Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of Mu-opioid receptors

Journal of Biological Chemistry

Volumn 278, Issue 21, 2003, Pages 18776-18784

  Borgland, Stephanie L ^a   Connor, Mark ^a   Osborne, Peregrine B ^c   Furness, John B ^d   Christie, MacDonald J ^b  

^a University of Sydney   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CALCIUM; CELLS; CYTOLOGY;

DESENSITIZATION;

PROTEINS;

CALCIUM CHANNEL; CHLORNALTREXAMINE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; FLAG PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; METHADONE; MORPHINE; MU OPIATE RECEPTOR; OPIATE; OPIATE AGONIST; PENTAZOCINE; PROTEIN; UNCLASSIFIED DRUG; CALCIUM CHANNEL BLOCKING AGENT; DRUG DERIVATIVE; NALTREXONE; NARCOTIC AGENT; NARCOTIC ANTAGONIST;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; DRUG EFFICACY; DRUG RECEPTOR BINDING; ENDOCYTOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR SENSITIVITY; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; COMPARATIVE STUDY; DRUG EFFECT; ELECTRIC CONDUCTIVITY; GENETIC TRANSFECTION; GENETICS; HYPOPHYSIS TUMOR; METABOLISM; NEUROBLASTOMA; PHYSIOLOGY;

ANIMALIA;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; ELECTRIC CONDUCTIVITY; ENDOCYTOSIS; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; GTP-BINDING PROTEINS; METHADONE; MICE; MORPHINE; NALTREXONE; NARCOTIC ANTAGONISTS; NARCOTICS; NEUROBLASTOMA; PENTAZOCINE; PITUITARY NEOPLASMS; RECEPTORS, OPIOID, MU; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0037805628     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M300525200     Document Type: Article

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