Analgesic tolerance to high-efficacy agonists but not to morphine is diminished in phosphorylation-deficient S375A μ-opioid receptor knock-in mice

Journal of Neuroscience

Volumn 31, Issue 39, 2011, Pages 13890-13896

  Grecksch, Gisela ^a   Just, Sascha ^b   Pierstorff, Claudia ^a   Imhof, Anne Katja ^b   Glück, Laura ^b   Doll, Christian ^b   Lupp, Amelie ^b   Becker, Axel ^a   Koch, Thomas ^a   Stumm, Ralf ^b   Höllt, Volker ^a   Schulz, Stefan ^b  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ETONITAZENE; FENTANYL; MORPHINE; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; SERINE; THREONINE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG TOLERANCE; IN VIVO STUDY; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; WILD TYPE;

ALANINE; ANALGESICS, OPIOID; ANIMALS; DRUG TOLERANCE; GENE KNOCK-IN TECHNIQUES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MORPHINE; PAIN MEASUREMENT; PHOSPHORYLATION; RECEPTORS, OPIOID, MU; SERINE;

EID: 80053276069     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2304-11.2011     Document Type: Article

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