Silencing of miR-1-1 and miR-133a-2 cluster expression by DNA hypermethylation in colorectal cancer

Oncology Reports

Volumn 28, Issue 3, 2012, Pages 1069-1076

  Chen, Wei Shone ^a   Leung, Chung Man ^b   Pan, Hung Wei ^b   Hu, Ling Yueh ^c   Li, Sung Chou ^d   Ho, Meng Ru ^d   Tsai, Kuo Wang ^b,e  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^c INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^d GENOMICS RESEARCH CENTER   (Taiwan)

^e TAJEN UNIVERSITY   (Taiwan)

Author keywords

Colon cancer; DNA methylation; MicroRNA; MiR 1; MiR 133a

Indexed keywords

MESSENGER RNA; MICRORNA; MICRORNA 1 1; MICRORNA 133A 2; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER INVASION; CANCER TISSUE; COLORECTAL CANCER; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DOWN REGULATION; EPIGENETICS; GENE ACTIVITY; GENE CLUSTER; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; LASP1 GENE; LIVER METASTASIS; MAJOR CLINICAL STUDY; ONCOGENE; PRIORITY JOURNAL; TAGLN2 GENE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CARCINOMA; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; CPG ISLANDS; CYTOSKELETAL PROTEINS; DNA METHYLATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; LIM DOMAIN PROTEINS; LIVER NEOPLASMS; MICROFILAMENT PROTEINS; MICRORNAS; MULTIGENE FAMILY; MUSCLE PROTEINS; TRANSCRIPTION, GENETIC;

EID: 84865341390     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.1899     Document Type: Article

References (45)

1. Shike M, Winawer SJ, Greenwald PH, Bloch A, Hill MJ and Swaroop SV: Primary prevention of colorectal cancer. The WHO Collaborating Centre for the Prevention of Colorectal Cancer. Bull World Health Organ 68: 377-385, 1990.
2. Sasaki H, Miura K, Horii A, et al: Orthotopic implantation mouse model and cDNA microarray analysis indicates several genes potentially involved in lymph node metastasis of colorectal cancer. Cancer Sci 99: 711-719, 2008.
3. Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297, 2004.
4. Wu WK, Law PT, Lee CW, et al: MicroRNA in colorectal cancer: from benchtop to bedside. Carcinogenesis 32: 247-253, 2011.
5. Zhang B, Pan X, Cobb GP and Anderson TA: microRNAs as oncogenes and tumor suppressors. Dev Biol 302: 1-12, 2007.
6. Babashah S and Soleimani M: The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis. Eur J Cancer 47: 1127-1137, 2011.
7. Lima RT, Busacca S, Almeida GM, Gaudino G, Fennell DA and Vasconcelos MH: MicroRNA regulation of core apoptosis pathways in cancer. Eur J Cancer 47: 163-174, 2011.
8. Wilmott JS, Zhang XD, Hersey P and Scolyer RA: The emerging important role of microRNAs in the pathogenesis, diagnosis and treatment of human cancers. Pathology 43: 657-671, 2011.
9. Luo X, Burwinkel B, Tao S and Brenner H: MicroRNA signatures: novel biomarker for colorectal cancer? Cancer Epidemiol Biomarkers Prev 20: 1272-1286, 2011.
10. Dhayat S, Mardin WA, Mees ST and Haier J: Epigenetic markers for chemosensitivity and chemoresistance in pancreatic cancer - a review. Int J Cancer 129: 1031-1041, 2011.
11. Kim TY, Jong HS, Jung Y, Kim TY, Kang GH and Bang YJ: DNA hypermethylation in gastric cancer. Aliment Pharmacol Ther 20 (Suppl 1): S131-S142, 2004.
12. Oue N, Kuraoka K, Kuniyasu H, et al: DNA methylation status of hMLH1, p16(INK4a), and CDH1 is not associated with mRNA expression levels of DNA methyltransferase and DNA demethylase in gastric carcinomas. Oncol Rep 8: 1085-1089, 2001.
13. Momparler RL: Epigenetic therapy of cancer with 5-aza-2′- deoxycytidine (decitabine). Semin Oncol 32: 443-451, 2005.
14. Kozaki K, Imoto I, Mogi S, Omura K and Inazawa J: Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. Cancer Res 68: 2094-2105, 2008.
15. Lewis A, Mitsuya K, Umlauf D, et al: Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation. Nat Genet 36: 1291-1295, 2004.
16. Balaguer F, Link A, Lozano JJ, et al: Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis. Cancer Res 70: 6609-6618, 2011.
17. Bandres E, Agirre X, Bitarte N, et al: Epigenetic regulation of microRNA expression in colorectal cancer. Int J Cancer 125: 2737-2743, 2009.
18. Toyota M, Suzuki H, Sasaki Y, et al: Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. Cancer Res 68: 4123-4132, 2008.
19. Lujambio A, Ropero S, Ballestar E, et al: Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res 67: 1424-1429, 2007.
20. Chiyomaru T, Enokida H, Kawakami K, et al: Functional role of LASP1 in cell viability and its regulation by microRNAs in bladder cancer. Urol Oncol: Sep 14, 2010 (Epub ahead of print).
21. Kojima S, Chiyomaru T, Kawakami K, et al: Tumour suppressors miR-1 and miR-133a target the oncogenic function of purine nucleoside phosphorylase (PNP) in prostate cancer. Br J Cancer 106: 405-413, 2012.
22. Nohata N, Hanazawa T, Kikkawa N, et al: Identification of novel molecular targets regulated by tumor suppressive miR-1/ miR-133a in maxillary sinus squamous cell carcinoma. Int J Oncol 39: 1099-1107, 2011.
23. Rao PK, Missiaglia E, Shields L, et al: Distinct roles for miR-1 and miR-133a in the proliferation and differentiation of rhabdomyosarcoma cells. FASEB J 24: 3427-3437, 2010.
24. Yoshino H, Chiyomaru T, Enokida H, et al: The tumoursuppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer. Br J Cancer 104: 808-818, 2011.
25. Datta J, Kutay H, Nasser MW, et al: Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis. Cancer Res 68: 5049-5058, 2008.
26. Chen C, Ridzon DA, Broomer AJ, et al: Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 33: e179, 2005.
27. Zhang Y, Ye Y, Shen D, et al: Identification of transgelin-2 as a biomarker of colorectal cancer by laser capture microdissection and quantitative proteome analysis. Cancer Sci 101: 523-529, 2010.
28. Zhao L, Wang H, Liu C, et al: Promotion of colorectal cancer growth and metastasis by the LIM and SH3 domain protein 1. Gut 59: 1226-1235, 2010.
29. Kuwabara Y, Ono K, Horie T, et al: Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage. Circ Cardiovasc Genet 4: 446-454, 2011.
30. He B, Xiao J, Ren AJ, et al: Role of miR-1 and miR-133a in myocardial ischemic postconditioning. J Biomed Sci 18: 22, 2011.
31. Bostjancic E, Zidar N, Stajer D and Glavac D: MicroRNAs miR-1, miR-133a, miR-133b and miR-208 are dysregulated in human myocardial infarction. Cardiology 115: 163-169, 2010.
32. Hudson RS, Yi M, Esposito D, et al: MicroRNA-1 is a candidate tumor suppressor and prognostic marker in human prostate cancer. Nucleic Acids Res 40: 3689-3703, 2012.
33. Migliore C, Martin V, Leoni VP, et al: MiR-1 downregulation cooperates with MACC1 in promoting MET overexpression in human colon cancer. Clin Cancer Res 18: 737-747, 2012.
34. Nasser MW, Datta J, Nuovo G, et al: Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1. J Biol Chem 283: 33394-33405, 2008.
35. Sarver AL, French AJ, Borralho PM, et al: Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states. BMC Cancer 9: 401, 2009.
36. Yan D, Dong Xda E, Chen X, et al: MicroRNA-1/206 targets c-Met and inhibits rhabdomyosarcoma development. J Biol Chem 284: 29596-29604, 2009.
37. Yoshino H, Enokida H, Chiyomaru T, et al: Tumor suppressive microRNA-1 mediated novel apoptosis pathways through direct inhibition of splicing factor serine/arginine-rich 9 (SRSF9/ SRp30c) in bladder cancer. Biochem Biophys Res Commun 417: 588-593, 2012.
38. Kano M, Seki N, Kikkawa N, et al: miR-145, miR-133a and miR-133b: Tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma. Int J Cancer 127: 2804-2814, 2010.
39. Ma Y, Zhang P, Yang J, Liu Z, Yang Z and Qin H: Candidate microRNA biomarkers in human colorectal cancer: Systematic review profiling studies and experimental validation. Int J Cancer 130: 2077-2087, 2012.
40. Moriya Y, Nohata N, Kinoshita T, et al: Tumor suppressive microRNA-133a regulates novel molecular networks in lung squamous cell carcinoma. J Hum Genet 57: 38-45, 2012.
41. Nohata N, Hanazawa T, Kikkawa N, et al: Caveolin-1 mediates tumor cell migration and invasion and its regulation by miR-133a in head and neck squamous cell carcinoma. Int J Oncol 38: 209-217, 2011.
42. Wu ZS, Wang CQ, Xiang R, et al: Loss of miR-133a expression associated with poor survival of breast cancer and restoration of miR-133a expression inhibited breast cancer cell growth and invasion. BMC Cancer 12: 51, 2012.
43. Rho JH, Roehrl MH and Wang JY: Tissue proteomics reveals differential and compartment-specific expression of the homologs transgelin and transgelin-2 in lung adenocarcinoma and its stroma. J Proteome Res 8: 5610-5618, 2009.
44. Leung WK, Ching AK, Chan AW, et al: A novel interplay between oncogenic PFTK1 protein kinase and tumor suppressor TAGLN2 in the control of liver cancer cell motility. Oncogene 30: 4464-4475, 2011.
45. Suzuki H, Takatsuka S, Akashi H, et al: Genome-wide profiling of chromatin signatures reveals epigenetic regulation of MicroRNA genes in colorectal cancer. Cancer Res 71: 5646-5658, 2011.