Differential activation and trafficking of μ-opioid receptors in brain slices

Molecular Pharmacology

Volumn 74, Issue 4, 2008, Pages 972-979

  Arttamangkul, Seksiri ^a   Quillinan, Nidia ^a   Low, Malcolm J ^b   Von Zastrow, Mark ^c   Pintar, John ^d   Williams, John T ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETORPHINE; METENKEPHALIN; METHADONE; MONOCLONAL ANTIBODY; MU OPIATE RECEPTOR; OPIATE AGONIST; OXYCODONE; OXYMORPHONE; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; HYPERPOLARIZATION; INTERNALIZATION; LOCUS CERULEUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; TRANSGENIC MOUSE;

ANALGESICS, OPIOID; ANIMALS; BRAIN; CHELATING AGENTS; EGTAZIC ACID; ELECTROPHYSIOLOGY; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ETORPHINE; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; LOCUS COERULEUS; METHADONE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MORPHINE; NEURONS; OXYCODONE; OXYMORPHONE; PROTEIN TRANSPORT; RADIOLIGAND ASSAY; RECEPTORS, OPIOID, MU; RECOMBINANT FUSION PROTEINS; TIME FACTORS;

EID: 52949125179     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.108.048512     Document Type: Article

References (37)

1. Alvarez VA, Arttamangkul S, Dang V, Salem A, Whistler JL, Von Zastrow M, Grandy DK, and Williams JT (2002) mu;-Opioid receptors: ligand dependent activation of potassium conductance, desensitization and internalization. J Neurosci 22:5769-5776.
2. Arttamangkul S, Torrecilla M, Kobayashi K, Okano H, and Williams JT (2006) Separation of mu-opioid receptor desensitization and internalization: endogenous receptors in primary neuronal cultures. J Neurosci 26:4118-4125.
3. Bohn LM, Gainetdinov RR, Lin FT, Lefkowitz RJ, and Caron MG (2000) Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. Nature 408:720-723.
4. Bohn LM, Dykstra LA, Lefkowitz RJ, Caron MG, and Barak LS (2004) Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery. Mol Pharmacol 66:106-112.
5. Borgland SL, Connor M, Osborne PB, Furness JB, and Christie MJ (2003) Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors. J Biol Chem 278:18776-18784.
6. Bunzow JR, Zhang G, Bouvier C, Saez C, Ronnekleiv OK, Kelly MJ, and Grandy DK (1995) Characterization and distribution of a cloned rat mu-opioid receptor. J Neurochem 64:14-24.
7. Christie MJ, Williams JT, and North RA (1987) Cellular mechanisms of opioid tolerance: studies in single brain neurons. Mol Pharmacol 32:633-638.
8. Connor M, Osborne PB, and Christie MJ (2004) Mu-opioid receptor desensitization: is morphine different? Br J Pharmacol 143:685-696.
9. Dang VC and Williams JT (2005) Morphine-induced mu-opioid receptor desensitization. Mol Pharmacol 68:1127-1132.
10. Ferguson SS, Zhang J, Barak LS, and Caron MG (1998) Molecular mechanisms of G protein-coupled receptor desensitization and resensitization. Life Sci 62:1561-1565.
11. Finn AK and Whistler JL (2001) Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal. Neuron 32:829-839.
12. Ford CP, Mark GP, and Williams JT (2006) Properties and opioid inhibition of mesolimbic dopamine neurons vary according to target location. J Neurosci 26:2788-2797.
13. Gainetdinov RR, Premont RT, Bohn LM, Lefkowitz RJ, and Caron MG (2004) Desensitization of G protein-coupled receptors and neuronal functions. Annu Rev Neurosci 27:107-144.
14. Haberstock-Debic H, Kim KA, Yu YJ, and von Zastrow M (2005) Morphine promotes rapid, arrestin-dependent endocytosis of mu-opioid receptors in striatal neurons. J Neurosci 25:7847-7857.
15. Harris GC and Williams JT (1991) Transient homologous mu-opioid receptor desensitization in rat locus coeruleus neurons. J Neurosci 11:2574-2581.
16. Kim KA and von Zastrow M (2003) Neurotrophin-regulated sorting of opioid receptors in the biosynthetic pathway of neurosecretory cells. J Neurosci 23:2075-2085.
17. Krupnick JG and Benovic JL (1998) The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annu Rev Pharmacol Toxicol 38:289-319.
18. Lefkowitz RJ, Pitcher J, Krueger K, and Daaka Y (1998) Mechanisms of beta-adrenergic receptor desensitization and resensitization. Adv Pharmacol 42:416-420.
19. Luttrell LM and Lefkowitz RJ (2002) The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. J Cell Sci 115:455-465.
20. Marie N, Aguila B, and Allouche S (2006) Tracking the opioid receptors on the way of desensitization. Cell Signal 18:1815-1833.
21. Min N, Joh TH, Kim KS, Peng C, and Son JH (1994) 5′ upstream DNA sequence of the rat tyrosine hydroxylase gene directs high-level and tissue-specific expression to catecholaminergic neurons in the central nervous system of transgenic mice. Brain Res Mol Brain Res 27:281-289.
22. Oakley RH, Laporte SA, Holt JA, Caron MG, and Barak LS (2000) Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors. J Biol Chem 275:17201-17210.
23. Pologruto TA, Sabatini BL, and Svoboda K (2003) ScanImage: flexible software for operating laser scanning microscopes. Biomed Eng Online 2:13.
24. Rodriguez-Martin I, Braksator E, Bailey CP, Goodchild S, Marrion NV, Kelly E, and Henderson G (2008) Methadone: does it really have low efficacy at mu-opioid receptors? Neuroreport 19:589-593.
25. Ryman-Rasmussen JP, Griffith A, Oloff S, Vaidehi N, Brown JT, Goddard WA 3rd, and Mailman RB (2007) Functional selectivity of dopamine D1 receptor agonists in regulating the fate of internalized receptors. Neuropharmacology 52:562-575.
26. Scherrer G, Tryoen-Tóth P, Filliol D, Matifas A, Laustriat D, Cao YQ, Basbaum AI, Dierich A, Vonesh JL, Gavériaux-Ruff C, et al. (2006) Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo. Proc Natl Acad Sci U S A 103:9691-9696.
27. Schuller AG, King MA, Zhang J, Bolan E, Pan YX, Morgan DJ, Chang A, Czick ME, Unterwald EM, Pasternak GW, et al. (1999) Retention of heroin and morphine-6 beta-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1. Nat Neurosci 2:151-156.
28. Stafford K, Gomes AB, Shen J, and Yoburn BC (2001) mu-Opioid receptor down-regulation contributes to opioid tolerance in vivo. Pharmacol Biochem Behav 69:233-237.
29. Swaminath G, Deupi X, Lee TW, Zhu W, Thian FS, Kobilka TS, and Kobilka B (2005) Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists. J Biol Chem 280:22165-22171.
30. Tanowitz M and von Zastrow M (2003) A novel endocytic recycling signal that distinguishes the membrane trafficking of naturally occurring opioid receptors. J Biol Chem 278:45978-45986.
31. Urban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H, Javitch JA, Roth BL, Christopoulos A, Sexton PM, et al. (2007) Functional selectivity and classical concepts of quantitative pharmacology. J Pharmacol Exp Ther 320:1-13.
32. Virk MS and Williams JT (2008) Agonist-specific regulation of mu;-opioid receptor desensitization and recovery from desensitization. Mol Pharmacol 73:1301-1308.
33. von Zastrow M, Svingos A, Haberstock-Debic H, and Evans C (2003) Regulated endocytosis of opioid receptors: cellular mechanisms and proposed roles in physiological adaptation to opiate drugs. Curr Opin Neurobiol 13:348-353.
34. Walwyn W, Evans CJ, and Hales TG (2007) β-arrestin2 and c-Src regulate the constitutive activity and recycling of mu; opioid receptors in dorsal root ganglion neurons. J Neurosci 27:5092-5104.
35. Whistler JL, Chuang HH, Chu P, Jan LY, and von Zastrow M (1999) Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction. Neuron 23:737-746.
36. Williams JT, Christie MJ, and Manzoni O (2001) Cellular and synaptic adaptations mediating opioid dependence. Physiol Rev 81:299-343.
37. Zhang J, Ferguson SS, Barak LS, Bodduluri SR, Laporte SA, Law PY, and Caron MG (1998) Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness. Proc Natl Acad Sci U S A 95:7157-7162.