Transcriptional stalling in B-lymphocytes A mechanism for antibody diversification and maintenance of genomic integrity

Transcription

Volumn 4, Issue 3, 2013, Pages

  Sun, Jianbo ^a   Rothschild, Gerson ^a   Pefanis, Evangelos ^a   Basu, Uttiya ^a  

^a Columbia University ^*  (United States)

Author keywords

Activation induced deaminase; RNA polymerase II regulation; Somatic mutation

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; DEOXYCYTIDINE; DEOXYURIDINE; GUANINE; IMMUNOGLOBULIN HEAVY CHAIN; PURINE; PYRIMIDINE; RNA POLYMERASE II; SINGLE STRANDED DNA; THYMIDINE; ANTIBODY; CYTIDINE DEAMINASE; ANTIGEN;

ANTIBODY SPECIFICITY; ANTIGEN RECOGNITION; ARTICLE; B LYMPHOCYTE; CHROMOSOME TRANSLOCATION; CLASS SWITCH RECOMBINATION; DEAMINATION; DNA RECOMBINATION; DNA REPAIR; DNA SEQUENCE; ENZYME ACTIVITY; GENE REARRANGEMENT; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; GENOMIC INSTABILITY; HUMAN; MOLECULAR INTERACTION; NONHUMAN; NUCLEOTIDE MOTIF; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN PROCESSING; RGYW MOTIF; RNA DEGRADATION; SOMATIC HYPERMUTATION; TRANSCRIPTION TERMINATION; CHEMISTRY; IMMUNOLOGY; METABOLISM; VDJ RECOMBINATION; ANTIBODY PRODUCTION; MUTATION; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; RNA TRANSCRIPTION; TRANSCRIPTION REGULATION;

ANTIBODIES; B-LYMPHOCYTES; CYTIDINE DEAMINASE; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN HEAVY CHAINS; RNA POLYMERASE II; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; V(D)J RECOMBINATION;

EID: 84877616305     PISSN: 21541264     EISSN: 21541272     Source Type: Journal    
DOI: 10.4161/trans.24556     Document Type: Article

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