A Single Nucleotide Polymorphic Mutation in the Human μ-Opioid Receptor Severely Impairs Receptor Signaling

Journal of Biological Chemistry

Volumn 276, Issue 5, 2001, Pages 3130-3137

  Befort, Katia ^a   Filliol, Dominique ^a   Décaillot, Fabien M ^a   Gavériaux Ruff, Claire ^a   Hoehe, Margret R ^b   Kieffer, Brigitte L ^c  

^a CNRS   (France)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BIOCHEMISTRY; CHEMICAL BONDS; COMPLEXATION; CYTOLOGY; MUTAGENESIS; NEUROLOGY;

DRUG ADDICTION; OPIOID PEPTIDES;

GENES;

BETA ENDORPHIN; COMPLEMENTARY DNA; DIAMORPHINE; DIPRENORPHINE; DYNORPHIN A; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; METENKEPHALIN; MORPHINE; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; NALOXONE; TRITIUM; ASPARAGINE; ASPARTIC ACID; CYCLIC AMP; NARCOTIC AGENT; NARCOTIC ANALGESIC AGENT; PROLINE; SERINE; SULFUR;

ANIMAL CELL; ARTICLE; DRUG RECEPTOR BINDING; EMBRYO; GENE MUTATION; HUMAN; HUMAN CELL; ISOTOPE LABELING; LIGAND BINDING; NONHUMAN; PAIN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RECEPTOR GENE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SITE DIRECTED MUTAGENESIS; ANIMAL; CELL CULTURE; CELL STRAIN COS1; DRUG POTENTIATION; GENETICS; METABOLISM; PHYSIOLOGY;

ANIMALIA; MAMMALIA;

ANALGESICS, OPIOID; ANIMALS; ASPARAGINE; ASPARTIC ACID; CELLS, CULTURED; COS CELLS; CYCLIC AMP; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; MUTAGENESIS, SITE-DIRECTED; NARCOTICS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROLINE; RECEPTORS, OPIOID, MU; SERINE; SIGNAL TRANSDUCTION; SULFUR RADIOISOTOPES;

EID: 0035793631     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M006352200     Document Type: Article

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