PKC and PKA inhibitors reverse tolerance to morphine-induced hypothermia and supraspinal analgesia in mice

European Journal of Pharmacology

Volumn 492, Issue 2-3, 2004, Pages 149-157

  Javed, Ruby R ^a   Dewey, William L ^a   Smith, Paul A ^a   Smith, Forrest L ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

(Mouse); Adenylyl cyclase cascade; Analgesia; Hypothermia; Morphine tolerance; Phosphatidylinositol cascade

Indexed keywords

BISINDOLYLMALEIMIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; GO 7874; KT 5720; MORPHINE SULFATE; PROTEIN KINASE C INHIBITOR;

ANALGESIA; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; HOT PLATE TEST; HYPOTHERMIA; MALE; MECHANICAL STIMULATION; MORPHINE TOLERANCE; MOUSE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL;

ANALGESICS, OPIOID; ANIMALS; CARBAZOLES; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; HYPOTHERMIA, INDUCED; INDOLES; INJECTIONS, INTRAVENTRICULAR; INJECTIONS, SPINAL; MALE; MALEIMIDES; MICE; MORPHINE; PAIN MEASUREMENT; PROTEIN KINASE C; PYRROLES; TAIL;

EID: 2642511324     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.03.061     Document Type: Article

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