Methylation changes in faecal DNA: A marker for colorectal cancer screening?

Lancet

Volumn 363, Issue 9417, 2004, Pages 1283-1285

  Müller, Hannes M ^a   Oberwalder, Michael ^a   Fiegl, Heidi ^a   Morandell, Maria ^a   Goebel, Georg ^a   Zitt, Matthias ^a   Mühlthaler, Markus ^b   Öfner, Dietmar ^a   Margreiter, Raimund ^a   Widschwendter, Martin ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b St Vinzenz Hospital   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

DNA MARKER;

ACCURACY; ADULT; AGED; ARTICLE; CANCER CELL; CANCER SCREENING; CANCER STAGING; COLORECTAL CANCER; CONTROLLED STUDY; DNA DETERMINATION; DNA METHYLATION; EPIGENETICS; FEASIBILITY STUDY; FECES ANALYSIS; FEMALE; GENE; GENETIC MARKER; HUMAN; MALE; PRIORITY JOURNAL; SFRP 2 GENE;

EID: 11144356831     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(04)16002-9     Document Type: Article

References (6)

1. Etzioni R., Urban N., Ramsey S., et al. The case for early detection. Nat Rev Cancer. 3:2003;243-252.
2. Traverso G., Shuber A., Levin B., et al. Detection of APC mutations in faecal DNA from patients with colorectal tumors. N Engl J Med. 346:2002;311-320.
3. Tagore K.S., Lawson M.J., Yucaitis J.A., et al. Sensitivity and specificity of a stool DNA multitarget assay panel for the detection of advanced colorectal neoplasia. Clin Colorectal Cancer. 3:2003;47-53.
4. Suzuki H., Gabrielson E., Chen W., et al. A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat Genet. 31:2002;141-149.
5. Müller H.M., Widschwendter A., Fiegl H., et al. DNA methylation in serum of breast cancer patients: an independent prognostic marker. Cancer Res. 63:2003;7641-7645.
6. Davies R.J., Freeman A., Morris L.S., et al. Analysis of minichromosome maintenance proteins as a novel method for detection of colorectal cancer in stool. Lancet. 359:2002;1917-1919.