Pharmacoepigenetics: Its role in interindividual differences in drug response

Clinical Pharmacology and Therapeutics

Volumn 85, Issue 4, 2009, Pages 426-430

  Gomez, A ^a   Ingelman Sundberg, M ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AZACITIDINE; CELL NUCLEUS RECEPTOR; CYTOCHROME P450; DNA; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE INHIBITOR; ESTROGEN RECEPTOR; HISTONE; HISTONE DEACETYLASE INHIBITOR; MG 98; MICRORNA; NATURAL PRODUCT; PSAMMAPLIN; RECEPTOR SUBTYPE; RETINOIC ACID RECEPTOR; RG 108; UNCLASSIFIED DRUG; ZEBULARINE;

ANTINEOPLASTIC ACTIVITY; CELL STRAIN MCF 7; DNA METHYLATION; DRUG METABOLISM; DRUG TRANSPORT; ENZYME ACTIVITY; ENZYME INHIBITION; EPIGENETICS; GENE EXPRESSION; GENETIC POLYMORPHISM; GENOME; HELA CELL; HUMAN; HUMAN CELL; PHARMACOEPIGENETICS; PHARMACOGENETICS; PRIORITY JOURNAL; REVIEW;

CYTOCHROME P-450 ENZYME SYSTEM; DNA METHYLATION; EPIGENESIS, GENETIC; GENETIC VARIATION; HUMANS; PHARMACEUTICAL PREPARATIONS; PHARMACOGENETICS;

EID: 62649101737     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2009.2     Document Type: Review

References (31)

1. Anttila, S. et al. Methylation of cytochrome P4501A1 promoter in the lung is associated with tobacco smoking. Cancer Res. 63, 8623-8628 (2003).
2. Ingelman-Sundberg, M., Sim, S.C., Gomez, A. & Rodriguez-Antona, C. Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects. Pharmacol. Ther. 116, 496-526 (2007).
3. Nakajima, M., Iwanari, M. & Yokoi, T. Effects of histone deacetylation and DNA methylation on the constitutive and TCDD-inducible expressions of the human CYP1 family in MCF-7 and HeLa cells. Toxicol. Lett. 144, 247-256 (2003).
4. Hammons, G.J., Yan-Sanders, Y., Jin, B., Blann, E., Kadlubar, F.F. & Lyn-Cook, B.D. Specific site methylation in the 5′-flanking region of CYP1A2 interindividual differences in human livers. Life Sci. 69, 839-845 (2001).
5. Ghotbi, R. et al. Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers. Pharmacogenomics J. (in press).
6. Tokizane, T. et al. Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer. Clin. Cancer Res. 11, 5793-5801 (2005).
7. Jones, S.M., Boobis, A.R., Moore, G.E. & Stanier, P.M. Expression of CYP2E1 during human fetal development: methylation of the CYP2E1 gene in human fetal and adult liver samples. Biochem. Pharmacol. 43, 1876-1879 (1992).
8. Gomez, A., Karlgren, M., Edler, D., Bernal, M.L., Mkrtchian, S. & Ingelman-Sundberg, M. Expression of CYP2W1 in colon tumors: regulation by gene methylation. Pharmacogenomics 8, 1315-1325 (2007).
9. Karlgren, M. et al. Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1. Biochem. Biophys. Res. Commun. 341, 451-458 (2006).
10. Edler, S.K. et al. The expression of the novel CYP2W1 enzyme is an independent prognostic factor in colorectal cancer. A pilot study. Eur. J. Cancer (2008); e-pub ahead of print 30 December 2008.
11. Rønneberg, J.A. et al. GSTP1 promoter haplotypes affect DNA methylation levels and promoter activity in breast carcinomas. Cancer Res. 68, 5562-5571 (2008).
12. Woodson, K., O'Reilly, K.J., Hanson, J.C., Nelson, D., Walk, E.L. & Tangrea, J.A. The usefulness of the detection of GSTP1 methylation in urine as a biomarker in the diagnosis of prostate cancer. J. Urol. 179, 508-511; discussion 511-512 (2008).
13. David, G.L. et al. MDR1 promoter hypermethylation in MCF-7 human breast cancer cells: changes in chromatin structure induced by treatment with 5-Aza-cytidine. Cancer Biol. Ther. 3, 540-548 (2004).
14. Kusaba, H. et al. Association of 5′ CpG demethylation and altered chromatin structure in the promoter region with transcriptional activation of the multidrug resistance 1 gene in human cancer cells. Eur. J. Biochem. 262, 924-932 (1999).
15. Baker, E.K., Johnstone, R.W., Zalcberg, J.R. & El-Osta, A. Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs. Oncogene 24, 8061-8075 (2005).
16. Michelotti, G.A., Brinkley, D.M., Morris, D.P., Smith, M.P., Louie, R.J. & Schwinn, D.A. Epigenetic regulation of human alpha1d-adrenergic receptor gene expression: a role for DNA methylation in Sp1-dependent regulation. FASEB J. 21, 1979-1993 (2007).
17. Sato, N., Matsubayashi, H., Fukushima, N. & Goggins, M. The chemokine receptor CXCR4 is regulated by DNA methylation in pancreatic cancer. Cancer Biol. Ther. 4, 70-76 (2005).
18. Kubarek, L. & Jagodzinski, P.P. Epigenetic up-regulation of CXCR4 and CXCL12 expression by 17 beta-estradiol and tamoxifen is associated with formation of DNA methyltransferase 3B4 splice variant in Ishikawa endometrial adenocarcinoma cells. FEBS Lett. 581, 1441-1448 (2007).
19. Youssef, E.M. et al. Hypermethylation of the retinoic acid receptor-beta(2) gene in head and neck carcinogenesis. Clin. Cancer Res. 10, 1733-1742 (2004).
20. Bovenzi, V. & Momparler, R.L. Antineoplastic action of 5-aza-2′-deoxycytidine and histone deacetylase inhibitor and their effect on the expression of retinoic acid receptor beta and estrogen receptor alpha genes in breast carcinoma cells. Cancer Chemother. Pharmacol. 48, 71-76 (2001).
21. Westberry, J.M., Prewitt, A.K. & Wilson, M.E. Epigenetic regulation of the estrogen receptor alpha promoter in the cerebral cortex following ischemia in male and female rats. Neuroscience 152, 982-989 (2008).
22. Zeng, Y. Principles of micro-RNA production and maturation. Oncogene 25, 6156-6162 (2006).
23. Jackson, R.J. & Standart, N. How do microRNAs regulate gene expression? Sci. STKE 2007, re1 (2007).
24. Tsuchiya, Y., Nakajima, M., Takagi, S., Taniya, T. & Yokoi, T. MicroRNA regulates the expression of human cytochrome P450 1B1. Cancer Res. 66, 9090-9098 (2006).
25. Takagi, S., Nakajima, M., Mohri, T. & Yokoi, T. Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4. J. Biol. Chem. 283, 9674-9680 (2008).
26. To, K.K., Zhan, Z., Litman, T. & Bates, S.E. Regulation of ABCG2 expression at the 3′ untranslated region of its mRNA through modulation of transcript stability and protein translation by a putative microRNA in the S1 colon cancer cell line. Mol. Cell. Biol. 28, 5147-5161 (2008).
27. Zhu, H. et al. Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells. Biochem. Pharmacol. 76, 582-588 (2008).
28. Kovalchuk, O. et al. Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin. Mol. Cancer Ther. 7, 2152-2159 (2008).
29. Onica, T. et al. Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoter. Mol. Pharmacol. 73, 451-460 (2008).
30. Bolden, J.E., Peart, M.J. & Johnstone, R.W. Anticancer activities of histone deacetylase inhibitors. Nat. Rev. Drug Discov. 5, 769-784 (2006).
31. Dannenberg, L.O. & Edenberg, H.J. Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation. BMC Genomics 7, 181 (2006).