Methadone-induced desensitization of the δ-opioid receptor is mediated by uncoupling of receptor from G protein

European Journal of Pharmacology

Volumn 374, Issue 2, 1999, Pages 301-308

  Liu, Jing Gen ^a   Liao, Xiao Ping ^a   Gong, Ze Hui ^a   Qin, Boy Yi ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

Author keywords

Opioid receptor; cAMP; Desensitization; Down regulation; Methadone; Morphine

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; ADENYLATE CYCLASE; CHELERYTHRINE; CYCLIC AMP; DELTA OPIATE RECEPTOR; ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; GUANINE NUCLEOTIDE BINDING PROTEIN; METHADONE; MORPHINE; NALOXONE; PROTEIN KINASE INHIBITOR; UNCOUPLING PROTEIN;

ARTICLE; CHO CELL; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION;

ANIMALS; CHO CELLS; CRICETINAE; CYCLIC AMP; DOWN-REGULATION; DRUG INTERACTIONS; GLIOMA; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); METHADONE; MORPHINE; NEUROBLASTOMA; PROTEIN BINDING; RATS; RECEPTORS, OPIOID, DELTA; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0033061108     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00322-2     Document Type: Article

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