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Volumn 33, Issue 3S, 2003, Pages 238-244

The genetics and genomics of cancer

Author keywords

[No Author keywords available]

Indexed keywords

IMATINIB; PROTEIN TYROSINE KINASE INHIBITOR; TRASTUZUMAB;

EID: 0037370476     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1107     Document Type: Review
Times cited : (474)

References (108)
  • 1
    • 0015043748 scopus 로고
    • Mutation and cancer: Statistical study of retinoblastoma
    • Knudson, A.G. Jr. Mutation and cancer: Statistical study of retinoblastoma. Proc. Natl. Acad. Sci. USA 68, 820-823 (1971).
    • (1971) Proc. Natl. Acad. Sci. USA , vol.68 , pp. 820-823
    • Knudson, A.G.1
  • 2
    • 0022506980 scopus 로고
    • A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
    • Friend, S.H. et al. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 323, 643-646 (1986).
    • (1986) Nature , vol.323 , pp. 643-646
    • Friend, S.H.1
  • 3
    • 0019829568 scopus 로고
    • The causes of cancer: Quantitative estimates of avoidable risks of cancer in the United States today
    • Doll, R. and Peto, R. The causes of cancer: Quantitative estimates of avoidable risks of cancer in the United States today. J. Natl. Cancer Inst. 66, 1191-1308 (1981).
    • (1981) J. Natl. Cancer Inst , vol.66 , pp. 1191-1308
    • Doll, R.1    Peto, R.2
  • 4
    • 0035902067 scopus 로고    scopus 로고
    • Cancer epidemiology in the last century and the next decade
    • Peto, J. Cancer epidemiology in the last century and the next decade. Nature 411, 390-395 (2001).
    • (2001) Nature , vol.411 , pp. 390-395
    • Peto, J.1
  • 5
    • 0000219461 scopus 로고
    • Cancer mortality among Japanese Issei and Nisei of California
    • Buell, P. and Dunn, J.E. Cancer mortality among Japanese Issei and Nisei of California. Cancer18, 656-664 (1965).
    • (1965) Cancer18 , pp. 656-664
    • Buell, P.1    Dunn, J.E.2
  • 6
    • 2742525287 scopus 로고
    • Inheritance of human breast cancer: Evidence for autosomal dominant transmission in high-risk families
    • Newman, B., Austin, M.A., Lee, M. and King, M.C. Inheritance of human breast cancer: Evidence for autosomal dominant transmission in high-risk families. Proc. Natl. Acad. Sci. USA 85, 3044-3048 (1988).
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 3044-3048
    • Newman, B.1    Austin, M.A.2    Lee, M.3    King, M.C.4
  • 7
    • 0026092912 scopus 로고
    • Genetic analysis of breast cancer in the cancer and steroid hormone study
    • Claus, E.B., Risch, N. and Thompson, W.D. Genetic analysis of breast cancer in the cancer and steroid hormone study. Am. J. Hum. Genet. 48, 232-242 (1991).
    • (1991) Am. J. Hum. Genet , vol.48 , pp. 232-242
    • Claus, E.B.1    Risch, N.2    Thompson, W.D.3
  • 8
    • 0343533306 scopus 로고
    • (eds. Cairns, J., Lyon, J.L. & Skolnik, M., Cold Spring Harbor Press, Cold Spring Harbor, NY
    • Peto, J. in Cancer Incidence in Defined Populations Vol. 4, Banbury Report (eds. Cairns, J., Lyon, J.L. & Skolnik, M.) 203-213 (Cold Spring Harbor Press, Cold Spring Harbor, NY, 1980).
    • (1980) Cancer Incidence in Defined Populations , vol.4 , pp. 203-213
    • Peto, J.1
  • 9
    • 0025613812 scopus 로고
    • Linkage of early-onset familial breast cancer to chromosome 17q21
    • Hall, J.M. et al. Linkage of early-onset familial breast cancer to chromosome 17q21. Science 250, 1684-1689 (1990).
    • (1990) Science , vol.250 , pp. 1684-1689
    • Hall, J.M.1
  • 10
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg, R.A. The retinoblastoma protein and cell cycle control. Cell 81, 323-330 (1995).
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 11
    • 0018760324 scopus 로고
    • Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
    • Linzer, D.I. and Levine, A.J. Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell 17, 43-52 (1979).
    • (1979) Cell , vol.17 , pp. 43-52
    • Linzer, D.I.1    Levine, A.J.2
  • 12
    • 0018348655 scopus 로고
    • Tantigen is bound to a host protein in SV40- transformed cells
    • Lane, D.P. and Crawford, L.V. Tantigen is bound to a host protein in SV40- transformed cells. Nature 278, 261-263 (1979).
    • (1979) Nature , vol.278 , pp. 261-263
    • Lane, D.P.1    Crawford, L.V.2
  • 13
    • 0024536654 scopus 로고
    • Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas
    • Baker, S.J. et al. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 244, 217-221 (1989).
    • (1989) Science , vol.244 , pp. 217-221
    • Baker, S.J.1
  • 14
    • 0025633582 scopus 로고
    • Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
    • Malkin, D. et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250, 1233-1238 (1990).
    • (1990) Science , vol.250 , pp. 1233-1238
    • Malkin, D.1
  • 16
    • 0032475861 scopus 로고    scopus 로고
    • Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
    • Stambolic, V. et al. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95, 29-39 (1998).
    • (1998) Cell , vol.95 , pp. 29-39
    • Stambolic, V.1
  • 17
    • 0013457194 scopus 로고    scopus 로고
    • Cowden syndrome
    • (ed. Kinzler, K.W., McGraw Hill, New York
    • Eng, C. and Parsons, R. Cowden syndrome. In The Genetic Basis of Human Cancer (ed. Kinzler, K.W.) 527-537 (McGraw Hill, New York 2002).
    • (2002) The Genetic Basis of Human Cancer , pp. 527-537
    • Eng, C.1    Parsons, R.2
  • 19
    • 0037169354 scopus 로고    scopus 로고
    • Cancer susceptibility and the functions of BRCA1 and BRCA2
    • Venkitaraman, A.R. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 108, 171-182 (2002).
    • (2002) Cell , vol.108 , pp. 171-182
    • Venkitaraman, A.R.1
  • 20
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • Hoeijmakers, J.H. Genome maintenance mechanisms for preventing cancer. Nature 411, 366-374 (2001).
    • (2001) Nature , vol.411 , pp. 366-374
    • Hoeijmakers, J.H.1
  • 21
    • 0021893246 scopus 로고
    • Skin fibroblasts obtained from cancer patients display foetal-like migratory behaviour on collagen gels
    • Schor, S.L., Schor, A.M., Durning, P. and Rushton, G. Skin fibroblasts obtained from cancer patients display foetal-like migratory behaviour on collagen gels. J. Cell Sci. 73, 235-244 (1985).
    • (1985) J. Cell Sci , vol.73 , pp. 235-244
    • Schor, S.L.1    Schor, A.M.2    Durning, P.3    Rushton, G.4
  • 22
    • 0033215242 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium
    • Olumi, A.F. et al. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res. 59, 5002-5011 (1999).
    • (1999) Cancer Res , vol.59 , pp. 5002-5011
    • Olumi, A.F.1
  • 23
    • 0036843937 scopus 로고    scopus 로고
    • Frequent somatic mutations in PTEN. And TP53 are mutually exclusive in the stroma of breast carcinomas
    • Kurose, K. et al. Frequent somatic mutations in PTEN. and TP53 are mutually exclusive in the stroma of breast carcinomas. Nat. Genet. 32, 355-357 (2002).
    • (2002) Nat. Genet , vol.32 , pp. 355-357
    • Kurose, K.1
  • 24
    • 0037012848 scopus 로고    scopus 로고
    • Neurofibromas in NF1: Schwann cell origin and role of tumor environment
    • Zhu, Y., Ghosh, P., Charnay, P., Burns, D.K. and Parada, L.F. Neurofibromas in NF1: Schwann cell origin and role of tumor environment. Science 296, 920-922 (2002).
    • (2002) Science , vol.296 , pp. 920-922
    • Zhu, Y.1    Ghosh, P.2    Charnay, P.3    Burns, D.K.4    Parada, L.F.5
  • 25
    • 0034644254 scopus 로고    scopus 로고
    • Will genetics revolutionize medicine
    • Holtzman, N.A. and Marteau, T.M. Will genetics revolutionize medicine? N. Engl. J. Med. 343, 141-144 (2000).
    • (2000) N. Engl. J. Med , vol.343 , pp. 141-144
    • Holtzman, N.A.1    Marteau, T.M.2
  • 26
    • 0032554222 scopus 로고    scopus 로고
    • The new genetics in clinical practice
    • Bell, J. The new genetics in clinical practice. Br. Med. J. 316, 618-620 (1998).
    • (1998) Br. Med. J , vol.316 , pp. 618-620
    • Bell, J.1
  • 27
    • 0036578764 scopus 로고    scopus 로고
    • Polygenic susceptibility to breast cancer and implications for prevention
    • Pharoah, P.D. et al. Polygenic susceptibility to breast cancer and implications for prevention. Nat. Genet. 31, 33-36 (2002).
    • (2002) Nat. Genet , vol.31 , pp. 33-36
    • Pharoah, P.D.1
  • 28
    • 0034644185 scopus 로고    scopus 로고
    • Environmental and heritable factors in the causation of cancer—analyses of cohorts of twins from Sweden, Denmark, and Finland
    • Lichtenstein, P. et al. Environmental and heritable factors in the causation of cancer—analyses of cohorts of twins from Sweden, Denmark, and Finland. N. Engl. J. Med. 343, 78-85 (2000).
    • (2000) N. Engl. J. Med , vol.343 , pp. 78-85
    • Lichtenstein, P.1
  • 29
    • 0035130162 scopus 로고    scopus 로고
    • After BRCA1 and BRCA2—what next? Multifactorial segregation analyses of three-generation, population-based Australian families affected by female breast cancer
    • Cui, J. et al. After BRCA1 and BRCA2—what next? Multifactorial segregation analyses of three-generation, population-based Australian families affected by female breast cancer. Am. J. Hum. Genet. 68, 420-31 (2001).
    • (2001) Am. J. Hum. Genet , vol.68 , pp. 420-431
    • Cui, J.1
  • 30
    • 0037033733 scopus 로고    scopus 로고
    • A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes
    • Antoniou, A.C. et al. A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes. Br. J. Cancer 86, 76-83 (2002).
    • (2002) Br. J. Cancer , vol.86 , pp. 76-83
    • Antoniou, A.C.1
  • 31
    • 0036595321 scopus 로고    scopus 로고
    • Breast cancer susceptibility—a new look at an old model
    • Peto, J. Breast cancer susceptibility—a new look at an old model. Cancer Cell 1, 411-412 (2002).
    • (2002) Cancer Cell , vol.1 , pp. 411-412
    • Peto, J.1
  • 32
    • 0034892062 scopus 로고    scopus 로고
    • Complex genetic diseases: Controversy over the Croesus code
    • COMMENT2007
    • Wright, A.F. & Hastie, N.D. Complex genetic diseases: Controversy over the Croesus code. Genome Biol. 2, COMMENT2007 (2001).
    • (2001) Genome Biol , vol.2
    • Wright, A.F.1    Hastie, N.D.2
  • 33
    • 0035257236 scopus 로고    scopus 로고
    • Association study designs for complex diseases
    • Cardon, L.R. and Bell, J.I. Association study designs for complex diseases. Nat. Rev. Genet. 2, 91-99 (2001).
    • (2001) Nat. Rev. Genet , vol.2 , pp. 91-99
    • Cardon, L.R.1    Bell, J.I.2
  • 34
    • 0037373275 scopus 로고    scopus 로고
    • Discovering genotypes underlying human phenotypes: Past successes for mendelian disease, future approaches for complex disease. Nat
    • Botstein, D. and Rich, N. Discovering genotypes underlying human phenotypes: Past successes for mendelian disease, future approaches for complex disease. Nat. Genet., 33,.228-237 (2003)
    • (2003) Genet , vol.33 , pp. 228-237
    • Botstein, D.1    Rich, N.2
  • 35
    • 18444369013 scopus 로고    scopus 로고
    • The structure of haplotype blocks in the human genome
    • Gabriel, S.B. et al. The structure of haplotype blocks in the human genome. Science 296, 2225-2229 (2002).
    • (2002) Science , vol.296 , pp. 2225-2229
    • Gabriel, S.B.1
  • 36
    • 0037165976 scopus 로고    scopus 로고
    • New mapping project splits the community
    • Couzin, J. Genomics. New mapping project splits the community. Science 296, 1391-3139 (2002).
    • (2002) Science , vol.296 , pp. 1391-3139
    • Couzin, J.G.1
  • 37
    • 0033772073 scopus 로고    scopus 로고
    • Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
    • Horikawa, Y. et al. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat. Genet. 26, 163-175 (2000).
    • (2000) Nat. Genet , vol.26 , pp. 163-175
    • Horikawa, Y.1
  • 38
    • 0031955368 scopus 로고    scopus 로고
    • Cancer resistance genes in mice: Models for the study of tumour modifiers
    • Balmain, A. and Nagase, H. Cancer resistance genes in mice: Models for the study of tumour modifiers. Trends Genet. 14, 139-144 (1998).
    • (1998) Trends Genet , vol.14 , pp. 139-144
    • Balmain, A.1    Nagase, H.2
  • 39
    • 0035802288 scopus 로고    scopus 로고
    • Complexity of lung cancer modifiers: Mapping of thirty genes and twenty-five interactions in half of the mouse genome
    • Tripodis, N., Hart, A.A., Fijneman, R.J. and Demant, P. Complexity of lung cancer modifiers: Mapping of thirty genes and twenty-five interactions in half of the mouse genome. J. Natl. Cancer Inst. 93, 1484-1491 (2001).
    • (2001) J. Natl. Cancer Inst , vol.93 , pp. 1484-1491
    • Tripodis, N.1    Hart, A.A.2    Fijneman, R.J.3    Demant, P.4
  • 40
    • 0033592852 scopus 로고    scopus 로고
    • Subset of skin tumor modifier loci determines survival time of tumor-bearing mice
    • Nagase, H., Mao, J.H. and Balmain, A. A subset of skin tumor modifier loci determines survival time of tumor-bearing mice. Proc. Natl. Acad. Sci. USA 96, 15032-15037 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 15032-15037
    • Nagase, H.1    Mao, J.H.2    Balmain, A.A.3
  • 41
    • 0033819561 scopus 로고    scopus 로고
    • Genetics of chemical carcinogenesis: Analysis of bidirectional selective breeding inducing maximal resistance or maximal susceptibility to 2-stage skin tumorigenesis in the mouse
    • Saran, A. et al. Genetics of chemical carcinogenesis: Analysis of bidirectional selective breeding inducing maximal resistance or maximal susceptibility to 2-stage skin tumorigenesis in the mouse. Int. J. Cancer 88, 424-431 (2000).
    • (2000) Int. J. Cancer , vol.88 , pp. 424-431
    • Saran, A.1
  • 42
    • 0029847373 scopus 로고    scopus 로고
    • Complex interactions of new quantitative trait loci, Sluc1, Sluc2, Sluc3, and Sluc4, that influence the susceptibility to lung cancer in the mouse
    • Fijneman, R.J., de Vries, S.S., Jansen, R.C. and Demant, P. Complex interactions of new quantitative trait loci, Sluc1, Sluc2, Sluc3, and Sluc4, that influence the susceptibility to lung cancer in the mouse. Nat. Genet. 14, 465-467 (1996).
    • (1996) Nat. Genet , vol.14 , pp. 465-467
    • Fijneman, R.J.1    de Vries, S.S.2    Jansen, R.C.3    Demant, P.4
  • 43
    • 0029807806 scopus 로고    scopus 로고
    • Gene interaction and single gene effects in colon tumour susceptibility in mice
    • van Wezel, T. et al. Gene interaction and single gene effects in colon tumour susceptibility in mice. Nat. Genet. 14, 468-470 (1996).
    • (1996) Nat. Genet , vol.14 , pp. 468-470
    • Van Wezel, T.1
  • 44
    • 0035866354 scopus 로고    scopus 로고
    • Epistatic interactions between skin tumor modifier loci in interspecific (Spretus/musculus) backcross mice
    • Nagase, H., Mao, J.H., de Koning, J.P., Minami, T. and Balmain, A. Epistatic interactions between skin tumor modifier loci in interspecific (spretus/musculus) backcross mice. Cancer Res. 61, 1305-1308 (2001).
    • (2001) Cancer Res , vol.61 , pp. 1305-1308
    • Nagase, H.1    Mao, J.H.2    de Koning, J.P.3    Minami, T.4    Balmain, A.5
  • 45
    • 0037178748 scopus 로고    scopus 로고
    • Interfaces between the detection, signaling, and repair of DNA damage
    • Rouse, J. and Jackson, S.P. Interfaces between the detection, signaling, and repair of DNA damage. Science 297, 547-551 (2002).
    • (2002) Science , vol.297 , pp. 547-551
    • Rouse, J.1    Jackson, S.P.2
  • 46
    • 0037178722 scopus 로고    scopus 로고
    • Maintenance of genome stability in Saccharomyces cerevisiae
    • Kolodner, R.D., Putnam, C.D. and Myung, K. Maintenance of genome stability in Saccharomyces cerevisiae. Science 297, 552-557 (2002).
    • (2002) Science , vol.297 , pp. 552-557
    • Kolodner, R.D.1    Putnam, C.D.2    Myung, K.3
  • 47
    • 0037178761 scopus 로고    scopus 로고
    • Connecting chromosomes, crisis, and cancer
    • Maser, R.S. and DePinho, R.A. Connecting chromosomes, crisis, and cancer. Science 297, 565-569 (2002).
    • (2002) Science , vol.297 , pp. 565-569
    • Maser, R.S.1    Depinho, R.A.2
  • 48
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • Lengauer, C., Kinzler, K.W. and Vogelstein, B. Genetic instabilities in human cancers. Nature 396, 643-649 (1998).
    • (1998) Nature , vol.396 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 49
    • 0035495386 scopus 로고    scopus 로고
    • How nucleotide excision repair protects against cancer
    • Friedberg, E.C. How nucleotide excision repair protects against cancer. Nat. Rev. Cancer 1, 22-33 (2001).
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 22-33
    • Friedberg, E.C.1
  • 50
    • 0027285475 scopus 로고
    • Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
    • Ionov, Y., Peinado, M.A., Malkhosyan, S., Shibata, D. and Perucho, M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 363, 558-561 (1993).
    • (1993) Nature , vol.363 , pp. 558-561
    • Ionov, Y.1    Peinado, M.A.2    Malkhosyan, S.3    Shibata, D.4    Perucho, M.5
  • 51
    • 0027314411 scopus 로고
    • Microsatellite instability in cancer of the proximal colon
    • Thibodeau, S.N., Bren, G. and Schaid, D. Microsatellite instability in cancer of the proximal colon. Science 260, 816-819 (1993).
    • (1993) Science , vol.260 , pp. 816-819
    • Thibodeau, S.N.1    Bren, G.2    Schaid, D.3
  • 52
    • 0027137935 scopus 로고
    • Hypermutability and mismatch repair deficiency in RER+ tumor cells
    • Parsons, R. et al. Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell 75, 1227-1236 (1993).
    • (1993) Cell , vol.75 , pp. 1227-1236
    • Parsons, R.1
  • 53
    • 0032730774 scopus 로고    scopus 로고
    • A. Genetic susceptibility to non-polyposis colorectal cancer
    • Lynch, H.T. and de la Chapelle, A. Genetic susceptibility to non-polyposis colorectal cancer. J. Med. Genet. 36, 801-818 (1999).
    • (1999) J. Med. Genet , vol.36 , pp. 801-818
    • Lynch, H.T.1    Chapelle, D.L.2
  • 54
    • 0031018674 scopus 로고    scopus 로고
    • Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
    • Rampino, N. et al. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 275, 967-969 (1997).
    • (1997) Science , vol.275 , pp. 967-969
    • Rampino, N.1
  • 55
    • 0028785603 scopus 로고
    • Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer
    • Parsons, R. et al. Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. Cancer Res. 55, 5548-5550 (1995).
    • (1995) Cancer Res , vol.55 , pp. 5548-5550
    • Parsons, R.1
  • 56
    • 0025143252 scopus 로고
    • Telomere reduction in human colorectal carcinoma and with ageing
    • Hastie, N.D. et al. Telomere reduction in human colorectal carcinoma and with ageing. Nature 346, 866-868 (1990).
    • (1990) Nature , vol.346 , pp. 866-868
    • Hastie, N.D.1
  • 57
    • 0021256990 scopus 로고
    • Identification of a telomeric DNA sequence in Trypanosoma brucei
    • Blackburn, E.H. and Challoner, P.B. Identification of a telomeric DNA sequence in Trypanosoma brucei. Cell 36, 447-457 (1984).
    • (1984) Cell , vol.36 , pp. 447-457
    • Blackburn, E.H.1    Challoner, P.B.2
  • 58
    • 0032546360 scopus 로고    scopus 로고
    • Mutations of mitotic checkpoint genes in human cancers
    • Cahill, D.P. et al. Mutations of mitotic checkpoint genes in human cancers. Nature 392, 300-303 (1998).
    • (1998) Nature , vol.392 , pp. 300-303
    • Cahill, D.P.1
  • 59
    • 0035524309 scopus 로고    scopus 로고
    • Chromosome segregation and cancer: Cutting through the mystery
    • Jallepalli, P.V. and Lengauer, C. Chromosome segregation and cancer: Cutting through the mystery. Nat. Rev. Cancer1, 109-117 (2001).
    • (2001) Nat. Rev. Cancer1 , pp. 109-117
    • Jallepalli, P.V.1    Lengauer, C.2
  • 60
    • 0035496104 scopus 로고    scopus 로고
    • Signal transduction and genetic instability in colorectal cancer
    • Fodde, R., Smits, R. and Clevers, H. APC, signal transduction and genetic instability in colorectal cancer. Nat. Rev. Cancer1, 55-67 (2001).
    • (2001) Nat. Rev. Cancer1 , pp. 55-67
    • Fodde, R.1    Smits, R.2    Clevers, H.3
  • 61
    • 0032100685 scopus 로고    scopus 로고
    • A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers
    • Bischoff, J.R. et al. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J. 17, 3052-3065 (1998).
    • (1998) EMBO J , vol.17 , pp. 3052-3065
    • Bischoff, J.R.1
  • 62
    • 0031714080 scopus 로고    scopus 로고
    • Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
    • Zhou, H. et al. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat. Genet. 20, 189-193 (1998).
    • (1998) Nat. Genet , vol.20 , pp. 189-193
    • Zhou, H.1
  • 63
  • 64
    • 0034676455 scopus 로고    scopus 로고
    • Surfing the p53 network
    • Vogelstein, B., Lane, D. and Levine, A.J. Surfing the p53 network. Nature 408, 307-310 (2000).
    • (2000) Nature , vol.408 , pp. 307-310
    • Vogelstein, B.1    Lane, D.2    Levine, A.J.3
  • 65
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon, E.R. and Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell 61, 759-767 (1990).
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 66
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell, P.C. The clonal evolution of tumor cell populations. Science 194, 23-28 (1976).
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 67
    • 0034002461 scopus 로고    scopus 로고
    • Integration of positive and negative growth signals during ras pathway activation in vivo
    • Frame, S. and Balmain, A. Integration of positive and negative growth signals during ras pathway activation in vivo. Curr. Opin. Genet. Dev. 10, 106-113 (2000).
    • (2000) Curr. Opin. Genet. Dev , vol.10 , pp. 106-113
    • Frame, S.1    Balmain, A.2
  • 68
    • 0037178734 scopus 로고    scopus 로고
    • Debate surges over the origins of genomic defects in cancer
    • Marx, J. Debate surges over the origins of genomic defects in cancer. Science 297, 544-546 (2002).
    • (2002) Science , vol.297 , pp. 544-546
    • Marx, J.1
  • 69
    • 0030459428 scopus 로고    scopus 로고
    • Frequent clones of p53-mutated keratinocytes in normal human skin
    • Jonason, A.S. et al. Frequent clones of p53-mutated keratinocytes in normal human skin. Proc. Natl. Acad. Sci. USA 93, 14025-14029 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 14025-14029
    • Jonason, A.S.1
  • 70
    • 0030461224 scopus 로고    scopus 로고
    • Loss of heterozygosity in normal tissue adjacent to breast carcinomas
    • Deng, G., Lu, Y., Zlotnikov, G., Thor, A.D. and Smith, H.S. Loss of heterozygosity in normal tissue adjacent to breast carcinomas. Science 274, 2057-2059 (1996).
    • (1996) Science , vol.274 , pp. 2057-2059
    • Deng, G.1    Lu, Y.2    Zlotnikov, G.3    Thor, A.D.4    Smith, H.S.5
  • 71
    • 0028021871 scopus 로고
    • High frequency of loss of heterozygosity in actinic keratoses, a usually benign disease
    • Rehman, I., Quinn, A.G., Healy, E. and Rees, J.L. High frequency of loss of heterozygosity in actinic keratoses, a usually benign disease. Lancet 344, 788-789 (1994).
    • (1994) Lancet , vol.344 , pp. 788-789
    • Rehman, I.1    Quinn, A.G.2    Healy, E.3    Rees, J.L.4
  • 72
    • 0034885252 scopus 로고    scopus 로고
    • Genetic changes in paired atypical and usual ductal hyperplasia of the breast by comparative genomic hybridization
    • Gong, G. et al. Genetic changes in paired atypical and usual ductal hyperplasia of the breast by comparative genomic hybridization. Clin. Cancer Res. 7, 2410-2414 (2001).
    • (2001) Clin. Cancer Res , vol.7 , pp. 2410-2414
    • Gong, G.1
  • 73
    • 0036209289 scopus 로고    scopus 로고
    • Histopathologic types of benign breast lesions and the risk of breast cancer: Case-control study
    • Shaaban, A.M. et al. Histopathologic types of benign breast lesions and the risk of breast cancer: Case-control study. Am J. Surg. Pathol. 26, 421-430 (2002).
    • (2002) Am J. Surg. Pathol , vol.26 , pp. 421-430
    • Shaaban, A.M.1
  • 74
    • 0032559976 scopus 로고    scopus 로고
    • The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted
    • Brown, K., Strathdee, D., Bryson, S., Lambie, W. and Balmain, A. The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted. Curr. Biol. 8, 516-524 (1998).
    • (1998) Curr. Biol , vol.8 , pp. 516-524
    • Brown, K.1    Strathdee, D.2    Bryson, S.3    Lambie, W.4    Balmain, A.5
  • 75
    • 0343319476 scopus 로고
    • Fluorescence in situ hybridization with human chromosome-specific libraries: Detection of trisomy 21 and translocations of chromosome 4
    • Pinkel, D. et al. Fluorescence in situ hybridization with human chromosome-specific libraries: Detection of trisomy 21 and translocations of chromosome 4. Proc. Natl. Acad. Sci. USA 85, 9138-9142 (1988).
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 9138-9142
    • Pinkel, D.1
  • 76
    • 0034016185 scopus 로고    scopus 로고
    • Genome changes and gene expression in human solid tumors
    • Gray, J.W. and Collins, C. Genome changes and gene expression in human solid tumors. Carcinogenesis 21, 443-452 (2000).
    • (2000) Carcinogenesis , vol.21 , pp. 443-452
    • Gray, J.W.1    Collins, C.2
  • 77
    • 0027316298 scopus 로고
    • Restriction landmark genomic scanning method and its various applications
    • Hayashizaki, Y. et al. Restriction landmark genomic scanning method and its various applications. Electrophoresis 14, 251-258 (1993).
    • (1993) Electrophoresis , vol.14 , pp. 251-258
    • Hayashizaki, Y.1
  • 78
    • 0026495364 scopus 로고
    • Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors
    • Kallioniemi, A. et al. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science 258, 818-821 (1992).
    • (1992) Science , vol.258 , pp. 818-821
    • Kallioniemi, A.1
  • 79
    • 0034306983 scopus 로고    scopus 로고
    • Measurement of DNA copy number at microsatellite loci using quantitative PCR analysis
    • Ginzinger, D.G. et al. Measurement of DNA copy number at microsatellite loci using quantitative PCR analysis. Cancer Res. 60, 5405-5409 (2000).
    • (2000) Cancer Res , vol.60 , pp. 5405-5409
    • Ginzinger, D.G.1
  • 80
    • 0027468779 scopus 로고
    • Cloning the differences between two complex genomes
    • Lisitsyn, N. and Wigler, M. Cloning the differences between two complex genomes. Science 259, 946-951 (1993).
    • (1993) Science , vol.259 , pp. 946-951
    • Lisitsyn, N.1    Wigler, M.2
  • 81
    • 0036844322 scopus 로고    scopus 로고
    • Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors
    • Zardo, G. et al. Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors. Nat. Genet. 32, 453-458 (2002).
    • (2002) Nat. Genet , vol.32 , pp. 453-458
    • Zardo, G.1
  • 82
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies, H. et al. Mutations of the BRAF gene in human cancer. Nature 417, 949-954 (2002).
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1
  • 83
    • 0028806048 scopus 로고
    • Quantitative monitoring of gene expression patterns with a complementary DNA microarray
    • Schena, M., Shalon, D., Davis, R.W. and Brown, P.O. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 270, 467-470 (1995).
    • (1995) Science , vol.270 , pp. 467-470
    • Schena, M.1    Shalon, D.2    Davis, R.W.3    Brown, P.O.4
  • 84
    • 0036320413 scopus 로고    scopus 로고
    • Real-time PCR technology for cancer diagnostics
    • Bernard, P.S. and Wittwer, C.T. Real-time PCR technology for cancer diagnostics. Clin. Chem. 48, 1178-1185 (2002).
    • (2002) Clin. Chem , vol.48 , pp. 1178-1185
    • Bernard, P.S.1    Wittwer, C.T.2
  • 85
    • 0034661893 scopus 로고    scopus 로고
    • Utility of accurate mass tags for proteome-wide protein identification
    • Conrads, T.P., Anderson, G.A., Veenstra, T.D., Pasa-Tolic, L. and Smith, R.D. Utility of accurate mass tags for proteome-wide protein identification. Anal Chem. 72, 3349-3354 (2000).
    • (2000) Anal Chem , vol.72 , pp. 3349-3354
    • Conrads, T.P.1    Erson, G.A.2    Veenstra, T.D.3    Pasa-Tolic, L.4    Smith, R.D.5
  • 86
    • 0035491482 scopus 로고    scopus 로고
    • Proteomic profiling of the cancer microenvironment by antibody arrays
    • Knezevic, V. et al. Proteomic profiling of the cancer microenvironment by antibody arrays. Proteomics 1, 1271-1278 (2001).
    • (2001) Proteomics 1 , pp. 1271-1278
    • Knezevic, V.1
  • 87
    • 0021811764 scopus 로고
    • Structural organization of the BCR gene and its role in the Ph’ translocation
    • Heisterkamp, N., Stam, K., Groffen, J., de Klein, A. and Grosveld, G. Structural organization of the BCR gene and its role in the Ph’ translocation. Nature 315, 758-761 (1985).
    • (1985) Nature , vol.315 , pp. 758-761
    • Heisterkamp, N.1    Stam, K.2    Groffen, J.3    de Klein, A.4    Grosveld, G.5
  • 88
    • 0037071401 scopus 로고    scopus 로고
    • Modelling haematopoietic malignancies in the mouse and therapeutical implications
    • Bernardi, R., Grisendi, S. and Pandolfi, P.P. Modelling haematopoietic malignancies in the mouse and therapeutical implications. Oncogene 21, 3445-3458 (2002).
    • (2002) Oncogene , vol.21 , pp. 3445-3458
    • Bernardi, R.1    Grisendi, S.2    Pandolfi, P.P.3
  • 89
    • 0035810142 scopus 로고    scopus 로고
    • Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
    • Druker, B.J. et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N. Engl. J. Med. 344, 1038-1042 (2001).
    • (2001) N. Engl. J. Med , vol.344 , pp. 1038-1042
    • Druker, B.J.1
  • 90
    • 0026718827 scopus 로고
    • ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization
    • Kallioniemi, O.P. et al. ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization. Proc. Natl. Acad. Sci. USA 89, 5321-5325 (1992).
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 5321-5325
    • Kallioniemi, O.P.1
  • 91
    • 17944379907 scopus 로고    scopus 로고
    • First-line Herceptin monotherapy in metastatic breast cancer
    • Vogel, C.L. et al. First-line Herceptin monotherapy in metastatic breast cancer. Oncology 61 (suppl. 2), 37-42 (2001).
    • (2001) Oncology , vol.61 , Issue.2 , pp. 37-42
    • Vogel, C.L.1
  • 92
    • 0034784725 scopus 로고    scopus 로고
    • Discovery of a novel Raf kinase inhibitor. Endocr
    • Lyons, J.F., Wilhelm, S., Hibner, B. and Bollag, G. Discovery of a novel Raf kinase inhibitor. Endocr. Relat. Cancer 8, 219-225 (2001).
    • (2001) Relat. Cancer , vol.8 , pp. 219-225
    • Lyons, J.F.1    Wilhelm, S.2    Hibner, B.3    Bollag, G.4
  • 93
    • 0037118044 scopus 로고    scopus 로고
    • Cancer: New-age tumour suppressors
    • Balmain, A. Cancer: New-age tumour suppressors. Nature 417, 235-237 (2002).
    • (2002) Nature , vol.417 , pp. 235-237
    • Balmain, A.1
  • 94
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation: How the genome integrates intrinsic and environmental signals
    • Jaenisch R, and Adrian, B. Epigenetic regulation: How the genome integrates intrinsic and environmental signals. Nat. Genet., 33, 245-254 (2003)
    • (2003) Nat. Genet , vol.33 , pp. 245-254
    • Jaenisch, R.1    Adrian, B.2
  • 95
    • 0036561649 scopus 로고    scopus 로고
    • Altered methylation patterns in cancer cell genomes: Cause or consequence
    • Baylin, S. and Bestor, T.H. Altered methylation patterns in cancer cell genomes: Cause or consequence? Cancer Cell 1, 299-305 (2002).
    • (2002) Cancer Cell 1 , pp. 299-305
    • Baylin, S.1    Bestor, T.H.2
  • 96
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones, P.A. and Baylin, S.B. The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3, 415-428 (2002).
    • (2002) Nat. Rev. Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 97
    • 0032541321 scopus 로고    scopus 로고
    • Retention of wild-type p53 in tumors from p53 heterozygous mice: Reduction of p53 dosage can promote cancer formation
    • Venkatachalam, S. et al. Retention of wild-type p53 in tumors from p53 heterozygous mice: Reduction of p53 dosage can promote cancer formation. EMBO J. 17, 4657-4667 (1998).
    • (1998) EMBO J , vol.17 , pp. 4657-4667
    • Venkatachalam, S.1
  • 98
    • 2642614530 scopus 로고    scopus 로고
    • Transforming growth factor-p1 is a new form of tumor suppressor with true haploid insufficiency
    • Tang, B. et al. Transforming growth factor-p1 is a new form of tumor suppressor with true haploid insufficiency. Nat. Med. 4, 802-807 (1998).
    • (1998) Nat. Med , vol.4 , pp. 802-807
    • Tang, B.1
  • 99
    • 0032511848 scopus 로고    scopus 로고
    • The murine gene p27Kip1 is haplo-insufficient for tumour suppression
    • Fero, M.L., Randel, E., Gurley, K.E., Roberts, J.M. and Kemp, C.J. The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature 396, 177-180 (1998).
    • (1998) Nature , vol.396 , pp. 177-180
    • Fero, M.L.1    Randel, E.2    Gurley, K.E.3    Roberts, J.M.4    Kemp, C.J.5
  • 100
    • 0035890273 scopus 로고    scopus 로고
    • Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas
    • Inoue, K., Zindy, F., Randle, D.H., Rehg, J.E. and Sherr, C.J. Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas. Genes Dev. 15, 2934-2939 (2001).
    • (2001) Genes Dev , vol.15 , pp. 2934-2939
    • Inoue, K.1    Zindy, F.2    Randle, D.H.3    Rehg, J.E.4    Sherr, C.J.5
  • 101
    • 0036569946 scopus 로고    scopus 로고
    • Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo
    • Ji, L. et al. Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo. Cancer Res. 62, 2715-2720 (2002).
    • (2002) Cancer Res , vol.62 , pp. 2715-2720
    • Ji, L.1
  • 102
    • 0026764662 scopus 로고
    • Parental bias of Ki-ras oncogenes detected in lung tumors from mouse hybrids
    • You, M. et al. Parental bias of Ki-ras oncogenes detected in lung tumors from mouse hybrids. Proc. Natl. Acad. Sci. USA 89, 5804-5808 (1992).
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 5804-5808
    • You, M.1
  • 103
    • 0034672287 scopus 로고    scopus 로고
    • Allele-specific loss or imbalance of chromosomes 9, 15, and 16 in B-cell tumors from interspecific F1 hybrid mice carrying Emu-c-myc or N-myc transgenes
    • Linardopoulos, S., Silva, S., Klein, G. and Balmain, A. Allele-specific loss or imbalance of chromosomes 9, 15, and 16 in B-cell tumors from interspecific F1 hybrid mice carrying Emu-c-myc or N-myc transgenes. Int. J. Cancer 88, 920-927 (2000).
    • (2000) Int. J. Cancer , vol.88 , pp. 920-927
    • Linardopoulos, S.1    Silva, S.2    Klein, G.3    Balmain, A.4
  • 104
    • 18344392245 scopus 로고    scopus 로고
    • Genome scanning with array CGH delineates regional alterations in mouse islet carcinomas
    • Hodgson, G. et al. Genome scanning with array CGH delineates regional alterations in mouse islet carcinomas. Nat. Genet. 29, 459-464 (2001).
    • (2001) Nat. Genet , vol.29 , pp. 459-464
    • Hodgson, G.1
  • 105
    • 0036515416 scopus 로고    scopus 로고
    • Emerging molecular markers of cancer
    • Sidransky, D. Emerging molecular markers of cancer. Nat. Rev. Cancer 2, 210-219 (2002).
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 210-219
    • Sidransky, D.1
  • 106
    • 0036606404 scopus 로고    scopus 로고
    • Analysis of minichromosome maintenance proteins as a novel method for detection of colorectal cancer in stool
    • Davies, R.J. et al. Analysis of minichromosome maintenance proteins as a novel method for detection of colorectal cancer in stool. Lancet 359, 1917-1919 (2002).
    • (2002) Lancet , vol.359 , pp. 1917-1919
    • Davies, R.J.1
  • 107
    • 0037137519 scopus 로고    scopus 로고
    • A gene-expression signature as a predictor of survival in breast cancer
    • van de Vijver, M.J. et al. A gene-expression signature as a predictor of survival in breast cancer. N. Engl. J. Med. 347, 1999-2009 (2002).
    • (2002) N. Engl. J. Med , vol.347 , pp. 1999-2009
    • Van De Vijver, M.J.1
  • 108
    • 0034721164 scopus 로고    scopus 로고
    • Error and attack tolerance of complex networks
    • Albert, R., Jeong, H. and Barabasi, A.L. Error and attack tolerance of complex networks. Nature 406, 378-382 (2000).
    • (2000) Nature , vol.406 , pp. 378-382
    • Albert, R.1    Jeong, H.2    Barabasi, A.L.3


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