • 38
    • 0029814965 scopus 로고    scopus 로고
    • DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences
    • Coumo, C.A., C.L. Mundy, and M.A. Oettinger. 1996. DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences. Mol. Cell. Biol. 16: 5683-5690.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 5683-5690
    • Coumo, C.A.1    Mundy, C.L.2    Oettinger, M.A.3
  • 40
    • 0020658557 scopus 로고
    • Evolutionary aspects of immunoglobulin heavy chain variable region (VH) gene subgroups
    • Rechavi, G., D. Ram, L. Glazer, R. Zakut, and D. Givol. 1983. Evolutionary aspects of immunoglobulin heavy chain variable region (VH) gene subgroups. Proc. Natl. Acad. Sci. USA. 80:855-859.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 855-859
    • Rechavi, G.1    Ram, D.2    Glazer, L.3    Zakut, R.4    Givol, D.5
  • 41
    • 0023268717 scopus 로고
    • A novel family of variable region genes of the human immunoglobulin heavy chain
    • Lee, K.H., F. Matsuda, T. Kinashi, M. Kodaira, and T. Honjo. 1987. A novel family of variable region genes of the human immunoglobulin heavy chain. J. Mol. Biol. 195:761-768.
    • (1987) J. Mol. Biol. , vol.195 , pp. 761-768
    • Lee, K.H.1    Matsuda, F.2    Kinashi, T.3    Kodaira, M.4    Honjo, T.5
  • 43
    • 0001923233 scopus 로고
    • National Biomedical Research Foundation, Georgetown University Medical Center, Washington D.C.
    • Dayhoff, M.O. Atlas of Protein Sequence and Structure. Vol. 5 (Suppl. 2). 1976. National Biomedical Research Foundation, Georgetown University Medical Center, Washington D.C. 1-8.
    • (1976) Atlas of Protein Sequence and Structure , vol.5 , Issue.2 SUPPL. , pp. 1-8
    • Dayhoff, M.O.1
  • 44
    • 0021274960 scopus 로고
    • The phylogeny of the hominoid primates, as indicated by DNA-DNA hybridization
    • Sibley, C.G., and J.E. Ahlquist. 1984. The phylogeny of the hominoid primates, as indicated by DNA-DNA hybridization. J. Mol. Evol. 20:2-15.
    • (1984) J. Mol. Evol. , vol.20 , pp. 2-15
    • Sibley, C.G.1    Ahlquist, J.E.2
  • 46
    • 0029655169 scopus 로고
    • Prediction of the coding sequences of unidentified human genes. IV. the coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1
    • Nagase, T., N. Seki, A. Tanaka, K. Ishikawa, and N. Nomura. 1995. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. 2:167-174.
    • (1995) DNA Res. , vol.2 , pp. 167-174
    • Nagase, T.1    Seki, N.2    Tanaka, A.3    Ishikawa, K.4    Nomura, N.5
  • 47
    • 0028218938 scopus 로고
    • Parental imprinting of autosomal mammalian genes
    • Efstratiadis, A. 1994. Parental imprinting of autosomal mammalian genes. Curr. Opin. Genet. Dev. 4:265-280.
    • (1994) Curr. Opin. Genet. Dev. , vol.4 , pp. 265-280
    • Efstratiadis, A.1
  • 49
    • 0030099403 scopus 로고    scopus 로고
    • Imprinted genes have few and small introns
    • Hurst, D., G. McVean, and T. Moore. 1996. Imprinted genes have few and small introns. Nat. Genet. 12:234-237.
    • (1996) Nat. Genet. , vol.12 , pp. 234-237
    • Hurst, D.1    McVean, G.2    Moore, T.3
  • 50
    • 0027523056 scopus 로고
    • The structure of the human intron-contaimng S8 ribosomal protein gene and determination of its chromosomal location at 1p32-p34.1
    • Davies, B., and M. Fried. 1993. The structure of the human intron-contaimng S8 ribosomal protein gene and determination of its chromosomal location at 1p32-p34.1. Genomics. 15:68-75.
    • (1993) Genomics , vol.15 , pp. 68-75
    • Davies, B.1    Fried, M.2
  • 51
    • 0028864725 scopus 로고
    • Analysis of transcripts encoding novel members of the mammalian metalloprotease-like, disintegrin-like, cysteine-rich (MDC) protein family and their expression in reproductive and non-reproductive monkey tissues
    • Perry, A.C., R. Jones, and L. Hall. 1995. Analysis of transcripts encoding novel members of the mammalian metalloprotease-like, disintegrin-like, cysteine-rich (MDC) protein family and their expression in reproductive and non-reproductive monkey tissues. Biochem. J. 312:239-244.
    • (1995) Biochem. J. , vol.312 , pp. 239-244
    • Perry, A.C.1    Jones, R.2    Hall, L.3
  • 53
    • 0029873481 scopus 로고    scopus 로고
    • Molecular characterization of trans-Golgi p230. a human peripheral membrane protein encoded by a gene on chromosome 6p12-22 contains extensive coiled-coil alpha-helical domains and a granin motif
    • Erlich, R., P.A. Gleeson, P. Campbell, E. Dietzsch, and B. Toh. 1996. Molecular characterization of trans-Golgi p230. A human peripheral membrane protein encoded by a gene on chromosome 6p12-22 contains extensive coiled-coil alpha-helical domains and a granin motif. J. Biol. Chem. 271:8328-8337.
    • (1996) J. Biol. Chem. , vol.271 , pp. 8328-8337
    • Erlich, R.1    Gleeson, P.A.2    Campbell, P.3    Dietzsch, E.4    Toh, B.5
  • 55
    • 0024332738 scopus 로고
    • Evolution of chromosome bands: Molecular ecology of noncoding DNA
    • Holmquist, G.P. 1989. Evolution of chromosome bands: molecular ecology of noncoding DNA. J. Mol. Evol. 28:469-486.
    • (1989) J. Mol. Evol. , vol.28 , pp. 469-486
    • Holmquist, G.P.1
  • 57
    • 0009673698 scopus 로고    scopus 로고
    • Undermethylation associated with retroelement activation and chromosome remodelling in an interspecific mammalian hybrid
    • O'Neill, R.J., M.J. O'Neill, and J.A. Graves. 1998. Undermethylation associated with retroelement activation and chromosome remodelling in an interspecific mammalian hybrid. Nature. 393:68-72.
    • (1998) Nature , vol.393 , pp. 68-72
    • O'Neill, R.J.1    O'Neill, M.J.2    Graves, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.