Dietary, lifestyle and clinicopathological factors associated with APC mutations and promoter methylation in colorectal cancers from the EPIC-Norfolk study

Journal of Pathology

Volumn 228, Issue 3, 2012, Pages 405-415

  Gay, Laura J ^a   Mitrou, Panagiota N ^b   Keen, Jennifer ^a   Bowman, Richard ^a   Naguib, Adam ^a   Cooke, James ^a   Kuhnle, Gunter G ^a,b,c   Burns, Philip A ^d   Luben, Robert ^b   Lentjes, Marleen ^b   Khaw, Kay Tee ^b   Ball, Richard Y ^e   Ibrahim, Ashraf E K ^b   Arends, Mark J ^b  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF READING   (United Kingdom)

^d ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^e NORFOLK AND NORWICH UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

APC; cancer; clinicopathological; colorectal; compounds; diet; methylation; mutation; N nitroso; promoter

Indexed keywords

APC PROTEIN; FOLIC ACID; IRON;

ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; CODON; COLORECTAL CANCER; DIET; DNA BASE COMPOSITION; FEMALE; FIBER; FOOD INTAKE; GENE CLUSTER; GENE MUTATION; GENETIC ANALYSIS; HISTOPATHOLOGY; HUMAN; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; MEAT INDUSTRY; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN METHYLATION; RED MEAT; SMOKING;

ADENOMATOUS POLYPOSIS COLI PROTEIN; AGED; ALCOHOL DRINKING; COLORECTAL NEOPLASMS; DIET; DIET RECORDS; EUROPE; FEMALE; HUMANS; LIFE STYLE; LOGISTIC MODELS; MALE; MEAT; METHYLATION; MICROSATELLITE INSTABILITY; MIDDLE AGED; MUTATION; PROMOTER REGIONS, GENETIC; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; SMOKING;

EID: 84867583304     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4085     Document Type: Article

References (67)

1. Frayling IM, Arends MJ,. Adenomatous polyposis coli. In Brenner's Encyclopedia of Genetics, 2nd edn, Maloy S, Hughes K, (eds). Elsevier: Edinburgh, London, 2011; Ch 16.
2. Jeon CH, Lee HI, Shin IH, et al., Genetic alterations of APC, K-ras, p53, MSI and MAGE in Korean colorectal cancer patients. Int J Colorectal Dis 2008; 23: 29-35.
3. Rowan AJ, Lamlum H, Ilyas M, et al., APC mutations in sporadic colorectal tumors: a mutational 'hotspot' and interdependence of the 'two hits'. Proc Natl Acad Sci USA 2000; 97: 3352-3357.
4. Miyoshi Y, Nagase H, Ando H, et al., Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet 1992; 1: 229-233.
5. Cheadle JP, Krawczak M, Thomas MW, et al., Different combinations of biallelic APC mutation confer different growth advantages in colorectal tumours. Cancer Res 2002; 62: 363-366.
6. Beroud C, Soussi T,. APC gene: database of germline and somatic mutations in human tumors and cell lines. Nucleic Acids Res 1996; 24: 121-124.
7. Rubinfeld B, Albert I, Porfiri E, et al., Loss of β-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene. Cancer Res 1997; 57: 4624-4630.
8. Derks S, Postma C, Carvalho B, et al., Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations. Carcinogenesis 2008; 29: 434-439.
9. Esteller M, Sparks A, Toyota M, et al., Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer. Cancer Res 2000; 60: 4366-4371.
10. Arnold CN, Goel A, Niedzwiecki D, et al., APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q. Cancer Biol Ther 2004; 3: 960-964.
11. Ferlay J, Shin HR, Bray F, et al., Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010; 127: 2893-2917.
12. WCRF/AICR. Colorectal Cancer Report, Continuous Update Project. AICR: Washington DC, 2011.
13. McKeown NM, Day NE, Welch AA, et al., Use of biological markers to validate self-reported dietary intake in a random sample of the European Prospective Investigation into Cancer United Kingdom Norfolk cohort. Am J Clin Nutr 2001; 74: 188-196.
14. Naguib A, Mitrou PN, Gay LJ, et al., Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study. BMC Cancer 2010; 10: 99-109.
15. Park JY, Mitrou PN, Keen J, et al., Lifestyle factors and p53 mutation patterns in colorectal cancer patients in the EPIC-Norfolk study. Mutagenesis 2010; 25: 351-358.
16. Bonfield JK, Rada C, Staden R,. Automated detection of point mutations using fluorescent sequence trace subtraction. Nucleic Acids Res 1998; 26: 3404-3409.
17. Day N, Oakes S, Luben R, et al., EPIC-Norfolk: study design and characteristics of the cohort. European Prospective Investigation of Cancer. Br J Cancer 1999; 80 (suppl 1): 95-103.
18. Wu K, Bowman R, Welch AA, et al., Apolipoprotein E polymorphisms, dietary fat and fibre, and serum lipids: the EPIC Norfolk study. Eur Heart J 2007; 28: 2930-2936.
19. Gay LJ, Arends MJ, Mitrou PN, et al., MLH1 promoter methylation, diet and lifestyle factors in mismatch repair deficient colorectal cancer patients from EPIC-Norfolk. Nutr Cancer 2011; 63: 1000-1010.
20. Boland CR, Thibodeau SN, Hamilton SR, et al., A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 1998; 58: 5248-5257.
21. Frayling IM, Happerfield L, Mattocks C, et al., Application of molecular diagnostics to hereditary nonpolyposis colorectal cancer. In Molecular Diagnostics for the Clinical Laboratorian, (2nd edition) Coleman WB & Tsongalis GJ (ed). Humana Press Inc., NJ, USA. 2005; 375-554.
22. Sargeant LA, Khaw KT, Bingham S, et al., Cigarette smoking and glycaemia: the EPIC-Norfolk study. European Prospective Investigation into Cancer. Int J Epidemiol 2001; 30: 547-554.
23. Bingham SA, Welch AA, McTaggart A, et al., Nutritional methods in the European Prospective Investigation of Cancer in Norfolk. Public Health Nutr 2001; 4: 847-858.
24. Welch AA, McTaggart A, Mulligan AA, et al., DINER (data into nutrients for epidemiological research)-a new data-entry program for nutritional analysis in the EPIC-Norfolk cohort and the 7-day diary method. Public Health Nutr 2001; 4: 1253-1265.
25. Fodde R, Smits R, Clevers H,. APC, signal transduction and genetic instability in colorectal cancer. Nat Rev Cancer 2001; 1: 55-67.
26. Calmels S, Ohshima H, Rosenkranz H, et al., Biochemical studies on the catalysis of nitrosation by bacteria. Carcinogenesis 1987; 8: 1085-1088.
27. Cross AJ, Pollock JR, Bingham SA,. Haem, not protein or inorganic iron, is responsible for endogenous intestinal N-nitrosation arising from red meat. Cancer Res 2003; 63: 2358-2360.
28. 6-carboxy- methyl-2'-deoxyguanosine in DNA following reaction of nitric oxide with glycine and in human blood DNA, using a quantitative immunoslot blot assay. Chem Res Toxicol 2004; 17: 294-300.
29. Hughes R, Cross AJ, Pollock JR, et al., Dose-dependent effect of dietary meat on endogenous colonic N-nitrosation. Carcinogenesis 2001; 22: 199-202.
30. 6-methylguanine in DNA. Cancer Res 1997; 57: 366-369.
31. Saffhill R, Margison GP, O'Connor PJ,. Mechanisms of carcinogenesis induced by alkylating agents. Biochim Biophys Acta 1985; 823: 111-145.
32. Kuhnle GG, Story GW, Reda T, et al., Diet-induced endogenous formation of nitroso compounds in the GI tract. Free Radic Biol Med 2007; 43: 1040-1047.
33. Loh YH, Jakszyn P, Luben RN, et al., N-Nitroso compounds and cancer incidence: the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk Study. Am J Clin Nutr 2011; 93: 1053-1061.
34. Lakshmi VM, Clapper ML, Chang WC, et al., Hemin potentiates nitric oxide-mediated nitrosation of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) to 2-nitrosoamino-3-methylimidazo[4,5-f]quinoline. Chem Res Toxicol 2005; 18: 528-535.
35. 6-carboxymethyl guanine: implications for colorectal cancer risk. Cancer Res 2006; 66: 1859-1865.
36. 6-methyl-2'-deoxyguanosine DNA adducts: relevance for gastrointestinal cancer. Carcinogenesis 2007; 28: 356-362.
37. Burns PA, Gordon AJ, Glickman BW,. Mutational specificity of N-methyl-N-nitrosourea in the lacI gene of Escherichia coli. Carcinogenesis 1988; 9: 1607-1610.
38. Luchtenborg M, Weijenberg MP, de Goeij AF, et al., Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer: a prospective cohort study (The Netherlands). Cancer Causes Control 2005; 16: 1041-1054.
39. Brink M, Weijenberg MP, de Goeij AF, et al., Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study. Br J Cancer 2005; 92: 1310-1320.
40. Diergaarde B, van Geloof WL, van Muijen GN, et al., Dietary factors and the occurrence of truncating APC mutations in sporadic colon carcinomas: a Dutch population-based study. Carcinogenesis 2003; 24: 283-290.
41. Diergaarde B, Tiemersma EW, Braam H, et al., Dietary factors and truncating APC mutations in sporadic colorectal adenomas. Int J Cancer 2005; 113: 126-132.
42. Seitz HK, Meier P,. The role of acetaldehyde in upper digestive tract cancer in alcoholics. Transl Res 2007; 149: 293-297.
43. Poschl G, Stickel F, Wang XD, et al., Alcohol and cancer: genetic and nutritional aspects. Proc Nutr Soc 2004; 63: 65-71.
44. Langevin F, Crossan GP, Rosado IV, et al., Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice. Nature 2011; 475: 53-58.
45. 6-methylguanine transferase. Carcinogenesis 1988; 9: 761-766.
46. Dahm CC, Keogh RH, Spencer EA, et al., Dietary fiber and colorectal cancer risk: a nested case-control study using food diaries. J Natl Cancer Inst 2010; 102: 614-626.
47. Bingham SA, Day NE, Luben R, et al., Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study. Lancet 2003; 361: 1496-1501.
48. Avivi-Green C, Polak-Charcon S, Madar Z, et al., Apoptosis cascade proteins are regulated in vivo by high intracolonic butyrate concentration: correlation with colon cancer inhibition. Oncol Res 2000; 12: 83-95.
49. van Engeland M, Weijenberg MP, Roemen GM, et al., Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: The Netherlands cohort study on diet and cancer. Cancer Res 2003; 63: 3133-3137.
50. Kim YI,. Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal cancer? Cancer Epidemiol Biomarkers Prev 2004; 13: 511-519.
51. Homann N, Tillonen J, Salaspuro M,. Microbially produced acetaldehyde from ethanol may increase the risk of colon cancer via folate deficiency. Int J Cancer 2000; 86: 169-173.
52. 6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. Cancer Res 2000; 60: 2368-2371.
53. Esteller M, Risques RA, Toyota M, et al., Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis. Cancer Res 2001; 61: 4689-4692.
54. Salahshor S, Kressner U, Pahlman L, et al., Colorectal cancer with and without microsatellite instability involves different genes. Genes Chromosomes Cancer 1999; 26: 247-252.
55. Kawasaki T, Nosho K, Ohnishi M, et al., Correlation of β-catenin localization with cyclooxygenase-2 expression and CpG island methylator phenotype (CIMP) in colorectal cancer. Neoplasia 2007; 9: 569-577.
56. Xu XL, Yu J, Zhang HY, et al., Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. World J Gastroenterol 2004; 10: 3441-3454.
57. Lindblom A,. Different mechanisms in the tumorigenesis of proximal and distal colon cancers. Curr Opin Oncol 2001; 13: 63-69.
58. Yamauchi M, Morikawa T, Kuchiba A, et al., Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum. Gut 2012; 61: 847-854.
59. Samowitz WS, Slattery ML, Sweeney C, et al., APC mutations and other genetic and epigenetic changes in colon cancer. Mol Cancer Res 2007; 5: 165-170.
60. Denissenko MF, Chen JX, Tang MS, et al., Cytosine methylation determines hot spots of DNA damage in the human p53 gene. Proc Natl Acad Sci USA 1997; 94: 3893-3898.
61. Wei SC, Su YN, Tsai-Wu JJ, et al., Genetic analysis of the APC gene in Taiwanese familial adenomatous polyposis. J Biomed Sci 2004; 11: 260-265.
62. Shibata D, Peinado MA, Ionov Y, et al., Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation. Nat Genet 1994; 6: 273-281.
63. Streisinger G, Okada Y, Emrich J, et al., Frameshift mutations and the genetic code. Cold Spring Harb Symp Quant Biol 1966; 31: 77-84.
64. Su LK, Barnes CJ, Yao W, et al., Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis. Am J Hum Genet 2000; 67: 582-590.
65. Morikawa T, Kuchiba A, Yamauchi M, et al., Association of CTNNB1 (β-catenin) alterations, body mass index, and physical activity with survival in patients with colorectal cancer. J Am Med Assoc 2011; 305: 1685-1694.
66. Riboli E, Hunt KJ, Slimani N, et al., European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection. Public Health Nutr 2002; 5: 1113-1124.
67. Ogino S, Chan AT, Fuchs CS, et al., Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field. Gut 2011; 60: 397-411.