메뉴 건너뛰기




Volumn 79, Issue 4, 2011, Pages 768-775

Protein kinase C-mediated phosphorylation of the μ-opioid receptor and its effects on receptor signaling

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; GUANINE NUCLEOTIDE BINDING PROTEIN; MU OPIATE RECEPTOR; PHORBOL MYRISTATE; PROTEIN KINASE C; SERINE;

EID: 79953003015     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.110.069096     Document Type: Article
Times cited : (42)

References (38)
  • 1
    • 58449100187 scopus 로고    scopus 로고
    • Role of protein kinase C and mu-opioid receptor (MOPr) desensitization in tolerance to morphine in rat locus coeruleus neurons
    • Bailey CP, Llorente J, Gabra BH, Smith FL, Dewey WL, Kelly E, and Henderson G (2009) Role of protein kinase C and mu-opioid receptor (MOPr) desensitization in tolerance to morphine in rat locus coeruleus neurons. Eur J Neurosci 29:307-318.
    • (2009) Eur J Neurosci , vol.29 , pp. 307-318
    • Bailey, C.P.1    Llorente, J.2    Gabra, B.H.3    Smith, F.L.4    Dewey, W.L.5    Kelly, E.6    Henderson, G.7
  • 2
    • 0035204621 scopus 로고    scopus 로고
    • Protein kinase C isoforms as therapeutic targets in nervous system disease states
    • Battaini F (2001) Protein kinase C isoforms as therapeutic targets in nervous system disease states. Pharmacol Res 44:353-361.
    • (2001) Pharmacol Res , vol.44 , pp. 353-361
    • Battaini, F.1
  • 3
    • 0032052168 scopus 로고    scopus 로고
    • mu-opioid receptor down-regulation and cAMP-dependent protein kinase pbosphorylation in a mouse model of chronic morphine tolerance
    • DOI 10.1016/S0169-328X(98)00005-9, PII S0169328X98000059
    • Bernstein MA and Welch SP (1998) mu-Opioid receptor down-regulation and cAMP-dependent protein kinase phosphorylation in a mouse model of chronic morphine tolerance. Brain Res Mol Brain Res 55:237-242. (Pubitemid 28248040)
    • (1998) Molecular Brain Research , vol.55 , Issue.2 , pp. 237-242
    • Bernstein, M.A.1    Welch, S.P.2
  • 4
    • 23944513243 scopus 로고    scopus 로고
    • PKC-delta sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M3 receptor activation in HEK-293 cells
    • Breitwieser GE (2005) GIRK channels: hierarchy of control. Focus on "PKC-delta sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M3 receptor activation in HEK-293 cells". Am J Physiol Cell Physiol 289:C509-C511.
    • (2005) Am J Physiol Cell Physiol , vol.289
    • Breitwieser, G.E.1
  • 5
    • 0032545499 scopus 로고    scopus 로고
    • Identification of serine 356 and serine 363 as the amino acids involved in etorphine-induced down-regulation of the mu-opioid receptor
    • DOI 10.1074/jbc.273.51.34488
    • Burd AL, El-Kouhen R, Erickson LJ, Loh HH, and Law PY (1998) Identification of serine 356 and serine 363 as the amino acids involved in etorphine-induced down-regulation of the mu-opioid receptor. J Biol Chem 273:34488-34495. (Pubitemid 29008929)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.51 , pp. 34488-34495
    • Burd, A.L.1    El-Kouhen, R.2    Erickson, L.J.3    Loh, H.H.4    Law, P.-Y.5
  • 6
    • 0035895932 scopus 로고    scopus 로고
    • Threonine 180 is required for G-protein-coupled receptor kinase 3- and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in Xenopus oocytes
    • Celver JP, Lowe J, Kovoor A, Gurevich VV, and Chavkin C (2001) Threonine 180 is required for G-protein-coupled receptor kinase 3- and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in Xenopus oocytes. J Biol Chem 276:4894-4900.
    • (2001) J Biol Chem , vol.276 , pp. 4894-4900
    • Celver, J.P.1    Lowe, J.2    Kovoor, A.3    Gurevich, V.V.4    Chavkin, C.5
  • 7
    • 1542440929 scopus 로고    scopus 로고
    • betagamma stimulation of adenylyl cyclase activity
    • DOI 10.1016/j.molbrainres.2003.09.002
    • Chakrabarti S and Gintzler AR (2003) Phosphorylation of Gbeta is augmented by chronic morphine and enhances Gbetagamma stimulation of adenylyl cyclase activity. Brain Res Mol Brain Res 119:144-151. (Pubitemid 37415087)
    • (2003) Molecular Brain Research , vol.119 , Issue.2 , pp. 144-151
    • Chakrabarti, S.1    Gintzler, A.R.2
  • 8
    • 0040735779 scopus 로고    scopus 로고
    • Role for the C-terminus in agonist-induced mu opioid receptor phosphorylation and desensitization
    • DOI 10.1021/bi991938b
    • Deng HB, Yu Y, Pak Y, O'Dowd BF, George SR, Surratt CK, Uhl GR, and Wang JB (2000) Role for the C-terminus in agonist-induced mu opioid receptor phosphorylation and desensitization. Biochemistry 39:5492-5499. (Pubitemid 30257091)
    • (2000) Biochemistry , vol.39 , Issue.18 , pp. 5492-5499
    • Deng, H.B.1    Yu, Y.2    Pak, Y.3    O'Dowd, B.F.4    George, S.R.5    Surratt, C.K.6    Uhl, G.R.7    Wang, J.B.8
  • 9
    • 0035918284 scopus 로고    scopus 로고
    • Phosphorylation of Ser363, Thr370, and Ser375 residues within the carboxyl tail differentially regulates mu-opioid receptor internalization
    • El Kouhen R, Burd AL, Erickson-Herbrandson LJ, Chang CY, Law PY, and Loh HH (2001) Phosphorylation of Ser363, Thr370, and Ser375 residues within the carboxyl tail differentially regulates mu-opioid receptor internalization. J Biol Chem 276:12774-12780.
    • (2001) J Biol Chem , vol.276 , pp. 12774-12780
    • El Kouhen, R.1    Burd, A.L.2    Erickson-Herbrandson, L.J.3    Chang, C.Y.4    Law, P.Y.5    Loh, H.H.6
  • 10
    • 0032571340 scopus 로고    scopus 로고
    • Molecular mechanisms of G protein-coupled receptor desensitization and resensitization
    • DOI 10.1016/S0024-3205(98)00107-6, PII S0024320598001076
    • Ferguson SS, Zhang J, Barak LS, and Caron MG (1998) Molecular mechanisms of G protein-coupled receptor desensitization and resensitization. Life Sci 62:1561-1565. (Pubitemid 28210241)
    • (1998) Life Sciences , vol.62 , Issue.17-18 , pp. 1561-1565
    • Ferguson, S.S.G.1    Zhang, J.2    Barak, L.S.3    Caron, M.G.4
  • 11
    • 0034176522 scopus 로고    scopus 로고
    • Spinal PKC activity and expression: Role in tolerance produced by continuous spinal morphine infusion
    • DOI 10.1016/S0304-3959(99)00281-X, PII S030439599900281X
    • Granados-Soto V, Kalcheva I, Hua X, Newton A, and Yaksh TL (2000) Spinal PKC activity and expression: role in tolerance produced by continuous spinal morphine infusion. Pain 85:395-404. (Pubitemid 30214166)
    • (2000) Pain , vol.85 , Issue.3 , pp. 395-404
    • Granados-Soto, V.1    Kalcheva, I.2    Hua, X.-Y.3    Newton, A.4    Yaksh, T.L.5
  • 12
    • 33646414189 scopus 로고    scopus 로고
    • The structural basis of arrestin-mediated regulation of G-protein-coupled receptors
    • Gurevich VV and Gurevich EV (2006) The structural basis of arrestin-mediated regulation of G-protein-coupled receptors. Pharmacol Ther 110:465-502.
    • (2006) Pharmacol Ther , vol.110 , pp. 465-502
    • Gurevich, V.V.1    Gurevich, E.V.2
  • 13
    • 37349045964 scopus 로고    scopus 로고
    • v1.3 subunit of the L-type calcium channel
    • DOI 10.1016/j.ejphar.2007.09.003, PII S0014299907009806
    • Haller VL, Bernstein MA, and Welch SP (2008) Chronic morphine treatment decreases the Cav1.3 subunit of the L-type calcium channel. Eur J Pharmacol 578:101-107. (Pubitemid 350309572)
    • (2008) European Journal of Pharmacology , vol.578 , Issue.2-3 , pp. 101-107
    • Haller, V.L.1    Bernstein, M.A.2    Welch, S.P.3
  • 14
    • 0032428284 scopus 로고    scopus 로고
    • Opiate tolerance and dependence: Receptors, G-proteins, and antiopiates
    • DOI 10.1016/S0196-9781(98)00126-0, PII S0196978198001260
    • Harrison LM, Kastin AJ, and Zadina JE (1998) Opiate tolerance and dependence: receptors, G-proteins, and antiopiates. Peptides 19:1603-1630. (Pubitemid 29015903)
    • (1998) Peptides , vol.19 , Issue.9 , pp. 1603-1630
    • Harrison, L.M.1    Kastin, A.J.2    Zadina, J.E.3
  • 15
    • 0037423307 scopus 로고    scopus 로고
    • N-formyl peptide receptor phosphorylation domains differentially regulate arrestin and agonist affinity
    • DOI 10.1074/jbc.M204687200
    • Key TA, Foutz TD, Gurevich VV, Sklar LA, and Prossnitz ER (2003) N-formyl peptide receptor phosphorylation domains differentially regulate arrestin and agonist affinity. J Biol Chem 278:4041-4047. (Pubitemid 36801138)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.6 , pp. 4041-4047
    • Key, T.A.1    Foutz, T.D.2    Gurevich, V.V.3    Sklar, L.A.4    Prossnitz, E.R.5
  • 16
    • 0032892815 scopus 로고    scopus 로고
    • Kappa- and mu-Opioid inhibition of N-type calcium currents is attenuated by 4beta-phorbol 12-myristate 13-acetate and protein kinase C in rat dorsal root ganglion neurons
    • King AP, Hall KE, and Macdonald RL (1999) Kappa- and mu-opioid inhibition of N-type calcium currents is attenuated by 4beta-phorbol 12-myristate 13-acetate and protein kinase C in rat dorsal root ganglion neurons. J Pharmacol Exp Ther 289:312-320. (Pubitemid 29156044)
    • (1999) Journal of Pharmacology and Experimental Therapeutics , vol.289 , Issue.1 , pp. 312-320
    • King, A.P.J.1    Hall, K.E.2    Macdonald, R.L.3
  • 17
    • 0030922877 scopus 로고    scopus 로고
    • Site mutation in the rat mu-opioid receptor demonstrates the involvement of calcium/calmodulin-dependent protein kinase II in agonist-mediated desensitization
    • Koch T, Kroslak T, Mayer P, Raulf E, and Höllt V (1997) Site mutation in the rat mu-opioid receptor demonstrates the involvement of calcium/calmodulin-dependent protein kinase II in agonist-mediated desensitization. J Neurochem 69:1767-1770. (Pubitemid 27406979)
    • (1997) Journal of Neurochemistry , vol.69 , Issue.4 , pp. 1767-1770
    • Koch, T.1    Kroslak, T.2    Mayer, P.3    Raulf, E.4    Hollt, V.5
  • 18
    • 0032577554 scopus 로고    scopus 로고
    • Carboxyl-terminal splicing of the rat mu opioid receptor modulates agonist-mediated internalization and receptor resensitization
    • DOI 10.1074/jbc.273.22.13652
    • Koch T, Schulz S, Schröder H, Wolf R, Raulf E, and Höllt V (1998) Carboxyl-terminal splicing of the rat mu opioid receptor modulates agonist-mediated internalization and receptor resensitization. J Biol Chem 273:13652-13657. (Pubitemid 28268410)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.22 , pp. 13652-13657
    • Koch, T.1    Schulz, S.2    Schroder, H.3    Wolf, R.4    Raulf, E.5    Hollt, V.6
  • 19
    • 0030736086 scopus 로고    scopus 로고
    • Mu and delta opioid receptors are differentially desensitized by the coexpression of beta-adrenergic receptor kinase 2 and beta-arrestin 2 in Xenopus oocytes
    • DOI 10.1074/jbc.272.44.27605
    • Kovoor A, Nappey V, Kieffer BL, and Chavkin C (1997) Mu and delta opioid receptors are differentially desensitized by the coexpression of beta-adrenergic receptor kinase 2 and beta-arrestin 2 in xenopus oocytes. J Biol Chem 272:27605-27611. (Pubitemid 27473552)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.44 , pp. 27605-27611
    • Kovoor, A.1    Nappey, V.2    Kieffer, B.L.3    Chavkin, C.4
  • 20
    • 0032933689 scopus 로고    scopus 로고
    • Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: I. PKC translocation to the membrane of SH-SY5Y neuroblastoma cells is induced by mu-opioid agonists
    • DOI 10.1046/j.1471-4159.1999.0720585.x
    • Kramer HK and Simon EJ (1999a) Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: I. PKC translocation to the membrane of SH-SY5Y neuroblastoma cells is induced by mu-opioid agonists. J Neurochem 72:585-593. (Pubitemid 29055220)
    • (1999) Journal of Neurochemistry , vol.72 , Issue.2 , pp. 585-593
    • Kramer, H.K.1    Simon, E.J.2
  • 21
    • 0032902147 scopus 로고    scopus 로고
    • Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: II. Activation and involvement of the alpha, epsilon, and zeta isoforms of PKC
    • DOI 10.1046/j.1471-4159.1999.0720594.x
    • Kramer HK and Simon EJ (1999b) Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: II. Activation and involvement of the alpha, epsilon, and zeta isoforms of PKC. J Neurochem 72:594-604. (Pubitemid 29055221)
    • (1999) Journal of Neurochemistry , vol.72 , Issue.2 , pp. 594-604
    • Kramer, H.K.1    Simon, E.J.2
  • 22
    • 0032901479 scopus 로고    scopus 로고
    • Regulation of opioid receptor activities
    • Law PY and Loh HH (1999) Regulation of opioid receptor activities. J Pharmacol Exp Ther 289:607-624.
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 607-624
    • Law, P.Y.1    Loh, H.H.2
  • 23
    • 0037013316 scopus 로고    scopus 로고
    • Protein kinase C inhibits type VI adenylyl cyclase by phosphorylating the regulatory N domain and two catalytic C1 and C2 domains
    • Lin TH, Lai HL, Kao YY, Sun CN, Hwang MJ, and Chern Y (2002) Protein kinase C inhibits type VI adenylyl cyclase by phosphorylating the regulatory N domain and two catalytic C1 and C2 domains. J Biol Chem 277:15721-15728.
    • (2002) J Biol Chem , vol.277 , pp. 15721-15728
    • Lin, T.H.1    Lai, H.L.2    Kao, Y.Y.3    Sun, C.N.4    Hwang, M.J.5    Chern, Y.6
  • 24
    • 0036073214 scopus 로고    scopus 로고
    • Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: A molecular mechanism for heterologous cross-talk
    • DOI 10.1124/jpet.102.033159
    • Mandyam CD, Thakker DR, Christensen JL, and Standifer KM (2002) Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk. J Pharmacol Exp Ther 302:502-509. (Pubitemid 34787212)
    • (2002) Journal of Pharmacology and Experimental Therapeutics , vol.302 , Issue.2 , pp. 502-509
    • Mandyam, C.D.1    Thakker, D.R.2    Christensen, J.L.3    Standifer, K.M.4
  • 25
    • 0032104245 scopus 로고    scopus 로고
    • The extended protein kinase C superfamily
    • Mellor H and Parker PJ (1998) The extended protein kinase C superfamily. Biochem J 332:281-292. (Pubitemid 28271856)
    • (1998) Biochemical Journal , vol.332 , Issue.2 , pp. 281-292
    • Mellor, H.1    Parker, P.J.2
  • 27
    • 0030875721 scopus 로고    scopus 로고
    • Agonist-induced desensitization of the mu opioid receptor is determined by threonine 394 preceded by acidic amino acids in the COOH-terminal tail
    • DOI 10.1074/jbc.272.40.24961
    • Pak Y, O'Dowd BF, and George SR (1997) Agonist-induced desensitization of the mu opioid receptor is determined by threonine 394 preceded by acidic amino acids in the COOH-terminal tail. J Biol Chem 272:24961-24965. (Pubitemid 27415673)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.40 , pp. 24961-24965
    • Pak, Y.1    O'Dowd, B.F.2    George, S.R.3
  • 29
    • 4644343161 scopus 로고    scopus 로고
    • Multiple opiate receptors: Déjà vu all over again
    • Pasternak GW (2004) Multiple opiate receptors: déjà vu all over again. Neuropharmacology 47:312-323.
    • (2004) Neuropharmacology , vol.47 , pp. 312-323
    • Pasternak, G.W.1
  • 30
    • 4444311166 scopus 로고    scopus 로고
    • Morphine induces terminal micro-opioid receptor desensitization by sustained phosphorylation of serine-375
    • DOI 10.1038/sj.emboj.7600334
    • Schulz S, Mayer D, Pfeiffer M, Stumm R, Koch T, and Höllt V (2004) Morphine induces terminal micro-opioid receptor desensitization by sustained phosphorylation of serine-375. EMBO J 23:3282-3289. (Pubitemid 39209152)
    • (2004) EMBO Journal , vol.23 , Issue.16 , pp. 3282-3289
    • Schulz, S.1    Mayer, D.2    Pfeiffer, M.3    Stumm, R.4    Koch, T.5    Hollt, V.6
  • 31
    • 0035341402 scopus 로고    scopus 로고
    • Protein kinase C-mediated inhibition of mu-opioid receptor internalization and its involvement in the development of acute tolerance to peripheral mu-agonist analgesia
    • Ueda H, Inoue M, and Matsumoto T (2001) Protein kinase C-mediated inhibition of mu-opioid receptor internalization and its involvement in the development of acute tolerance to peripheral mu-agonist analgesia. J Neurosci 21:2967-2973. (Pubitemid 32323477)
    • (2001) Journal of Neuroscience , vol.21 , Issue.9 , pp. 2967-2973
    • Ueda, H.1    Inoue, M.2    Matsumoto, T.3
  • 33
    • 0037099297 scopus 로고    scopus 로고
    • Identification of two C-terminal amino acids, Ser(355) and Thr(357), required for short-term homologous desensitization of mu-opioid receptors
    • Wang HL, Chang WT, Hsu CY, Huang PC, Chow YW, and Li AH (2002) Identification of two C-terminal amino acids, Ser(355) and Thr(357), required for short-term homologous desensitization of mu-opioid receptors. Biochem Pharmacol 64:257-266.
    • (2002) Biochem Pharmacol , vol.64 , pp. 257-266
    • Wang, H.L.1    Chang, W.T.2    Hsu, C.Y.3    Huang, P.C.4    Chow, Y.W.5    Li, A.H.6
  • 34
    • 0029904231 scopus 로고    scopus 로고
    • Relevance of phosphorylation state to opioid responsiveness in opiate naive and tolerant/dependent tissue
    • DOI 10.1016/0006-8993(96)00217-X
    • Wang L, Medina VM, Rivera M, and Gintzler AR (1996) Relevance of phosphorylation state to opioid responsiveness in opiate naive and tolerant/dependent tissue. Brain Res 723:61-69. (Pubitemid 26200127)
    • (1996) Brain Research , vol.723 , Issue.1-2 , pp. 61-69
    • Wang, L.1    Medina, V.M.2    Rivera, M.3    Gintzler, A.R.4
  • 35
    • 0032981172 scopus 로고    scopus 로고
    • Replacement of threonine 394 by alanine facilitates internalization and resensitization of the rat mu opioid receptor
    • Wolf R, Koch T, Schulz S, Klutzny M, Schröder H, Raulf E, Bühling F, and Höllt V (1999) Replacement of threonine 394 by alanine facilitates internalization and resensitization of the rat mu opioid receptor. Mol Pharmacol 55:263-268. (Pubitemid 29076022)
    • (1999) Molecular Pharmacology , vol.55 , Issue.2 , pp. 263-268
    • Wolf, R.1    Koch, T.2    Schulz, S.3    Klutzny, M.4    Schroder, H.5    Raulf, E.6    Buhling, F.7    Hollt, V.8
  • 36
    • 0030691760 scopus 로고    scopus 로고
    • Mu Opioid receptor phosphorylation, desensitization, and ligand efficacy
    • DOI 10.1074/jbc.272.46.28869
    • Yu Y, Zhang L, Yin X, Sun H, Uhl GR, and Wang JB (1997) Mu opioid receptor phosphorylation, desensitization, and ligand efficacy. J Biol Chem 272:28869-28874. (Pubitemid 27498167)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.46 , pp. 28869-28874
    • Yu, Y.1    Zhang, L.2    Yin, X.3    Sun, H.4    Uhl, G.R.5    Wang, J.B.6
  • 38
    • 15844416295 scopus 로고    scopus 로고
    • Differential mu opiate receptor phosphorylation and desensitization induced by agonists and phorbol esters
    • DOI 10.1074/jbc.271.19.11449
    • Zhang L, Yu Y, Mackin S, Weight FF, Uhl GR, and Wang JB (1996) Differential mu opiate receptor phosphorylation and desensitization induced by agonists and phorbol esters. J Biol Chem 271:11449-11454. (Pubitemid 26155986)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.19 , pp. 11449-11454
    • Zhangt, L.1    Yu, Y.2    Mackin, S.3    Weight, F.F.4    Uhl, G.R.5    Wang, J.B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.