Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage

Proteins: Structure, Function and Bioinformatics

Volumn 83, Issue 4, 2015, Pages 771-780

  Xu, Huafeng ^a   Schmidt, Aaron G ^b   O'Donnell, Timothy ^a   Therkelsen, Matthew D ^b   Kepler, Thomas B ^c   Moody, M Anthony ^d   Haynes, Barton F ^d   Liao, Hua Xin ^d   Harrison, Stephen C ^b   Shaw, David E ^a,e  

^a D E SHAW RESEARCH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Acquired immunity; Kinetics measurements; Molecular dynamics; Protein evolution; Protein protein interaction

Indexed keywords

NEUTRALIZING ANTIBODY; PROTEIN BINDING; VIRUS ANTIBODY;

ANTIGEN BINDING; ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; CELL LINEAGE; CELL MATURATION; CONFORMATION; CRYSTAL STRUCTURE; HEAVY CHAIN; HUMAN; HUMAN CELL; INFLUENZA VIRUS; LIGHT CHAIN; MOLECULAR DYNAMICS; MUTATION; PRIORITY JOURNAL; AMINO ACID SEQUENCE; ANTIBODY COMBINING SITE; CHEMISTRY; IMMUNOLOGY; INFLUENZA A VIRUS; KINETICS; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN STABILITY;

ORTHOMYXOVIRIDAE;

AMINO ACID SEQUENCE; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; BINDING SITES, ANTIBODY; HUMANS; INFLUENZA A VIRUS; KINETICS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN STABILITY;

EID: 84925306148     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24745     Document Type: Article

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