Prolonged Kappa Opioid Receptor Phosphorylation Mediated by G-protein Receptor Kinase Underlies Sustained Analgesic Tolerance

Journal of Biological Chemistry

Volumn 279, Issue 3, 2004, Pages 1810-1818

  McLaughlin, Jay P ^a   Myers, Lisa C ^a   Zarek, Paul E ^a   Caron, Marc G ^b   Lefkowitz, Robert J ^b   Czyzyk, Traci A ^c   Pintar, John E ^c   Chavkin, Charles ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; BRAIN; CELLS;

KAPPA OPIOID RECEPTORS (KOR);

PROTEINS;

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; ANALGESIC AGENT; ANTIBODY; BETA ARRESTIN; G PROTEIN COUPLED RECEPTOR KINASE; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR AGONIST; PHOSPHORUS 32; PHOSPHOSERINE; SERINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEPHOSPHORYLATION; DRUG POTENCY; DRUG TOLERANCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR DOWN REGULATION; REGENERATION; WESTERN BLOTTING;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANALGESICS, OPIOID; ANIMALS; CELL LINE; DRUG TOLERANCE; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NALTREXONE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, OPIOID, KAPPA;

ANIMALIA;

EID: 0346457178     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M305796200     Document Type: Article

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