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Volumn 16, Issue 2, 2015, Pages 2472-2496

Promoter hypermethylation of tumour suppressor genes as potential biomarkers in colorectal cancer

Author keywords

Biomarkers; Colorectal cancer; CpG islands; Promoter methylation; Tumour suppressor gene

Indexed keywords

ALPHA4 INTEGRIN; APC PROTEIN; BIOLOGICAL MARKER; CYCLIN DEPENDENT KINASE INHIBITOR; GATA BINDING PROTEIN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MICRORNA; MICROSATELLITE DNA; NERVE GROWTH FACTOR RECEPTOR; NEUROGENIN 1; NUCLEAR PROTEIN; OSTEOGENIN; PROTEIN P53; SECRETED FRIZZLED RELATED PROTEIN 2; SEPTIN; SEPTIN 9; TISSUE FACTOR PATHWAY INHIBITOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR RUNX; UNCLASSIFIED DRUG; TUMOR MARKER; TUMOR SUPPRESSOR PROTEIN;

EID: 84921874682     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms16022472     Document Type: Review
Times cited : (157)

References (149)
  • 3
    • 84912088844 scopus 로고    scopus 로고
    • Methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer
    • Toiyama, Y.; Okugawa, Y.; Goel, A. DNA methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer. Biochem. Biophys. Res. Commun. 2014, 455, 43-57.
    • (2014) Biochem. Biophys. Res. Commun , vol.455 , pp. 43-57
    • Toiyama, Y.1    Okugawa, Y.2    Goel, A.3
  • 4
    • 0036184605 scopus 로고    scopus 로고
    • Treatment and prevention of intraepithelial neoplasia: An important target for accelerated new agent development recommendations of the American Association for Cancer Research Task Force on the treatment and prevention of intraepithelial neoplasia
    • O’Shaughnessy, J.A.; Kelloff, G.J.; Gordon, G.B.; Dannenberg, A.J.; Hong, W.K.; Fabian, C.J.; Sigman, C.C.; Bertagnolli, M.M.; Stratton, S.P.; Lam, S, et al. Treatment and prevention of intraepithelial neoplasia: An important target for accelerated new agent development recommendations of the American Association for Cancer Research Task Force on the treatment and prevention of intraepithelial neoplasia. Clin. Cancer Res. 2002, 8, 314-346.
    • (2002) Clin. Cancer Res , vol.8 , pp. 314-346
    • O’Shaughnessy, J.A.1    Kelloff, G.J.2    Gordon, G.B.3    Dannenberg, A.J.4    Hong, W.K.5    Fabian, C.J.6    Sigman, C.C.7    Bertagnolli, M.M.8    Stratton, S.P.9    Lam, S.10
  • 6
    • 79751489596 scopus 로고    scopus 로고
    • Molecular genetics of colorectal cancer
    • Fearon, E.R. Molecular genetics of colorectal cancer. Annu. Rev. Pathol. Mech. Dis. 2011, 6,479-507.
    • (2011) Annu. Rev. Pathol. Mech. Dis , vol.6 , pp. 479-507
    • Fearon, E.R.1
  • 7
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D.; Weinberg, R.A. Hallmarks of cancer: The next generation. Cell 2011, 144, 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 11
    • 10344260184 scopus 로고    scopus 로고
    • CpG island methylator phenotype in cancer
    • Issa, J.-P. CpG island methylator phenotype in cancer. Nat. Rev. Cancer 2004, 4, 988-993.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 988-993
    • Issa, J.-P.1
  • 12
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird, A. DNA methylation patterns and epigenetic memory. Genes Dev. 2002, 16, 6-21.
    • (2002) Genes Dev , vol.16 , pp. 6-21
    • Bird, A.1
  • 13
    • 0025294471 scopus 로고
    • CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2
    • Comb, M.; Goodman, H.M. CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2. Nucleic Acids Res. 1990, 18, 3975-3982.
    • (1990) Nucleic Acids Res , vol.18 , pp. 3975-3982
    • Comb, M.1    Goodman, H.M.2
  • 14
    • 0026198118 scopus 로고
    • CpG methylation inhibits binding of several sequence-specific DNA-binding proteins from pea, wheat, soybean and cauliflower
    • Inamdar, N.M.; Ehrlich, K.C.; Ehrlich, M. CpG methylation inhibits binding of several sequence-specific DNA-binding proteins from pea, wheat, soybean and cauliflower. Plant Mol. Biol. 1991, 17, 111-123.
    • (1991) Plant Mol. Biol , vol.17 , pp. 111-123
    • Inamdar, N.M.1    Ehrlich, K.C.2    Ehrlich, M.3
  • 16
    • 0035950541 scopus 로고    scopus 로고
    • Methylation in hMLH1 promoter interferes with its binding to transcription factor CBF and inhibits gene expression
    • Deng, G.; Chen, A.; Pong, E.; Kim, Y.S. Methylation in hMLH1 promoter interferes with its binding to transcription factor CBF and inhibits gene expression. Oncogene 2001, 20, 7120-7127.
    • (2001) Oncogene , vol.20 , pp. 7120-7127
    • Deng, G.1    Chen, A.2    Pong, E.3    Kim, Y.S.4
  • 17
    • 0025944899 scopus 로고
    • DNA CpG methylation inhibits binding of NF-κB proteins to the HIV-1 long terminal repeat cognate DNA motifs
    • Bednarik, D.P.; Duckett, C.; Kim, S.U.; Perez, V.L.; Griffis, K.; Guenthner, P.C.; Folks, T.M. DNA CpG methylation inhibits binding of NF-κB proteins to the HIV-1 long terminal repeat cognate DNA motifs. New Biol. 1991, 3, 969-976.
    • (1991) New Biol , vol.3 , pp. 969-976
    • Bednarik, D.P.1    Duckett, C.2    Kim, S.U.3    Perez, V.L.4    Griffis, K.5    Guenthner, P.C.6    Folks, T.M.7
  • 18
    • 0032574977 scopus 로고    scopus 로고
    • Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
    • Nan, X.; Ng, H.-H.; Johnson, C.A.; Laherty, C.D.; Turner, B.M.; Eisenman, R.N.; Bird, A. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 1998, 393, 386-389.
    • (1998) Nature , vol.393 , pp. 386-389
    • Nan, X.1    Ng, H.-H.2    Johnson, C.A.3    Laherty, C.D.4    Turner, B.M.5    Eisenman, R.N.6    Bird, A.7
  • 19
    • 0036561649 scopus 로고    scopus 로고
    • Baylin, S.; Bestor, T.H. Altered methylation patterns in cancer cell genomes: Cause or consequence? Cancer Cell 2002, 1, 299-305.
    • Baylin, S.1    Bestor, T.H.2
  • 21
    • 84867400649 scopus 로고    scopus 로고
    • DNA methylation based biomarkers: Practical considerations and applications
    • Kit, A.H.; Nielsen, H.M.; Tost, J. DNA methylation based biomarkers: Practical considerations and applications. Biochimie 2012, 94, 2314-2337.
    • (2012) Biochimie , vol.94 , pp. 2314-2337
    • Kit, A.H.1    Nielsen, H.M.2    Tost, J.3
  • 23
    • 0037370476 scopus 로고    scopus 로고
    • The genetics and genomics of cancer
    • Balmain, A.; Gray, J.; Ponder, B. The genetics and genomics of cancer. Nat. Genet. 2003, 33, 238-244.
    • (2003) Nat. Genet , vol.33 , pp. 238-244
    • Balmain, A.1    Gray, J.2    Ponder, B.3
  • 24
    • 0015295131 scopus 로고
    • Mutation and cancer: A model for Wilms’ tumor of the kidney
    • Knudson, A.G., Jr.; Strong, L. Mutation and cancer: A model for Wilms’ tumor of the kidney. J. Natl. Cancer Inst. 1972, 48, 313-324.
    • (1972) J. Natl. Cancer Inst , vol.48 , pp. 313-324
    • Knudson, A.G.1    Strong, L.2
  • 26
    • 84867583304 scopus 로고    scopus 로고
    • Dietary, lifestyle and clinicopathological factors associated with APC mutations and promoter methylation in colorectal cancers from the EPIC-Norfolk study
    • Gay, L.J.; Mitrou, P.N.; Keen, J.; Bowman, R.; Naguib, A.; Cooke, J.; Kuhnle, G.G.; Burns, P.A.; Luben, R.; Lentjes, M, et al. Dietary, lifestyle and clinicopathological factors associated with APC mutations and promoter methylation in colorectal cancers from the EPIC-Norfolk study. J. Pathol. 2012, 228, 405-415.
    • (2012) J. Pathol , vol.228 , pp. 405-415
    • Gay, L.J.1    Mitrou, P.N.2    Keen, J.3    Bowman, R.4    Naguib, A.5    Cooke, J.6    Kuhnle, G.G.7    Burns, P.A.8    Luben, R.9    Lentjes, M.10
  • 27
    • 77949950879 scopus 로고    scopus 로고
    • Dietary folate, alcohol and B vitamins in relation to LINE-1 hypomethylation in colon cancer
    • Schernhammer, E.S.; Giovannucci, E.; Kawasaki, T.; Rosner, B.; Fuchs, C.S.; Ogino, S. Dietary folate, alcohol and B vitamins in relation to LINE-1 hypomethylation in colon cancer. Gut 2010, 59, 794-799.
    • (2010) Gut , vol.59 , pp. 794-799
    • Schernhammer, E.S.1    Giovannucci, E.2    Kawasaki, T.3    Rosner, B.4    Fuchs, C.S.5    Ogino, S.6
  • 29
    • 84897998756 scopus 로고    scopus 로고
    • Mutations and CDKN2A promoter methylation show an interactive adverse effect on survival and predict recurrence of rectal cancer
    • Kohonen-Corish, M.R.J.; Tseung, J.; Chan, C.; Currey, N.; Dent, O.F.; Clarke, S.; Bokey, L.; Chapuis, P.H. KRAS mutations and CDKN2A promoter methylation show an interactive adverse effect on survival and predict recurrence of rectal cancer. Int. J. Cancer 2014, 134, 2820-2828.
    • (2014) Int. J. Cancer , vol.134 , pp. 2820-2828
    • Kohonen-Corish, M.1    Tseung, J.2    Chan, C.3    Currey, N.4    Dent, O.F.5    Clarke, S.6    Bokey, L.7    Chapuis, P.8
  • 32
    • 33745500432 scopus 로고    scopus 로고
    • CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies
    • Ogino, S.; Cantor, M.; Kawasaki, T.; Brahmandam, M.; Kirkner, G.J.; Weisenberger, D.J.; Campan, M.; Laird, P.W.; Loda, M.; Fuchs, C.S. CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies. Gut 2006, 55, 1000-1006.
    • (2006) Gut , vol.55 , pp. 1000-1006
    • Ogino, S.1    Cantor, M.2    Kawasaki, T.3    Brahmandam, M.4    Kirkner, G.J.5    Weisenberger, D.J.6    Campan, M.7    Laird, P.W.8    Loda, M.9    Fuchs, C.S.10
  • 37
    • 33749069927 scopus 로고    scopus 로고
    • CpG Island Methylator Phenotype-Low (CIMP-Low) in colorectal cancer: Possible associations with male sex and KRAS mutations
    • Ogino, S.; Kawasaki, T.; Kirkner, G.J.; Loda, M.; Fuchs, C.S. CpG Island Methylator Phenotype-Low (CIMP-Low) in colorectal cancer: Possible associations with male sex and KRAS mutations. J. Mol. Diagn. 2006, 8, 582-588.
    • (2006) J. Mol. Diagn , vol.8 , pp. 582-588
    • Ogino, S.1    Kawasaki, T.2    Kirkner, G.J.3    Loda, M.4    Fuchs, C.S.5
  • 42
    • 84865341390 scopus 로고    scopus 로고
    • Silencing of miR-1-1 and miR-133a-2 cluster expression by DNA hypermethylation in colorectal cancer
    • Chen, W.-S.; Leung, C.-M.; Pan, H.-W.; Hu, L.-Y.; Li, S.-C.; Ho, M.-R.; Tsai, K.-W. Silencing of miR-1-1 and miR-133a-2 cluster expression by DNA hypermethylation in colorectal cancer. Oncol. Rep. 2012, 28, 1069-1076.
    • (2012) Oncol. Rep , vol.28 , pp. 1069-1076
    • Chen, W.-S.1    Leung, C.-M.2    Pan, H.-W.3    Hu, L.-Y.4    Li, S.-C.5    Ho, M.-R.6    Tsai, K.-W.7
  • 43
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • Ambros, V. The functions of animal microRNAs. Nature 2004, 431, 350-355.
    • (2004) Nature , vol.431 , pp. 350-355
    • Ambros, V.1
  • 44
    • 58249088751 scopus 로고    scopus 로고
    • Target recognition and regulatory functions
    • Bartel, D.P. MicroRNAs: Target recognition and regulatory functions. Cell 2009, 136, 215-233.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 45
    • 33846188098 scopus 로고    scopus 로고
    • MicroRNAs as oncogenes and tumor suppressors
    • Zhang, B.; Pan, X.; Cobb, G.P.; Anderson, T.A. microRNAs as oncogenes and tumor suppressors.Dev. Biol. 2007, 302, 1-12.
    • (2007) Dev. Biol , vol.302 , pp. 1-12
    • Zhang, B.1    Pan, X.2    Cobb, G.P.3    Anderson, T.A.4
  • 46
    • 84882686726 scopus 로고    scopus 로고
    • Epigenetic silencing of miR-126 contributes to tumor invasion and angiogenesis in colorectal cancer
    • Zhang, Y.; Wang, X.; Xu, B.; Wang, B.; Wang, Z.; Liang, Y.; Zhou, J.; Hu, J.; Jiang, B. Epigenetic silencing of miR-126 contributes to tumor invasion and angiogenesis in colorectal cancer. Oncol. Rep. 2013, 30, 1976-1984.
    • (2013) Oncol. Rep , vol.30 , pp. 1976-1984
    • Zhang, Y.1    Wang, X.2    Xu, B.3    Wang, B.4    Wang, Z.5    Liang, Y.6    Zhou, J.7    Hu, J.8    Jiang, B.9
  • 49
    • 0037112364 scopus 로고    scopus 로고
    • Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2
    • Cui, H.; Onyango, P.; Brandenburg, S.; Wu, Y.; Hsieh, C.-L.; Feinberg, A.P. Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2. Cancer Res. 2002, 62, 6442-6446.
    • (2002) Cancer Res , vol.62 , pp. 6442-6446
    • Cui, H.1    Onyango, P.2    Brandenburg, S.3    Wu, Y.4    Hsieh, C.-L.5    Feinberg, A.P.6
  • 51
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones, P.A.; Baylin, S.B. The fundamental role of epigenetic events in cancer. Nat. Rev. Genet.2002, 3, 415-428.
    • (2002) Nat. Rev. Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 52
    • 84860711163 scopus 로고    scopus 로고
    • Loss of imprinting of IGF2correlates with hypomethylation of the H19 differentially methylated region in the tumor tissue of colorectal cancer patients
    • Tian, F.; Tang, Z.; Song, G.; Pan, Y.; He, B.; Bao, Q.; Wang, S. Loss of imprinting of IGF2correlates with hypomethylation of the H19 differentially methylated region in the tumor tissue of colorectal cancer patients. Mol. Med. Rep. 2012, 5, 1536-1540.
    • (2012) Mol. Med. Rep , vol.5 , pp. 1536-1540
    • Tian, F.1    Tang, Z.2    Song, G.3    Pan, Y.4    He, B.5    Bao, Q.6    Wang, S.7
  • 53
    • 84895494085 scopus 로고    scopus 로고
    • Hypomethylation of long interspersed nuclear element-1 (LINE-1) leads to activation of proto-oncogenes in human colorectal cancer metastasis
    • Hur, K.; Cejas, P.; Feliu, J.; Moreno-Rubio, J.; Burgos, E.; Boland, C.R.; Goel, A. Hypomethylation of long interspersed nuclear element-1 (LINE-1) leads to activation of proto-oncogenes in human colorectal cancer metastasis. Gut 2013, 63, 635-646.
    • (2013) Gut , vol.63 , pp. 635-646
    • Hur, K.1    Cejas, P.2    Feliu, J.3    Moreno-Rubio, J.4    Burgos, E.5    Boland, C.R.6    Goel, A.7
  • 54
    • 0026546877 scopus 로고
    • Genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands
    • USA
    • Frommer, M.; McDonald, L.E.; Millar, D.S.; Collis, C.M.; Watt, F.; Grigg, G.W.; Molloy, P.L.; Paul, C.L. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc. Natl. Acad. Sci. USA 1992, 89, 1827-1831.
    • (1992) Proc. Natl. Acad. Sci , vol.89 , pp. 1827-1831
    • Frommer, M.1    McDonald, L.E.2    Millar, D.S.3    Collis, C.M.4    Watt, F.5    Grigg, G.W.6    Molloy, P.L.7    Paul, C.8
  • 55
    • 0038576158 scopus 로고    scopus 로고
    • The power and the promise of DNA methylation markers
    • Laird, P.W. The power and the promise of DNA methylation markers. Nat. Rev. Cancer 2003, 3, 253-266.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 253-266
    • Laird, P.W.1
  • 56
    • 79959832394 scopus 로고    scopus 로고
    • The DNA methylome
    • Pelizzola, M.; Ecker, J.R. The DNA methylome. FEBS Lett. 2011, 585, 1994-2000.
    • (2011) FEBS Lett , vol.585 , pp. 1994-2000
    • Pelizzola, M.1    Ecker, J.R.2
  • 58
    • 84878822005 scopus 로고    scopus 로고
    • Epigenetics and colorectal cancer pathogenesis
    • Bardhan, K.; Liu, K. Epigenetics and colorectal cancer pathogenesis. Cancers 2013, 5, 676-713.
    • (2013) Cancers , vol.5 , pp. 676-713
    • Bardhan, K.1    Liu, K.2
  • 62
    • 84892564202 scopus 로고    scopus 로고
    • Systematic assessment of normalization approaches for the Infinium 450 K methylation platform
    • Wu, M.C.; Joubert, B.R.; Kuan, P.; Håberg, S.E.; Nystad, W.; Peddada, S.D.; London, S.J.A systematic assessment of normalization approaches for the Infinium 450 K methylation platform. Epigenetics 2014, 9, 318-329.
    • (2014) Epigenetics , vol.9 , pp. 318-329
    • Wu, M.C.1    Joubert, B.R.2    Kuan, P.3    Håberg, S.E.4    Nystad, W.5    Peddada, S.D.6    London, S.7
  • 63
    • 84859931424 scopus 로고    scopus 로고
    • A comparison of feature selection and classification methods in DNA methylation studies using the Illumina Infinium platform
    • Zhuang, J.; Widschwendter, M.; Teschendorff, A.E. A comparison of feature selection and classification methods in DNA methylation studies using the Illumina Infinium platform. BMC Bioinform. 2012, 13, 59.
    • (2012) BMC Bioinform , vol.13 , pp. 59
    • Zhuang, J.1    Widschwendter, M.2    Teschendorff, A.E.3
  • 67
    • 42449142344 scopus 로고    scopus 로고
    • Sensitive Melting Analysis after Real Time- Methylation Specific PCR (SMART-MSP): High-throughput and probe-free quantitative DNA methylation detection
    • Kristensen, L.S.; Mikeska, T.; Krypuy, M.; Dobrovic, A. Sensitive Melting Analysis after Real Time- Methylation Specific PCR (SMART-MSP): High-throughput and probe-free quantitative DNA methylation detection. Nucleic Acids Res. 2008, 36, e42.
    • (2008) Nucleic Acids Res , vol.42 , pp. 36
    • Kristensen, L.S.1    Mikeska, T.2    Krypuy, M.3    Dobrovic, A.4
  • 68
    • 77956143206 scopus 로고    scopus 로고
    • Development of a multiplex MethyLight assay for the detection of multigene methylation in human colorectal cancer
    • He, Q.; Chen, H.-Y.; Bai, E.-Q.; Luo, Y.-X.; Fu, R.-J.; He, Y.-S.; Jiang, J.; Wang, H.-Q. Development of a multiplex MethyLight assay for the detection of multigene methylation in human colorectal cancer. Cancer Genet. Cytogenet. 2010, 202, 1-10.
    • (2010) Cancer Genet. Cytogenet , vol.202 , pp. 1-10
    • He, Q.1    Chen, H.-Y.2    Bai, E.-Q.3    Luo, Y.-X.4    Fu, R.-J.5    He, Y.-S.6    Jiang, J.7    Wang, H.-Q.8
  • 69
    • 33644856123 scopus 로고    scopus 로고
    • Epigenetic therapy of cancer: Past, present and future
    • Yoo, C.B.; Jones, P.A. Epigenetic therapy of cancer: Past, present and future. Nat. Rev. Drug Discov.2006, 5, 37-50.
    • (2006) Nat. Rev. Drug Discov , vol.5 , pp. 37-50
    • Yoo, C.B.1    Jones, P.A.2
  • 71
    • 34547490717 scopus 로고    scopus 로고
    • Screening for colorectal cancer using the faecal occult blood test, Hemoccult
    • Reviews; John Wiley & Sons, Ltd.: Hoboken, NJ, USA
    • Hewitson, P.; Glasziou, P.P.; Irwig, L.; Towler, B.; Watson, E. Screening for colorectal cancer using the faecal occult blood test, Hemoccult. In Cochrane Database of Systematic Reviews; John Wiley & Sons, Ltd.: Hoboken, NJ, USA, 1996.
    • Cochrane Database of Systematic , pp. 1996
    • Hewitson, P.1    Glasziou, P.P.2    Irwig, L.3    Towler, B.4    Watson, E.5
  • 72
    • 48449090298 scopus 로고    scopus 로고
    • Epigenetic biomarkers for human cancer: The time is now
    • Mulero-Navarro, S.; Esteller, M. Epigenetic biomarkers for human cancer: The time is now. Crit. Rev. Oncol. Hematol. 2008, 68, 1-11.
    • (2008) Crit. Rev. Oncol. Hematol , vol.68 , pp. 1-11
    • Mulero-Navarro, S.1    Esteller, M.2
  • 73
    • 29244469466 scopus 로고    scopus 로고
    • The epigenetic progenitor origin of human cancer. Nat
    • Feinberg, A.P.; Ohlsson, R.; Henikoff, S. The epigenetic progenitor origin of human cancer. Nat. Rev. Genet. 2006, 7, 21-33.
    • (2006) Rev. Genet , vol.7 , pp. 21-33
    • Feinberg, A.P.1    Ohlsson, R.2    Henikoff, S.3
  • 74
    • 33947498117 scopus 로고    scopus 로고
    • Wang, J.-F. Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions
    • Huang, Z.-H.; Li, L.-H.; Yang, F.; Wang, J.-F. Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions. World J. Gastroenterol.2007, 13, 950-954.
    • (2007) World J. Gastroenterol , vol.13 , pp. 950-954
    • Huang, Z.-H.1    Li, L.-H.2    Yang, F.3
  • 75
    • 79957458567 scopus 로고    scopus 로고
    • Cell-free nucleic acids as biomarkers in cancer patients
    • Schwarzenbach, H.; Hoon, D.S.B.; Pantel, K. Cell-free nucleic acids as biomarkers in cancer patients. Nat. Rev. Cancer 2011, 11, 426-437.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 426-437
    • Schwarzenbach, H.1    Hoon, D.2    Pantel, K.3
  • 79
    • 0035117962 scopus 로고    scopus 로고
    • Detection of aberrantly methylatedhMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer
    • Grady, W.M.; Rajput, A.; Lutterbaugh, J.D.; Markowitz, S.D. Detection of aberrantly methylatedhMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer. Cancer Res. 2001, 61, 900-902.
    • (2001) Cancer Res , vol.61 , pp. 900-902
    • Grady, W.M.1    Rajput, A.2    Lutterbaugh, J.D.3    Markowitz, S.D.4
  • 82
    • 27744526931 scopus 로고    scopus 로고
    • Quantitative detection of promoter hypermethylation in multiple genes in the serum of patients with colorectal cancer
    • Leung, W.K.; To, K.-F.; Man, E.P.; Chan, M.W.; Bai, A.H.; Hui, A.J.; Chan, F.K.; Sung, J.J. Quantitative detection of promoter hypermethylation in multiple genes in the serum of patients with colorectal cancer. Am. J. Gastroenterol. 2005, 100, 2274-2279.
    • (2005) Am. J. Gastroenterol , vol.100 , pp. 2274-2279
    • Leung, W.K.1    To, K.-F.2    Man, E.P.3    Chan, M.W.4    Bai, A.H.5    Hui, A.J.6    Chan, F.K.7    Sung, J.J.8
  • 85
    • 79960914809 scopus 로고    scopus 로고
    • Diagnostic and prognostic value of the methylation status of secreted frizzled-related protein 2 in colorectal cancer
    • Tang, D.; Liu, J.; Wang, D.; Yu, H.; Li, Y.; Zhang, J. Diagnostic and prognostic value of the methylation status of secreted frizzled-related protein 2 in colorectal cancer. Clin. Investig. Med. 2011, 34, E88-E95.
    • (2011) Clin. Investig. Med , vol.34 , pp. E88-E95
    • Tang, D.1    Liu, J.2    Wang, D.3    Yu, H.4    Li, Y.5    Zhang, J.6
  • 86
    • 38449110073 scopus 로고    scopus 로고
    • Detection of promoter hypermethylation in serum samples of cancer patients by methylation-specific polymerase chain reaction for tumour suppressor genes including RUNX3
    • Tan, S.-H.; Ida, H.; Lau, Q.-C.; Goh, B.-C.; Chieng, W.-S.; Loh, M.; Ito, Y. Detection of promoter hypermethylation in serum samples of cancer patients by methylation-specific polymerase chain reaction for tumour suppressor genes including RUNX3. Oncol. Rep. 2007, 18, 1225-1230.
    • (2007) Oncol. Rep , vol.18 , pp. 1225-1230
    • Tan, S.-H.1    Ida, H.2    Lau, Q.-C.3    Goh, B.-C.4    Chieng, W.-S.5    Loh, M.6    Ito, Y.7
  • 89
    • 11144285448 scopus 로고    scopus 로고
    • Stool screening for colorectal cancer: Molecular approaches
    • Osborn, N.K.; Ahlquist, D.A. Stool screening for colorectal cancer: Molecular approaches. Gastroenterology 2005, 128, 192-206.
    • (2005) Gastroenterology , vol.128 , pp. 192-206
    • Osborn, N.K.1    Ahlquist, D.A.2
  • 93
    • 40049096639 scopus 로고    scopus 로고
    • Hypermethylated SFRP2 gene in fecal DNA is a high potential biomarker for colorectal cancer noninvasive screening
    • Wang, D.-R. Hypermethylated SFRP2 gene in fecal DNA is a high potential biomarker for colorectal cancer noninvasive screening. World J. Gastroenterol. 2008, 14, 524.
    • (2008) World J. Gastroenterol , vol.14 , pp. 524
    • Wang, D.-R.1
  • 99
    • 78149260396 scopus 로고    scopus 로고
    • Detection of colorectal neoplasm using promoter methylation of ITGA4, SFRP2, and p16 in stool samples: A preliminary report in Korean patients
    • Chang, E.; Park, D.I.; Kim, Y.J.; Kim, B.K.; Park, J.H.; Kim, H.J.; Cho, Y.K.; Sohn, C.I.; Jeon, W.K.; Kim, B.I, et al. Detection of colorectal neoplasm using promoter methylation of ITGA4, SFRP2, and p16 in stool samples: A preliminary report in Korean patients. Hepatogastroenterology 2010, 57, 720-727.
    • (2010) Hepatogastroenterology , vol.57 , pp. 720-727
    • Chang, E.1    Park, D.I.2    Kim, Y.J.3    Kim, B.K.4    Park, J.H.5    Kim, H.J.6    Cho, Y.K.7    Sohn, C.I.8    Jeon, W.K.9    Kim, B.I.10
  • 101
    • 84893156509 scopus 로고    scopus 로고
    • Multi-gene methylation detection increases positive methylation rate in colorectal cancer
    • Shao, S.; Liao, X.; Zhang, Y.; Qiu, J.; Zhang, X.; Yang, G. Multi-gene methylation detection increases positive methylation rate in colorectal cancer. Chin. J. Gastrointest. Surg. 2012, 15, 629-632.
    • (2012) Chin. J. Gastrointest. Surg , vol.15 , pp. 629-632
    • Shao, S.1    Liao, X.2    Zhang, Y.3    Qiu, J.4    Zhang, X.5    Yang, G.6
  • 105
    • 84905005712 scopus 로고    scopus 로고
    • Tomao, S. Focus on genetic and epigenetic events of colorectal cancer pathogenesis: Implications for molecular diagnosis
    • Zoratto, F.; Rossi, L.; Verrico, M.; Papa, A.; Basso, E.; Zullo, A.; Tomao, L.; Romiti, A.; Russo, G.L.; Tomao, S. Focus on genetic and epigenetic events of colorectal cancer pathogenesis: Implications for molecular diagnosis. Tumor Biol. 2014, 35, 6195-6206
    • (2014) Tumor Biol , vol.35 , pp. 6195-6206
    • Zoratto, F.1    Rossi, L.2    Verrico, M.3    Papa, A.4    Basso, E.5    Zullo, A.6    Tomao, L.7    Romiti, A.8    Russo, G.L.9
  • 106
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon, E.R.; Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell 1990, 61, 759-767
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 108
    • 3843118863 scopus 로고    scopus 로고
    • Reproducibility of a multitarget stool-based DNA assay for colorectal cancer detection
    • Brand, R.E.; Ross, M.E.; Shuber, A.P. Reproducibility of a multitarget stool-based DNA assay for colorectal cancer detection. Am. J. Gastroenterol. 2004, 99, 1338-1341.
    • (2004) Am. J. Gastroenterol , vol.99 , pp. 1338-1341
    • Brand, R.E.1    Ross, M.E.2    Shuber, A.P.3
  • 111
    • 0037872037 scopus 로고    scopus 로고
    • Sensitivity and specificity of a stool DNA multitarget assay panel for the detection of advanced colorectal neoplasia
    • Tagore, K.S.; Lawson, M.J.; Yucaitis, J.A.; Gage, R.; Orr, T.; Shuber, A.P.; Ross, M.E. Sensitivity and specificity of a stool DNA multitarget assay panel for the detection of advanced colorectal neoplasia. Clin. Colorectal Cancer 2003, 3, 47-53.
    • (2003) Clin. Colorectal Cancer , vol.3 , pp. 47-53
    • Tagore, K.S.1    Lawson, M.J.2    Yucaitis, J.A.3    Gage, R.4    Orr, T.5    Shuber, A.P.6    Ross, M.E.7
  • 112
    • 84859055066 scopus 로고    scopus 로고
    • Novel molecular screening approaches in colorectal cancer
    • Miller, S.; Steele, S. Novel molecular screening approaches in colorectal cancer. J. Surg. Oncol.2012, 105, 459-467.
    • (2012) J. Surg. Oncol , vol.105 , pp. 459-467
    • Miller, S.1    Steele, S.2
  • 114
    • 42949177399 scopus 로고    scopus 로고
    • Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: A joint guideline from the American Cancer Society, the US Multi-Society Task Force on colorectal cancer, and the American College of Radiology
    • Levin, B.; Lieberman, D.A.; McFarland, B.; Smith, R.A.; Brooks, D.; Andrews, K.S.; Dash, C.; Giardiello, F.M.; Glick, S.; Levin, T.R, et al. Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: A joint guideline from the American Cancer Society, the US Multi-Society Task Force on colorectal cancer, and the American College of Radiology. CA Cancer J. Clin. 2008, 58, 130-160.
    • (2008) CA Cancer J. Clin , vol.58 , pp. 130-160
    • Levin, B.1    Lieberman, D.A.2    McFarland, B.3    Smith, R.A.4    Brooks, D.5    Andrews, K.S.6    Dash, C.7    Giardiello, F.M.8    Glick, S.9    Levin, T.R.10
  • 115
    • 78649984065 scopus 로고    scopus 로고
    • Epigenetic inactivation of T-box transcription factor 5, a novel tumor suppressor gene, is associated with colon cancer
    • Yu, J.; Ma, X.; Cheung, K.F.; Li, X.; Tian, L.; Wang, S.; Wu, C.W.; Wu, W.K.K.; He, M.; Wang, M, et al. Epigenetic inactivation of T-box transcription factor 5, a novel tumor suppressor gene, is associated with colon cancer. Oncogene 2010, 29, 6464-6474.
    • (2010) Oncogene , vol.29 , pp. 6464-6474
    • Yu, J.1    Ma, X.2    Cheung, K.F.3    Li, X.4    Tian, L.5    Wang, S.6    Wu, C.W.7    Wu, W.8    He, M.9    Wang, M.10
  • 116
    • 79952532412 scopus 로고    scopus 로고
    • Cancer epigenetics: Linking basic biology to clinical medicine
    • Tsai, H.-C.; Baylin, S.B. Cancer epigenetics: Linking basic biology to clinical medicine. Cell Res. 2011, 21, 502-517.
    • (2011) Cell Res , vol.21 , pp. 502-517
    • Tsai, H.-C.1    Baylin, S.B.2
  • 119
    • 67651158856 scopus 로고    scopus 로고
    • Methylation of helicase-like transcription factor in serum of patients with colorectal cancer is an independent predictor of disease recurrence
    • Herbst, A.; Wallner, M.; Rahmig, K.; Stieber, P.; Crispin, A.; Lamerz, R.; Kolligs, F.T. Methylation of helicase-like transcription factor in serum of patients with colorectal cancer is an independent predictor of disease recurrence. J. Gastroenterol. 2009, 21, 565-569.
    • (2009) J. Gastroenterol , vol.21 , pp. 565-569
    • Herbst, A.1    Wallner, M.2    Rahmig, K.3    Stieber, P.4    Crispin, A.5    Lamerz, R.6    Kolligs, F.T.7
  • 120
    • 77954954112 scopus 로고    scopus 로고
    • Promoter methylation of specific genes is associated with the phenotype and progression of colorectal adenocarcinomas
    • Kim, J.C.; Choi, J.S.; Roh, S.A.; Cho, D.H.; Kim, T.W.; Kim, Y.S. Promoter methylation of specific genes is associated with the phenotype and progression of colorectal adenocarcinomas. Ann. Surg. Oncol. 2010, 17, 1767-1776.
    • (2010) Ann. Surg. Oncol. , vol.17 , pp. 1767-1776
    • Kim, J.C.1    Choi, J.S.2    Roh, S.A.3    Cho, D.H.4    Kim, T.W.5    Kim, Y.S.6
  • 121
    • 78650733422 scopus 로고    scopus 로고
    • Prognostic significance of CDKN2A (P16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review
    • Shima, K.; Nosho, K.; Baba, Y.; Cantor, M.; Meyerhardt, J.A.; Giovannucci, E.L.; Fuchs, C.S.; Ogino, S. Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review. Int. J. Cancer 2011, 128, 1080-1094.
    • (2011) Int. J. Cancer , vol.128 , pp. 1080-1094
    • Shima, K.1    Nosho, K.2    Baba, Y.3    Cantor, M.4    Meyerhardt, J.A.5    Giovannucci, E.L.6    Fuchs, C.S.7    Ogino, S.8
  • 123
    • 84938068432 scopus 로고    scopus 로고
    • DACT2 is a functional tumor suppressor through inhibiting Wnt/β-catenin pathway and associated with poor survival in colon cancer
    • Wang, S.; Dong, Y.; Zhang, Y.; Wang, X.; Xu, L.; Yang, S.; Li, X.; Dong, H.; Xu, L.; Su, L, et al.DACT2 is a functional tumor suppressor through inhibiting Wnt/β-catenin pathway and associated with poor survival in colon cancer. Oncogene 2014, doi:10.1038/onc.2014.201.
    • (2014) Oncogene
    • Wang, S.1    Dong, Y.2    Zhang, Y.3    Wang, X.4    Xu, L.5    Yang, S.6    Li, X.7    Dong, H.8    Xu, L.9    Su, L.10
  • 125
    • 84892715391 scopus 로고    scopus 로고
    • And biomarkers in colorectal cancer
    • Grady, W.M.; Pritchard, C.C. Molecular alterations and biomarkers in colorectal cancer. Toxicol. Pathol. 2014, 42, 124-139.
    • (2014) Toxicol. Pathol , vol.42 , pp. 124-139
    • Grady, W.M.1    Pritchard, C.C.A.2
  • 126
    • 0038793948 scopus 로고    scopus 로고
    • Apoptosis and melanoma chemoresistance
    • Soengas, M.S.; Lowe, S.W. Apoptosis and melanoma chemoresistance. Oncogene 2003, 22, 3138-3151.
    • (2003) Oncogene , vol.22 , pp. 3138-3151
    • Soengas, M.S.1    Lowe, S.W.2
  • 130
    • 62649101737 scopus 로고    scopus 로고
    • Pharmacoepigenetics: Its role in interindividual differences in drug response
    • Gomez, A.; Ingelman-Sundberg, M. Pharmacoepigenetics: Its role in interindividual differences in drug response. Clin. Pharmacol. Ther. 2009, 85, 426-430.
    • (2009) Clin. Pharmacol. Ther , vol.85 , pp. 426-430
    • Gomez, A.1    Ingelman-Sundberg, M.2
  • 133
  • 134
    • 84868208197 scopus 로고    scopus 로고
    • Clinical outcomes of patients with microsatellite-unstable colorectal carcinomas depend on L1 methylation level
    • Rhee, Y.-Y.; Kim, M.J.; Bae, J.M.; Koh, J.M.; Cho, N.-Y.; Juhnn, Y.-S.; Kim, D.; Kang, G.H. Clinical outcomes of patients with microsatellite-unstable colorectal carcinomas depend on L1 methylation level. Ann. Surg. Oncol. 2012, 19, 3441-3448.
    • (2012) Ann. Surg. Oncol , vol.19 , pp. 3441-3448
    • Rhee, Y.-Y.1    Kim, M.J.2    Bae, J.M.3    Koh, J.M.4    Cho, N.-Y.5    Juhnn, Y.-S.6    Kim, D.7    Kang, G.H.8
  • 138
    • 73449118889 scopus 로고    scopus 로고
    • Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers
    • Kim, J.H.; Shin, S.H.; Kwon, H.J.; Cho, N.Y.; Kang, G.H. Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers. Virchows Arch. 2009, 455, 485-494.
    • (2009) Virchows Arch , vol.455 , pp. 485-494
    • Kim, J.H.1    Shin, S.H.2    Kwon, H.J.3    Cho, N.Y.4    Kang, G.H.5
  • 139
    • 79961137937 scopus 로고    scopus 로고
    • The CpG island methylator phenotype may confer a survival benefit in patients with stage II or III colorectal carcinomas receiving fluoropyrimidine-based adjuvant chemotherapy
    • Min, B.-H.; Bae, J.M.; Lee, E.J.; Yu, H.S.; Kim, Y.-H.; Chang, D.K.; Kim, H.C.; Park, C.K.; Lee, S.-H.; Kim, K.-M, et al. The CpG island methylator phenotype may confer a survival benefit in patients with stage II or III colorectal carcinomas receiving fluoropyrimidine-based adjuvant chemotherapy. BMC Cancer 2011, 11, 344.
    • (2011) BMC Cancer , vol.11 , pp. 344
    • Min, B.-H.1    Bae, J.M.2    Lee, E.J.3    Yu, H.S.4    Kim, Y.-H.5    Chang, D.K.6    Kim, H.C.7    Park, C.K.8    Lee, S.-H.9    Kim, K.-M.10
  • 140
    • 0142087630 scopus 로고    scopus 로고
    • Adverse prognostic effect of methylation in colorectal cancer is reversed by microsatellite instability
    • Ward, R.L.; Cheong, K.; Ku, S.-L.; Meagher, A.; O’Connor, T.; Hawkins, N.J. Adverse prognostic effect of methylation in colorectal cancer is reversed by microsatellite instability. J. Clin. Oncol. 2003, 21, 3729-3736.
    • (2003) J. Clin. Oncol , vol.21 , pp. 3729-3736
    • Ward, R.L.1    Cheong, K.2    Ku, S.-L.3    Meagher, A.4    O’Connor, T.5    Hawkins, N.J.6
  • 141
    • 57849086513 scopus 로고    scopus 로고
    • Predicting clinical outcome of 5-fluorouracil-based chemotherapy for colon cancer patients: Is the CpG island methylator phenotype the 5-fluorouracil responsive subgroup
    • Iacopetta, B.; Kawakami, K.; Watanabe, T. Predicting clinical outcome of 5-fluorouracil-based chemotherapy for colon cancer patients: Is the CpG island methylator phenotype the 5-fluorouracil responsive subgroup? Int. J. Clin. Oncol. 2008, 13, 498-503.
    • (2008) Int. J. Clin. Oncol , vol.13 , pp. 498-503
    • Iacopetta, B.1    Kawakami, K.2    Watanabe, T.3
  • 143
    • 43049130760 scopus 로고    scopus 로고
    • LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
    • Ogino, S.; Kawasaki, T.; Nosho, K.; Ohnishi, M.; Suemoto, Y.; Kirkner, G.J.; Fuchs, C.S. LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. Int. J. Cancer 2008, 122, 2767-2773.
    • (2008) Int. J. Cancer , vol.122 , pp. 2767-2773
    • Ogino, S.1    Kawasaki, T.2    Nosho, K.3    Ohnishi, M.4    Suemoto, Y.5    Kirkner, G.J.6    Fuchs, C.S.7
  • 148
    • 79851511414 scopus 로고    scopus 로고
    • Molecular pathological epidemiology of colorectal neoplasia: An emerging transdisciplinary and interdisciplinary field
    • Ogino, S.; Chan, A.T.; Fuchs, C.S.; Giovannucci, E. Molecular pathological epidemiology of colorectal neoplasia: An emerging transdisciplinary and interdisciplinary field. Gut 2011, 60, 397-411.
    • (2011) Gut , vol.60 , pp. 397-411
    • Ogino, S.1    Chan, A.T.2    Fuchs, C.S.3    Giovannucci, E.4
  • 149
    • 84903878816 scopus 로고    scopus 로고
    • Multitarget stool DNA testing for colorectal-cancer screening
    • Imperiale, T.F.; Ransohoff, D.F.; Itzkowitz, S.H. Multitarget stool DNA testing for colorectal-cancer screening. N. Engl. J. Med. 2014, 371, 187-188.
    • (2014) N. Engl. J. Med , vol.371 , pp. 187-188
    • Imperiale, T.F.1    Ransohoff, D.F.2    Itzkowitz, S.H.3


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