Aristaless-like Homeobox-4 Gene Methylation Is a Potential Marker for Colorectal Adenocarcinomas

Gastroenterology

Volumn 131, Issue 5, 2006, Pages 1418-1430

  Ebert, Matthias P A ^a,b,c   Model, Fabian ^a   Mooney, Suzanne ^a   Hale, Kari ^a   Lograsso, Joe ^a   Tonnes Priddy, Lori ^a   Hoffmann, Juliane ^d   Csepregi, Antal ^d   Röcken, Christoph ^d,e   Molnar, Bela ^f   Schulz, Hans Ulrich ^d   Malfertheiner, Peter ^d   Lofton Day, Catherine ^a  

^a EPIGENOMICS AG   (Germany)

^b Fred Hutchinson Cancer Research Center   (United States)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d OTTO VON GUERICKE UNIVERSITY   (Germany)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^f SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA;

ADOLESCENT; ADULT; AGED; ARISTALESS LIKE HOMEOBOX 4 GENE; ARTICLE; BARRETT ESOPHAGUS; BILE DUCT CARCINOMA; CANCER LOCALIZATION; COLON ADENOMA; COLON MUCOSA; COLORECTAL CANCER; CONTROLLED STUDY; DIAGNOSTIC VALUE; DNA METHYLATION; ESOPHAGEAL ADENOCARCINOMA; FEMALE; GALLBLADDER CARCINOMA; GENE; GENETIC ASSOCIATION; GENETIC MARKER; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; LIVER METASTASIS; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; STOMACH ADENOCARCINOMA; STOMACH CANCER;

EID: 33750701826     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2006.08.034     Document Type: Article

References (40)

1. Jemal A., Murray T., Ward E., Samuels A., Tiwari R.C., Ghafoor A., Feuer E.J., and Thun M.J. Cancer statistics, 2005. CA Cancer J Clin 55 (2005) 10-30
2. Benson A.B., Schrag D., Somerfield M.R., Cohen A.M., Figueredo A.T., Flynn P.J., Krzyzanowska M.K., Maroun J., McAllister P., Van Cutsem E., Brouwers M., Charette M., and Haller D.G. American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer. J Clin Oncol 22 (2004) 3408-3419
3. Agrawal J., and Syngal S. Colon cancer screening strategies. Curr Opin Gastroenterol 21 (2005) 59-63
4. Chung D.C. The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesis. Gastroenterology 119 (2000) 854-865
5. Radtke F., and Clevers H. Self-renewal and cancer of the gut: two sides of a coin. Science 307 (2005) 1904-1909
6. Pollock C.B., Shirasawa S., Sasazuki T., Kolch W., and Dhillon A.S. Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells. Cancer Res 65 (2005) 1244-1250
7. Jones P.A., and Laird P.W. Cancer epigenetics comes of age. Nat Genet 21 (1999) 163-167
8. Esteller M. Relevance of DNA methylation in the management of cancer. Lancet Oncol 4 (2003) 351-358
9. Kondo Y., and Issa J.P. Epigenetic changes in colorectal cancer. Cancer Metastasis Rev 23 (2004) 29-39
10. Petko Z., Ghiassi M., Shuber A., Gorham J., Smalley W., Washington M.K., Schultenover S., Gautam S., Markowitz S.D., and Grady W.M. Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps. Clin Cancer Res 11 (2005) 1203-1209
11. Ebert M.P., Yu J., Hoffmann J., Rocco A., Rocken C., Kahmann S., Muller O., Korc M., Sung J.J., and Malfertheiner P. Loss of beta-catenin expression in metastatic gastric cancer. J Clin Oncol 21 (2003) 1708-1714
12. Sobin L.H., and Wittekind C.H. TNM classification of malignant tumours (2002), Wiley, Hoboken, NJ
13. Liang G., Salem C.E., Yu M.C., Nguyen H.D., Gonzales F.A., Nguyen T.T., Nichols P.W., and Jones P.A. DNA methylation differences associated with tumor tissues identified by genome scanning analysis. Genomics 53 (1998) 260-268
14. Liang G., Robertson K.D., Talmadge C., Sumegi J., and Jones P.A. The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells. Cancer Res 60 (2000) 4907-4912
15. Young J., Biden K.G., Simms L.A., Huggard P., Karamatic R., Eyre H.J., Sutherland G.R., Herath N., Barker M., Anderson G.J., Fitzpatrick D.R., Ramm G.A., Jass J.R., and Leggett B.A. HPP1: a transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers. Proc Natl Acad Sci U S A 98 (2001) 265-270
16. Eads C.A., Lord R.V., Wickramasinghe K., Long T.I., Kurumboor S.K., Bernstein L., Peters J.H., DeMeester S.R., DeMeester T.R., Skinner K.A., and Laird P.W. Epigenetic patterns in the progression of esophageal adenocarcinoma. Cancer Res 61 (2001) 3410-3418
17. Eads C.A., Lord R.V., Kurumboor S.K., Wickramasinghe K., Skinner M.L., Long T.I., Peters J.H., DeMeester T.R., Danenberg K.D., Danenberg P.V., Laird P.W., and Skinner K.A. Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma. Cancer Res 60 (2000) 5021-5026
18. Fraga M.F., and Esteller M. DNA methylation: a profile of methods and applications. Biotechniques 33 (2002) 636-649
19. Ebert M.P., Mooney S.H., Tonnes-Priddy L., Lograsso J., Hoffmann J., Chen J., Röcken C., Schulz H.U., Malfertheiner P., and Lofton-Day C. Hypermethylation of the TPEF/HPP1 gene in primary and metastatic colorectal cancers. Neoplasia 7 (2005) 771-778
20. Wuyts W., Cleiren E., Homfray T., Rasore-Quartino A., Vanhoenacker F., and Van Hul W. The ALX4 homeobox gene is mutated in patients with ossification defects of the skull. J Med Genet 37 (2000) 916-920
21. Yan P.S., Perry M.R., Laux D.E., Asare A.L., Caldwell C.W., and Huang T.H. CpG island arrays: an application toward deciphering epigenetic signatures of breast cancer. Clin Cancer Res 6 (2000) 1432-1438
22. Qu S., Li L., and Wisdom R. Alx-4: cDNA cloning and characterization of a novel paired-type homeodomain protein. Gene 203 (1997) 217-223
23. Qu S., Tucker S.C., Zhao Q., de Crombrugghe B., and Wisdom R. Physical and genetic interactions between ALX4 and Cart1. Development 126 (1999) 359-369
24. Qu S., Tucker S.C., Ehrlich J.S., Levorse J.M., Flaherty L.A., Wisdom R., and Vogt T.F. Mutations in mouse Aristaless-like4 cause Strong's luxoid polydactyly. Development 125 (1998) 2711-2721
25. Mavrogiannis L.A., Antonopoulou I., Baxova A., Kutilek S., Kim C.A., Sugayama S.M., Salamanca A., Wall S.A., Morriss-Kay G.M., and Wilkie A.O. Haploinsufficiency of the human homeobox gene ALX4 causes skull ossification defects. Nat Genet 27 (2001) 17-18
26. Takahashi M., Tamura K., Buscher D., Masuya H., Yonei-Tamura S., Matsumoto K., Naitoh-Matsuo M., Takeuchi J., Ogura K., Shiroishi T., Ogura T., and Belmonte J.C. The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development. Development 125 (1998) 4417-4425
27. Boras K., and Hamel P.A. ALX4 binding to LEF-1 regulates N-CAM promoter activity. J Biol Chem 277 (2002) 1120-1127
28. Widschwendter M., and Jones P.A. The potential prognostic, predictive, and therapeutic values of DNA methylation in cancer. Clin Cancer Res 8 (2002) 17-21
29. Nam M.J., Kee M.K., Kuick R., and Hanash S.M. Identification of defensin alpha 6 as a potential biomarker in colon adenocarcinoma. J Biol Chem 280 (2005) 8260-8265
30. Habal N., Gupta R.K., Bilchik A.J., Johnson T., and Morton D.L. TA90-IC, a new marker for advanced colon cancer. Ann Surg Oncol 7 (2000) 352-356
31. Boddy J.L., Gal S., Malone P.R., Harris A.L., and Wainscoat J.S. Prospective study of quantitation of plasma DNA levels in the diagnosis of malignant versus benign prostate disease. Clin Cancer Res 11 (2005) 1394-1399
32. Lee T.H., Montalvo L., Chrebtow V., and Busch M.P. Quantitation of genomic DNA in plasma and serum samples: higher concentrations of genomic DNA found in serum than in plasma. Transfusion 41 (2001) 276-282
33. Wang M., Block T.M., Steel L., Brenner D.E., and Su Y.H. Preferential isolation of fragmented DNA enhances the detection of circulating mutated k-ras DNA. Clin Chem 50 (2004) 211-213
34. Williams A.C., Collard T.J., Perks C.M., Newcomb P., Moorghen M., Holly J.M., and Paraskeva C. Increased p53-dependent apoptosis by the insulin-like growth factor binding protein IGFBP-3 in human colonic adenoma-derived cells. Cancer Res 60 (2000) 22-27
35. Sabbioni S., Miotto E., Veronese A., Sattin E., Gramantieri L., Bolondi L., Calin G.A., Gafa R., Lanza G., Carli G., Ferrazzi E., Feo C., Liboni A., Gullini S., and Negrini M. Multigene methylation analysis of gastrointestinal tumors: TPEF emerges as a frequent tumor-specific aberrantly methylated marker that can be detected in peripheral blood. Mol Diagn 7 (2003) 201-207
36. Grady W.M., Rajput A., Lutterbaugh J.D., and Markowitz S.D. Detection of aberrantly methylated hMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer. Cancer Res 61 (2001) 900-902
37. Leung W.K., To K.F., Man E.P., Chan M.W., Bai A.H., Hui A.J., Chan F.K., and Sung J.J. Quantitative detection of promoter hypermethylation in multiple genes in the serum of patients with colorectal cancer. Am J Gastroenterol 100 (2005) 2274-2279
38. Yamaguchi S., Asao T., Nakamura J., Ide M., and Kuwano H. High frequency of DAP-kinase gene promoter methylation in colorectal cancer specimens and its identification in serum. Cancer Lett 194 (2003) 99-105
39. Nakayama H., Hibi K., Taguchi M., Takase T., Yamazaki T., Kasai Y., Ito K., Akiyama S., and Nakao A. Molecular detection of p16 promoter methylation in the serum of colorectal cancer patients. Cancer Lett 188 (2002) 115-119
40. Zou H.Z., Yu B.M., Wang Z.W., Sun J.Y., Cang H., Gao F., Li D.H., Zhao R., Feng G.G., and Yi J. Detection of aberrant p16 methylation in the serum of colorectal cancer patients. Clin Cancer Res 8 (2002) 188-191