Opioid receptor desensitization: Mechanisms and its link to tolerance

Frontiers in Pharmacology

Volumn 5, Issue DEC, 2014, Pages

  Allouche, Stéphane ^a   Noble, Florence ^b,c,d   Marie, Nicolas ^b,c,d  

^a France   (France)

^b CNRS   (France)

^c INSERM   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Biased signaling; Desensitization; Opioid receptors; Receptor trafficking; Tolerance mechanisms

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; 4 [ALPHA (4 ALLYL 2,5 DIMETHYL 1 PIPERAZINYL) 3 METHOXYBENZYL] N,N DIETHYLBENZAMIDE; ARRESTIN 3; DELTA OPIATE RECEPTOR; DELTORPHIN; DYNORPHIN; ENKEPHALIN; ETORPHINE; G PROTEIN COUPLED RECEPTOR; GENISTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR AGONIST; LEVORPHANOL; MEMBRANE PROTEIN; METHADONE; MORPHINE; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; OPIATE AGONIST; OPIATE RECEPTOR; PROTEIN TYROSINE KINASE; REMIFENTANIL; STAUROSPORINE; UNCLASSIFIED DRUG;

AMYGDALOID NUCLEUS; BINDING SITE; BRAIN CORTEX; CARBOXY TERMINAL SEQUENCE; COGNITION; DEPHOSPHORYLATION; DOWN REGULATION; DRUG PROTEIN BINDING; DRUG TOLERANCE; ENDOCYTOSIS; HIPPOCAMPUS; HUMAN; IN VIVO STUDY; INTERNALIZATION; INTESTINE MOTILITY; LIGAND BINDING; LOCOMOTION; MOOD; NEUROBLASTOMA; NOCICEPTION; NONHUMAN; NUCLEUS ACCUMBENS; OXIDATIVE PHOSPHORYLATION UNCOUPLING; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; RECEPTOR DOWN REGULATION; RECEPTOR UNCOUPLING; REVIEW; SIGNAL TRANSDUCTION; SMELLING; THALAMUS; UBIQUITINATION;

EID: 84921808230     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2014.00280     Document Type: Review

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