Differential efficacies of κ agonists to induce homologous desensitization of human κ opioid receptor

Neuroscience Letters

Volumn 240, Issue 1, 1998, Pages 25-28

  Ling, Kun ^a   Ma, Lan ^b   Pei, Gang ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Agonists; Opioid receptor; Desensitization; Differential efficacy; Dynorphin A; Extracellular acidification; Microphysiometry

Indexed keywords

DYNORPHIN A; ETORPHINE; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR AGONIST; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE;

ACIDIFICATION; ANIMAL CELL; ARTICLE; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG RECEPTOR BINDING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION;

ANIMALS; BENZENEACETAMIDES; CHO CELLS; CRICETINAE; DYNORPHINS; ETORPHINE; EXTRACELLULAR SPACE; HUMANS; HYDROGEN-ION CONCENTRATION; PYRROLIDINES; RECEPTORS, OPIOID, KAPPA;

EID: 0032472190     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00921-X     Document Type: Article

References (14)

1. Avidor-Reiss T., Zippel R., Levy R., Saya D., Era V., Barg J., Matus L.N., Vogel Z. kappa-Opioid receptor-transfected cell line: modulation of adenylyl cyclase activity following acute and chronic opioid treatments. FEBS Lett. 361:1995;70-74.
2. Blake A.D., Bot G., Li S., Freeman J.C., Reisine T. Differential agonist regulation of the human kappa-opioid receptor. J. Biol. Chem. 272:1997;782-790.
3. Knapp R.J., Malatynska E., Collins N., Fang L., Wang J.-Y., Hruby V.J., Roecke W.R., Yamamura H.I. Molecular biology and pharmacology of cloned opioid receptors. FASEB J. 9(7):1995;516-525.
4. Kong H., Raynor K., Yano H., Takeda J., Bell G.T., Reisine T. Agonists and antagonists bind to different domains of the cloned kappa opioid receptor. Proc. Natl. Sci. Acad. USA. 91:1994;8042-8046.
5. 2 on kappa receptor selectivity and potency. J. Med. Chem. 39(13):1996;2456-2460.
6. Matthes H.W.D., Maldonado R., Simonin F., Valverdo O., Slowe S., Kitchen I., Befort K., Dierich A., LeMeur M., Dolle P., Tzavara E., Hanoune J., Roques B.P., Kieffer B. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature. 383:1996;819-823.
7. McConnel H.M., Owicki J.C., Parce J.W., Miller D.J., Baxter G.T., Wada H.G., Pitchford S. The cytosensor microphysiometer: biological application of silicon technology. Science. 257:1992;1905-1912.
8. Meunier J.C. Opioid receptors, tolerance and dependence. Therapie. 47(6):1992;495-502.
9. Nestler E.J., Aghajanian G.K. Molecular and cellular basis of addiction. Science. 278:1997;58-63.
10. Pei G., Ling K., Pu L., Martin D.C., Ma L. Nociceptin/orphanin FQ stimulates extracellular acidification and desensitization of the response involves protein kinase C. FEBS Lett. 412:1997;253-256.
11. Raynor K., Kong H., Hines J., Kong G., Binovic J., Yasuda K., Bell G.T., Reisine T. Molecular mechanisms of agonist-induced desensitization of the cloned mouse kappa opioid receptor. J. Pharmacol. Exp. Ther. 270:1994;1381-1386.
12. Reisine, T. and Pasternak, G., Opioid analgesics and antagonists. In J.G. Hardman, L.E. Molinoff, R.W. Ruddon and A.G. Gilman (Eds.), The Pharmacological Basis of Therapeutics, McGraw-Hill, New York, 1996, p. 521-555.
13. Salon J.A., Owicki J.C. Real-time measurements of receptor activity: application of microphysiometric techniques to receptor biology. Methods Neurosci. Recept. Mol. Biol. 25:1994;201-224.
14. Selley D.E., Sim L.J., Xiao R., Liu Q., Childers S.R. mu-Opioid receptor-stimulated guanosine-5′-O-(gamma-thio)-triphosphate binding in rat thalamus and cultured cell lines: signal transduction mechanisms underlying agonist efficacy. Mol. Pharmacol. 51(1):1997;87-96.