-
1
-
-
84889636479
-
Phosphoinositide 3-kinases as accelerators and brakes of autophagy
-
O’Farrell, F.; Rusten, T.E.; Stenmark, H. Phosphoinositide 3-kinases as accelerators and brakes of autophagy. FEBS J. 2013, 280, 6322–6337.
-
(2013)
FEBS J
, vol.280
, pp. 6322-6337
-
-
O’Farrell, F.1
Rusten, T.E.2
Stenmark, H.3
-
2
-
-
77951621262
-
The emerging mechanisms of isoform-specific PI3K signalling
-
Vanhaesebroeck, B.; Guillermet-Guibert, J.; Graupera, M.; Bilanges, B. The emerging mechanisms of isoform-specific PI3K signalling. Nat. Rev. Mol. Cell Biol. 2010, 11, 329–341.
-
(2010)
Nat. Rev. Mol. Cell Biol
, vol.11
, pp. 329-341
-
-
Vanhaesebroeck, B.1
Guillermet-Guibert, J.2
Graupera, M.3
Bilanges, B.4
-
3
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
Engelman, J.A.; Luo, J.; Cantley, L.C. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat. Rev. Genet. 2006, 7, 606–619.
-
(2006)
Nat. Rev. Genet
, vol.7
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
4
-
-
84907062975
-
The PTEN/PI3K/AKT pathway in vivo, cancer mouse models
-
Carnero, A.; Paramio, J.M. The PTEN/PI3K/AKT pathway in vivo, cancer mouse models. Front. Oncol. 2014, doi:10.3389/fonc.2014.00252.
-
(2014)
Front. Oncol
-
-
Carnero, A.1
Paramio, J.M.2
-
5
-
-
38549092474
-
Membrane recognition by phospholipid-binding domains
-
Lemmon, M.A. Membrane recognition by phospholipid-binding domains. Nat. Rev. Mol. Cell Biol. 2008, 9, 99–111.
-
(2008)
Nat. Rev. Mol. Cell Biol
, vol.9
, pp. 99-111
-
-
Lemmon, M.A.1
-
6
-
-
43749120732
-
The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications
-
Carnero, A.; Blanco-Aparicio, C.; Renner, O.; Link, W.; Leal, J.F. The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications. Curr. Cancer Drug Targets2008, 8, 187–198.
-
(2008)
Curr. Cancer Drug Targets
, vol.8
, pp. 187-198
-
-
Carnero, A.1
Blanco-Aparicio, C.2
Renner, O.3
Link, W.4
Leal, J.F.5
-
7
-
-
79959761278
-
Basu, A. Regulation of autophagy by kinases
-
Sridharan, S.; Jain, K.; Basu, A. Regulation of autophagy by kinases. Cancers2011, 3, 2630–2654.
-
(2011)
Cancers
, vol.3
, pp. 2630-2654
-
-
Sridharan, S.1
Jain, K.2
-
8
-
-
79952262412
-
The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in cancer stem cell biology
-
Martelli, A.M.; Evangelisti, C.; Chiarini, F.; Grimaldi, C.; McCubrey, J.A. The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in cancer stem cell biology. Cancers2010, 2, 1576–1596.
-
(2010)
Cancers
, vol.2
, pp. 1576-1596
-
-
Martelli, A.M.1
Evangelisti, C.2
Chiarini, F.3
Grimaldi, C.4
McCubrey, J.A.5
-
9
-
-
79957523828
-
BRAF, PIK3CA, and PTEN mutations: Implications for targeted therapies in metastatic colorectal cancer
-
De Roock, W.; de Vriendt, V.; Normanno, N.; Ciardiello, F.; Tejpar, S. KRAS, BRAF, PIK3CA, and PTEN mutations: Implications for targeted therapies in metastatic colorectal cancer. Lancet Oncol. 2011, 12, 594–603.
-
(2011)
Lancet Oncol
, vol.12
, pp. 594-603
-
-
De Roock, W.1
De Vriendt, V.2
Normanno, N.3
Ciardiello, F.4
Tejpar, S.5
-
10
-
-
84868628069
-
Mazzarino, M.C.; et al. Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response
-
McCubrey, J.A.; Steelman, L.S.; Chappell, W.H.; Abrams, S.L.; Montalto, G.; Cervello, M.; Nicoletti, F.; Fagone, P.; Malaponte, G.; Mazzarino, M.C.; et al. Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response. Oncotarget2012, 3, 954–987.
-
(2012)
Oncotarget
, vol.3
, pp. 954-987
-
-
McCubrey, J.A.1
Steelman, L.S.2
Chappell, W.H.3
Abrams, S.L.4
Montalto, G.5
Cervello, M.6
Nicoletti, F.7
Fagone, P.8
Malaponte, G.9
-
11
-
-
84911863692
-
A point of convergence in the action of insulin/IGF-1 and G protein-coupled receptor agonists in pancreatic cancer cells
-
Mechanistic target of rapamycin (mTOR)
-
Rozengurt, E. Mechanistic target of rapamycin (mTOR): A point of convergence in the action of insulin/IGF-1 and G protein-coupled receptor agonists in pancreatic cancer cells. Front. Physiol. 2014, doi:10.3389/fphys.2014.00357.
-
(2014)
Front. Physiol
-
-
Rozengurt, E.1
-
12
-
-
84860206692
-
Regulation and cellular functions of class II phosphoinositide 3-kinases
-
Falasca, M.; Maffucci, T. Regulation and cellular functions of class II phosphoinositide 3-kinases. Biochem. J. 2012, 443, 587–601.
-
(2012)
Biochem. J
, vol.443
, pp. 587-601
-
-
Falasca, M.1
Maffucci, T.2
-
13
-
-
84880507763
-
-
Posor, Y.; Eichhorn-Gruenig, M.; Puchkov, D.; Schöneberg, J.; Ullrich, A.; Lampe, A.; Müller, R.; Zarbakhsh, S.; Gulluni, F.; Hirsch, E.; et al. Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate. Nature2013, 499, 233–237.
-
(2013)
Nature
, vol.499
, pp. 233-237
-
-
Posor, Y.1
Eichhorn-Gruenig, M.2
Puchkov, D.3
Schöneberg, J.4
Ullrich, A.5
Lampe, A.6
Müller, R.7
Zarbakhsh, S.8
Gulluni, F.9
Hirsch, E.10
-
14
-
-
0141668947
-
Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans
-
Xue, Y.; Fares, H.; Grant, B.; Li, Z.; Rose, A.M.; Clark, S.G.; Skolnik, E.Y. Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans. J. Biol. Chem. 2003, 278, 34380–34386.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 34380-34386
-
-
Xue, Y.1
Fares, H.2
Grant, B.3
Li, Z.4
Rose, A.M.5
Clark, S.G.6
Skolnik, E.Y.7
-
15
-
-
39749141485
-
The regulation and function of Class III PI3Ks: Novel roles for Vps34
-
Backer, J.M. The regulation and function of Class III PI3Ks: Novel roles for Vps34. Biochem. J. 2008, 410, 1–17.
-
(2008)
Biochem. J
, vol.410
, pp. 1-17
-
-
Backer, J.M.1
-
16
-
-
0027942615
-
AtVPS34, a phosphatidylinositol 3-kinase of Arabidopsis thaliana, is an essential protein with homology to a calcium-dependent lipid binding domain
-
Welters, P.; Takegawa, K.; Emr, S.D.; Chrispeels, M.J. AtVPS34, a phosphatidylinositol 3-kinase of Arabidopsis thaliana, is an essential protein with homology to a calcium-dependent lipid binding domain. Proc. Natl. Acad. Sci. USA1994, 91, 11398–11402.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 11398-11402
-
-
Welters, P.1
Takegawa, K.2
Emr, S.D.3
Chrispeels, M.J.4
-
17
-
-
0027905021
-
Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting
-
Schu, P.V.; Takegawa, K.; Fry, M.J.; Stack, J.H.; Waterfield, M.D.; Emr, S.D. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science1993, 260, 88–91.
-
(1993)
Science
, vol.260
, pp. 88-91
-
-
Schu, P.V.1
Takegawa, K.2
Fry, M.J.3
Stack, J.H.4
Waterfield, M.D.5
Emr, S.D.6
-
18
-
-
77952107472
-
Unveiling the secrets of the ancestral PI3 kinase Vps34
-
Workman, P.; van Montfort, R.L. Unveiling the secrets of the ancestral PI3 kinase Vps34. Cancer Cell2010, 17, 421–423.
-
(2010)
Cancer Cell
, vol.17
, pp. 421-423
-
-
Workman, P.1
Van Montfort, R.L.2
-
19
-
-
0034282751
-
Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells
-
Gillooly, D.J.; Morrow, I.C.; Lindsay, M.; Gould, R.; Bryant, N.J.; Gaullier, J.M.; Parton, R.G.; Stenmark, H. Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells. EMBO J. 2000, 19, 4577–4588.
-
(2000)
EMBO J
, vol.19
, pp. 4577-4588
-
-
Gillooly, D.J.1
Morrow, I.C.2
Lindsay, M.3
Gould, R.4
Bryant, N.J.5
Gaullier, J.M.6
Parton, R.G.7
Stenmark, H.8
-
20
-
-
0035899869
-
Phosphatidylinositol 3-phosphate is generated in phagosomal membranes
-
Ellson, C.D.; Anderson, K.E.; Morgan, G.; Chilvers, E.R.; Lipp, P.; Stephens, L.R.; Hawkins, P.T. Phosphatidylinositol 3-phosphate is generated in phagosomal membranes. Curr. Biol. 2001, 11, 1631–1635.
-
(2001)
Curr. Biol
, vol.11
, pp. 1631-1635
-
-
Ellson, C.D.1
Anderson, K.E.2
Morgan, G.3
Chilvers, E.R.4
Lipp, P.5
Stephens, L.R.6
Hawkins, P.T.7
-
21
-
-
0035494493
-
Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation
-
Vieira, O.V.; Botelho, R.J.; Rameh, L.; Brachmann, S.M.; Matsuo, T.; Davidson, H.W.; Schreiber, A.; Backer, J.M.; Cantley, L.C.; Grinstein, S. Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation. J. Cell Biol. 2001, 155, 19–25.
-
(2001)
J. Cell Biol
, vol.155
, pp. 19-25
-
-
Vieira, O.V.1
Botelho, R.J.2
Rameh, L.3
Brachmann, S.M.4
Matsuo, T.5
Davidson, H.W.6
Schreiber, A.7
Backer, J.M.8
Cantley, L.C.9
Grinstein, S.10
-
22
-
-
77950510375
-
PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody
-
Sagona, A.P.; Nezis, I.P.; Pedersen, N.M.; Liestøl, K.; Poulton, J.; Rusten, T.E.; Skotheim, R.I.; Raiborg, C.; Stenmark, H. PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. Nat. Cell Biol. 2010, 12, 362–371.
-
(2010)
Nat. Cell Biol
, vol.12
, pp. 362-371
-
-
Sagona, A.P.1
Nezis, I.P.2
Pedersen, N.M.3
Liestøl, K.4
Poulton, J.5
Rusten, T.E.6
Skotheim, R.I.7
Raiborg, C.8
Stenmark, H.9
-
23
-
-
79251564891
-
The phosphoinositide-3-kinase Vps34p is required for pexophagy in Saccharomyces cerevisae
-
Grunau, S.; Lay, D.; Mindthoff, S.; Platta, H.W.; Girzalsky, W.; Just, W.W.; Erdmann, R. The phosphoinositide-3-kinase Vps34p is required for pexophagy in Saccharomyces cerevisae. Biochem. J.2011, 434, 161–170.
-
(2011)
Biochem. J
, vol.434
, pp. 161-170
-
-
Grunau, S.1
Lay, D.2
Mindthoff, S.3
Platta, H.W.4
Girzalsky, W.5
Just, W.W.6
Erdmann, R.7
-
24
-
-
50249084987
-
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
-
Axe, E.L.; Walker, S.A.; Manifava, M.; Chandra, P.; Roderick, H.L.; Habermann, A.; Griffiths, G.; Ktistakis, N.T. Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J. Cell Biol. 2008, 182, 685–701.
-
(2008)
J. Cell Biol
, vol.182
, pp. 685-701
-
-
Axe, E.L.1
Walker, S.A.2
Manifava, M.3
Chandra, P.4
Roderick, H.L.5
Habermann, A.6
Griffiths, G.7
Ktistakis, N.T.8
-
25
-
-
71649087199
-
A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation
-
Hayashi-Nishino, M.; Fujita, N.; Noda, T.; Yamaguchi, A.; Yoshimori, T.; Yamamoto, A. A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. Nat. Cell Biol. 2009, 11, 1433–1437.
-
(2009)
Nat. Cell Biol
, vol.11
, pp. 1433-1437
-
-
Hayashi-Nishino, M.1
Fujita, N.2
Noda, T.3
Yamaguchi, A.4
Yoshimori, T.5
Yamamoto, A.6
-
26
-
-
77953543377
-
The Beclin 1-VPS34 complex—At the crossroads of autophagy and beyond
-
Funderburk, S.F.; Wang, Q.J.; Yue, Z. The Beclin 1-VPS34 complex—At the crossroads of autophagy and beyond. Trends Cell Biol. 2010, 20, 355–362.
-
(2010)
Trends Cell Biol
, vol.20
, pp. 355-362
-
-
Funderburk, S.F.1
Wang, Q.J.2
Yue, Z.3
-
27
-
-
78049291288
-
The emerging role of PtdIns3P in cytokinesis
-
Nezis, I.P.; Sagona, A.P.; Schink, K.O.; Stenmark, H. Divide and ProsPer: The emerging role of PtdIns3P in cytokinesis. Trends Cell Biol. 2010, 20, 642–649.
-
(2010)
Trends Cell Biol
, vol.20
, pp. 642-649
-
-
Nezis, I.P.1
Sagona, A.P.2
Schink, K.O.3
Stenmark, H.D.4
ProsPer5
-
29
-
-
70349919804
-
Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes
-
Simonsen, A.; Tooze, S.A. Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes. J. Cell Biol. 2009, 186, 773–782.
-
(2009)
J. Cell Biol
, vol.186
, pp. 773-782
-
-
Simonsen, A.1
Tooze, S.A.2
-
30
-
-
78449300668
-
The Sir Hans Krebs Lecture. How a lipid mediates tumour suppression. Delivered on 29 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden
-
Stenmark, H. The Sir Hans Krebs Lecture. How a lipid mediates tumour suppression. Delivered on 29 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden. FEBS J. 2010, 277, 4837–4848.
-
(2010)
FEBS J
, vol.277
, pp. 4837-4848
-
-
Stenmark, H.1
-
31
-
-
84920892844
-
Tumor suppression and promotion by autophagy
-
603980
-
Avalos, Y.; Canales, J.; Bravo-Sagua, R.; Criollo, A.; Lavandero, S.; Quest, A.F. Tumor suppression and promotion by autophagy. Biomed. Res. Int. 2014, 2014 603980.
-
(2014)
Biomed. Res. Int
, vol.2014
-
-
Avalos, Y.1
Canales, J.2
Bravo-Sagua, R.3
Criollo, A.4
Lavandero, S.5
Quest, A.F.6
-
32
-
-
84861972253
-
Autophagy and cancer cell metabolism
-
Lozy, F.; Karantza, V. Autophagy and cancer cell metabolism. Semin. Cell. Dev. Biol. 2012, 23, 395–401.
-
(2012)
Semin. Cell. Dev. Biol
, vol.23
, pp. 395-401
-
-
Lozy, F.1
Karantza, V.2
-
33
-
-
67949104883
-
Autophagy in tumour suppression and promotion
-
Brech, A.; Ahlquist, T.; Lothe, R.A.; Stenmark, H. Autophagy in tumour suppression and promotion. Mol. Oncol. 2009, 3, 366–375.
-
(2009)
Mol. Oncol
, vol.3
, pp. 366-375
-
-
Brech, A.1
Ahlquist, T.2
Lothe, R.A.3
Stenmark, H.4
-
34
-
-
79952628267
-
The Beclin 1 network regulates autophagy and apoptosis
-
Kang, R.; Zeh, H.J.; Lotze, M.T.; Tang, D. The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ. 2011, 18, 571–580.
-
(2011)
Cell Death Differ
, vol.18
, pp. 571-580
-
-
Kang, R.1
Zeh, H.J.2
Lotze, M.T.3
Tang, D.4
-
35
-
-
0027256130
-
A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole
-
Stack, J.H.; Herman, P.K.; Schu, P.V.; Emr, S.D. A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole. EMBO J. 1993, 12, 2195–2204.
-
(1993)
EMBO J
, vol.12
, pp. 2195-2204
-
-
Stack, J.H.1
Herman, P.K.2
Schu, P.V.3
Emr, S.D.4
-
36
-
-
67650070480
-
Structure and function of Vps15 in the endosomal G protein signaling pathway
-
Heenan, E.J.; Vanhooke, J.L.; Temple, B.R.; Betts, L.; Sondek, J.E.; Dohlman, H.G. Structure and function of Vps15 in the endosomal G protein signaling pathway. Biochemistry2009, 48, 6390–6401.
-
(2009)
Biochemistry
, vol.48
, pp. 6390-6401
-
-
Heenan, E.J.1
Vanhooke, J.L.2
Temple, B.R.3
Betts, L.4
Sondek, J.E.5
Dohlman, H.G.6
-
37
-
-
33745685061
-
Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome
-
Slessareva, J.E.; Routt, S.M.; Temple, B.; Bankaitis, V.A.; Dohlman, H.G. Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome. Cell2006, 126, 191–203.
-
(2006)
Cell
, vol.126
, pp. 191-203
-
-
Slessareva, J.E.1
Routt, S.M.2
Temple, B.3
Bankaitis, V.A.4
Dohlman, H.G.5
-
38
-
-
77951237303
-
The Beclin 1 interactome
-
He, C.; Levine, B. The Beclin 1 interactome. Curr. Opin. Cell Biol. 2010, 22, 140–149.
-
(2010)
Curr. Opin. Cell Biol
, vol.22
, pp. 140-149
-
-
He, C.1
Levine, B.2
-
39
-
-
84861614439
-
Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression
-
Abrahamsen, H.; Stenmark, H.; Platta, H.W. Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression. FEBS Lett. 2012, 586, 1584–1591.
-
(2012)
FEBS Lett
, vol.586
, pp. 1584-1591
-
-
Abrahamsen, H.1
Stenmark, H.2
Platta, H.W.3
-
40
-
-
84887543464
-
Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity
-
Araki, Y.; Ku, W.C.; Akioka, M.; May, A.I.; Hayashi, Y.; Arisaka, F.; Ishihama, Y.; Ohsumi, Y. Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity. J. Cell Biol. 2013, 203, 299–313.
-
(2013)
J. Cell Biol
, vol.203
, pp. 299-313
-
-
Araki, Y.1
Ku, W.C.2
Akioka, M.3
May, A.I.4
Hayashi, Y.5
Arisaka, F.6
Ishihama, Y.7
Ohsumi, Y.8
-
41
-
-
0035809160
-
Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae
-
Kihara, A.; Noda, T.; Ishihara, N.; Ohsumi, Y. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J. Cell Biol. 2001, 152, 519–530.
-
(2001)
J. Cell Biol
, vol.152
, pp. 519-530
-
-
Kihara, A.1
Noda, T.2
Ishihara, N.3
Ohsumi, Y.4
-
42
-
-
75149143548
-
Roles of Pichia pastoris Uvrag in vacuolar protein sorting and the phosphatidylinositol 3-kinase complex in phagophore elongation in autophagy pathways
-
Farré, J.C.; Mathewson, R.D.; Manjithaya, R.; Subramani, S. Roles of Pichia pastoris Uvrag in vacuolar protein sorting and the phosphatidylinositol 3-kinase complex in phagophore elongation in autophagy pathways. Autophagy2010, 6, 86–99.
-
(2010)
Autophagy
, vol.6
, pp. 86-99
-
-
Farré, J.C.1
Mathewson, R.D.2
Manjithaya, R.3
Subramani, S.4
-
43
-
-
59249089394
-
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG
-
Itakura, E.; Kishi, C.; Inoue, K.; Mizushima, N. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol. Biol. Cell2008, 19, 5360–5372.
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 5360-5372
-
-
Itakura, E.1
Kishi, C.2
Inoue, K.3
Mizushima, N.4
-
44
-
-
58049192897
-
Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase
-
Sun, Q.; Fan, W.; Chen, K.; Ding, X.; Chen, S.; Zhong, Q. Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. USA2008, 105, 19211–11226.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 11226-19211
-
-
Sun, Q.1
Fan, W.2
Chen, K.3
Ding, X.4
Chen, S.5
Zhong, Q.6
-
45
-
-
64049113909
-
Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex
-
Zhong, Y.; Wang, Q.J.; Li, X.; Yan, Y.; Backer, J.M.; Chait, B.T.; Heintz, N.; Yue, Z. Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat. Cell Biol. 2009, 11, 468–476.
-
(2009)
Nat. Cell Biol
, vol.11
, pp. 468-476
-
-
Zhong, Y.1
Wang, Q.J.2
Li, X.3
Yan, Y.4
Backer, J.M.5
Chait, B.T.6
Heintz, N.7
Yue, Z.8
-
46
-
-
64049086758
-
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
-
Matsunaga, K.; Saitoh, T.; Tabata, K.; Omori, H.; Satoh, T.; Kurotori, N.; Maejima, I.; Shirahama-Noda, K.; Ichimura, T.; Isobe, T.; et al. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat. Cell Biol. 2009, 11, 385–396.
-
(2009)
Nat. Cell Biol
, vol.11
, pp. 385-396
-
-
Matsunaga, K.1
Saitoh, T.2
Tabata, K.3
Omori, H.4
Satoh, T.5
Kurotori, N.6
Maejima, I.7
Shirahama-Noda, K.8
Ichimura, T.9
Isobe, T.10
-
47
-
-
77955895424
-
Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L
-
Matsunaga, K.; Morita, E.; Saitoh, T.; Akira, S.; Ktistakis, N.T.; Izumi, T.; Noda, T.; Yoshimori, T. Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. J. Cell Biol. 2010, 190, 511–521.
-
(2010)
J. Cell Biol
, vol.190
, pp. 511-521
-
-
Matsunaga, K.1
Morita, E.2
Saitoh, T.3
Akira, S.4
Ktistakis, N.T.5
Izumi, T.6
Noda, T.7
Yoshimori, T.8
-
48
-
-
84875365804
-
Autophagosomes form at ER-mitochondria contact sites
-
Hamasaki, M.; Furuta, N.; Matsuda, A.; Nezu, A.; Yamamoto, A.; Fujita, N.; Oomori, H.; Noda, T.; Haraguchi, T.; Hiraoka, Y.; et al. Autophagosomes form at ER-mitochondria contact sites. Nature2013, 495, 389–393.
-
(2013)
Nature
, vol.495
, pp. 389-393
-
-
Hamasaki, M.1
Furuta, N.2
Matsuda, A.3
Nezu, A.4
Yamamoto, A.5
Fujita, N.6
Oomori, H.7
Noda, T.8
Haraguchi, T.9
Hiraoka, Y.10
-
49
-
-
79956358522
-
Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L)
-
Fan, W.; Nassiri, A.; Zhong, Q. Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L). Proc. Natl. Acad. Sci. USA2011, 108, 7769–7774.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 7769-7774
-
-
Fan, W.1
Nassiri, A.2
Zhong, Q.3
-
50
-
-
84883499836
-
Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy
-
Fogel, A.I.; Dlouhy, B.J.; Wang, C.; Ryu, S.W.; Neutzner, A.; Hasson, S.A.; Sideris, D.P.; Abeliovich, H.; Youle, R.J. Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy. Mol. Cell. Biol. 2013, 33, 3675–3688.
-
(2013)
Mol. Cell. Biol
, vol.33
, pp. 3675-3688
-
-
Fogel, A.I.1
Dlouhy, B.J.2
Wang, C.3
Ryu, S.W.4
Neutzner, A.5
Hasson, S.A.6
Sideris, D.P.7
Abeliovich, H.8
Youle, R.J.9
-
51
-
-
34347344990
-
Ambra1 regulates autophagy and development of the nervous system
-
Fimia, G.M.; Stoykova, A.; Romagnoli, A.; Giunta, L.; di Bartolomeo, S.; Nardacci, R.; Corazzari, M.; Fuoco, C.; Ucar, A.; Schwartz, P.; et al. Ambra1 regulates autophagy and development of the nervous system. Nature2007, 447, 1121–1125.
-
(2007)
Nature
, vol.447
, pp. 1121-1125
-
-
Fimia, G.M.1
Stoykova, A.2
Romagnoli, A.3
Giunta, L.4
Di Bartolomeo, S.5
Nardacci, R.6
Corazzari, M.7
Fuoco, C.8
Ucar, A.9
Schwartz, P.10
-
52
-
-
77957728513
-
The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy
-
Di Bartolomeo, S.; Corazzari, M.; Nazio, F.; Oliverio, S.; Lisi, G.; Antonioli, M.; Pagliarini, V.; Matteoni, S.; Fuoco, C.; Giunta, L.; et al. The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy. J. Cell Biol. 2010, 191, 155–168.
-
(2010)
J. Cell Biol
, vol.191
, pp. 155-168
-
-
Di Bartolomeo, S.1
Corazzari, M.2
Nazio, F.3
Oliverio, S.4
Lisi, G.5
Antonioli, M.6
Pagliarini, V.7
Matteoni, S.8
Fuoco, C.9
Giunta, L.10
-
53
-
-
84922506220
-
AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1
-
Strappazzon, F.; Nazio, F.; Corrado, M.; Cianfanelli, V.; Romagnoli, A.; Fimia, G.M.; Campello, S.; Nardacci, R.; Piacentini, M.; Campanella, M.; et al. AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1. Cell Death Differ. 2014, doi:10.1038/cdd.2014.1139.
-
(2014)
Cell Death Differ
-
-
Strappazzon, F.1
Nazio, F.2
Corrado, M.3
Cianfanelli, V.4
Romagnoli, A.5
Fimia, G.M.6
Campello, S.7
Nardacci, R.8
Piacentini, M.9
Campanella, M.10
-
54
-
-
84880302335
-
Ambra1 at the crossroad between autophagy and cell death
-
Fimia, G.M.; Corazzari, M.; Antonioli, M.; Piacentini, M. Ambra1 at the crossroad between autophagy and cell death. Oncogene2013, 32, 3311–3318.
-
(2013)
Oncogene
, vol.32
, pp. 3311-3318
-
-
Fimia, G.M.1
Corazzari, M.2
Antonioli, M.3
Piacentini, M.4
-
55
-
-
84871002075
-
Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking
-
Kim, H.J.; Zhong, Q.; Sheng, Z.H.; Yoshimori, T.; Liang, C.; Jung, J.U. Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking. J. Cell Sci. 2012, 125, 4740–4750.
-
(2012)
J. Cell Sci
, vol.125
, pp. 4740-4750
-
-
Kim, H.J.1
Zhong, Q.2
Sheng, Z.H.3
Yoshimori, T.4
Liang, C.5
Jung, J.U.6
-
56
-
-
84870984887
-
Endocytosis and autophagy: Shared machinery for degradation
-
Lamb, C.A.; Dooley, H.C.; Tooze, S.A. Endocytosis and autophagy: Shared machinery for degradation. Bioessays2013, 35, 34–45.
-
(2013)
Bioessays
, vol.35
, pp. 34-45
-
-
Lamb, C.A.1
Dooley, H.C.2
Tooze, S.A.3
-
57
-
-
84871903696
-
. Maturation of autophagosomes and endosomes: A key role for Rab7
-
Hyttinen, J.M.; Niittykoski, M.; Salminen, A.; Kaarniranta, K. Maturation of autophagosomes and endosomes: A key role for Rab7. Biochim. Biophys. Acta2013, 1833, 503–510.
-
(2013)
Biochim. Biophys. Acta
, vol.1833
, pp. 503-510
-
-
Hyttinen, J.M.1
Niittykoski, M.2
Salminen, A.3
Kaarniranta, K.4
-
58
-
-
69449089915
-
How do ESCRT proteins control autophagy?
-
Rusten, T.E.; Stenmark, H. How do ESCRT proteins control autophagy? J. Cell Sci. 2009, 122, 2179–2183.
-
(2009)
J. Cell Sci
, vol.122
, pp. 2179-2183
-
-
Rusten, T.E.1
Stenmark, H.2
-
59
-
-
46449120732
-
-
Liang, C.; Lee, J.S.; Inn, K.S.; Gack, M.U.; Li, Q.; Roberts, E.A.; Vergne, I.; Deretic, V.; Feng, P.; Akazawa, C.; et al. Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat. Cell Biol. 2008, 10, 776–787.
-
(2008)
Nat. Cell Biol
, vol.10
, pp. 776-787
-
-
Liang, C.1
Lee, J.S.2
Inn, K.S.3
Gack, M.U.4
Li, Q.5
Roberts, E.A.6
Vergne, I.7
Deretic, V.8
Feng, P.9
Akazawa, C.10
-
60
-
-
84885175531
-
-
He, S.; Ni, D.; Ma, B.; Lee, J.H.; Zhang, T.; Ghozalli, I.; Pirooz, S.D.; Zhao, Z.; Bharatham, N.; Li, B.; et al. PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex. Nat. Cell Biol. 2013, 15, 1206–1219.
-
(2013)
Nat. Cell Biol
, vol.15
, pp. 1206-1219
-
-
He, S.1
Ni, D.2
Ma, B.3
Lee, J.H.4
Zhang, T.5
Ghozalli, I.6
Pirooz, S.D.7
Zhao, Z.8
Bharatham, N.9
Li, B.10
-
61
-
-
34848899280
-
-
Takahashi, Y.; Coppola, D.; Matsushita, N.; Cualing, H.D.; Sun, M.; Sato, Y.; Liang, C.; Jung, J.U.; Cheng, J.Q.; Mulé, J.J.; et al. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat. Cell Biol. 2007, 9, 1142–1151.
-
(2007)
Nat. Cell Biol
, vol.9
, pp. 1142-1151
-
-
Takahashi, Y.1
Coppola, D.2
Matsushita, N.3
Cualing, H.D.4
Sun, M.5
Sato, Y.6
Liang, C.7
Jung, J.U.8
Cheng, J.Q.9
Mulé, J.J.10
-
62
-
-
63249119848
-
Endophilin B1/Bif-1 stimulates BAX activation independently from its capacity to produce large scale membrane morphological rearrangements
-
Etxebarria, A.; Terrones, O.; Yamaguchi, H.; Landajuela, A.; Landeta, O.; Antonsson, B.; Wang, H.G.; Basañez, G. Endophilin B1/Bif-1 stimulates BAX activation independently from its capacity to produce large scale membrane morphological rearrangements. J. Biol. Chem. 2009, 284, 4200–4212.
-
(2009)
J. Biol. Chem
, vol.284
, pp. 4200-4212
-
-
Etxebarria, A.1
Terrones, O.2
Yamaguchi, H.3
Landajuela, A.4
Landeta, O.5
Antonsson, B.6
Wang, H.G.7
Basañez, G.8
-
63
-
-
67549096696
-
Bif-1/endophilin B1: A candidate for crescent driving force in autophagy
-
Takahashi, Y.; Meyerkord, C.L.; Wang, H.G. Bif-1/endophilin B1: A candidate for crescent driving force in autophagy. Cell Death Differ. 2009, 16, 947–955.
-
(2009)
Cell Death Differ
, vol.16
, pp. 947-955
-
-
Takahashi, Y.1
Meyerkord, C.L.2
Wang, H.G.3
-
64
-
-
78650936005
-
The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression
-
Sun, Q.; Zhang, J.; Fan, W.; Wong, K.N.; Ding, X.; Chen, S.; Zhong, Q. The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression. J. Biol. Chem. 2011, 286, 185–191.
-
(2011)
J. Biol. Chem
, vol.286
, pp. 185-191
-
-
Sun, Q.1
Zhang, J.2
Fan, W.3
Wong, K.N.4
Ding, X.5
Chen, S.6
Zhong, Q.7
-
65
-
-
54049139685
-
Endophilin B1 as a novel regulator of nerve growth factor/TrkA trafficking and neurite outgrowth
-
Wan, J.; Cheung, A.Y.; Fu, W.Y.; Wu, C.; Zhang, M.; Mobley, W.C.; Cheung, Z.H.; Ip, N.Y. Endophilin B1 as a novel regulator of nerve growth factor/TrkA trafficking and neurite outgrowth. J. Neurosci. 2008, 28, 9002–9012.
-
(2008)
J. Neurosci
, vol.28
, pp. 9002-9012
-
-
Wan, J.1
Cheung, A.Y.2
Fu, W.Y.3
Wu, C.4
Zhang, M.5
Mobley, W.C.6
Cheung, Z.H.7
Ip, N.Y.8
-
66
-
-
84864538866
-
Bif-1 suppresses breast cancer cell migration by promoting EGFR endocytic degradation
-
Runkle, K.B.; Meyerkord, C.L.; Desai, N.V.; Takahashi, Y.; Wang, H.G. Bif-1 suppresses breast cancer cell migration by promoting EGFR endocytic degradation. Cancer Biol. Ther. 2012, 13, 956–966.
-
(2012)
Cancer Biol. Ther
, vol.13
, pp. 956-966
-
-
Runkle, K.B.1
Meyerkord, C.L.2
Desai, N.V.3
Takahashi, Y.4
Wang, H.G.5
-
67
-
-
78650600158
-
Rubicon controls endosome maturation as a Rab7 effector
-
Sun, Q.; Westphal, W.; Wong, K.N.; Tan, I.; Zhong, Q. Rubicon controls endosome maturation as a Rab7 effector. Proc. Natl. Acad. Sci. USA2010, 107, 19338–19343.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 19338-19343
-
-
Sun, Q.1
Westphal, W.2
Wong, K.N.3
Tan, I.4
Zhong, Q.5
-
68
-
-
34248998801
-
-
Maiuri, M.C.; le Toumelin, G.; Criollo, A.; Rain, J.C.; Gautier, F.; Juin, P.; Tasdemir, E.; Pierron, G.; Troulinaki, K.; Tavernarakis, N.; et al. Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J. 2007, 26, 2527–2539.
-
(2007)
EMBO J
, vol.26
, pp. 2527-2539
-
-
Maiuri, M.C.1
Le Toumelin, G.2
Criollo, A.3
Rain, J.C.4
Gautier, F.5
Juin, P.6
Tasdemir, E.7
Pierron, G.8
Troulinaki, K.9
Tavernarakis, N.10
-
69
-
-
25144457455
-
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
-
Pattingre, S.; Tassa, A.; Qu, X.; Garuti, R.; Liang, X.H.; Mizushima, N.; Packer, M.; Schneider, M.D.; Levine, B. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell2005, 122, 927–939.
-
(2005)
Cell
, vol.122
, pp. 927-939
-
-
Pattingre, S.1
Tassa, A.2
Qu, X.3
Garuti, R.4
Liang, X.H.5
Mizushima, N.6
Packer, M.7
Schneider, M.D.8
Levine, B.9
-
70
-
-
84865736998
-
Targeting the B-cell lymphoma/leukemia 2 family in cancer
-
Davids, M.S.; Letai, A. Targeting the B-cell lymphoma/leukemia 2 family in cancer. J. Clin. Oncol. 2012, 30, 3127–3135.
-
(2012)
J. Clin. Oncol
, vol.30
, pp. 3127-3135
-
-
Davids, M.S.1
Letai, A.2
-
71
-
-
34249037565
-
Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein
-
Oberstein, A.; Jeffrey, P.D.; Shi, Y. Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. J. Biol. Chem. 2007, 282, 13123–13132.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 13123-13132
-
-
Oberstein, A.1
Jeffrey, P.D.2
Shi, Y.3
-
72
-
-
77954917377
-
Beclin 1 self-association is independent of autophagy induction by amino acid deprivation and rapamycin treatment
-
Adi-Harel, S.; Erlich, S.; Schmukler, E.; Cohen-Kedar, S.; Segev, O.; Mizrachy, L.; Hirsch, J.A.; Pinkas-Kramarski, R. Beclin 1 self-association is independent of autophagy induction by amino acid deprivation and rapamycin treatment. J. Cell. Biochem. 2010, 110, 1262–1271.
-
(2010)
J. Cell. Biochem
, vol.110
, pp. 1262-1271
-
-
Adi-Harel, S.1
Erlich, S.2
Schmukler, E.3
Cohen-Kedar, S.4
Segev, O.5
Mizrachy, L.6
Hirsch, J.A.7
Pinkas-Kramarski, R.8
-
73
-
-
43949139277
-
An insight into the mechanistic role of Beclin 1 and its inhibition by prosurvival Bcl-2 family proteins
-
Ku, B.; Woo, J.S.; Liang, C.; Lee, K.H.; Jung, J.U.; Oh, B.H. An insight into the mechanistic role of Beclin 1 and its inhibition by prosurvival Bcl-2 family proteins. Autophagy2008, 4, 519–520.
-
(2008)
Autophagy
, vol.4
, pp. 519-520
-
-
Ku, B.1
Woo, J.S.2
Liang, C.3
Lee, K.H.4
Jung, J.U.5
Oh, B.H.6
-
74
-
-
84862023791
-
Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG
-
Li, X.; He, L.; Che, K.H.; Funderburk, S.F.; Pan, L.; Pan, N.; Zhang, M.; Yue, Z.; Zhao, Y. Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG. Nat. Commun. 2012, 3, 662.
-
(2012)
Nat. Commun
, vol.3
, pp. 662
-
-
Li, X.1
He, L.2
Che, K.H.3
Funderburk, S.F.4
Pan, L.5
Pan, N.6
Zhang, M.7
Yue, Z.8
Zhao, Y.9
-
75
-
-
54449099779
-
Bcl-xL and UVRAG cause a monomer-dimer switch in Beclin1
-
Noble, C.G.; Dong, J.M.; Manser, E.; Song, H. Bcl-xL and UVRAG cause a monomer-dimer switch in Beclin1. J. Biol. Chem. 2008, 283, 26274–26282.
-
(2008)
J. Biol. Chem
, vol.283
, pp. 26274-26282
-
-
Noble, C.G.1
Dong, J.M.2
Manser, E.3
Song, H.4
-
76
-
-
84905095317
-
Gene of the month: BECN1
-
Sahni, S.; Merlot, A.M.; Krishan, S.; Jansson, P.J.; Richardson, D.R. Gene of the month: BECN1. J. Clin. Pathol. 2014, 67, 656–660.
-
(2014)
J. Clin. Pathol
, vol.67
, pp. 656-660
-
-
Sahni, S.1
Merlot, A.M.2
Krishan, S.3
Jansson, P.J.4
Richardson, D.R.5
-
77
-
-
84906084536
-
Limiting the power of p53 through the ubiquitin proteasome pathway
-
Pant, V.; Lozano, G. Limiting the power of p53 through the ubiquitin proteasome pathway. Genes Dev. 2014, 28, 1739–1751.
-
(2014)
Genes Dev
, vol.28
, pp. 1739-1751
-
-
Pant, V.1
Lozano, G.2
-
78
-
-
65549120715
-
Gu, W. Modes of p53 Regulation
-
Kruse, J.P.; Gu, W. Modes of p53 Regulation. Cell2009, 137, 609–622.
-
(2009)
Cell
, vol.137
, pp. 609-622
-
-
Kruse, J.P.1
-
79
-
-
49149086504
-
A default gate-keeping tumor suppressor with a versatile tail
-
Wang, X.; Jiang, X. PTEN: A default gate-keeping tumor suppressor with a versatile tail. Cell Res. 2008, 18, 807–816.
-
(2008)
Cell Res
, vol.18
, pp. 807-816
-
-
Wang, X.1
Jiang, X.2
-
80
-
-
84872170622
-
PTEN at a glance
-
Shi, Y.; Paluch, B.E.; Wang, X.; Jiang, X. PTEN at a glance. J. Cell Sci. 2012, 125, 4687–4692.
-
(2012)
J. Cell Sci
, vol.125
, pp. 4687-4692
-
-
Shi, Y.1
Paluch, B.E.2
Wang, X.3
Jiang, X.4
-
81
-
-
84920892843
-
Regulation of androgen receptor by E3 ubiquitin ligases: For more or less
-
e122
-
Li, B.; Lu, W.; Chen, Z. Regulation of androgen receptor by E3 ubiquitin ligases: For more or less. Recept. Clin. Investig. 2014, 1, e122.
-
(2014)
Recept. Clin. Investig
, vol.1
-
-
Li, B.1
Lu, W.2
Chen, Z.3
-
82
-
-
84920931204
-
The cycling peroxisomal targeting signal type 1—Receptor Pex5p: Reaching the circle’s end with ubiquitin
-
Platta, H.W. The cycling peroxisomal targeting signal type 1—Receptor Pex5p: Reaching the circle’s end with ubiquitin. Recept. Clin. Investig. 2014, 1, 55–68.
-
(2014)
Recept. Clin. Investig
, vol.1
, pp. 55-68
-
-
Platta, H.W.1
-
83
-
-
84895142640
-
The peroxisomal receptor dislocation pathway: To the exportomer and beyond
-
Platta, H.W.; Hagen, S.; Reidick, C.; Erdmann, R. The peroxisomal receptor dislocation pathway: To the exportomer and beyond. Biochimie2014, 98C, 16–28.
-
(2014)
Biochimie
, vol.98
, pp. 16-28
-
-
Platta, H.W.1
Hagen, S.2
Reidick, C.3
Erdmann, R.4
-
84
-
-
80053501671
-
Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13
-
Liu, J.; Xia, H.; Kim, M.; Xu, L.; Li, Y.; Zhang, L.; Cai, Y.; Norberg, H.V.; Zhang, T.; Furuya, T.; et al. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell2011, 147, 223–234.
-
(2011)
Cell
, vol.147
, pp. 223-234
-
-
Liu, J.1
Xia, H.2
Kim, M.3
Xu, L.4
Li, Y.5
Zhang, L.6
Cai, Y.7
Norberg, H.V.8
Zhang, T.9
Furuya, T.10
-
85
-
-
78049271501
-
A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic
-
Thoresen, S.B.; Pedersen, N.M.; Liestøl, K.; Stenmark, H. A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic. Exp. Cell Res. 2010, 316, 3368–3378.
-
(2010)
Exp. Cell Res
, vol.316
, pp. 3368-3378
-
-
Thoresen, S.B.1
Pedersen, N.M.2
Liestøl, K.3
Stenmark, H.4
-
86
-
-
84899091326
-
Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia
-
Shao, S.; Li, S.; Qin, Y.; Wang, X.; Yang, Y.; Bai, H.; Zhou, L.; Zhao, C.; Wang, C. Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia. Int. J. Oncol. 2014, 44, 1661–1668.
-
(2014)
Int. J. Oncol
, vol.44
, pp. 1661-1668
-
-
Shao, S.1
Li, S.2
Qin, Y.3
Wang, X.4
Yang, Y.5
Bai, H.6
Zhou, L.7
Zhao, C.8
Wang, C.9
-
87
-
-
84906828707
-
Combination of AKT inhibition with autophagy blockade effectively reduces ascites-derived ovarian cancer cell viability
-
Correa, R.J.; Valdes, Y.R.; Peart, T.M.; Fazio, E.N.; Bertrand, M.; McGee, J.; Préfontaine, M.; Sugimoto, A.; DiMattia, G.E.; Shepherd, T.G. Combination of AKT inhibition with autophagy blockade effectively reduces ascites-derived ovarian cancer cell viability. Carcinogenesis2014, 35, 1951–1961.
-
(2014)
Carcinogenesis
, vol.35
, pp. 1951-1961
-
-
Correa, R.J.1
Valdes, Y.R.2
Peart, T.M.3
Fazio, E.N.4
Bertrand, M.5
McGee, J.6
Préfontaine, M.7
Sugimoto, A.8
Dimattia, G.E.9
Shepherd, T.G.10
-
88
-
-
67649634849
-
Defining the human deubiquitinating enzyme interaction landscape
-
Sowa, M.E.; Bennett, E.J.; Gygi, S.P.; Harper, J.W. Defining the human deubiquitinating enzyme interaction landscape. Cell2009, 138, 389–403.
-
(2009)
Cell
, vol.138
, pp. 389-403
-
-
Sowa, M.E.1
Bennett, E.J.2
Gygi, S.P.3
Harper, J.W.4
-
89
-
-
79959963047
-
Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop
-
Löffler, A.S.; Alers, S.; Dieterle, A.M.; Keppeler, H.; Franz-Wachtel, M.; Kundu, M.; Campbell, D.G.; Wesselborg, S.; Alessi, D.R.; Stork, B. Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. Autophagy2011, 7, 696–706.
-
(2011)
Autophagy
, vol.7
, pp. 696-706
-
-
Löffler, A.S.1
Alers, S.2
Dieterle, A.M.3
Keppeler, H.4
Franz-Wachtel, M.5
Kundu, M.6
Campbell, D.G.7
Wesselborg, S.8
Alessi, D.R.9
Stork, B.10
-
90
-
-
84880343182
-
ULK1 targets Beclin-1 in autophagy
-
Nazarko, V.Y.; Zhong, Q. ULK1 targets Beclin-1 in autophagy. Nat. Cell Biol. 2013, 15, 727–728.
-
(2013)
Nat. Cell Biol
, vol.15
, pp. 727-728
-
-
Nazarko, V.Y.1
Zhong, Q.2
-
91
-
-
84880331368
-
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
-
Russell, R.C.; Tian, Y.; Yuan, H.; Park, H.W.; Chang, Y.Y.; Kim, J.; Kim, H.; Neufeld, T.P.; Dillin, A.; Guan, K.L. ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat. Cell Biol. 2013, 15, 741–750.
-
(2013)
Nat. Cell Biol
, vol.15
, pp. 741-750
-
-
Russell, R.C.1
Tian, Y.2
Yuan, H.3
Park, H.W.4
Chang, Y.Y.5
Kim, J.6
Kim, H.7
Neufeld, T.P.8
Dillin, A.9
Guan, K.L.10
-
92
-
-
84876488191
-
-
Nazio, F.; Strappazzon, F.; Antonioli, M.; Bielli, P.; Cianfanelli, V.; Bordi, M.; Gretzmeier, C.; Dengjel, J.; Piacentini, M.; Fimia, G.M.; et al. mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6. Nat. Cell Biol. 2013, 15, 406–416.
-
(2013)
Nat. Cell Biol
, vol.15
, pp. 406-416
-
-
Nazio, F.1
Strappazzon, F.2
Antonioli, M.3
Bielli, P.4
Cianfanelli, V.5
Bordi, M.6
Gretzmeier, C.7
Dengjel, J.8
Piacentini, M.9
Fimia, G.M.10
-
93
-
-
78651488777
-
-
Bodemann, B.O.; Orvedahl, A.; Cheng, T.; Ram, R.R.; Ou, Y.H.; Formstecher, E.; Maiti, M.; Hazelett, C.C.; Wauson, E.M.; Balakireva, M.; et al. RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly. Cell2011, 144, 253–267.
-
(2011)
Cell
, vol.144
, pp. 253-267
-
-
Bodemann, B.O.1
Orvedahl, A.2
Cheng, T.3
Ram, R.R.4
Ou, Y.H.5
Formstecher, E.6
Maiti, M.7
Hazelett, C.C.8
Wauson, E.M.9
Balakireva, M.10
-
94
-
-
84885183894
-
-
Simicek, M.; Lievens, S.; Laga, M.; Guzenko, D.; Aushev, V.N.; Kalev, P.; Baietti, M.F.; Strelkov, S.V.; Gevaert, K.; Tavernier, J.; et al. The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response. Nat. Cell Biol. 2013, 15, 1220–1230.
-
(2013)
Nat. Cell Biol
, vol.15
, pp. 1220-1230
-
-
Simicek, M.1
Lievens, S.2
Laga, M.3
Guzenko, D.4
Aushev, V.N.5
Kalev, P.6
Baietti, M.F.7
Strelkov, S.V.8
Gevaert, K.9
Tavernier, J.10
-
95
-
-
75749132016
-
USP10 regulates p53 localization and stability by deubiquitinating p53
-
Yuan, J.; Luo, K.; Zhang, L.; Cheville, J.C.; Lou, Z. USP10 regulates p53 localization and stability by deubiquitinating p53. Cell2010, 140, 384–396.
-
(2010)
Cell
, vol.140
, pp. 384-396
-
-
Yuan, J.1
Luo, K.2
Zhang, L.3
Cheville, J.C.4
Lou, Z.5
-
96
-
-
84911376426
-
Beclin-1-p53 interaction is crucial for cell fate determination in embryonal carcinoma cells
-
Tripathi, R.; Ash, D.; Shaha, C. Beclin-1-p53 interaction is crucial for cell fate determination in embryonal carcinoma cells. J. Cell. Mol. Med. 2014, 18, 2275–2286.
-
(2014)
J. Cell. Mol. Med
, vol.18
, pp. 2275-2286
-
-
Tripathi, R.1
Ash, D.2
Shaha, C.3
-
97
-
-
84890522100
-
Functions of the Hsp90 chaperone system: Lifting client proteins to new heights
-
Eckl, J.M.; Richter, K. Functions of the Hsp90 chaperone system: Lifting client proteins to new heights. Int. J. Biochem. Mol. Biol. 2013, 4, 157–165.
-
(2013)
Int. J. Biochem. Mol. Biol
, vol.4
, pp. 157-165
-
-
Eckl, J.M.1
Richter, K.2
-
98
-
-
80051688648
-
Functional interaction of heat shock protein 90 and Beclin 1 modulates Toll-like receptor-mediated autophagy
-
Xu, C.; Liu, J.; Hsu, L.C.; Luo, Y.; Xiang, R.; Chuang, T.H. Functional interaction of heat shock protein 90 and Beclin 1 modulates Toll-like receptor-mediated autophagy. FASEB J. 2011, 25, 2700–2710.
-
(2011)
FASEB J
, vol.25
, pp. 2700-2710
-
-
Xu, C.1
Liu, J.2
Hsu, L.C.3
Luo, Y.4
Xiang, R.5
Chuang, T.H.6
-
99
-
-
15544385359
-
Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents
-
Miyata, Y. Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents. Curr. Pharm. Des. 2005, 11, 1131–1138.
-
(2005)
Curr. Pharm. Des
, vol.11
, pp. 1131-1138
-
-
Miyata, Y.1
-
100
-
-
73949114912
-
Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase
-
Ehrlich, E.S.; Wang, T.; Luo, K.; Xiao, Z.; Niewiadomska, A.M.; Martinez, T.; Xu, W.; Neckers, L.; Yu, X.F. Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase. Proc. Natl. Acad. Sci. USA2009, 106, 20330–20335.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 20330-20335
-
-
Ehrlich, E.S.1
Wang, T.2
Luo, K.3
Xiao, Z.4
Niewiadomska, A.M.5
Martinez, T.6
Xu, W.7
Neckers, L.8
Yu, X.F.9
-
101
-
-
84899837467
-
E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells
-
Samant, R.S.; Clarke, P.A.; Workman, P. E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells. Proc. Natl. Acad. Sci. USA2014, 111, 6834–6839.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 6834-6839
-
-
Samant, R.S.1
Clarke, P.A.2
Workman, P.3
-
102
-
-
84903553389
-
P53 modulates Hsp90 ATPase activity and regulates aryl hydrocarbon receptor signaling
-
Kochhar, A.; Kopelovich, L.; Sue, E.; Guttenplan, J.B.; Herbert, B.S.; Dannenberg, A.J.; Subbaramaiah, K. p53 modulates Hsp90 ATPase activity and regulates aryl hydrocarbon receptor signaling. Cancer Prev. Res. 2014, 7, 596–606.
-
(2014)
Cancer Prev. Res
, vol.7
, pp. 596-606
-
-
Kochhar, A.1
Kopelovich, L.2
Sue, E.3
Guttenplan, J.B.4
Herbert, B.S.5
Dannenberg, A.J.6
Subbaramaiah, K.7
-
103
-
-
84896799669
-
P53 protein regulates Hsp90 ATPase activity and thereby Wnt signaling by modulating Aha1 expression
-
Okayama, S.; Kopelovich, L.; Balmus, G.; Weiss, R.S.; Herbert, B.S.; Dannenberg, A.J.; Subbaramaiah, K. p53 protein regulates Hsp90 ATPase activity and thereby Wnt signaling by modulating Aha1 expression. J. Biol. Chem. 2014, 289, 6513–6525.
-
(2014)
J. Biol. Chem
, vol.289
, pp. 6513-6525
-
-
Okayama, S.1
Kopelovich, L.2
Balmus, G.3
Weiss, R.S.4
Herbert, B.S.5
Dannenberg, A.J.6
Subbaramaiah, K.7
-
104
-
-
84880787644
-
Inhibition of HSP90 molecular chaperones: Moving into the clinic
-
Garcia-Carbonero, R.; Carnero, A.; Paz-Ares, L. Inhibition of HSP90 molecular chaperones: Moving into the clinic. Lancet Oncol. 2013, 14, e358–e369.
-
(2013)
Lancet Oncol
, vol.14
, pp. e358-e369
-
-
Garcia-Carbonero, R.1
Carnero, A.2
Paz-Ares, L.3
-
105
-
-
84880679940
-
Discovery and development of heat shock protein 90 inhibitors as anticancer agents: A review of patented potent geldanamycin derivatives
-
Kim, T.; Keum, G.; Pae, A.N. Discovery and development of heat shock protein 90 inhibitors as anticancer agents: A review of patented potent geldanamycin derivatives. Expert Opin. Ther. Pat. 2013, 23, 919–943.
-
(2013)
Expert Opin. Ther. Pat
, vol.23
, pp. 919-943
-
-
Kim, T.1
Keum, G.2
Pae, A.N.3
-
106
-
-
84055219407
-
Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1
-
Platta, H.W.; Abrahamsen, H.; Thoresen, S.B.; Stenmark, H. Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1. Biochem. J. 2012, 441, 399–406.
-
(2012)
Biochem. J
, vol.441
, pp. 399-406
-
-
Platta, H.W.1
Abrahamsen, H.2
Thoresen, S.B.3
Stenmark, H.4
-
107
-
-
77954237882
-
Network organization of the human autophagy system
-
Behrends, C.; Sowa, M.E.; Gygi, S.P.; Harper, J.W. Network organization of the human autophagy system. Nature2010, 466, 68–76.
-
(2010)
Nature
, vol.466
, pp. 68-76
-
-
Behrends, C.1
Sowa, M.E.2
Gygi, S.P.3
Harper, J.W.4
-
108
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
Maehama, T.; Dixon, J.E. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 1998, 273, 13375–13378.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
109
-
-
77950501014
-
MTOR regulation of autophagy
-
Jung, C.H.; Ro, S.H.; Cao, J.; Otto, N.M.; Kim, D.H. mTOR regulation of autophagy. FEBS Lett. 2010, 584, 1287–1295.
-
(2010)
FEBS Lett
, vol.584
, pp. 1287-1295
-
-
Jung, C.H.1
Ro, S.H.2
Cao, J.3
Otto, N.M.4
Kim, D.H.5
-
110
-
-
78650510609
-
MTOR: From growth signal integration to cancer, diabetes and ageing
-
Zoncu, R.; Efeyan, A.; Sabatini, D.M. mTOR: From growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 2011, 12, 21–35.
-
(2011)
Nat. Rev. Mol. Cell Biol
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
-
111
-
-
84869147050
-
Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation
-
Wang, R.C.; Wei, Y.; An, Z.; Zou, Z.; Xiao, G.; Bhagat, G.; White, M.; Reichelt, J.; Levine, B. Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. Science2012, 338, 956–959.
-
(2012)
Science
, vol.338
, pp. 956-959
-
-
Wang, R.C.1
Wei, Y.2
An, Z.3
Zou, Z.4
Xiao, G.5
Bhagat, G.6
White, M.7
Reichelt, J.8
Levine, B.9
-
112
-
-
0035929650
-
The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway
-
Arico, S.; Petiot, A.; Bauvy, C.; Dubbelhuis, P.F.; Meijer, A.J.; Codogno, P.; Ogier-Denis, E. The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J. Biol. Chem. 2001, 276, 35243–35246.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 35243-35246
-
-
Arico, S.1
Petiot, A.2
Bauvy, C.3
Dubbelhuis, P.F.4
Meijer, A.J.5
Codogno, P.6
Ogier-Denis, E.7
-
113
-
-
33845991111
-
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN
-
Wang, X.; Trotman, L.C.; Koppie, T.; Alimonti, A.; Chen, Z.; Gao, Z.; Wang, J.; Erdjument-Bromage, H.; Tempst, P.; Cordon-Cardo, C.; et al. NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell2007, 128, 129–139.
-
(2007)
Cell
, vol.128
, pp. 129-139
-
-
Wang, X.1
Trotman, L.C.2
Koppie, T.3
Alimonti, A.4
Chen, Z.5
Gao, Z.6
Wang, J.7
Erdjument-Bromage, H.8
Tempst, P.9
Cordon-Cardo, C.10
-
114
-
-
84905233253
-
NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation
-
Fang, D.F.; He, K.; Wang, N.; Sang, Z.H.; Qiu, X.; Xu, G.; Jian, Z.; Liang, B.; Li, T.; Li, H.Y.; et al. NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation. Nat. Commun. 2014, doi:10.1038/ncomms5513.
-
(2014)
Nat. Commun
-
-
Fang, D.F.1
He, K.2
Wang, N.3
Sang, Z.H.4
Qiu, X.5
Xu, G.6
Jian, Z.7
Liang, B.8
Li, T.9
Li, H.Y.10
-
115
-
-
84891763776
-
Regulation of Mdm2 protein stability and the p53 response by NEDD4-1 E3 ligase
-
Xu, C.; Fan, C.D.; Wang, X. Regulation of Mdm2 protein stability and the p53 response by NEDD4-1 E3 ligase. Oncogene2014, doi:10.1038/onc.2013.1557.
-
(2014)
Oncogene
-
-
Xu, C.1
Fan, C.D.2
Wang, X.3
-
116
-
-
84921938541
-
The molecular mechanisms between autophagy and apoptosis: Potential role in central nervous system disorders
-
Wu, H.J.; Pu, J.L.; Krafft, P.R.; Zhang, J.M.; Chen, S. The molecular mechanisms between autophagy and apoptosis: Potential role in central nervous system disorders. Cell. Mol. Neurobiol. 2014, doi:10.1007/s10571-014-0116-z.
-
(2014)
Cell. Mol. Neurobiol
-
-
Wu, H.J.1
Pu, J.L.2
Krafft, P.R.3
Zhang, J.M.4
Chen, S.5
-
117
-
-
84894565195
-
Self-consumption: The interplay of autophagy and apoptosis
-
Mariño, G.; Niso-Santano, M.; Baehrecke, E.H.; Kroemer, G. Self-consumption: The interplay of autophagy and apoptosis. Nat. Rev. Mol. Cell Biol. 2014, 15, 81–94.
-
(2014)
Nat. Rev. Mol. Cell Biol
, vol.15
, pp. 81-94
-
-
Mariño, G.1
Niso-Santano, M.2
Baehrecke, E.H.3
Kroemer, G.4
-
118
-
-
84907334131
-
NEDD4: A promising target for cancer therapy
-
Ye, X.; Wang, L.; Shang, B.; Wang, Z.; Wei, W. NEDD4: A promising target for cancer therapy. Curr. Cancer Drug Targets2014, 14, 549–556.
-
(2014)
Curr. Cancer Drug Targets
, vol.14
, pp. 549-556
-
-
Ye, X.1
Wang, L.2
Shang, B.3
Wang, Z.4
Wei, W.5
-
119
-
-
77953858790
-
TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy
-
ra42
-
Shi, C.S.; Kehrl, J.H. TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy. Sci. Signal. 2010, 3,ra42.
-
(2010)
Sci. Signal
, Issue.3
-
-
Shi, C.S.1
Kehrl, J.H.2
-
120
-
-
37549043217
-
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis
-
Sanjuan, M.A.; Dillon, C.P.; Tait, S.W.; Moshiach, S.; Dorsey, F.; Connell, S.; Komatsu, M.; Tanaka, K.; Cleveland, J.L.; Withoff, S.; et al. Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature2007, 450, 1253–1257.
-
(2007)
Nature
, vol.450
, pp. 1253-1257
-
-
Sanjuan, M.A.1
Dillon, C.P.2
Tait, S.W.3
Moshiach, S.4
Dorsey, F.5
Connell, S.6
Komatsu, M.7
Tanaka, K.8
Cleveland, J.L.9
Withoff, S.10
-
121
-
-
79952357209
-
Lipopolysaccaride induces autophagic signaling in macrophages via a TLR4, heme oxygenase-1 dependent pathway
-
Waltz, P.; Carchman, E.H.; Young, A.C.; Rao, J.; Rosengart, M.R.; Kaczorowski, D.; Zuckerbraun, B.S. Lipopolysaccaride induces autophagic signaling in macrophages via a TLR4, heme oxygenase-1 dependent pathway. Autophagy2011, 7, 315–320.
-
(2011)
Autophagy
, vol.7
, pp. 315-320
-
-
Waltz, P.1
Carchman, E.H.2
Young, A.C.3
Rao, J.4
Rosengart, M.R.5
Kaczorowski, D.6
Zuckerbraun, B.S.7
-
122
-
-
57749100267
-
MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages
-
Shi, C.S.; Kehrl, J.H. MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages. J. Biol. Chem. 2008, 238, 33175–33182.
-
(2008)
J. Biol. Chem
, vol.238
, pp. 33175-33182
-
-
Shi, C.S.1
Kehrl, J.H.2
-
123
-
-
77957680501
-
Traf6 and A20 differentially regulate TLR4-induced autophagy by affecting the ubiquitination of Beclin 1
-
Shi, C.S.; Kehrl, J.H. Traf6 and A20 differentially regulate TLR4-induced autophagy by affecting the ubiquitination of Beclin 1. Autophagy2010, 6, 986–987.
-
(2010)
Autophagy
, vol.6
, pp. 986-987
-
-
Shi, C.S.1
Kehrl, J.H.2
-
124
-
-
61849102389
-
DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy
-
Zalckvar, E.; Berissi, H.; Mizrachy, L.; Idelchuk, Y.; Koren, I.; Eisenstein, M.; Sabanay, H.; Pinkas-Kramarski, R.; Kimchi, A. DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Rep. 2009, 10, 285–292.
-
(2009)
EMBO Rep
, vol.10
, pp. 285-292
-
-
Zalckvar, E.1
Berissi, H.2
Mizrachy, L.3
Idelchuk, Y.4
Koren, I.5
Eisenstein, M.6
Sabanay, H.7
Pinkas-Kramarski, R.8
Kimchi, A.9
-
125
-
-
84907013142
-
EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis
-
Feng, H.; Lopez, G.Y.; Kim, C.K.; Alvarez, A.; Duncan, C.G.; Nishikawa, R.; Nagane, M.; Su, A.J.; Auron, P.E.; Hedberg, M.L.; et al. EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis. J. Clin. Investig. 2014, 124, 3741–3756.
-
(2014)
J. Clin. Investig
, vol.124
, pp. 3741-3756
-
-
Feng, H.1
Lopez, G.Y.2
Kim, C.K.3
Alvarez, A.4
Duncan, C.G.5
Nishikawa, R.6
Nagane, M.7
Su, A.J.8
Auron, P.E.9
Hedberg, M.L.10
-
126
-
-
84892148717
-
Atg9 interacts with dTRAF2/TRAF6 to regulate oxidative stress-induced JNK activation and autophagy induction
-
Tang, H.W.; Liao, H.M.; Peng, W.H.; Lin, H.R.; Chen, C.H.; Chen, G.C. Atg9 interacts with dTRAF2/TRAF6 to regulate oxidative stress-induced JNK activation and autophagy induction. Dev. Cell2013, 27, 489–503.
-
(2013)
Dev. Cell
, vol.27
, pp. 489-503
-
-
Tang, H.W.1
Liao, H.M.2
Peng, W.H.3
Lin, H.R.4
Chen, C.H.5
Chen, G.C.6
-
127
-
-
33750366092
-
Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes
-
Young, A.R.; Chan, E.Y.; Hu, X.W.; Köchl, R.; Crawshaw, S.G.; High, S.; Hailey, D.W.; Lippincott-Schwartz, J.; Tooze, S.A. Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes. J. Cell Sci. 2006, 119, 3888–3900.
-
(2006)
J. Cell Sci
, vol.119
, pp. 3888-3900
-
-
Young, A.R.1
Chan, E.Y.2
Hu, X.W.3
Köchl, R.4
Crawshaw, S.G.5
High, S.6
Hailey, D.W.7
Lippincott-Schwartz, J.8
Tooze, S.A.9
-
128
-
-
0035913278
-
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
-
Wang, C.; Deng, L.; Hong, M.; Akkaraju, G.R.; Inoue, J.; Chen, Z.J. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature2001, 412, 346–351.
-
(2001)
Nature
, vol.412
, pp. 346-351
-
-
Wang, C.1
Deng, L.2
Hong, M.3
Akkaraju, G.R.4
Inoue, J.5
Chen, Z.J.6
-
129
-
-
84863338304
-
Ubiquitination in signaling to and activation of IKK
-
Chen, Z.J. Ubiquitination in signaling to and activation of IKK. Immunol. Rev. 2012, 246, 95–106.
-
(2012)
Immunol. Rev
, vol.246
, pp. 95-106
-
-
Chen, Z.J.1
-
130
-
-
44949237240
-
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy
-
Wei, Y.; Pattingre, S.; Sinha, S.; Bassik, M.; Levine, B. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol. Cell2008, 30, 678–688.
-
(2008)
Mol. Cell
, vol.30
, pp. 678-688
-
-
Wei, Y.1
Pattingre, S.2
Sinha, S.3
Bassik, M.4
Levine, B.5
-
131
-
-
84890828812
-
TRAF6 mediates ubiquitination of KIF23/MKLP1 and is required for midbody ring degradation by selective autophagy
-
Isakson, P.; Lystad, A.H.; Breen, K.; Koster, G.; Stenmark, H.; Simonsen, A. TRAF6 mediates ubiquitination of KIF23/MKLP1 and is required for midbody ring degradation by selective autophagy. Autophagy2013, 9, 1955–1964.
-
(2013)
Autophagy
, vol.9
, pp. 1955-1964
-
-
Isakson, P.1
Lystad, A.H.2
Breen, K.3
Koster, G.4
Stenmark, H.5
Simonsen, A.6
-
132
-
-
0342368772
-
Association between early-onset Parkinson’s disease and mutations in the parkin gene
-
Lucking, C.B.; Durr, A.; Bonifati, V.; Vaughan, J.; de Michele, G.; Gasser, T.; Harhangi, B.S.; Meco, G.; Denefle, P.; Wood, N.W.; et al. Association between early-onset Parkinson’s disease and mutations in the parkin gene. N. Engl. J. Med. 2000, 342, 1560–1567.
-
(2000)
N. Engl. J. Med
, vol.342
, pp. 1560-1567
-
-
Lucking, C.B.1
Durr, A.2
Bonifati, V.3
Vaughan, J.4
De Michele, G.5
Gasser, T.6
Harhangi, B.S.7
Meco, G.8
Denefle, P.9
Wood, N.W.10
-
133
-
-
84901471156
-
Parkin and mitochondrial quality control: Toward assembling the puzzle
-
Winklhofer, K.F. Parkin and mitochondrial quality control: Toward assembling the puzzle. Trends Cell Biol. 2014, 24, 332–341.
-
(2014)
Trends Cell Biol
, vol.24
, pp. 332-341
-
-
Winklhofer, K.F.1
-
134
-
-
78649653044
-
Parkin mono-ubiquitinates Bcl-2 and regulates autophagy
-
Chen, D.; Gao, F.; Li, B.; Wang, H.; Xu, Y.; Zhu, C.; Wang, G. Parkin mono-ubiquitinates Bcl-2 and regulates autophagy. J. Biol. Chem. 2010, 285, 38214–38223.
-
(2010)
J. Biol. Chem
, vol.285
, pp. 38214-38223
-
-
Chen, D.1
Gao, F.2
Li, B.3
Wang, H.4
Xu, Y.5
Zhu, C.6
Wang, G.7
-
135
-
-
23144452091
-
Ubiquitin-binding domains
-
Hicke, L.; Schubert, H.L.; Hill, C.P. Ubiquitin-binding domains. Nat. Rev. Mol. Cell Biol. 2005, 6, 610–621.
-
(2005)
Nat. Rev. Mol. Cell Biol
, vol.6
, pp. 610-621
-
-
Hicke, L.1
Schubert, H.L.2
Hill, C.P.3
-
136
-
-
79960407069
-
Parkin interacts with Ambra1 to induce mitophagy
-
Van Humbeeck, C.; Cornelissen, T.; Hofkens, H.; Mandemakers, W.; Gevaert, K.; de Strooper, B.; Vandenberghe, W. Parkin interacts with Ambra1 to induce mitophagy. J. Neurosci. 2011, 31, 10249–10261.
-
(2011)
J. Neurosci
, vol.31
, pp. 10249-10261
-
-
Van Humbeeck, C.1
Cornelissen, T.2
Hofkens, H.3
Mandemakers, W.4
Gevaert, K.5
De Strooper, B.6
Vandenberghe, W.7
-
137
-
-
84891300736
-
Ubiquitination increases parkin activity to promote autophagic α-synuclein clearance
-
e83914
-
Lonskaya, I.; Desforges, N.M.; Hebron, M.L.; Moussa, C.E. Ubiquitination increases parkin activity to promote autophagic α-synuclein clearance. PLOS ONE2013, 8, e83914.
-
(2013)
PLOS ONE
, vol.8
-
-
Lonskaya, I.1
Desforges, N.M.2
Hebron, M.L.3
Moussa, C.E.4
-
138
-
-
0035854437
-
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: Implications for Parkinson’s disease
-
Shimura, H.; Schlossmacher, M.G.; Hattori, N.; Frosch, M.P.; Trockenbacher, A.; Schneider, R.; Mizuno, Y.; Kosik, K.S.; Selkoe, D.J. Ubiquitination of a new form of alpha-synuclein by parkin from human brain: Implications for Parkinson’s disease. Science2001, 293, 263–269.
-
(2001)
Science
, vol.293
, pp. 263-269
-
-
Shimura, H.1
Schlossmacher, M.G.2
Hattori, N.3
Frosch, M.P.4
Trockenbacher, A.5
Schneider, R.6
Mizuno, Y.7
Kosik, K.S.8
Selkoe, D.J.9
-
139
-
-
84903635313
-
BECN1 is involved in the initiation of mitophagy: It facilitates PARK2 translocation to mitochondria
-
Choubey, V.; Cagalinec, M.; Liiv, J.; Safiulina, D.; Hickey, M.A.; Kuum, M.; Liiv, M.; Anwar, T.; Eskelinen, E.L.; Kaasik, A. BECN1 is involved in the initiation of mitophagy: It facilitates PARK2 translocation to mitochondria. Autophagy2014, 10, 1105–1119.
-
(2014)
Autophagy
, vol.10
, pp. 1105-1119
-
-
Choubey, V.1
Cagalinec, M.2
Liiv, J.3
Safiulina, D.4
Hickey, M.A.5
Kuum, M.6
Liiv, M.7
Anwar, T.8
Eskelinen, E.L.9
Kaasik, A.10
-
140
-
-
77952242572
-
The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy
-
Michiorri, S.; Gelmetti, V.; Giarda, E.; Lombardi, F.; Romano, F.; Marongiu, R.; Nerini-Molteni, S.; Sale, P.; Vago, R.; Arena, G.; et al. The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy. Cell Death Differ. 2010, 17, 962–974.
-
(2010)
Cell Death Differ
, vol.17
, pp. 962-974
-
-
Michiorri, S.1
Gelmetti, V.2
Giarda, E.3
Lombardi, F.4
Romano, F.5
Marongiu, R.6
Nerini-Molteni, S.7
Sale, P.8
Vago, R.9
Arena, G.10
-
141
-
-
77957969657
-
Beclin 1 complex in autophagy and Alzheimer disease
-
Jaeger, P.A.; Wyss-Coray, T. Beclin 1 complex in autophagy and Alzheimer disease. Arch. Neurol. 2010, 67, 1181–1184.
-
(2010)
Arch. Neurol
, vol.67
, pp. 1181-1184
-
-
Jaeger, P.A.1
Wyss-Coray, T.2
-
142
-
-
79956048660
-
Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated Abeta in AD models
-
Khandelwal, P.J.; Herman, A.M.; Hoe, H.S.; Rebeck, G.W.; Moussa, C.E. Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated Abeta in AD models. Hum. Mol. Genet. 2011, 20, 2091–2102.
-
(2011)
Hum. Mol. Genet
, vol.20
, pp. 2091-2102
-
-
Khandelwal, P.J.1
Herman, A.M.2
Hoe, H.S.3
Rebeck, G.W.4
Moussa, C.E.5
-
143
-
-
77956215864
-
Regulation of amyloid precursor protein processing by the Beclin 1 complex
-
e11102
-
Jaeger, P.A.; Pickford, F.; Sun, C.H.; Lucin, K.M.; Masliah, E.; Wyss-Coray, T. Regulation of amyloid precursor protein processing by the Beclin 1 complex. PLOS ONE2010, 5, e11102.
-
(2010)
PLOS ONE
, vol.5
-
-
Jaeger, P.A.1
Pickford, F.2
Sun, C.H.3
Lucin, K.M.4
Masliah, E.5
Wyss-Coray, T.6
-
144
-
-
84881025556
-
Impaired autophagy and APP processing in Alzheimer’s disease: The potential role of Beclin 1 interactome
-
Salminen, A.; Kaarniranta, K.; Kauppinen, A.; Ojala, J.; Haapasalo, A.; Soininen, H.; Hiltunen, M. Impaired autophagy and APP processing in Alzheimer’s disease: The potential role of Beclin 1 interactome. Prog. Neurobiol. 2013, 106, 33–54.
-
(2013)
Prog. Neurobiol
, vol.106
, pp. 33-54
-
-
Salminen, A.1
Kaarniranta, K.2
Kauppinen, A.3
Ojala, J.4
Haapasalo, A.5
Soininen, H.6
Hiltunen, M.7
-
145
-
-
45749114895
-
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice
-
Pickford, F.; Masliah, E.; Britschgi, M.; Lucin, K.; Narasimhan, R.; Jaeger, P.A.; Small, S.; Spencer, B.; Rockenstein, E.; Levine, B.; Wyss-Coray, T. The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J. Clin. Investig. 2008118, 2190–2199.
-
(2008)
J. Clin. Investig
, vol.118
, pp. 2190-2199
-
-
Pickford, F.1
Masliah, E.2
Britschgi, M.3
Lucin, K.4
Narasimhan, R.5
Jaeger, P.A.6
Small, S.7
Spencer, B.8
Rockenstein, E.9
Levine, B.10
Wyss-Coray, T.11
-
146
-
-
45749139570
-
Regulation of Abeta pathology by beclin 1: A protective role for autophagy
-
Lee, J.A.; Gao, F.B. Regulation of Abeta pathology by beclin 1: A protective role for autophagy? J. Clin. Investig. 2008, 118, 2015–2018.
-
(2008)
J. Clin. Investig
, vol.118
, pp. 2015-2018
-
-
Lee, J.A.1
Gao, F.B.2
-
147
-
-
84881490638
-
Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance
-
Lonskaya, I.; Hebron, M.L.; Desforges, N.M.; Franjie, A.; Moussa, C.E. Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance. EMBO Mol. Med. 2013, 5, 1247–1262.
-
(2013)
EMBO Mol. Med
, vol.5
, pp. 1247-1262
-
-
Lonskaya, I.1
Hebron, M.L.2
Desforges, N.M.3
Franjie, A.4
Moussa, C.E.5
-
148
-
-
84907904421
-
Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis
-
Guglielmotto, M.; Monteleone, D.; Piras, A.; Valsecchi, V.; Tropiano, M.; Ariano, S.; Fornaro, M.; Vercelli, A.; Puyal, J.; Arancio, O.; et al. Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis. Autophagy2014, 10, 1827–1843.
-
(2014)
Autophagy
, vol.10
, pp. 1827-1843
-
-
Guglielmotto, M.1
Monteleone, D.2
Piras, A.3
Valsecchi, V.4
Tropiano, M.5
Ariano, S.6
Fornaro, M.7
Vercelli, A.8
Puyal, J.O.9
-
149
-
-
70350359679
-
CRL4s: The CUL4-RING E3 ubiquitin ligases
-
Jackson, S.; Xiong, Y. CRL4s: The CUL4-RING E3 ubiquitin ligases. Trends Biochem. Sci. 2009, 34, 562–570.
-
(2009)
Trends Biochem. Sci
, vol.34
, pp. 562-570
-
-
Jackson, S.1
Xiong, Y.2
-
150
-
-
33747873322
-
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1
-
Jin, J.; Arias, E.E.; Chen, J.; Harper, J.W.; Walter, J.C. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol. Cell2006, 23, 709–721.
-
(2006)
Mol. Cell
, vol.23
, pp. 709-721
-
-
Jin, J.1
Arias, E.E.2
Chen, J.3
Harper, J.W.4
Walter, J.C.5
-
151
-
-
81855227619
-
The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation
-
Fischer, E.S.; Scrima, A.; Böhm, K.; Matsumoto, S.; Lingaraju, G.M.; Faty, M.; Yasuda, T.; Cavadini, S.; Wakasugi, M.; Hanaoka, F.; et al. The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation. Cell2011, 147, 1024–1039.
-
(2011)
Cell
, vol.147
, pp. 1024-1039
-
-
Fischer, E.S.1
Scrima, A.2
Böhm, K.3
Matsumoto, S.4
Lingaraju, G.M.5
Faty, M.6
Yasuda, T.7
Cavadini, S.8
Wakasugi, M.F.9
-
152
-
-
1342275414
-
Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase
-
Wertz, I.E.; O’Rourke, K.M.; Zhang, Z.; Dornan, D.; Arnott, D.; Deshaies, R.J.; Dixit, V.M. Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science2004, 303, 1371–1374.
-
(2004)
Science
, vol.303
, pp. 1371-1374
-
-
Wertz, I.E.1
O’Rourke, K.M.2
Zhang, Z.3
Dornan, D.4
Arnott, D.5
Deshaies, R.J.6
Dixit, V.M.7
-
153
-
-
84885869476
-
WASH inhibits autophagy through suppression of Beclin 1 ubiquitination
-
Xia, P.; Wang, S.; Du, Y.; Zhao, Z.; Shi, L.; Sun, L.; Huang, G.; Ye, B.; Li, C.; Dai, Z.; et al. WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. EMBO J. 2013, 32, 2685–2696.
-
(2013)
EMBO J
, vol.32
, pp. 2685-2696
-
-
Xia, P.1
Wang, S.2
Du, Y.3
Zhao, Z.4
Shi, L.5
Sun, L.6
Huang, G.7
Ye, B.8
Li, C.9
Dai, Z.10
-
154
-
-
37749037456
-
Human subtelomeric WASH genes encode a new subclass of the WASP family
-
e237
-
Linardopoulou, E.V.; Parghi, S.S.; Friedman, C.; Osborn, G.E.; Parkhurst, S.M.; Trask, B.J. Human subtelomeric WASH genes encode a new subclass of the WASP family. PLOS Genet. 2007, 3, e237.
-
(2007)
PLOS Genet
, vol.3
-
-
Linardopoulou, E.V.1
Parghi, S.S.2
Friedman, C.3
Osborn, G.E.4
Parkhurst, S.M.5
Trask, B.J.6
-
155
-
-
71549141976
-
Sorting out endosomes in the WASH
-
Bear, J.E. Sorting out endosomes in the WASH. Dev. Cell2009, 17, 583–584.
-
(2009)
Dev. Cell
, vol.17
, pp. 583-584
-
-
Bear, J.E.1
-
156
-
-
84905582805
-
RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy
-
Xia, P.; Wang, S.; Huang, G.; Du, Y.; Zhu, P.; Li, M.; Fan, Z. RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy. Cell Res. 2014, 24, 943–958.
-
(2014)
Cell Res
, vol.24
, pp. 943-958
-
-
Xia, P.1
Wang, S.2
Huang, G.3
Du, Y.4
Zhu, P.5
Li, M.6
Fan, Z.7
-
157
-
-
0038548210
-
Assembly of polycomb complexes and silencing mechanisms
-
Pirrotta, V.; Poux, S.; Melfi, R.; Pilyugin, M. Assembly of polycomb complexes and silencing mechanisms. Genetica2003, 117, 191–197.
-
(2003)
Genetica
, vol.117
, pp. 191-197
-
-
Pirrotta, V.1
Poux, S.2
Melfi, R.3
Pilyugin, M.4
-
158
-
-
84861197043
-
The RING-type ubiquitin ligases Pex2p, Pex10p and Pex12p form a heteromeric complex that displays enhanced activity in an ubiquitin conjugating enzyme-selective manner
-
El Magraoui, F.; Bäumer, B.E.; Platta, H.W.; Baumann, J.S.; Girzalsky, W.; Erdmann, R. The RING-type ubiquitin ligases Pex2p, Pex10p and Pex12p form a heteromeric complex that displays enhanced activity in an ubiquitin conjugating enzyme-selective manner. FEBS J. 2012, 279, 2060–2070.
-
(2012)
FEBS J
, vol.279
, pp. 2060-2070
-
-
El Magraoui, F.1
Bäumer, B.E.2
Platta, H.W.3
Baumann, J.S.4
Girzalsky, W.5
Erdmann, R.6
-
159
-
-
33747337000
-
Role of Bmi1 in H2A ubiquitylation and Hox gene silencing
-
Wei, J.; Zhai, L.; Xu, J.; Wang, H. Role of Bmi1 in H2A ubiquitylation and Hox gene silencing. J. Biol. Chem. 2006, 281, 22537–22544.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 22537-22544
-
-
Wei, J.1
Zhai, L.2
Xu, J.3
Wang, H.4
-
160
-
-
33745753378
-
Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b
-
Buchwald, G.; van der Stoop, P.; Weichenrieder, O.; Perrakis, A.; van Lohuizen, M.; Sixma, T.K. Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b. EMBO J.2006, 25, 2465–2474.
-
(2006)
EMBO J
, vol.25
, pp. 2465-2474
-
-
Buchwald, G.1
Van Der Stoop, P.2
Weichenrieder, O.3
Perrakis, A.4
Van Lohuizen, M.5
Sixma, T.K.6
-
161
-
-
7244234099
-
Role of histone H2A ubiquitination in Polycomb silencing
-
Wang, H.; Wang, L.; Erdjument-Bromage, H.; Vidal, M.; Tempst, P.; Jones, R.S.; Zhang, Y. Role of histone H2A ubiquitination in Polycomb silencing. Nature2004, 431, 873–878.
-
(2004)
Nature
, vol.431
, pp. 873-878
-
-
Wang, H.1
Wang, L.2
Erdjument-Bromage, H.3
Vidal, M.4
Tempst, P.5
Jones, R.S.6
Zhang, Y.7
-
162
-
-
48749092149
-
Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity
-
Ohtsubo, M.; Yasunaga, S.; Ohno, Y.; Tsumura, M.; Okada, S.; Ishikawa, N.; Shirao, K.; Kikuchi, A.; Nishitani, H.; Kobayashi, M.; et al. Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity. Proc. Natl. Acad. Sci. USA2008, 105, 10396–10401.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 10396-10401
-
-
Ohtsubo, M.1
Yasunaga, S.2
Ohno, Y.3
Tsumura, M.4
Okada, S.5
Ishikawa, N.6
Shirao, K.7
Kikuchi, A.8
Nishitani, H.9
Kobayashi, M.10
-
163
-
-
84873120891
-
RNF2/Ring1b negatively regulates p53 expression in selective cancer cell types to promote tumor development
-
Su, W.J.; Fang, J.S.; Cheng, F.; Liu, C.; Zhou, F.; Zhang, J. RNF2/Ring1b negatively regulates p53 expression in selective cancer cell types to promote tumor development. Proc. Natl. Acad. Sci. USA2013, 110, 1720–1725.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 1720-1725
-
-
Su, W.J.1
Fang, J.S.2
Cheng, F.3
Liu, C.4
Zhou, F.5
Zhang, J.6
-
164
-
-
66949152096
-
Parkinson’s disease
-
Lees, A.J.; Hardy, J.; Revesz, T. Parkinson’s disease. Lancet2009, 373, 2055–2066.
-
(2009)
Lancet
, vol.373
, pp. 2055-2066
-
-
Lees, A.J.1
Hardy, J.2
Revesz, T.3
-
165
-
-
78649463381
-
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy
-
Gegg, M.E.; Cooper, J.M.; Chau, K.Y.; Rojo, M.; Schapira, A.H.; Taanman, J.W. Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy. Hum. Mol. Genet. 2010, 19, 4861–4870.
-
(2010)
Hum. Mol. Genet
, vol.19
, pp. 4861-4870
-
-
Gegg, M.E.1
Cooper, J.M.2
Chau, K.Y.3
Rojo, M.4
Schapira, A.H.5
Taanman, J.W.6
-
166
-
-
75949130828
-
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
-
Geisler, S.; Holmström, K.M.; Skujat, D.; Fiesel, F.C.; Rothfuss, O.C.; Kahle, P.J.; Springer, W. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat. Cell Biol. 2010, 12, 119–131.
-
(2010)
Nat. Cell Biol
, vol.12
, pp. 119-131
-
-
Geisler, S.1
Holmström, K.M.2
Skujat, D.3
Fiesel, F.C.4
Rothfuss, O.C.5
Kahle, P.J.6
Springer, W.7
-
167
-
-
77954695260
-
P62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria
-
Okatsu, K.; Saisho, K.; Shimanuki, M.; Nakada, K.; Shitara, H.; Sou, Y.S.; Kimura, M.; Sato, S.; Hattori, N.; Komatsu, M.; et al. p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria. Genes Cells2010, 15, 887–900.
-
(2010)
Genes Cells
, vol.15
, pp. 887-900
-
-
Okatsu, K.1
Saisho, K.2
Shimanuki, M.3
Nakada, K.4
Shitara, H.5
Sou, Y.S.6
Kimura, M.7
Sato, S.8
Hattori, N.9
Komatsu, M.10
-
168
-
-
77950384477
-
Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin
-
Ziviani, E.; Tao, R.N.; Whitworth, A.J. Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin. Proc. Natl. Acad. Sci. USA2010, 107, 5018–5023.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 5018-5023
-
-
Ziviani, E.1
Tao, R.N.2
Whitworth, A.J.3
-
169
-
-
65649118917
-
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
-
Xiong, H.; Wang, D.; Chen, L.; Choo, Y.S.; Ma, H.; Tang, C.; Xia, K.; Jiang, W.; Ronai, Z.; Zhuang, X.; et al. Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J. Clin. Investig. 2009, 119, 650–660.
-
(2009)
J. Clin. Investig
, vol.119
, pp. 650-660
-
-
Xiong, H.1
Wang, D.2
Chen, L.3
Choo, Y.S.4
Ma, H.5
Tang, C.6
Xia, K.7
Jiang, W.8
Ronai, Z.9
Zhuang, X.10
-
170
-
-
84876886863
-
The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO
-
Müller-Rischart, A.K.; Pilsl, A.; Beaudette, P.; Patra, M.; Hadian, K.; Funke, M.; Peis, R.; Deinlein, A.; Schweimer, C.; Kuhn, P.H.; et al. The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO. Mol. Cell2013, 49, 908–921.
-
(2013)
Mol. Cell
, vol.49
, pp. 908-921
-
-
Müller-Rischart, A.K.1
Pilsl, A.2
Beaudette, P.3
Patra, M.4
Hadian, K.5
Funke, M.6
Peis, R.7
Deinlein, A.8
Schweimer, C.P.9
-
171
-
-
84868575932
-
Mitochondrial quality control mediated by PINK1 and Parkin: Links to parkinsonism
-
a011338
-
Narendra, D.; Walker, J.E.; Youle, R. Mitochondrial quality control mediated by PINK1 and Parkin: Links to parkinsonism. Cold Spring Harb. Perspect. Biol. 2012, 4, a011338.
-
(2012)
Cold Spring Harb. Perspect. Biol
, vol.4
-
-
Narendra, D.1
Walker, J.E.2
Youle, R.3
-
172
-
-
34548259958
-
P62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
-
Pankiv, S.; Clausen, T.H.; Lamark, T.; Brech, A.; Bruun, J.A.; Outzen, H.; Øvervatn, A.; Bjørkøy, G.; Johansen, T. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 2007, 282, 24131–24145.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 24131-24145
-
-
Pankiv, S.1
Clausen, T.H.2
Lamark, T.3
Brech, A.4
Bruun, J.A.5
Outzen, H.6
Øvervatn, A.7
Bjørkøy, G.8
Johansen, T.9
-
173
-
-
84920095272
-
The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy
-
Cornelissen, T.; Haddad, D.; Wauters, F.; van Humbeeck, C.; Mandemakers, W.; Koentjoro, B.; Sue, C.; Gevaert, K.; de Strooper, B.; Verstreken, P.; et al. The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy. Hum. Mol. Genet. 2014, 23, 5227–5242.
-
(2014)
Hum. Mol. Genet
, vol.23
, pp. 5227-5242
-
-
Cornelissen, T.1
Haddad, D.2
Wauters, F.3
Van Humbeeck, C.4
Mandemakers, W.5
Koentjoro, B.6
Sue, C.7
Gevaert, K.8
De Strooper, B.P.9
-
174
-
-
84903179483
-
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy
-
Bingol, B.; Tea, J.S.; Phu, L.; Reichelt, M.; Bakalarski, C.E.; Song, Q.; Foreman, O.; Kirkpatrick, D.S.; Sheng, M. The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. Nature2014, 510, 370–375.
-
(2014)
Nature
, vol.510
, pp. 370-375
-
-
Bingol, B.1
Tea, J.S.2
Phu, L.3
Reichelt, M.4
Bakalarski, C.E.5
Song, Q.6
Foreman, O.7
Kirkpatrick, D.S.8
Sheng, M.9
-
175
-
-
84920892842
-
USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin
-
Durcan, T.M.; Tang, M.Y.; Pérusse, J.R.; Dashti, E.A.; Aguileta, M.A.; McLelland, G.L.; Gros, P.; Shaler, T.A.; Faubert, D.; Coulombe, B.; et al. USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin. EMBO J. 2014, 33, 2473–2491.
-
(2014)
EMBO J
, vol.33
, pp. 2473-2491
-
-
Durcan, T.M.1
Tang, M.Y.2
Pérusse, J.R.3
Dashti, E.A.4
Aguileta, M.A.5
McLelland, G.L.6
Gros, P.7
Shaler, T.A.8
Faubert, D.9
Coulombe, B.10
-
176
-
-
82855170834
-
Ambra1: A Parkin-binding protein involved in mitophagy
-
Van Humbeeck, C.; Cornelissen, T.; Vandenberghe, W. Ambra1: A Parkin-binding protein involved in mitophagy. Autophagy2011, 7, 1555–1556.
-
(2011)
Autophagy
, vol.7
, pp. 1555-1556
-
-
Van Humbeeck, C.1
Cornelissen, T.2
Vandenberghe, W.3
-
177
-
-
84905573756
-
Bcl-2 family proteins participate in mitochondrial quality control by regulating Parkin/PINK1-dependent mitophagy
-
Hollville, E.; Carroll, R.G.; Cullen, S.P.; Martin, S.J. Bcl-2 family proteins participate in mitochondrial quality control by regulating Parkin/PINK1-dependent mitophagy. Mol. Cell2014, 55, 451–466.
-
(2014)
Mol. Cell
, vol.55
, pp. 451-466
-
-
Hollville, E.1
Carroll, R.G.2
Cullen, S.P.3
Martin, S.J.4
-
178
-
-
79953796695
-
Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy
-
Strappazzon, F.; Vietri-Rudan, M.; Campello, S.; Nazio, F.; Florenzano, F.; Fimia, G.M.; Piacentini, M.; Levine, B.; Cecconi, F. Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy. EMBO J. 2011, 30, 1195–1208.
-
(2011)
EMBO J
, vol.30
, pp. 1195-1208
-
-
Strappazzon, F.1
Vietri-Rudan, M.2
Campello, S.3
Nazio, F.4
Florenzano, F.5
Fimia, G.M.6
Piacentini, M.7
Levine, B.8
Cecconi, F.9
-
179
-
-
84876865718
-
Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy
-
Yang, Y.; Fiskus, W.; Yong, B.; Atadja, P.; Takahashi, Y.; Pandita, T.K.; Wang, H.G.; Bhalla, K.N. Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy. Proc. Natl. Acad. Sci. USA2013, 110, 6841–6846.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 6841-6846
-
-
Yang, Y.1
Fiskus, W.2
Yong, B.3
Atadja, P.4
Takahashi, Y.5
Pandita, T.K.6
Wang, H.G.7
Bhalla, K.N.8
-
180
-
-
77952566949
-
Mechanisms, regulation and consequences of protein SUMOylation
-
Wilkinson, K.A.; Henley, J.M. Mechanisms, regulation and consequences of protein SUMOylation. Biochem. J. 2010, 428, 133–145.
-
(2010)
Biochem. J
, vol.428
, pp. 133-145
-
-
Wilkinson, K.A.1
Henley, J.M.2
-
181
-
-
84870195275
-
Function and regulation of SUMO proteases
-
Hickey, C.M.; Wilson, N.R.; Hochstrasser, M. Function and regulation of SUMO proteases. Nat. Rev. Mol. Cell Biol. 2012, 13, 755–766.
-
(2012)
Nat. Rev. Mol. Cell Biol
, vol.13
, pp. 755-766
-
-
Hickey, C.M.1
Wilson, N.R.2
Hochstrasser, M.3
-
182
-
-
36749009119
-
PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing
-
Ivanov, A.V.; Peng, H.; Yurchenko, V.; Yap, K.L.; Negorev, D.G.; Schultz, D.C.; Psulkowski, E.; Fredericks, W.J.; White, D.E.; Maul, G.G.; et al. PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing. Mol. Cell2007, 28, 823–837.
-
(2007)
Mol. Cell
, vol.28
, pp. 823-837
-
-
Ivanov, A.V.1
Peng, H.2
Yurchenko, V.3
Yap, K.L.4
Negorev, D.G.5
Schultz, D.C.6
Psulkowski, E.7
Fredericks, W.J.8
White, D.E.9
-
183
-
-
84920873822
-
KAPtain in charge of multiple missions: Emerging roles of KAP1
-
Cheng, C.T.; Kuo, C.Y.; Ann, D.K. KAPtain in charge of multiple missions: Emerging roles of KAP1. World J. Biol. Chem. 2014, 5, 308–320.
-
(2014)
World J. Biol. Chem
, vol.5
, pp. 308-320
-
-
Cheng, C.T.1
Kuo, C.Y.2
Ann, D.K.3
-
184
-
-
84883492690
-
It takes two to tango: Ubiquitin and SUMO in the DNA damage response
-
Bologna, S.; Ferrari, S. It takes two to tango: Ubiquitin and SUMO in the DNA damage response. Front. Genet. 2013, 11, 106.
-
(2013)
Front. Genet
, vol.11
, pp. 106
-
-
Bologna, S.1
Ferrari, S.2
-
185
-
-
33748525164
-
Role of desumoylation in the development of prostate cancer
-
Cheng, J.; Bawa, T.; Lee, P.; Gong, L.; Yeh, E.T. Role of desumoylation in the development of prostate cancer. Neoplasia2006, 8, 667–676
-
(2006)
Neoplasia
, vol.8
, pp. 667-676
-
-
Cheng, J.1
Bawa, T.2
Lee, P.3
Gong, L.4
Yeh, E.T.5
-
186
-
-
17844401262
-
A role for Ubc9 in tumorigenesis
-
Mo, Y.Y.; Yu, Y.; Theodosiou, E.; Ee, P.L.; Beck, W.T. A role for Ubc9 in tumorigenesis. Oncogene2005, 24, 2677–2683.
-
(2005)
Oncogene
, vol.24
, pp. 2677-2683
-
-
Mo, Y.Y.1
Yu, Y.2
Theodosiou, E.3
Ee, P.L.4
Beck, W.T.5
|