Differential agonist regulation of the human ≃-opioid receptor

Journal of Neurochemistry

Volumn 68, Issue 5, 1997, Pages 1846-1852

  Blake, Allan D ^a   Bot, George ^a   Li, Shuixing ^a   Freeman, John C ^a   Reisine, Terry ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Desensitization; Down regulation; Opioid tolerance; Opioid receptor

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; CYCLIC AMP; DIPRENORPHINE; DYNORPHIN A; ETORPHINE; GUANINE NUCLEOTIDE BINDING PROTEIN; KAPPA OPIATE RECEPTOR; LEVORPHANOL; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; NORBINALTORPHIMINE; OPIATE AGONIST; OPIATE ANTAGONIST;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG TOLERANCE; EMBRYO; HUMAN; HUMAN CELL; NEUROPHARMACOLOGY; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RECEPTOR SENSITIVITY;

EID: 0030946553     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.68051846.x     Document Type: Article

References (25)

1. Arden J. R., Segredo V., Wang Z., Lameh J., and Sadée W. (1995) Phosphorylation and agonist-specific intracellular trafficking of an epitope-tagged μ-opioid receptor expressed in HEK 293 cells J. Neurochem. 65, 1636-1645.
2. Avidor-Reiss T., Zippel R., Levy R., Saya D., Ezra V., Barg J., Matus-Leibovitch N., and Vogel Z. (1995) κ-Opioid receptor transfected cell lines: modulation of adenylyl cyclase activity following acute and chronic opioid treatments. FEBS Lett. 361, 70-74.
3. Blake A. D., von Zastrow M., Freeman J., and Reisine T. (1995) Agonist induced regulation of the mu and delta opioid receptors. Soc. Neurosci. Abstr. 21, 1350.
4. Blake A. D., Bot G., Freeman J. C., and Reisine T. (1997) Differential opioid agonist regulation of the mouse μ opioid receptor. J. Biol. Chem. 272, 782-790.
5. Blane G. F., Boura A. L. A., Fitzgerald A. E., and Lister R. E. (1967) Actions of etorphine hydrochloride (M99), a potent morphine-like agent. Br. J. Pharmacol. Chemother. 30, 11-22.
6. Chen C. and Okayama H. (1987) High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7, 2745-2752.
7. Henry D. J., Grandy D. K., Lester H. A., Davidson N., and Chavkin C (1995) κ-Opioid receptors couple to inwardly rectifying potassium channels when coexpressed by Xenopus oocytes. Mol. Pharmacol. 47, 551-557.
8. Herz A., ed (1993) Opioids I. Springer-Verlag, New York.
9. Hjorth S. A., Thirstrup K., Grandy D. K., and Schwartz T. W. (1995) Analysis of selective binding epitopes for the κ-opioid receptor antagonist nor-binaltorphimine. Mol. Pharmacol. 47, 1089-1094.
10. Kong H., Raynor K., Yano H., Takeda J., Bell G. I., and Reisine T. (1994) Agonists and antagonists bind to different domains of the cloned κ opioid receptor. Proc. Natl. Acad. Sci. USA 91, 8042-8046.
11. Koob G. and Bloom F. (1988) Cellular and molecular mechanisms of drug dependence. Science 242, 715-719.
12. Li S., Zhu J., Chen C., Chen Y.-W., Deriel J. K., Ashby B., and Liu-Chen L.-Y. (1993) Molecular cloning and expression of a rat κ opioid receptor. Biochem. J. 295, 629-633.
13. Mansson E., Bare L., and Yang D. (1994) Isolation of a human κ opioid receptor from placenta. Biochem. Biophys. Res. Commun. 202, 1431-1437.
14. Pfeiffer A., Brantyl V., Herz A., and Emrich H. M. (1986) Pyschotomimesis mediated by κ opiate receptors. Science 233, 774-776.
15. α subunit and is similar to that of other opioid receptors. Mol. Brain Res. 29, 336-346.
16. Raynor K., Kong H., Chen Y., Yasuda K., Yu L., Bell G. I., and Reisine T. (1994a) Pharmacological characterization of the cloned κ-, δ-and μ-opioid receptors. Mol. Pharmacol. 45, 330-334.
17. Raynor K., Kong H., Hines J., Kong G., Benovic J., Yasuda K., Bell G. I., and Reisine T. (1994b) Molecular mechanisms of agonist-induced desensitization of the cloned κ opioid receptor. J. Pharmacol. Exp. Ther. 270, 1381-1386.
18. Reisine T. (1995) Opiate receptors. Neuropharmacology 34, 463-472.
19. Reisine T. and Bell G. (1993) Molecular biology of opiate receptors. Trends Neurosci. 16, 506-510.
20. Reisine T. and Pasternak G. (1996) Opioid analgesics and antagonists, in The Pharmacological Basis of Therapeutics (Hardman J. G., Limbird L. E., Molinoff P. B., Ruddon R. W., and Gilman A. G., eds), pp. 521-555. McGraw-Hill, New York.
21. Satoh M. and Minami M. (1995) Molecular pharmacology of the opioid receptors. Pharmacol. Ther. 68, 343-364.
22. Simonin F., Gavéraiux-Ruff C., Befort K., Matthes H., Lannes B., Micheletti G., Mattéi M.-G., Charron G., Bloch B., and Kieffer B. (1995) κ-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology and expression pattern in the central nervous system. Proc. Natl. Acad. Sci. USA 92, 7006-7010.
23. Tallent M., Dichter M. A., and Reisine T. (1995) Coupling of the cloned kappa and mu opioid receptor to the inward rectifier potassium current is differentially regulated. Soc. Neurosci. Abstr. 21, 1350.
24. Tsu R. C., Chan J. S. C., and Wong Y. H. (1995) Regulation of multiple effectors by the cloned δ-opioid receptor: stimulation of phospholipase C and type II adenylyl cyclase. J. Neurochem. 64, 2700-2707.
25. Wood P. L., Rackham A., and Richard J. (1981) Spinal analgesia: comparison of the μ agonist morphine and the κ agonist ethylketazociue. Life Sci. 28, 2119-2125.