Modulating μ-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCε activation and dendritic spine stability

Journal of Biological Chemistry

Volumn 286, Issue 14, 2011, Pages 12724-12733

  Zheng, Hui ^a,b   Chu, Ji ^a   Zhang, Yuhan ^a   Loh, Horace H ^a   Law, Ping Yee ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DENDRITIC SPINE; DIFFERENTIAL EFFECT; FENTANYLS; G PROTEIN-COUPLED RECEPTOR KINASE 2; G-PROTEIN COUPLED RECEPTORS; HIPPOCAMPAL NEURONS; LOW LEVEL; OPIOID RECEPTORS; PRIMARY CULTURE; RECEPTOR SIGNALING; WILD TYPES;

ANESTHETICS; NEURONS; SIGNALING;

PHOSPHORYLATION;

ALANINE; BETA ARRESTIN 2; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ETORPHINE; FENTANYL; G PROTEIN COUPLED RECEPTOR KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE; MORPHINE; MU OPIATE RECEPTOR; PROTEIN KINASE C EPSILON; SERINE; THREONINE; BETA ARRESTIN; NARCOTIC ANALGESIC AGENT; RETINA S ANTIGEN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DENDRITIC SPINE; EMBRYO; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; HIPPOCAMPUS; HUMAN; HUMAN CELL; MOUSE; NERVE CELL CULTURE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; DRUG EFFECT; METABOLISM; PHOSPHORYLATION;

ANALGESICS, OPIOID; ANIMALS; ARRESTINS; CELL LINE; DENDRITIC SPINES; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ETORPHINE; FENTANYL; HUMANS; MICE; MORPHINE; PHOSPHORYLATION; PROTEIN KINASE C-EPSILON; RECEPTORS, OPIOID, MU; SIGNAL TRANSDUCTION;

EID: 79953309073     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.177089     Document Type: Article

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