Detection of aberrantly methylated hMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer

Cancer Research

Volumn 61, Issue 3, 2001, Pages 900-902

  Grady, W M ^a   Rajput, A ^a   Lutterbaugh, J D ^a   Markowitz, S D ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PROTEIN MLH1; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL ARTICLE; COLON CANCER; CONTROLLED STUDY; DNA DAMAGE; DNA DETERMINATION; DNA METHYLATION; EARLY DIAGNOSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; MICROSATELLITE INSTABILITY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; SILENCER GENE;

CARRIER PROTEINS; COLONIC NEOPLASMS; DNA METHYLATION; DNA PRIMERS; DNA, NEOPLASM; HUMANS; MICROSATELLITE REPEATS; NEOPLASM PROTEINS; NUCLEAR PROTEINS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); SENSITIVITY AND SPECIFICITY; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 0035117962     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Cancer Statistics
2. Molecular detection of genetic alterations in the serum of colorectal cancer patients
3. Mutation of the transforming growth factor-β type II receptor gene in right-sided colorectal cancer: Relationship to clinicopathological features and genetic alterations
4. Sequence of molecular genetic events in colorectal tumorigenesis
5. Hereditary nonpolyposis colorectal cancer: The syndrome, the genes, and historical perspective
6. Hereditary nonpolyposis colorectal cancer (Lynch syndrome): An updated review
7. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
8. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
9. Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
10. Methylation-specific PCR, a novel PCR assay for methylation status of CpG islands
11. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability
12. Cell culture of human colon adenomas and carcinomas
13. Methylation-specific PCR
14. Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression
15. Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients
16. Aberrant DNA methylation of the p16ink4A gene in plasma of breast cancer patients
17. Gene promoter hypermethylation in tumors and serum of head and neck cancer patients
18. Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients