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Volumn 23, Issue 12, 2009, Pages 4327-4334

Biomarkers of morphine tolerance and dependence are prevented by morphine-induced endocytosis of a mutant μ-opioid receptor

Author keywords

Adenylyl cyclase; c fos; Glucocorticoid receptor; NMDA receptor; Trafficking

Indexed keywords

ADENYLATE CYCLASE; BIOLOGICAL MARKER; GLUCOCORTICOID RECEPTOR; MORPHINE; MU OPIATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN C FOS;

EID: 72749093104     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.09-133223     Document Type: Article
Times cited : (40)

References (50)
  • 3
    • 1542297686 scopus 로고    scopus 로고
    • Stress Enables Synaptic Depression in CA1 Synapses by Acute and Chronic Morphine: Possible Mechanism for Corticosterone on Opiate Addiction
    • DOI 10.1523/JNEUROSCI.5544-03.2004
    • Yang, Y., Zheng, X., Wang, Y., Cao, J., Dong, Z., Cai, J., Sui, N., and Xu, L. (2004) Stress enables synaptic depression in CA1 synapses by acute and chronic morphine: possible mechanisms for corticosterone on opiate addiction. J. Neurosci. 24, 2412-2420 (Pubitemid 38327954)
    • (2004) Journal of Neuroscience , vol.24 , Issue.10 , pp. 2412-2420
    • Yang, Y.1    Zheng, X.2    Wang, Y.3    Cao, J.4    Dong, Z.5    Cai, J.6    Sui, N.7    Xu, L.8
  • 4
    • 0042844731 scopus 로고    scopus 로고
    • Locus-specific rescue of Glurepsilon1 NMDA receptors in mutant mice identifies the brain regions important for morphine tolerance and dependence
    • Inoue, M., Mishina, M., and Ueda, H. (2003) Locus-specific rescue of GluRepsilon1 NMDA receptors in mutant mice identifies the brain regions important for morphine tolerance and dependence. J. Neurosci. 23, 6529-6536 (Pubitemid 36909879)
    • (2003) Journal of Neuroscience , vol.23 , Issue.16 , pp. 6529-6536
    • Inoue, M.1    Mishina, M.2    Ueda, H.3
  • 5
    • 36048993026 scopus 로고    scopus 로고
    • When it comes to opiates, just say NO
    • Pasternak, G. W. (2007) When it comes to opiates, just say NO. J. Clin. Invest. 117, 3185-3187
    • (2007) J. Clin. Invest. , vol.117 , pp. 3185-3187
    • Pasternak, G.W.1
  • 6
    • 0025971938 scopus 로고
    • Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801
    • Trujillo, K. A., and Akil, H. (1991) Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801. Science 251, 85-87
    • (1991) Science , vol.251 , pp. 85-87
    • Trujillo, K.A.1    Akil, H.2
  • 7
    • 30644480427 scopus 로고    scopus 로고
    • Expression of spinal NMDA receptor and PKCγ after chronic morphine is regulated by spinal glucocorticoid receptor
    • DOI 10.1523/JNEUROSCI.3768-05.2005
    • Lim, G., Wang, S., Zeng, Q., Sung, B., Yang, L., and Mao, J. (2005) Expression of spinal NMDA receptor and PKCγ after chronic morphine is regulated by spinal glucocorticoid receptor. J. Neurosci. 25, 11145-11154 (Pubitemid 43089559)
    • (2005) Journal of Neuroscience , vol.25 , Issue.48 , pp. 11145-11154
    • Lim, G.1    Wang, S.2    Zeng, Q.3    Sung, B.4    Yang, L.5    Mao, J.6
  • 8
    • 16244368052 scopus 로고    scopus 로고
    • Spinal glucocorticoid receptors contribute to the development of morphine tolerance in rats
    • DOI 10.1097/00000542-200504000-00020
    • Lim, G., Wang, S., Zeng, Q., Sung, B., and Mao, J. (2005) Spinal glucocorticoid receptors contribute to the development of morphine tolerance in rats. Anesthesiology 102, 832-837 (Pubitemid 40462864)
    • (2005) Anesthesiology , vol.102 , Issue.4 , pp. 832-837
    • Lim, G.1    Wang, S.2    Zeng, Q.3    Sung, B.4    Mao, J.5
  • 11
    • 0029040497 scopus 로고
    • The effect of intrinsic efficacy on opioid tolerance
    • Duttaroy, A., and Yoburn, B. C. (1995) The effect of intrinsic efficacy on opioid tolerance. Anesthesiology 82, 1226-1236
    • (1995) Anesthesiology , vol.82 , pp. 1226-1236
    • Duttaroy, A.1    Yoburn, B.C.2
  • 13
    • 0037169345 scopus 로고    scopus 로고
    • Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization
    • DOI 10.1016/S0092-8674(02)00613-X
    • He, L., Fong, J., von Zastrow, M., and Whistler, J. L. (2002) Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization. Cell 108, 271-282 (Pubitemid 34161146)
    • (2002) Cell , vol.108 , Issue.2 , pp. 271-282
    • He, L.1    Fong, J.2    Von Zastrow, M.3    Whistler, J.L.4
  • 14
    • 20144377958 scopus 로고    scopus 로고
    • An opiate cocktail that reduces morphine tolerance and dependence
    • DOI 10.1016/j.cub.2005.04.052, PII S0960982205004537
    • He, L., and Whistler, J. L. (2005) An opiate cocktail that reduces morphine tolerance and dependence. Curr. Biol. 15, 1028-1033 (Pubitemid 40772150)
    • (2005) Current Biology , vol.15 , Issue.11 , pp. 1028-1033
    • He, L.1    Whistler, J.L.2
  • 15
    • 0034555126 scopus 로고    scopus 로고
    • Postsynaptic signaling via the μ-opioid receptor: Responses of dorsal horn neurons to exogenous opioids and noxious stimulation
    • Trafton, J. A., Abbadie, C., Marek, K., and Basbaum, A. I. (2000) Postsynaptic signaling via the μ-opioid receptor: responses of dorsal horn neurons to exogenous opioids and noxious stimulation. J. Neurosci. 20, 8578-8584
    • (2000) J. Neurosci. , vol.20 , pp. 8578-8584
    • Trafton, J.A.1    Abbadie, C.2    Marek, K.3    Basbaum, A.I.4
  • 17
    • 0026597790 scopus 로고
    • Neural substrates of opiate withdrawal
    • Koob, G. F., Maldonado, R., and Stinus, L. (1992) Neural substrates of opiate withdrawal. Trends Neurosci. 15, 186-191
    • (1992) Trends Neurosci , vol.15 , pp. 186-191
    • Koob, G.F.1    Maldonado, R.2    Stinus, L.3
  • 18
    • 0027515248 scopus 로고
    • Differential regulation of adenylyl cyclase activity by mu and delta opioids in rat caudate putamen and nucleus accumbens
    • Izenwasser, S., Buzas, B., and Cox, B. M. (1993) Differential regulation of adenylyl cyclase activity by μ and δ opioids in rat caudate putamen and nucleus accumbens. J. Pharmacol. Exp. Ther. 267, 145-152 (Pubitemid 23325001)
    • (1993) Journal of Pharmacology and Experimental Therapeutics , vol.267 , Issue.1 , pp. 145-152
    • Izenwasser, S.1    Buzas, B.2    Cox, B.M.3
  • 19
    • 0029075591 scopus 로고
    • Characterization of NMDA receptor subunit-specific antibodies: Distribution of NR2A and NR2B receptor subunits in rat brain and ontogenic profile in the cerebellum
    • Wang, Y. H., Bosy, T. Z., Yasuda, R. P., Grayson, D. R., Vicini, S., Pizzorusso, T., and Wolfe, B. B. (1995) Characterization of NMDA receptor subunit-specific antibodies: distribution of NR2A and NR2B receptor subunits in rat brain and ontogenic profile in the cerebellum. J. Neurochem. 65, 176-183
    • (1995) J. Neurochem. , vol.65 , pp. 176-183
    • Wang, Y.H.1    Bosy, T.Z.2    Yasuda, R.P.3    Grayson, D.R.4    Vicini, S.5    Pizzorusso, T.6    Wolfe, B.B.7
  • 20
    • 33646540454 scopus 로고    scopus 로고
    • Development of tolerance and sensitization to different opioid agonists in rats
    • DOI 10.1007/s00213-006-0365-8
    • Grecksch, G., Bartzsch, K., Widera, A., Becker, A., Hollt, V., and Koch, T. (2006) Development of tolerance and sensitization to different opioid agonists in rats. Psychopharmacology 186, 177-184 (Pubitemid 43727334)
    • (2006) Psychopharmacology , vol.186 , Issue.2 , pp. 177-184
    • Grecksch, G.1    Bartzsch, K.2    Widera, A.3    Becker, A.4    Hollt, V.5    Koch, T.6
  • 21
    • 0035903152 scopus 로고    scopus 로고
    • C-terminal Splice Variants of the Mouse μ-Opioid Receptor Differ in Morphine-induced Internalization and Receptor Resensitization
    • DOI 10.1074/jbc.M100305200
    • Koch, T., Schulz, S., Pfeiffer, M., Klutzny, M., Schroder, H., Kahl, E., and Hollt, V. (2001) C-terminal splice variants of the mouse μ-opioid receptor differ in morphine-induced internalization and receptor resensitization. J. Biol. Chem. 276, 31408-31414 (Pubitemid 37385013)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.33 , pp. 31408-31414
    • Koch, T.1    Schulz, S.2    Pfeiffer, M.3    Klutzny, M.4    Schroder, H.5    Kahl, E.6    Hollt, V.7
  • 22
    • 34247169145 scopus 로고    scopus 로고
    • Opioid agonist efficacy predicts the magnitude of tolerance and the regulation of mu-opioid receptors and dynamin-2
    • DOI 10.1016/j.ejphar.2007.01.059, PII S0014299907001239
    • Pawar, M., Kumar, P., Sunkaraneni, S., Sirohi, S., Walker, E. A., and Yoburn, B. C. (2007) Opioid agonist efficacy predicts the magnitude of tolerance and the regulation of mu-opioid receptors and dynamin-2. Eur. J. Pharmacol. 563, 92-101 (Pubitemid 46602222)
    • (2007) European Journal of Pharmacology , vol.563 , Issue.1-3 , pp. 92-101
    • Pawar, M.1    Kumar, P.2    Sunkaraneni, S.3    Sirohi, S.4    Walker, E.A.5    Yoburn, B.C.6
  • 24
    • 0033179904 scopus 로고    scopus 로고
    • Functional dissociation of mu opioid receptor signaling and endocytosis: Implications for the biology of opiate tolerance and addiction
    • DOI 10.1016/S0896-6273(01)80032-5
    • Whistler, J. L., Chuang, H. H., Chu, P., Jan, L. Y., and von Zastrow, M. (1999) Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction. Neuron 23, 737-746 (Pubitemid 29411563)
    • (1999) Neuron , vol.23 , Issue.4 , pp. 737-746
    • Whistler, J.L.1    Chuang, H.-H.2    Chu, P.3    Jan, L.Y.4    Von Zastrow, M.5
  • 26
    • 0035819078 scopus 로고    scopus 로고
    • Endocytosis of the μ-opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal
    • Finn, A. K., and Whistler, J. L. (2001) Endocytosis of the μ-opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal. Neuron 32, 829-839
    • (2001) Neuron , vol.32 , pp. 829-839
    • Finn, A.K.1    Whistler, J.L.2
  • 27
    • 0011276168 scopus 로고
    • Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance
    • Sharma, S. K., Klee, W. A., and Nirenberg, M. (1975) Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance. Proc. Natl. Acad. Sci. U. S. A. 72, 3092-3096
    • (1975) Proc. Natl. Acad. Sci. U. S. A. , vol.72 , pp. 3092-3096
    • Sharma, S.K.1    Klee, W.A.2    Nirenberg, M.3
  • 28
    • 0025457883 scopus 로고
    • Opiate withdrawal and the rat locus coeruleus: Behavioral, electrophysiological, and biochemical correlates
    • Rasmussen, K., Beitner-Johnson, D. B., Krystal, J. H., Aghajanian, G. K., and Nestler, E. J. (1990) Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates. J. Neurosci. 10, 2308-2317
    • (1990) J. Neurosci. , vol.10 , pp. 2308-2317
    • Rasmussen, K.1    Beitner-Johnson, D.B.2    Krystal, J.H.3    Aghajanian, G.K.4    Nestler, E.J.5
  • 29
    • 0029810024 scopus 로고    scopus 로고
    • Chronic opioid treatment induces adenylyl cyclase V superactivation. Involvement of G(βγ)
    • DOI 10.1074/jbc.271.35.21309
    • Avidor-Reiss, T., Nevo, I., Levy, R., Pfeuffer, T., and Vogel, Z. (1996) Chronic opioid treatment induces adenylyl cyclase V superactivation. Involvement of Gβγ. J. Biol. Chem. 271, 21309-21315 (Pubitemid 26292991)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.35 , pp. 21309-21315
    • Avidor-Reiss, T.1    Nevo, I.2    Levy, R.3    Pfeuffer, T.4    Vogel, Z.5
  • 30
    • 0035138995 scopus 로고    scopus 로고
    • Cellular and synaptic adaptations mediating opioid dependence
    • Williams, J. T., Christie, M. J., and Manzoni, O. (2001) Cellular and synaptic adaptations mediating opioid dependence. Physiol. Rev. 81, 299-343
    • (2001) Physiol. Rev. , vol.81 , pp. 299-343
    • Williams, J.T.1    Christie, M.J.2    Manzoni, O.3
  • 31
    • 0029944959 scopus 로고    scopus 로고
    • Under siege: The brain on opiates
    • Nestler, E. J. (1996) Under siege: The brain on opiates. Neuron 16, 897-900
    • (1996) Neuron , vol.16 , pp. 897-900
    • Nestler, E.J.1
  • 32
    • 0034619796 scopus 로고    scopus 로고
    • Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence
    • Bohn, L. M., Gainetdinov, R. R., Lin, F. T., Lefkowitz, R. J., and Caron, M. G. (2000) Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. Nature 408, 720-723
    • (2000) Nature , vol.408 , pp. 720-723
    • Bohn, L.M.1    Gainetdinov, R.R.2    Lin, F.T.3    Lefkowitz, R.J.4    Caron, M.G.5
  • 34
    • 0033847254 scopus 로고    scopus 로고
    • Are NMDA receptors involved in opiate-induced neural and behavioral plasticity? A review of preclinical studies
    • Trujillo, K. A. (2000) Are NMDA receptors involved in opiate-induced neural and behavioral plasticity? A review of preclinical studies. Psychopharmacology 151, 121-141
    • (2000) Psychopharmacology , vol.151 , pp. 121-141
    • Trujillo, K.A.1
  • 35
    • 0037107189 scopus 로고    scopus 로고
    • Chronic morphine induces downregulation of spinal glutamate transporters: Implications in morphine tolerance and abnormal pain sensitivity
    • Mao, J., Sung, B., Ji, R. R., and Lim, G. (2002) Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity. J. Neurosci. 22, 8312-8323 (Pubitemid 35379137)
    • (2002) Journal of Neuroscience , vol.22 , Issue.18 , pp. 8312-8323
    • Mao, J.1    Sung, B.2    Ji, R.-R.3    Lim, G.4
  • 36
    • 33751117497 scopus 로고    scopus 로고
    • Primary afferent NMDA receptors increase dorsal horn excitation and mediate opiate tolerance in neonatal rats
    • DOI 10.1523/JNEUROSCI.2530-06.2006
    • Zeng, J., Thomson, L. M., Aicher, S. A., and Terman, G. W. (2006) Primary afferent NMDA receptors increase dorsal horn excitation and mediate opiate tolerance in neonatal rats. J. Neurosci. 26, 12033-12042 (Pubitemid 44772114)
    • (2006) Journal of Neuroscience , vol.26 , Issue.46 , pp. 12033-12042
    • Zeng, J.1    Thomson, L.M.2    Aicher, S.A.3    Terman, G.W.4
  • 37
    • 33644905540 scopus 로고    scopus 로고
    • Chronic morphine treatment alters expression of N-methyl-D-aspartate receptor subunits in the extended amygdala
    • DOI 10.1002/jnr.20756
    • Bajo, M., Crawford, E. F., Roberto, M., Madamba, S. G., and Siggins, G. R. (2006) Chronic morphine treatment alters expression of N-methyl-d-aspartate receptor subunits in the extended amygdala. J. Neurosci. Res. 83, 532-537 (Pubitemid 43384846)
    • (2006) Journal of Neuroscience Research , vol.83 , Issue.4 , pp. 532-537
    • Bajo, M.1    Crawford, E.F.2    Roberto, M.3    Madamba, S.G.4    Siggins, G.R.5
  • 38
    • 0030044516 scopus 로고    scopus 로고
    • Drugs of abuse and stress increase the expression of GluR1 and NMDAR1 glutamate receptor subunits in the rat ventral tegmental area: Common adaptations among cross-sensitizing agents
    • Fitzgerald, L. W., Ortiz, J., Hamedani, A. G., and Nestler, E. J. (1996) Drugs of abuse and stress increase the expression of GluR1 and NMDAR1 glutamate receptor subunits in the rat ventral tegmental area: common adaptations among cross-sensitizing agents. J. Neurosci. 16, 274-282 (Pubitemid 26010716)
    • (1996) Journal of Neuroscience , vol.16 , Issue.1 , pp. 274-282
    • Fitzgerald, L.W.1    Ortiz, J.2    Hamedani, A.G.3    Nestler, E.J.4
  • 39
    • 0030033903 scopus 로고    scopus 로고
    • Characterization of agonist-induced down-regulation of NMDA receptors in cerebellar granule cell cultures
    • Resink, A., Villa, M., Benke, D., Hidaka, H., Mohler, H., and Balazs, R. (1996) Characterization of agonist-induced downregulation of NMDA receptors in cerebellar granule cell cultures. J. Neurochem. 66, 369-377 (Pubitemid 26010802)
    • (1996) Journal of Neurochemistry , vol.66 , Issue.1 , pp. 369-377
    • Resink, A.1    Villa, M.2    Benke, D.3    Hidaka, H.4    Mohler, H.5    Balazs, R.6
  • 40
    • 0029128994 scopus 로고
    • Agonist-induced down-regulation of NMDA receptors in cerebellar granule cells in culture
    • Resink, A., Villa, M., Boer, G. J., Mohler, H., and Balazs, R. (1995) Agonist-induced down-regulation of NMDA receptors in cerebellar granule cells in culture. Eur. J. Neurosci. 7, 1700-1706
    • (1995) Eur. J. Neurosci. , vol.7 , pp. 1700-1706
    • Resink, A.1    Villa, M.2    Boer, G.J.3    Mohler, H.4    Balazs, R.5
  • 41
    • 40349094750 scopus 로고    scopus 로고
    • Innovative approaches for the treatment of depression: Targeting the HPA axis
    • DOI 10.1007/s11064-007-9518-3, Special Issue Dedicated to Dr. George Fink; Guest Editor: Ferenc Antoni
    • Thomson, F., and Craighead, M. (2008) Innovative approaches for the treatment of depression: targeting the HPA axis. Neurochem. Res. 33, 691-707 (Pubitemid 351341638)
    • (2008) Neurochemical Research , vol.33 , Issue.4 , pp. 691-707
    • Thomson, F.1    Craighead, M.2
  • 42
    • 52149097135 scopus 로고    scopus 로고
    • Hypothalamic-pituitary-adrenal axis dysregulation and behavioral analysis of mouse mutants with altered glucocorticoid or mineralocorticoid receptor function
    • Kolber, B. J., Wieczorek, L., and Muglia, L. J. (2008) Hypothalamic-pituitary-adrenal axis dysregulation and behavioral analysis of mouse mutants with altered glucocorticoid or mineralocorticoid receptor function. Stress 11, 321-338
    • (2008) Stress , vol.11 , pp. 321-338
    • Kolber, B.J.1    Wieczorek, L.2    Muglia, L.J.3
  • 43
    • 43049098972 scopus 로고    scopus 로고
    • Neuropharmacology of glucocorticoids: Focus on emotion, cognition and cocaine
    • De Kloet, E. R., de Jong, I. E., and Oitzl, M. S. (2008) Neuropharmacology of glucocorticoids: focus on emotion, cognition and cocaine. Eur. J. Pharmacol. 585, 473-482
    • (2008) Eur. J. Pharmacol. , vol.585 , pp. 473-482
    • De Kloet, E.R.1    De Jong, I.E.2    Oitzl, M.S.3
  • 44
    • 46149120544 scopus 로고    scopus 로고
    • A role for brain stress systems in addiction
    • Koob, G. F. (2008) A role for brain stress systems in addiction. Neuron 59, 11-34
    • (2008) Neuron , vol.59 , pp. 11-34
    • Koob, G.F.1
  • 45
    • 14044275565 scopus 로고    scopus 로고
    • Evidence for a long-term influence on morphie tolerance after previous morphine exposure: Role of neuronal glucocorticoid receptors
    • DOI 10.1016/j.pain.2004.11.019
    • Lim, G., Wang, S., Zeng, Q., Sung, B., and Mao, J. (2005) Evidence for a long-term influence on morphine tolerance after previous morphine exposure: role of neuronal glucocorticoid receptors. Pain 114, 81-92 (Pubitemid 40279090)
    • (2005) Pain , vol.114 , Issue.1-2 , pp. 81-92
    • Lim, G.1    Wang, S.2    Zeng, Q.3    Sung, B.4    Mao, J.5
  • 46
    • 43649109033 scopus 로고    scopus 로고
    • Brain regional Fos expression elicited by the activation of μ- But not -opioid receptors of the ventral tegmental area: Evidence for an implication of the ventral thalamus in opiate reward
    • DOI 10.1038/sj.npp.1301529, PII 1301529
    • David, V., Matifas, A., Gavello-Baudy, S., Decorte, L., Kieffer, B. L., and Cazala, P. (2008) Brain regional Fos expression elicited by the activation of μ- but not -opioid receptors of the ventral tegmental area: evidence for an implication of the ventral thalamus in opiate reward. Neuropsychopharmacology 33, 1746-1759 (Pubitemid 351684698)
    • (2008) Neuropsychopharmacology , vol.33 , Issue.7 , pp. 1746-1759
    • David, V.1    Matifas, A.2    Gavello-Baudy, S.3    Decorte, L.4    Kieffer, B.L.5    Cazala, P.6
  • 47
    • 0032846640 scopus 로고    scopus 로고
    • Long-lasting sensitization towards morphine in motoric and limbic areas as determined by c-fos expression in rat brain
    • DOI 10.1016/S0169-328X(99)00184-9, PII S0169328X99001849
    • Erdtmann-Vourliotis, M., Mayer, P., Linke, R., Riechert, U., and Hollt, V. (1999) Long-lasting sensitization towards morphine in motoric and limbic areas as determined by c-fos expression in rat brain. Brain Res. Mol. Brain Res. 72, 1-16 (Pubitemid 29474910)
    • (1999) Molecular Brain Research , vol.72 , Issue.1 , pp. 1-16
    • Erdtmann-Vourliotis, M.1    Mayer, P.2    Linke, R.3    Riechert, U.4    Hollt, V.5
  • 48
    • 0032582828 scopus 로고    scopus 로고
    • Identification of brain regions that are markedly activated by morphine in tolerant but not in naive rats
    • DOI 10.1016/S0169-328X(98)00197-1, PII S0169328X98001971
    • Erdtmann-Vourliotis, M., Mayer, P., Riechert, U., Grecksch, G., and Hollt, V. (1998) Identification of brain regions that are markedly activated by morphine in tolerant but not in naive rats. Brain Res. Mol. Brain Res. 61, 51-61 (Pubitemid 28511347)
    • (1998) Molecular Brain Research , vol.61 , Issue.1-2 , pp. 51-61
    • Erdtmann-Vourliotis, M.1    Mayer, P.2    Riechert, U.3    Grecksch, G.4    Hollt, V.5
  • 49
    • 0029960788 scopus 로고    scopus 로고
    • Induction of chronic fos-related antigens in rat brain by chronic morphine administration
    • Nye, H. E., and Nestler, E. J. (1996) Induction of chronic Fos-related antigens in rat brain by chronic morphine administration. Mol. Pharmacol. 49, 636-645 (Pubitemid 26117147)
    • (1996) Molecular Pharmacology , vol.49 , Issue.4 , pp. 636-645
    • Nye, H.E.1    Nestler, E.J.2
  • 50
    • 3242685661 scopus 로고    scopus 로고
    • Morphine-induced c-fos mRNA expression in striatofugal circuits: Modulation by dose, environmental context, and drug history
    • Ferguson, S. M., Thomas, M. J., and Robinson, T. E. (2004) Morphine-induced c-fos mRNA expression in striatofugal circuits: modulation by dose, environmental context, and drug history. Neuropsychopharmacology 29, 1664-1674
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1664-1674
    • Ferguson, S.M.1    Thomas, M.J.2    Robinson, T.E.3


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