μ-opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence

Nature

Volumn 408, Issue 6813, 2000, Pages 720-723

  Bohn, Laura M ^a   Gainetdinov, Raul R ^a   Lin, Fang Tsyr ^a   Lefkowitz, Robert J ^a   Caron, Marc G ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; BETA ARRESTIN; CELL MARKER; G PROTEIN COUPLED RECEPTOR; MORPHINE; MU OPIATE RECEPTOR; REGULATOR PROTEIN;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG USE; ENZYME ACTIVITY; KNOCKOUT MOUSE; MORPHINE TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION;

ADENYLATE CYCLASE; ANALGESICS, OPIOID; ANIMALS; ARRESTINS; BRAIN STEM; DRUG IMPLANTS; DRUG TOLERANCE; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MEMBRANES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MORPHINE; MORPHINE DEPENDENCE; MUTATION; RECEPTORS, OPIOID, MU;

EID: 0034619796     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35047086     Document Type: Article

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